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Vetivex Solutions for Injection or Infusion

Vetivex Solutions for Injection or Infusion
Isolec Hartmann's Solution » 250ml
No. 1 » Normal Saline » 100ml

  • Isolec Hartmann's Solution » 250ml £5.99
  • Isolec Hartmann's Solution » 500ml £7.99
  • Isolec Hartmann's Solution » 1 litre £8.50
  • Isolec Hartmann's Solution » 3 litre £19.49
  • Isolec Hartmann's Solution » 5 litre £18.49
  • No. 1 » Normal Saline » 100ml £4.99
  • No. 1 » Normal Saline » 500ml £6.49
  • No. 1 » Normal Saline » 1 litre £7.49
  • No. 1 » Normal Saline » 2 litre £19.49

Selection of 9 products from

£4.99 to £19.49

Description

A range of solutions designed to be given usually by intra-venous infusion.

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Medication Datasheets

No. 1 » Normal Saline » 1 litre

Vetivex® 1 (9 mg/ml) Solution for Infusion for Cattle, Horses, Dogs and Cats

Qualitative and quantitative composition

1 ml contains: Active substance:

Sodium chloride 9 mg

Sodium 150 mmol/litre

Chloride 150 mmol/litre

Pharmaceutical form

Solution for infusion. Clear, colourless solution.

Clinical particulars

Target species

Cattle, horses, dogs and cats.

Indications for use

This product is administered by intravenous infusion for the treatment of dehydration in cattle, horses, dogs and cats. It may be used to correct hypovolaemia resulting from shock or gastrointestinal disease (especially where metabolic alkalosis is present, e.g. in cases of sustained vomiting or abomasal disorders in cattle). It may be administered to meet normal fluid and electrolyte requirements when fluids cannot be given orally.

Contraindications

Do not use in animals with:

- hypernatraemia

- hyperchloraemia

- hyperhydration

- oedema (hepatic, renal, or cardiac)

Special precautions for use in animals

Do not use unless the solution is clear, free from visible particles and the container is undamaged. Sodium overload may occur in animals with cardiac or renal impairment. It should be noted that sodium excretion may be impaired post-surgery/trauma.

A risk of thrombosis with intravenous infusion should be considered.

Maintain aseptic precautions.

The product should be warmed to approximately 37°C prior to the administration of large volumes, or if the administration rate is high, in order to avoid hypothermia.

Use with caution in animals with hypokalaemia.

Serum electrolyte levels, water and acid-base balance and the clinical condition of the animal should be closely monitored during the treatment in order to prevent overdose, particularly in cases of renal or metabolic changes.

This product should not be used for longer than is necessary to correct and sustain circulating volume. This solution does not contain the appropriate electrolyte balance for longer term maintenance fluid administration.

Inappropriate/excessive use may worsen or create a metabolic acidosis.

Use during pregnancy and lactation

The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Use only accordingly to the benefit/risk assessment by the responsible veterinarian.

Interactions

It is recommended to take appropriate precautions in animals receiving corticosteroids or corticotrophins to prevent high blood pressure and excessive fluid retention during administration of large volumes.

Concomitant administration of colloids requires a dose reduction.

Amounts to be administered and administration route

Intravenous use.

The volume and rate of infusion will depend upon the clinical condition, existing deficits of the animal, maintenance needs and continuing losses.

Generally aim to correct hypovolaemia by 50% initially (ideally over 6 hours but faster if necessary) and reassess by clinical examination.

Deficits are generally in the range of 50 ml/kg (mild) to 150 ml/kg (severe). An infusion rate of 15 ml/kg/hour is recommended in the absence of shock (range 5-75 ml/kg/hour).

In shock, high initial infusion rates, up to 90 ml/kg/hour, are needed. High infusion rates should not be continued for longer than 1 hour unless urine output is restored. The maximum infusion rate should be decreased in the presence of cardiac, renal and pulmonary disease.

Overdose

It is recommended to maintain a serum sodium less than or equal to 130 mEq / l. In the presence of volume overload signs, treatment should involve administering diuretics and stopping the infusion.

Overdose may lead to hypernatraemia, hyperchloraemia, hypokalaemia, cardiac decompensation, hyperhydration and metabolic acidosis.

Clinical signs of excessive overdose include restlessness, hypersalivation, shivering, tachycardia, serous nasal discharge, tachypnoea, moist lung sounds, coughing, protrusion of the eye from the orbit, widespread oedema, vomiting and diarrhoea.

Long-term infusion may cause electrolyte imbalance. Saline solution is not balanced and it may cause acidaemia because it will increase renal elimination of bicarbonate. Prolonged use may cause hypokalaemia.

