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Active ingredient eprinomectin. In a convenient pour-on formulation, broad spectrum anthelmintic for the control of roundworms, lungworms, warbles, mange mites and lice on beef and dairy cattle. 21 days meat withdrawl. Nil milk withdrawl. POM-VPS.
Below is the product datasheet. This has been provided by the manufacturer and should always be provided with the medication.
Company name: Merial Animal Health Ltd
Address: PO Box 327
Harlow Business Park
Essex CM19 5TG
Telephone: Companion Animals 0870 6000123
Production Animals 0800 592699
Fax: 01279 775888
A pour-on solution containing 0.5% w/v eprinomectin for topical use in cattle.
For treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi and Cooperia spp.), lungworms, warbles, sucking and biting lice, chorioptic and sarcoptic mange mites in beef and dairy cattle.
EPRINEX Pour-On for Beef and Dairy Cattle, applied at the recommended dose volume of 1 ml/10 kg bodyweight, to achieve a dose level of 500 micrograms eprinomectin/kg, is indicated for treatment and control of the following parasites:
|Warbles (parasitic stages):||Adult||Immature|
|Sarcoptes scabiei var. bovis||•||•|
EPRINEX Pour-On for Beef and Dairy Cattle, applied as recommended, controls re-infections with the following parasites:
|Dictyocaulus viviparus||up to 28 days|
|Ostertagia ostertagi||up to 28 days|
|Ostertagia lyrata||up to 28 days|
|Oesophagostomum radiatum||up to 28 days|
|Cooperia oncophora||up to 21 days|
|Cooperia punctata||up to 21 days|
|Cooperia surnabada||up to 21 days|
|Trichostrongylus axei||up to 21 days|
|Trichostrongylus colubriformis||up to 21 days|
|Haemonchus placei||up to 14 days|
|Nematodirus helvetianus||up to 14 days|
For best results EPRINEX Pour-On for Beef and Dairy Cattle should be part of a programme to control both internal and external parasites of cattle based on the epidemiology of these parasites.
Administer only by topical application at the dose rate of 1 ml per 10 kg bodyweight, corresponding to the recommended dose rate of 0.5mg eprinomectin per kg bodyweight. The product should be applied topically by pouring along the backline in a narrow strip extending from the withers to the tailhead.
To ensure administration of a correct dose, bodyweight should be determined as accurately as possible; accuracy of the dosing device should be checked.
For animal treatment only.
This product is formulated only for topical application to beef and dairy cattle, including lactating dairy cattle. Do not use in other animal species; avermectins can cause fatalities in dogs. Do not administer orally or by injection.
Do not apply to areas of the backline covered with mud or manure.
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:-
- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
- Underdosing, which may be due to underestimation of bodyweight, misadministration of the product, or lack of calibration of the dosing device (if any).
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
To date no resistance to eprinomectin (a macrocyclic lactone) has been reported within the EU. However resistance to other macrocyclic lactones has been reported in parasite species in cattle within the EU.
Therefore, use of this product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.
Use during pregnancy and lactation
Milk from cows may be used for human consumption at any time following treatment with EPRINEX Pour-On for Beef and Dairy Cattle. Studies have demonstrated a wide safety margin. Studies conducted at three times the recommended use level of 0.5 mg eprinomectin per kg bodyweight had no adverse effect on breeding performance of cows or bulls. EPRINEX Pour-On for Beef and Dairy Cattle may be used in dairy cattle during all stages of pregnancy and lactation.
Safety in target species
Studies have demonstrated a wide safety margin.
Meat may only be taken for human consumption from 15 days after the last treatment.
There is no milk withdrawal period for lactating dairy cattle. Milk from treated cows may be used for human consumption at any time following treatment with EPRINEX Pour-On for Beef and Dairy Cattle.
Operators should wear rubber gloves when applying the product.
If accidental skin contact occurs, wash the affected area immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water.
Do not smoke, eat or drink while handling the product.
Wash hands after use.
Should clothing become contaminated, remove as soon as possible and launder before re-use. In the event of ingestion, wash out mouth with water and seek medical advice.
DANGEROUS TO FISH AND AQUATIC LIFE. Do not contaminate surface waters or ditches with the product or used container. Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Keep container in the outer carton. Protect from light.
Keep out of the reach and sight of children.
EPRINEX Pour-On for Beef and Dairy Cattle is available in four pack sizes – 250 ml, 1 litre, 2.5 litres and 5 litres.
Rainfall at any time before or after treatment will not affect the efficacy of the product.
While mite and louse numbers decline rapidly following treatment, due to the feeding habits of the parasites, in some cases several weeks may be required for complete eradication.
No signs of toxicity appeared when 8-week old calves were treated at up to 5 times the therapeutic dose (i.e. 2.5 mg eprinomectin per kg bodyweight), 3 times at 7-day intervals. One calf treated once at 10 times the therapeutic dose (i.e. 5 mg per kg bodyweight) in the tolerance study showed transient mydriasis. There were no other adverse reactions to treatment. No antidote has been identified.
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