UK Registered Veterinary Retailer

Tylan Antibiotic

Tylan Antibiotic
200 Injection » 100 Multi-dose Glass Vial

  • 200 Injection » 100 Multi-dose Glass Vial £37.99
  • G20 Premix Powder » 25kg £184.00
  • G50 Premix Powder » 2kg £33.49
  • Soluble » 100g £25.49

Selection of 4 products from

£25.49 to £184.00

Description

Tylan contains the antibiotic tylosin, whihch is used in cattle, pigs and poultry. There are formulations for adding to food or drinking water. A veterinary prescription is required for this to be supplied, and the prescription will detail all dosing information. For full datasheet, click on the individual products below.

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Medication Datasheets

200 Injection » 100 Multi-dose Glass Vial

Tylan 200, 200 mg/ml Solution for Injection

Qualitative and quantitative composition

Active substance:

Tylosin activity 200 mg/ml

Excipients:

Benzyl alcohol 40 mg/ml

For a full list of excipients, see Pharmaceutical Particulars

Pharmaceutical form

Solution for Injection.

Sterile yellow aqueous solution.

Clinical particulars

Target species

Tylan 200 mg/ml Solution for Injection is indicated for use in cattle and pigs.

Indications for use, specifying the target species

Tylan 200 mg/ml injection is indicated in all conditions associated with bacteria sensitive to tylosin which includes organisms in the following genera:StreptococcusCampylobacterBacillusSpirochaetesStaphylococcusFusiformisCorynebacteriumPasteurellaClostridiumChlamydiaErysipelothrixCampylobacter

Streptococcus

Campylobacter

Bacillus

Spirochaetes

Staphylococcus

Fusiformis

Corynebacterium

Pasteurella

Clostridium

Chlamydia

Erysipelothrix

Campylobacter

Tylan 200 mg ml injection has been successfully used in respiratory and genito-urinary tract infections, otitis, cellulitis and secondary bacterial conditions associated with virus disease or post operative infections.

Specific disease entities treated successfully with Tylan include swine dysentery, erysipelas and enzootic pneumonia in pigs, foul in the foot, mastitis and calf pneumonia in cattle.

Contraindications

Tylan 200 should not be given to chickens or turkeys.

Do not administer to horses or other equines in which injection of tylosin may be fatal.

Special warnings for each target species

None.

Special precautions for use

(i) Special precautions for use in animals

Use of the product should be based on susceptibility testing of the bacteria isolated from the animal. If this is not possible, therapy should be based on local epidemiological information.

For administration by the intramuscular route only.

Use different injection sites for repeat injections.

The efficacy data do not support the use of tylosin for the treatment of bovine mastitis caused by Mycoplasma spp.

(ii) Special precautions to be taken by the person administering the veterinary medicinal product to animals

Care should be taken to avoid accidental self-injection.

If accidental self-injection occurs, seek medical attention immediately.

In the event of accidental skin contact, wash thoroughly with soap and water. In case of accidental eye contact, flush the eyes with plenty of clean, running water.

Wash hands after use.

Tylosin may induce irritation. Macrolides, such as tylosin, may also cause hypersensitivity (allergy) following injection, inhalation, ingestion or contact with skin or eye. Hypersensitivity to tylosin may lead to cross reactions to other macrolides and vice versa. Allergic reactions to these substances may occasionally be serious and therefore direct contact should be avoided.

Do not handle the product if you are allergic to ingredients in the product.

If you develop symptoms following exposure, such as skin rash, you should seek medical advice and show the physician this warning. Swelling of the face, lips and eyes or difficulty in breathing are more serious symptoms and require urgent medical attention.

(iii) Other precautions

Blemishes may occur at the site of injection and can persist for up to 21 days following administration.

Adverse reactions (frequency and seriousness)

Possible adverse reactions attributed to the product when used as recommended and their frequency are: In very rare cases the following have been observed;

- swelling/inflammation at the site of injection,

- vulvular swelling in cattle,

- oedema of the rectal mucosa, partial anal protrusion (‘rosebudding’), erythema and pruritus in pigs.

- Anaphylactic shock and death.

Use during pregnancy, lactation or lay

No adverse effects to tylosin have been seen in fertility, multi-generation or teratology studies.

Interaction with other medicinal products and other forms of interaction

None observed.

Amounts to be administered and administration route

Tylan should be given by intramuscular injection at the following dose rates:

Cattle and calves: 4 to 10 mg per kg bodyweight daily.

Pigs: 2 to 10 mg per kg bodyweight daily.

