Xeno 450 Spot-On Parasite & Flea Treatment

Xeno 450 Spot-On Parasite & Flea Treatment
Pack of 6

Images are for illustration purposes only. Packaging may change from time to time and images on our website may or may not be updated.

  • Pack of 6 £36.99


Xeno 450 is a convenient and effective spot-on treatment for use on rabbits, guinea pigs and ferrets over 1.2kg, and birds over 666g. The treatment contains 450 micrograms of the active ingredient Ivermectin- an antiparasitic medicine effective against both ecto and endo-parasites, including fleas, lice, mites and intestinal round-worms. The spot-on is not suitable for use on pregnant or lactating animals, or animals under 16 weeks of age, but is an effective treatment against fur, mange and ear mites in rabbits and guinea pigs, as well as lice in guinea pigs and heartworm in ferrets. The treatment may also be used for rats, mice and gerbils.



Company name: Dechra Veterinary Products Limited

Address: (A business unit of Dechra Pharmaceuticals PLC)

Sansaw Business Park

Hadnall, Shrewsbury

Shropshire SY4 4AS

Telephone: 01939 211200

Fax: 01939 211201

Email: [email protected]

Website: www.dechra.com

Small Animal Exemption Scheme (SAES) product

Qualitative and quantitative composition

1 pipette contains: Active substance: Ivermectin 450 µg

Pharmaceutical form

Spot-on solution for topical administration.

Clinical particulars

Target species

Rabbits, guinea pigs and ferrets over 1.2 kg body weight, and birds over 666 g body weight.

Indications for use

Topical insecticidal and acaricidal spot-on solution. A simple and effective spot-on solution for prevention and treatment of common internal and external parasites of small mammals and birds.

Applied to the skin, Xeno 450 is absorbed into the body and is particularly effective against the parasites which cause ear disease in the rabbit and ferret, and the mites that cause skin disease in guinea pigs and rabbits, including mange in guinea pigs and the condition known as walking dandruff in rabbits. It is also effective against many of the parasites which cause skin and feather problems in birds.

The active substance, ivermectin, is a substance known as an endectocide because it kills parasites that cause infestation inside the body (endoparasites) as well as those living outside the body on the skin (ectoparasites). Ivermectin is used in many species for the control of mites, roundworms and lice.


Do not use in animals other than those indicated. Serious reactions, including deaths, have been reported in dogs (especially Collies, Old English Sheepdogs and related breeds), tortoises and turtles treated with products containing the active substance.

This product is toxic to chelonians. Do not use in tortoises, turtles or related species.

Special warnings

Do not overdose.

If you are uncertain about the condition of your pet, consult a veterinary surgeon.

If symptoms persist, consult a veterinary surgeon.

Special precautions to be taken by the person administering the product to animals

Wash hands with soap and water following treatment.

Adverse reactions

Occasionally, central nervous system disorders, lethargy, inappetance, local irritation and/or hypersensitivity reactions may be observed. These signs may be more common in young animals. Should such a reaction occur, discontinue use and seek veterinary advice.

If you notice any serious effects or other effects not mentioned in this data sheet, please inform your veterinary surgeon.

Method of administration

Topical insecticidal and acaricidal spot-on solution. Each pipette contains 450 μg ivermectin. Each pipette contains approximately 20 drops. Each drop will deliver approximately 22.5 μg ivermectin.

Xeno 450 Spot-on Dosage Guidelines


Body weight

Amount to use

Rabbits, guinea pigs and ferrets (200-400 μg/kg)

1.2 kg to

2.25 kg

1 pipette

Rabbits, guinea pigs and ferrets (200-400 μg/kg)

2.25 kg to

4.5 kg

2 pipettes

Rabbits, guinea pigs and ferrets (200-400 μg/kg)

4.5 kg to

6.75 kg

3 pipettes


(225 μg/kg)

Over 666 g body weight

1 drop per

100 g body weight

( μg = microgram )

Avoid use in or around the eyes. Do not overdose. In order to apply a correct dosage it is essential to accurately weigh the animal. Your veterinary practice can help you to do this. For birds less than 666 g consider the use of Xeno 50-mini or Xeno 200 spray.

Mammals: Using the dosage table, apply the correct number of drops or pipettes onto the skin on the back of the neck and down the spine.

Birds: Apply 1 drop (22.5 μg) per 100 g body weight under the feathers onto the skin of the back between the wings.

For routine prevention of common ectoparasites this dose should be repeated monthly.

For the treatment of an existing infestation, repeat doses are required two weeks and four weeks after the initial application.

Withdrawal period

For pet animals only. Do not use in animals intended for human consumption. Do not eat eggs from treated birds.

Pharmaceutical particulars

Special precautions for storage

Keep out of the sight and reach of children. Do not store above 25°C. Protect from direct sunlight.

Immediate packaging

Cartons containing 6 polypropylene tubes, each of 450 µg ivermectin.


Discard remaining contents of any opened pipettes immediately following use. Dispose of waste materials in accordance with local requirements.

Legal category


Further information

Manufacturer's authorisation number: SAM 0011

For animal treatment only.

This product is not effective against ringworm. Ringworm is a skin disease which can be passed on from your pet to humans. If you think your pet may have ringworm, you should consult a veterinary surgeon.