Withdrawal period

Meat and offal: zero days; Milk: zero hours.

Pharmacological particulars

Pharmacotherapeutic group: Electrolytes

ATCvet code: QB05BB01

Pharmacodynamic properties

Sodium chloride and water are normal constituents of the plasma of animals.

Sodium is the major cation of the extracellular space and regulates the size of this space together with other anions.

The sodium content and the fluid homeostasis of the body are closely related. Each deviation of the plasma sodium concentration from the physiological one simultaneously affects the fluid status of the body.

An increase in the sodium content of the body also means reduction of the body's free water content independent of the serum osmolarity.

A 0.9 per cent sodium chloride solution has the same osmolarity as plasma. Administration of this solution primarily leads to a replenishment of the interstitial space which is about 2/3 of the entire extracellular space. Only 1/3 of the administered volume remains in the intravascular space.

Pharmacokinetic properties

Sodium chloride administered by the intravenous route quickly joins the normal distribution and metabolism of sodium chloride and water, in the intracellular and extracellular spaces.

Sodium and chloride are normal components of the body and their balance is maintained by the kidneys. The sodium level of the veterinary medicinal product is similar to the physiological level in the serum.

The kidneys are the major regulator of the sodium and water balance. In cooperation with the hormonal control mechanisms (renin-angiotensin-aldosterone system, antidiuretic hormone), the kidneys are primarily responsible for the maintenance of a constant volume of the extracellular space and regulation of its fluid composition.

Chloride is exchanged for hydrogen carbonate in the tubule system. Thus, it is involved in the regulation of the acid-base balance.

Pharmaceutical particulars

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale:

100 ml: 18 months

500 ml, 1000 ml and 2000 ml: 2 years

The product should be used immediately and not stored after opening.

Special precautions for storage

Do not store above 25°C.

Do not freeze.

Immediate packaging

Polyvinylchloride infusion bag overwrapped with polypropylene.

Pack sizes: Individual fluid bags of 100 ml, 500 ml, 1000 ml and 2000 ml, each supplied with a package leaflet, or boxes containing 50 x 100 ml, 20 x 500 ml, 10 x 1000 ml, 4 x 2000 ml.

Not all pack sizes may be marketed.

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Dechra Limited, Snaygill Industrial Estate, Keighley Road, Skipton, North Yorkshire, BD23 2RW, United Kingdom.

Marketing Authorisation Number

Vm 10434/4079

Date of the first authorisation or date of renewal

20 June 2013

Date of revision of the text

November 2018

Any other information

For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children.

Manufacturer responsible for batch release: S C Infomed Fluids SRL, 50 Theodor Pallady blvd, District 3, 032266 Bucharest, Romania.

Legal category

Isolec Hartmann's Solution » 500ml

Vetivex® (Hartmann's) 11 Solution for Infusion for Cattle, Horses, Dogs and Cats

Qualitative and quantitative composition

1 ml contains: Active substances:

Sodium lactate 3.20 mg

Sodium chloride 6.00 mg

Potassium chloride 0.40 mg

Calcium chloride 0.20 mg

(equivalent to Calcium chloride dihydrate 0.27 mg)

Sodium 131 mmol/litre

Potassium 5 mmol/litre

Calcium 2 mmol/litre

Bicarbonate (as lactate) 29 mmol/litre

Chloride 111 mmol/litre

Pharmaceutical form

Solution for infusion. Clear, colourless solution.

Clinical particulars

Target species

Cattle, horses, dogs and cats.

Indications for use

This veterinary medicinal product is administered by intravenous infusion for the treatment of dehydration and metabolic acidosis in cattle, horses, dogs and cats. It may be used to correct volume depletion (hypovolaemia) resulting from gastrointestinal disease or shock.

Contraindications

Do not use in animals with:

- hyperkalaemia

- hypercalcaemia

- hypernatraemia

- hyperlactataemia

- hyperhydration

- metabolic alkalosis

- oedema (hepatic, renal, or cardiac)

- Addison's disease

Special precautions for use in animals

Do not use unless the solution is clear, free from visible particles, and the container is undamaged.

A risk of thrombosis with intravenous infusion should be considered.

Maintain aseptic precautions.

This veterinary medicinal product should be warmed to approximately 37°C prior to the administration of large volumes, or if the administration rate is high, in order to avoid hypothermia.

This veterinary medicinal product does not contain an antimicrobial preservative. It is intended for single use only and any unused contents should be discarded.

Use of this solution requires monitoring of the clinical and physiological status of the animal especially in cases of:

- severe renal impairment

- cardiac impairment

- sodium retention with oedema

- treatments with corticosteroids and their derivatives.

