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Vectra 3D Spot-on Solution is a new and effective treatment for dogs with activity against fleas, ticks, sand flies, mosquitoes and stable flies. It is applied once per month and provides a constant insecticidal and repellent activity over this period. It can be used to control fleas as well as help to prevent several important diseases which are transmitted by biting insects. This activity is particularly important for dogs traveling to Southern Europe, but even within the UK, diseases which were once only found on the continent are now being seen more regularly.
Vectra 3D will remain effective on dogs which go swimming periodically or are shampooed occasionally. The product should not be used on cats. For full information, see below.
All prices include VAT where applicable.
Pale yellow solution for topical application to the skin. Each ml contains 54 mg dinotefuran, 4.84 mg pyriproxyfen and 397 mg permethrin.
Fleas: Treatment and prevention of flea infestations (Ctenocephalides felis and Ctenocephalides canis). The treatment prevents flea infestations for one month. It also prevents multiplication of fleas for two months after application by inhibiting egg hatching (ovicidal activity) and by inhibiting the emergence of adults from eggs laid by adult fleas (larvicidal activity). The veterinary medicinal product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).
Ticks: The veterinary medicinal product has persistent acaricidal and repellent efficacy against tick infestations (Rhipicephalus sanguineus and Ixodes ricinus for one month, and Dermacentor reticulatus for up to three weeks). If ticks are present when the veterinary medicinal product is applied, the ticks may not all be killed within the first 48 hours, but they may be killed within a week. To remove ticks, it is recommended to use an appropriate tick removal device.
Sand flies, mosquitoes and stable flies: The treatment provides persistent repellent (anti-feeding) activity. It prevents biting from sand flies (Phlebotomus perniciosus), mosquitoes (Culex pipiens, Aedes aegypti) and from stable flies (Stomoxys calcitrans) for one month post-application. The treatment also provides persistent insecticidal activity for one month against mosquitoes (Aedes aegypti) and stable flies (Stomoxys calcitrans).
The minimum recommended dose is 6.4 mg dinotefuran/kg body weight, 0.6 mg pyriproxyfen/kg body weight and 46.6 mg permethrin/kg body weight, equivalent to 0.12 ml of the veterinary medicinal product per kg body weight.
The following table shows the size of spot-on applicator to be used according to the weight of the dog:
Method and route of administration
Spot-on use. Care should be taken to apply the veterinary medicinal product only onto intact skin.
How to apply:
Remove the spot-on applicator from the pack.
|Step 1: Hold the applicator upright, placing fingers below the larger disk as shown.|
|Step 2: With the other hand, press downwards on the smalle disk until the 2 disks meet evenly. This will pierce the seal.|
|Step 3: The dog should be standing or in a comfortable position for easy application. Part the hair until the skin is visible. Apply the veterinary medicinal product (as directed in step 4 below) slowly with the tip of the applicator on the skin.|
Use according to 4a or 4b recommendation:
4a recommendation: Gently squeeze the applicator and apply the veterinary medicinal product to the skin along the dog's back, beginning between the shoulder blades, in the number of spots and order shown in the diagrams below and squeezing until the applicator is empty. Avoid superficial application to the dog’s hair. The number of application spots will depend on the body weight of the dog.
|Dogs from 1.5 to 4 kg body weight|
|Dogs over 4 kg up up to 10 kg body weight|
|Dogs over 10 kg and up to 40 kg body weight|
|Dogs over 40 kg body weight|
4b recommendation: Regardless of the dog’s body weight, using the applicator tip, part the hair at the base of the tail and begin applying the veterinary medicinal product directly onto the skin in a continuous line from the base of the tail along the centre of the back all the way up to the shoulder blades, as shown in the diagram, squeezing the applicator until it is empty.
Following a single administration, the veterinary medicinal product will prevent infestation for one month. The treatment can be repeated once a month.
Do not use in cases of hypersensitivity to any of the active substances or to any of the excipients.
Do not use on cats. Due to their unique physiology and inability to metabolise permethrin, this veterinary medicinal product must not be used on cats. If applied to a cat, or ingested by a cat that actively grooms a recently treated dog, this veterinary medicinal product may have serious harmful effects.
All dogs within the household should be treated. Cats in the household should only be treated with a veterinary medicinal product authorised for use in that species.
Fleas can infest the dog’s basket, bedding and regular resting areas such as carpets and soft furnishings. In case of massive flea infestation and at the beginning of the control measures, these areas should be treated with a suitable insecticide and then vacuumed regularly.
Special precautions for use in animals
This veterinary medicinal product can induce convulsions in cats that could be fatal, due to the unique physiology of this species which is unable to metabolise certain compounds, including permethrin. In case of accidental exposure, if undesirable effects occur, wash the cat with shampoo or soap. To prevent cats from being accidentally exposed to the veterinary medicinal product, keep cats away from treated dogs until the application site is dry. It is important to ensure that cats do not groom the site of application on a dog which has been treated with this veterinary medicinal product.
The safety of the veterinary medicinal product has not been established in dogs younger than 7 weeks or weighing less than 1.5 kg.
Care should be taken to avoid contact between the veterinary medicinal product and the eyes of the dog. If in eyes, immediately flush with water.
The attachment of a single tick after treatment cannot be excluded. For this reason the transmission of infectious diseases cannot be completely excluded if conditions are favourable.