For any information about this veterinary medicinal product, please contact the distributor.

Date of last review: September 2013

GTIN (Global Trade Item No)

Xeno 450 Spot-on Solution for Topical Administration 6 pipettes:


Need help or advice? Contact us:

All prices include VAT where applicable.

Reviews (5)

Summary of Reviews for Xeno 450 Spot-On Parasite & Flea Treatment

Overall 5
Ease Of Use
Value For Money
Absence Of Side Effects
5 out of 5 (100%) customers would recommend this product.
5 stars (4 reviews)
4 stars (1 reviews)
3 stars (0 reviews)
2 stars (0 reviews)
1 stars (0 reviews)

Only verified purchasers of this product can leave a review.

55 Bought for chickens
Verified Purchase

By on 5 November 2023

Very effective at eliminating parasites and fleas on chickens.

Customer recommends this product

45 Xeno450
Verified Purchase

By on 4 November 2023

Good product sent promptly

Customer recommends this product

55 Good
Verified Purchase

By on 19 August 2018

Delivered quickly

Customer recommends this product

55 Works well as an earmite treatment for ferrets
Verified Purchase

By on 24 June 2015

I generally use as a treatment for earmites, simply spotting on the back of the neck as per the instructions seems to work well if any of the ferrets have earmites (case of having to treat all of them even if its only the one ferret with signs). Have also used it for flea treatment if a stray has arrived and I have had no other treatment to hand as it will kill adult fleas. As with most spotons the ferrets arent so keen at having it on their necks but hasnt caused any adverse effects.

Customer recommends this product

55 Xeno 450 parasite treatment
Verified Purchase

By on 12 October 2014

Arrived super quick the v next morning. Sorted problem v quickly also

Customer recommends this product

Q & A

Below are some recent questions we've received regarding Xeno 450 Spot-On Parasite & Flea Treatment, including answers from our team.

4 June 2022 at 2:05pm

Does this treatment kill fleas?


Does this treatment actually kill the fleas and if so how long does it take? My rabbit was treated a week ago but still has a lot of fleas crawling in his fur.

  • VioVet Staff

This product contains ivermectin which does not kill fleas unfortunately. It is advised to use Advantage to treat fleas in your rabbit instead. I also advise reading our blog on approaching the condition, link provided here. It is worth noting that Advantage must be used weekly whilst clearing the flea problem in rabbits.

26 June 2020 at 11:50pm

Can Xeno Spot-on treatment be used with open wounds?


My pet got into a fight and has a cut along their back. It's not deep, but is pretty long.

Is it safe to still use the Xeno treatment on the skin with the open wound?

  • VioVet Staff

This medication should only be applied as directed to areas of skin that are broken. It should not be used directly on cuts/open wounds.

4 April 2020 at 11:51am

Does zeno450 work immediately


In a bad case of ear mites will Zeno 450 stop discomfort immediately.

  • VioVet Staff


The product is applied to the back of the neck and down the spine, and is absorbed into the blood stream where it will then have an effect on the ear mites. You should notice a reduction in the infestation within the first 24 hours but the product does not have any action against the discomfort your pet will feel. However, as the mites are killed and there are fewer in the ears, biting anf causing irritation, your pet should quickly start to feel more comfortable as the ears get chance to heal.

I hope this helps!

23 April 2016 at 12:58pm

Dwarf hamster mites

Theresa Floyd

Is this suitable to use on dwarf hamsters, Russian winter white, to prevent problems with parasites please.

  • VioVet Staff

It depends on the type of parasite being considered. Generally speaking this is one of the best type of anti-parasite product for use in small animals. However, hamsters are unusual in that their most common internal parasites are tapeworms, which are not affected by this type of wormer. Hamsters do also get pin worms sometimes as well as skin mites and these do all usually respond to this form of treatment. The drug praziquantel is best used for tapeworms usually, which is present in the Droncit products. Your vet should be able to help you decide what needs to be done with your hamster.

4 June 2015 at 9:40am

Application Type


How is the medication administered to my Rabbit. Does it come in pipette form or power and do I have to measure the dosage?

  • VioVet Staff

You can click on the headings in the description and read the full information provided there. Basically these are pipettes of liquid, applied to the skin. The active ingredient is absorbed through the skin. You use one pipette for a rabbit weighing between 1.2kg and 2.25kg, or 2 pipettes for between 2.25kg and 4.5kg, or 3 pipettes for 4.5kg to 6.75kg, or 4 pipettes of over that weight.

10 June 2014 at 11:31pm

How often can xeno be applyed

anne otway

How often can i apply xeno to my ageing ferret he is 1-500kg my vet said 2 peppets for his size but i want to know how long to use it for.

  • VioVet Staff

The usual recommendation is to apply monthly if you need to. It is safe to apply as often as every 2 weeks as long as you do not overdose at the time. Monthly is normally plenty however.

4 May 2014 at 2:19am

Is Xeno safe to be used with Suprelorin implant?

VioVet Visitor

Is xeno safe to use with thesupperlorin implant in my ferret as he is old and has coushings .

  • VioVet Staff

Xeno 450 can certainly be used along with the Suprelorin implant. An older ferret with Cushings is probably quite frail anyway, but both of these products are safe to use in theory.

Delivery Information