This veterinary medicinal product should be used with caution in animals with cardiac or renal impairment as sodium overload may occur. It should be noted that sodium excretion may be impaired post-surgery/trauma.

Monitor serum potassium and serum calcium in treated animals, particularly potassium levels in cases at risk of hyperkalaemia, such as during chronic renal failure.

In animals with hepatic impairment, the product may not produce its alkalising action since lactate metabolism may be altered.

Adverse reactions

Skin reactions (urticarial, eczema, skin lesions) and allergic oedema are very rarely observed.

The frequency of adverse reactions is defined using the following convention:

- very common (more than 1 in 10 animals displaying adverse reaction(s))

- common (more than 1 but less than 10 animals in 100 animals treated)

- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)

- rare (more than 1 but less than 10 animals in 10,000 animals treated)

- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).

Use during pregnancy and lactation

The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Use only according to the benefit/risk assessment by the responsible veterinarian.

Interactions

This veterinary medicinal product is incompatible with methylprednisolone, and sodium lactate or sodium bicarbonate intravenous infusions.

Interactions linked to calcium.

In case of concomitant blood transfusion, the product should not be administered with the blood in the same infusion set due to the risk of clotting. This veterinary medicinal product contains calcium. Do not add drugs to this solution that may bind (chelate) to calcium.

Amounts to be administered and administration route

Intravenous use.

The infusion should ideally be warmed to approximately 37°C prior to administration.

The volume and rate of infusion will depend upon the clinical condition, existing deficits of the animal, maintenance needs and continuing losses.

Generally aim to correct hypovolaemia by 50% initially (ideally over 6 hours but faster if necessary) and reassess by clinical examination.

Deficits are generally in the range of 50 ml/kg (mild) to 150 ml/kg (severe). An infusion rate of 15 ml/kg/hour is recommended in the absence of shock (range 5-75 ml/kg/hour).

In shock, high initial infusion rates, up to 90 ml/kg/hour, are needed. High infusion rates should not be continued for longer than 1 hour unless renal function and urine output are restored. The maximum infusion rate should be decreased in the presence of cardiac, renal and pulmonary disease.

Overdose

In the presence of volume overload signs (eg restlessness, moist lung sounds, tachycardia, tachypnoea, nasal discharge, coughing, vomiting and diarrhoea), treatment should involve administering diuretics and stopping the infusion. An excessive infusion of product may cause metabolic alkalosis due to the presence of lactate ions.

Withdrawal periods

Meat and offal: zero days.

Milk: zero hours.

Pharmacological particulars

Pharmacotherapeutic group: Electrolytes

ATCvet code: QB05BB01

Pharmacodynamic properties

Isotonic crystalloid solutions are for vascular filling and electrolyte replacement. They have an ionic composition very close to the extracellular fluid.

Sodium is the major cation of extracellular fluid. It is responsible for maintaining the volume of liquid and extracellular osmolarity.

Potassium is mainly an intracellular cation.

99% of calcium is present in the skeleton.

Chloride is essentially an extracellular anion.

Lactate produces bicarbonate salts (hence its alkalising effect).

Pharmacokinetic properties

The solution diffuses into the extracellular space whose volume is increased accordingly.

The lactate ion is rapidly metabolised by the liver where it is converted to pyruvate used in the Krebs cycle with production of bicarbonates.

Pharmaceutical particulars

Incompatibilities

This veterinary medicinal product is incompatible with methylprednisolone, and sodium lactate or sodium bicarbonate intravenous infusions.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

The veterinary medicinal product should be used immediately and not stored after opening.

Special precautions for storage

Do not store above 25°C.

Do not freeze.

Immediate packaging

Polyvinylchloride infusion bags overwrapped with polypropylene.

All pack sizes have two ports. In place of the additive port on the 5000 ml combi pack is a combi port. This enables two such bags to be connected in sequence and volumes greater than 5000 ml to be administered during one infusion.

Pack sizes: Individual fluid bags of 250 ml, 500 ml, 1000 ml, 3000 ml, 5000 ml and 5000 ml combi, each supplied with a package leaflet, or boxes containing 20 x 250 ml, 20 x 500 ml, 10 x 1000 ml, 4 x 3000 ml, 2 x 5000 ml, 2 x 5000 ml combi.

Not all pack sizes may be marketed.

Disposal

Any unused veterinary medicinal product or waste materials derived from such medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Dechra Limited, Snaygill Industrial Estate, Keighley Road, Skipton, North Yorkshire, BD23 2RW, United Kingdom.

Marketing Authorisation Number

Vm 10434/4080

Date of the first authorisation or date of renewal

20 June 2013

Date of revision of the text

July 2018

Any other information

For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children.

Legal category

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

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