The veterinary medicinal product remains effective when treated animals are immersed in water (e.g. swimming, bathing). Water immersion repeated weekly for one month and starting 48 hours after treatment, as well as shampooing 2 weeks after treatment do not affect the efficacy of this product. However, in case of frequent shampooing, or bathing within 48 hours after treatment, the duration of activity may be reduced.
Do not mix with any other veterinary medicinal product, and do not apply together with any other veterinary medicinal product at the same time and site.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Do not eat, drink or smoke while handling the veterinary medicinal product. Wash hands thoroughly and immediately after use. This veterinary medicinal product is irritating to the eyes and skin. Avoid contact with the skin. In case of accidental spillage onto skin, wash off immediately with soap and water. If the veterinary medicinal product accidentally gets into the eyes, they should be thoroughly flushed with water. If skin or eye irritation persists, or if the veterinary medicinal product is accidentally swallowed, seek medical advice immediately and show the package leaflet or the label to the physician.
People with known hypersensitivity to any of the ingredients should avoid contact with the veterinary medicinal product.
Children must not handle treated dogs for at least four hours after administration of the veterinary medicinal product. It is therefore recommended to treat dogs in the evening, or before taking them for a walk. On the day of treatment, treated dogs should not be permitted to sleep with their owners, especially children. Used applicators should be disposed of immediately and not left within the sight or reach of children.
Wait for the application site to dry before allowing the treated dog to come in contact with fabrics or furnishings.
Transient erythema, pruritus or other signs of discomfort at the application site have been reported rarely and usually disappear spontaneously, within 24 hours following administration of the product. Behavioural disorders such as hyperactivity, vocalisation or anxiety, systemic signs such as lethargy or anorexia, and neurological signs such as muscle tremor have been reported in rare cases. Signs of ataxia such as unsteady movement have been reported in very rare cases. Gastrointestinal signs such as vomiting or diarrhoea have also been reported very rarely. Transient cosmetic effects (wet appearance, spiking of hair coat and deposits) at the application site have been reported very rarely, however these effects are usually not noticeable after 48 hours.
Use during pregnancy, lactation or lay
The safety of the veterinary medicinal product in bitches has not been established during pregnancy and lactation. The use of the veterinary medicinal product in pregnant and lactating bitches or in dogs intended for breeding should be based on a benefit/risk assessment by the responsible veterinarian. Laboratory studies, with each of the components, dinotefuran, pyriproxyfen or permethrin, in rats and rabbits have not produced any evidence of maternotoxic, teratogenic or foetotoxic effects. Dinotefuran has been shown to cross the blood-milk barrier and is excreted in the milk. N-methylpyrrolidone, an excipient in the veterinary medicinal product, has shown to be teratogenic in laboratory animals.
Apart from erythema and cosmetic hair coat changes at the site of application, no adverse reactions were observed in healthy puppies aged 7 weeks, topically treated 7 times at 2 week intervals and with up to 5 times the highest recommended dose. After accidental ingestion of the highest recommended dose, vomiting, salivation and diarrhoea may occur, however these should resolve without treatment.
This veterinary medicinal product does not require any special storage conditions.
Treated dogs should not be allowed to enter surface water for 48 hours after treatment to avoid adverse effects on aquatic organisms.
The veterinary medicinal product should not enter water courses as it is dangerous for fish and other aquatic organisms. Do not contaminate ponds, waterways or ditches with the veterinary medicinal product or with used containers.
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
Packs containing 3 pipettes.
Pharmacotherapeutic group: Ectoparasiticides, insecticides and repellents, permethrin combinations. ATCvet code: QP53AC54.
Dinotefuran is an insecticide. Its structure is derived from the neurotransmitter acetylcholine and acts on nicotinic acetylcholine receptors of the insect nerve synapse. Once bound to these receptors, the agonist action of repeated excitatory impulses kills the insect. Insects do not have to ingest dinotefuran, it kills by contact. Dinotefuran has low affinity to mammalian acetylcholine receptor sites.
Pyriproxyfen is a photostable insect growth regulator (IGR). It acts through contact, by mimicking the juvenile hormone, which regulates the moulting of insects from one life stage to the next. Pyriproxyfen stops the flea life cycle by both inducing premature oviposition and also suppressing yolk deposition in flea eggs, leading to the production of infertile eggs. Pyriproxyfen also blocks the development of juvenile stages (larvae and early (pharate) pupae) into adult emergence. This prevents infestation within the environment of the treated animal.
Permethrin is a synthetic pyrethroid. Pyrethroids act as neurotoxics on voltage-gated sodium channels by slowing their activation and inactivation properties. This results in hyperexcitability and death of the parasite. Permethrin is acaricide and insecticide. It also possesses repellent properties.
A synergistic effect was observed in vitro when dinotefuran was administered in conjunction with permethrin, leading to a faster onset of insecticidal activity in vivo. On the day of first treatment this veterinary medicinal product results in adequate flea adulticidal activity within 12 hours after application.
The anticipated clinical benefit resulting from a combination of dinotefuran with permethrin was demonstrated in one laboratory study on dogs which showed a prolongation of the duration of efficacy against C. canis fleas to 4 weeks.
Following topical application, dinotefuran and pyriproxyfen are partially absorbed through the dog’s skin leading to systemic exposure. For permethrin, the plasma levels remain under the limit of quantification. The three active substances rapidly distribute over the body surface of the animal within the first day, with maximum concentrations obtained 3 days after the application. The three active substances were still measurable in different zones of the hair coat one month after treatment.
Ceva Sante Animale
10 Avenue de la Ballastiere
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