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Broadline is the latest all-round parasite treatment for cats. It is easily applied to the back of the neck as a simple spot-on and then provides effective treatment against all major internal and external parasites.
It contains a range of ingredients to produce a powerful effect against fleas, ticks, internal roundworms and tapeworms. At the time of introduction, this is the widest range of parasites treated by one simple medication available for cats.
Broadline is applied once a month for complete parasite control in cats.
A new product has taken a leap closer to joining Advocate and Stronghold in the fight to be called the UK's 'top feline anti-parasitic'. Merial have furthered their leading flea and tick treatments 'Frontline' and 'Frontline Combo' and taken things not one, but two steps further . In order to beat products currently seen as 'the best', Merial had to come up with something that does that little bit extra; Broadline is a broad spectrum insecticidal, miticidal, anthelmintic spot on, able to provide total coverage of common feline parasites.
Broadline contains four active ingredients: fipronil, (S)-methoprene, praziquantel and eprinomectin. As an E-SQP reading about this for the first time, I immediately recognised and could relate to three of the active ingredients. Eprinomectin was a new name to me but I was at least able to link it to a group of wormers, the macrocyclic lactones (MLs)- quite exciting as I realised this meant that roundworms, fleas, ticks and tapeworms were all covered in one treatment. Furthermore, MLs are also highly effective against both lice and mites, conveying greater protection as an endectoside.
I am sure SQPs who have studied the Farm Animal Module will be familiar with the Merial's POM-VPS 'Eprinex Pour-On', a topical solution for cattle containing eprinomectin. If like me you hadn't heard of it, it is still clear to see that it only seems natural to try and combine active ingredients from two successful products.
I've never been one to just accept that something does a job- I need an explanation because quite frankly, I would forget its importance otherwise! I started looking into eprinomectin and found that it is a semi-synthetic avermectin, indeed a derivative of MLs. In keeping with a ML mechanism of action, eprinomectin binds to invertebrate ligand-gated ion channels and in particular, has a high affinity for glutamate-gate chloride channels (GluCls) and exerts anti-parasitic properties by causing neurotoxicosis. GluCls play vital roles in feeding, locomotion and other behaviours. When a ML such as eprinomectin binds to and opens these channels, the cell membrane is made more permeable to chloride ions. Subsequent influx of ions produces hyperpolarisation of either the muscle or nerve cell and paralysis which ultimately leads to death of the parasite. Mammals do not have GluCls and eprinomectin has low affinity for other ligand-gated ion channels mammals possess. Additionally, while the chemical is absorbed into the bloodstream, it is unable to cross the blood-brain barrier and along with other MLs well known to E-SQPs such as ivermectin, is very safe.
Alongside eprinomectin's action against the wide range of roundworms, lice and mites, the remaining three active ingredients target fleas, ticks and tapeworms. Fipronil and (S)-methoprene are renowned for their efficacy against fleas, working in different ways to break their life cycle. Fipronil acts through non-competitive inhibition of insect GABA receptors, blocking flow of ions and leaving the central nervous system uncontrolled, resulting in death of the adult fleas. It is effective against ticks in the same way. Females are sterilised by (S)-methoprene, as it mimics an insect hormone to prevent sexual development and further build up of eggs in the environment. Praziquantel delivers the final blow to the yet untouched tapeworm population, leaving them paralysed and unable to resist digestion by the host. They lose hold of their position in the gut and are either fully digested and or passed out in fragments.
Each unit dose applicator delivers:
Broadline Spot-on Solution
Volume of unit dose (ml)
Cats <2.5 kg
Cats 2.5-7.5 kg
Excipient: Butylhydroxytoluene (E321) 1 mg/ml. For a full list of excipients, see below.
Spot-on solution. Clear colourless to yellow solution.
For cats with or at risk from mixed infestations by cestodes, nematodes and ectoparasites. The product is exclusively indicated when all three groups are targeted at the same time.
- Treatment and prevention of infestations by fleas (Ctenocephalides felis). Elimination of fleas within 24 hours. One treatment prevents further infestations for at least one month.
- Prevention of environmental flea contamination by inhibiting the development of flea immature stages (eggs, larvae and pupae) for over one month.
- Can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).
- Treatment and prevention of infestations by ticks (Ixodes ricinus). Elimination of ticks within 48 hours. One treatment prevents further infestations for up to 3 weeks.
- Treatment of infestations with tapeworms (Dipylidium caninum, Taenia taeniaeformis, Echinococcus multilocularis).
- Treatment of infestations with gastrointestinal nematodes (L3, L4 larvae and adults of Toxocara cati, L4 larvae and adults of Ancylostoma tubaeforme, and adult forms of Toxascaris leonina and Ancylostoma brazilienze).
- Treatment of infestations with vesical worms (Capillaria plica).
- Prevention of heartworm disease (Dirofilaria immitis larvae) for one month.
Do not use in sick or convalescent cats.
Do not use in rabbits.
Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
When applying the product, special attention should be paid in long hair breeds in order to ensure that it is applied directly to the skin and not on the hair, as this could lead to a lower bioavailability of the active substances and thus, to a reduced efficacy.
It is important to apply the product to an area of skin where the cat cannot lick it off. Avoid animals licking each other following treatment.
No data on the effect of bathing/shampooing on the efficacy of the product in cats is available. However, brief contact of the animal with water on one or two occasions within the month following application is unlikely to significantly reduce its efficacy. As a precaution, it is not recommended to bathe animals within 2 days after treatment.
After treatment, ticks will generally be killed within 48 hours after infestation without having a blood meal. However, since the attachment of single ticks after treatment cannot be excluded, transmission of infectious diseases cannot be completely ruled out.
Tapeworm infestation may reoccur unless control of intermediate hosts such as fleas, mice etc. is undertaken.