If there is no response to treatment in 3 days, diagnosis and treatment should be reassessed.

The maximum injection volume for cattle is limited to 15ml per injection site.

To ensure the correct dosage, bodyweight should be determined as accurately as possible to avoid under dosing.

Overdose (symptoms, emergency procedures, antidotes), if necessary

Pigs and calves: Intramuscular injection of 30mg/kg bodyweight per day (three times maximum recommended dose) for five days produced no adverse effects.

The LD50 for subcutaneous injection of tylosin in mice is estimated to be >2500mg/kg bodyweight.

Withdrawal period(s)

Pigs: Meat - 9 days

Cattle: Meat - 28 daysMilk - 108 hoursWith cows milked twice daily, milk for human consumption may be taken only from 108 hours i.e. at the 9th milking) after the last treatment. With other dosing routines, the basis of the veterinary surgeons advice should be that milk may be taken for human consumption only after the same period from the last treatment (i.e. with three times a day milking, milk for human consumption may be taken only from 108 hours i.e. at the 14th milking).

Pharmacological particulars

Pharmacotherapeutic group: Macrolides

ATC vet code: QJ01FA90

Pharmacodynamic properties

Tylosin is a macrolide antibiotic produced by a strain of Streptomyces fradiae. It exerts its antimicrobial effect by inhibiting protein synthesis of susceptible micro-organisms.

The tylosin spectrum of activity includes Gram-positive bacteria, and some Gram-negative strains such as Pasteurella, at concentrations of 16µg/ml or less. It is not generally active against anaerobes.

Pharmacokinetic particulars

Absorption: Following intramuscular injection, tylosin blood levels peak 1-2 hours post-injection. Duration of activity is approximately 12 hours.

Distribution, Biotransformation and Elimination: Tylosin levels of 1.4 to 1.6 and 2.2 to 6.7 µg/ml were recorded in serum and lung tissue respectively following intramuscular injection of 8.8mg/kg bodyweight in pigs. Measurable amounts of tylosin were still present in both serum and lung tissue at 12 hours post injection. Tylosin concentrations were greater in lung tissue than serum at all sample times.

Pharmaceutical particulars

List of excipients

Propylene glycol Water for Injection

Incompatibilities

Do not mix with other solutions, since this may cause precipitation of the active ingredient.

Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 18 months.

Shelf life after first opening of the immediate packaging: 28 days.

Special precautions for storage

Do not store above 25°C.

Following withdrawal of the first dose use the product within 28 days. Discard unused material.

Nature and composition of immediate packaging

50ml, 100 ml or 250 ml clear glass vials sealed with a white or grey chlorobutyl rubber bung with aluminium overseal. Each vial is packed into a carton.

Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such products should be disposed of in accordance with national requirements.

Marketing Authorisation Holder (if different from distributor)

N/A

Marketing Authorisation Number

Vm: 00006/4098

Date of the first authorisation or date of renewal

5 January 1996

Date of revision of the text

August 2017

Any other information

Legal category

Soluble » 100g

Tylan Soluble Powder for Oral Solution

Presentation

Tylan Soluble is tylosin tartrate BP (Vet), a white to medium yellow coloured soluble powder for oral solution. Each bottle contains 100 g of tylosin tartrate activity. Each bag contains 1000 g of tylosin tartrate activity.

Uses

For the prevention and treatment of bovine pneumonia associated with bovine respiratory Mycoplasma or Pasteurella multocida sensitive to tylosin.

For the control of Mycoplasma synoviae airsacculitis in chickens and Mycoplasma gallisepticum S6 in chickens and turkeys. In the field Tylan Soluble has also proved useful in reducing the level of infection following stress association with live vaccination.

As an aid in the control of outbreaks of necrotic enteritis caused by Clostridia perfringens in chickens.

For the prevention and control of enzootic pneumonia and scours caused by organisms (e.g. Lawsonia intracellularis) sensitive to tylosin, in pigs.

Dosage and administration

To ensure a correct dosage, body weight should be determined as accurately as possible to avoid under-dosing.

Calves

One gram of Tylan Soluble per young calf administered orally twice daily for seven to fourteen days. The product may be incorporated into the milk or reconstituted milk replacer at the time of feeding.

Chickens and turkeys

Tylan Soluble is administered in the drinking water at a concentration of 0.5 g per litre to provide 50-200 mg/kg bw, depending on the age and the water consumption of the birds.