Parasite resistance to any particular class of antiparasitic drug may develop following frequent use of a compound of that class. Therefore, epidemiological information about current susceptibility of the target species should be taken into account in order to limit the possibility of a future selection for resistance.
Cats in areas endemic for heartworm, or those which have traveled to endemic areas, may be infected with adult heartworms. Although the product may be safely administered to cats infected with adult heartworms, no therapeutic effect against adult Dirofilaria immitis has been established. It is therefore recommended that all cats 6 months of age or more living in areas endemic for heartworm should be tested for existing adult heartworm infestation before being treated for heartwom prevention with the product.
In animals: Spot-on application only. Do not inject. Do not administer orally or via any other route. Avoid contact with the cat's eyes. The safety of the product has not been tested at intervals of less than 2 weeks or in kittens weighing less than 0.6 kg and/or under 7 weeks of age.
The product is not intended for use in dogs. Some dog breeds may present increased susceptibility to macrocyclic lactones, potentially leading to signs of neurotoxicity. Oral uptake by Collies, Old English Sheepdogs and related breeds or crossbreeds should thus be avoided. Echinococcosis represents a hazard for humans, and is a notifiable disease to the World Organisation for Animal Health (OIE).
Special precautions to be taken by the person administering the product to animals: DO not smoke, drink or eat during application. Wash hands after use. Unused applicators must be stored in the intact blister package.
Avoid contact of the applicator content with the fingers. If this occurs, wash off with soap and water. In case of accidental eye exposure flush the eyes thoroughly with water, as the product can cause slight mucous membrane and eye irritation. If eye irritation persists or if side effects are noted, seek medical advice and show the package leaflet or the label to the physician.
Handling of treated animals should be limited until the application site is dry, and children should not be allowed to play with treated animals during this period. It is therefore recommended that recently treated animals do not sleep with owners, especially children.
People with a known hypersensitivity to any of the active ingredients or excipients should avoid contact with the product.
A temporary clumping or spiking of the hair may be seen at the application site after treatment. Mild and transient skin reactions at the application site (itching, hair loss) may occur.
If the cat licks the application site after treatment, temporary excessive salivation can be observed. Oral ingestion of the product may also result in vomiting and/or in transient neurological signs such as ataxia, disorientation, apathy and pupil dilation.
All these signs resolve spontaneously within 24 hours. Correct application will minimise the occurrence of such events.
The safety of the product has not been established during pegnancy and lactation. Use only according to the benefit-risk assessment by the prescribing veterinarian.
The use of the product should exclusively be based on the confirmed mixed infestations or significant risk of such mixed infestations with ectoparasites and nematodes (including for heartworm disease prevention), and where concurrent treatment against cestodes is indicated.
In the absence of risk of co-infestation, the use of a narrow spectrum parasiticide should be considered as a first line therapy.
The rationale for prescription should be tailored to the individual needs of the cat, based on clinical assessment, the animal's lifestyle and on the local epidemiological situation 9including zoonotic risks, where relevant) in order to address exclusively situations of mixed infestations/risk of infestation.
Treatment should not be extrapolated from one animal to the other without veterinary opinion.
Dosage: The recommended minimum doses are 10 mg/kg bodyweight for fipronil, 12 mg/kg for (S)-methoprene, 0.5 mg/kg for eprinomectin and 10 mg/kg for praziquantel.
Select the appropriate applicator size for the weight of the cat.
1 x 0.3 ml applicator
2.5 - 7.5 kg
1 x 0.9 ml applicator
Appropriate combination of applicators
Method of administration: Use a pair of scissors to cut the blister along the dotted line, then pull the lid away. Remove the applicator from the package and hold it upright. Pull back the plunger slightly, twist and pull the cap off. Part the hair on the midline of the neck, between the base of the skull and the shoulder blades until the skin is visible. Place the tip of the applicator on the skin and apply the entire content directly onto the skin in one spot.
Prevention of heartworm disease should start within 1 month after the first expected exposure to mosquitoes.
Safety has been demonstrated with up to 5 times the maximum exposure dose (i.e. up to 15 times the recommended dose) in healthy kittens aged 7 weeks and older treated up to 6 times at four-week intervals. It has also been confirmed in healthy adult cats treated 3 times at two-week intervals with up to 5 times the recommended dose. Mild and transient nuerological signs such as ataxia, disorientation, apathy and pupil dilation may be observed, with spontaneous recovery the day after. Transient salivation and/or vomiting could also be observed, in both kittens and adult cats, in isolated cases.
Cats infected with adult heartworms tolerated up to 3 times the maximum exposure dose (i.e. up to 9 times the recommended dose), every 4 weeks for 3 treatments, without any adverse effects.
ATCvet code QP54AA
Disodium edetate (E385)
Propyl gallate (E310)
Shelf life of the product as packaged for sale: 2 years.
Store in the original package in order to protect from light. Stored applicators must be kept in the intact blister package. Opened applicators should be disposed of immediately.
Unit dose syringe-shaped applicator containing 0.3 ml or 0.9 ml of product, closed with a polymer cap and placed in individual plastic blisters. Cardboard box containing applicators of 3 x 0.3 ml, 3 x 0.9 ml or 6 x 0.9 ml.
Any unused product or waste materials derived from this product should be disposed of in accordance with local requirements. Do not contaminate ponds, waterways or ditches with the product or empty containers as this may be dangerous for fish and aquatic organisms.
Broadline spot-on for cats <2.5 kg 3x 0.3 ml
Broadline spot-on for cats 2.5-7.5 kg 3x 0.9 ml
Broadline spot-on for cats 2.5-7.5 kg 6x 0.9 ml
All prices include VAT where applicable.
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