For preventative medication in chickens and turkeys, the following programmes are recommended:

As an aid to mycoplasmosis prevention in chickens (refer to Table 1):

As an aid to mycoplasmosis prevention in turkeys (refer to Table 2):

For treatment of mycoplasmosis (refer to Table 3):

As an aid in the control of necrotic enteritis in chickens (refer to Table 4):

As an aid in the control of outbreaks of necrotic enteritis caused by Clostridium perfringens in chickens use Tylan in the drinking water for 5 days at a concentration of 0.15 g per litre water (150ppm), to provide 20-50 mg/kg bw, depending on the age and the water consumption of the birds.

Pigs

For the prevention and control of scours and enzootic pneumonia, Tylan soluble is administered in the drinking water to provide 25 mg/kg bodyweight. This may be achieved by adding 0.25g per litre (1.1 g/gal).

Tylan Soluble requirements per tonne of pigs daily:

A medicated solution of drinking water should be administered until 24 hours after scouring or respiratory symptoms have ceased, normally 3-10 days. The diagnosis should be reviewed if no response after 5 days of medication.

Contra-indications, warnings, etc

Keep out of reach of children.

For animal treatment only.

Do not use in known cases of hypersensitivity to tylosin or other macrolides.

Do not leave or dispose of water containing tylosin tartrate where it may be accessible to animals not under treatment, or wildlife.

Official, national and regional antimicrobial policies should be taken into account when the product is used.

A high rate of in vitro resistance has been demonstrated in European strains of Brachyspira Hyodysenteriae implying that the product will not be sufficiently efficacious against swine dysentery.

Special precautions for use in animals

Use of the product should be based on susceptibility testing of the bacteria isolated from the animal. If this is not possible, therapy should be based on local (regional, farm level) epidemiological information about susceptibility of the target bacteria.

Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to tylosin and may decrease the effectiveness of treatment with other macrolides, lincosamides and streptogramin B due to the potential for cross-resistance.

Operator warnings

Tylosin may induce irritation. Macrolides, such as tylosin, may also cause hypersensitivity (allergy) following injection, inhalation, ingestion or contact with skin or eye. Hypersensitivity to tylosin may lead to cross reactions to other macrolides and vice versa. Allergic reactions to these substances may occasionally be serious and therefore direct contact should be avoided.

To avoid exposure during preparation of the medicated drinking water, wear overalls, safety glasses, impervious gloves and wear either a disposable half mask respirator conforming to European Standard EN149 or a non-disposable respirator to European Standard EN140 with a filter to EN143. Wash hands after use.

In the event of accidental skin contact, wash thoroughly with soap and water. In case of accidental eye contact, flush the eyes with plenty of clean, running water.

Do not handle the product if you are allergic to ingredients in the product.

If you develop symptoms following exposure, such as skin rash, you should seek medical advice and show the physician this warning. Swelling of the face, lips and eyes or difficulty in breathing are more serious symptoms and require urgent medical attention.

Withdrawal Period

Refer to Table 5.

Pharmaceutical precautions

Store in a dry place below 25°C.

Any medicated water which is not consumed within 24h should be discarded.

Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.

Shelf-life after dilution according to directions: 24 hours

Legal category

Marketing Authorisation Number

Vm 00006/4091.

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (5)

Q & A

Below are some recent questions we've received regarding Tylan Antibiotic, including answers from our team.

20 August 2015 at 11:53am

Tylan sibo/sid dog

andrea

Can this be used for sibo/sid for dogs ? My dog has been on metronizadole and hasn't had big improvement. I've read that tylan is now the drug of choice for this and ibd.

  • Non-Executive Director

Tylan is one of several antibiotics used in this situation, but I would certainly not say that it is widely regarded as the antibiotic of choice. I am sure that some vets will think this and it might be very good in their experience, but not all vets would have the same opinion. In fact I have been to lectures on this recently and found that international speakers from the USA and UK tend to disagree, so there is not a general consensus on this point. I think that the choice of antibiotic is best left to your own vet. You can always discuss the matter fully with them, but if you are not happy with the choice of treatment your vet advises, I would wonder if you should see another vet. I really feel that the choice of prescription drugs should be led by your own vet who is familiar with your particular dog.

18 March 2015 at 8:17am

I have 10 chickens

how much will I need

I have 10 chickens so how much Tulane will I need to treat them all? I have defiantly 1 chicken with an upper resperoitry infection (confirmed by the vet) not in the lungs just upper section

  • Non-Executive Director

Since this is a prescription-only product, you would need to send us a prescription from your vet in order to buy it. Your vet should decide on how the treatment is given and put instructions on the prescription. As a guide, I would say that this is not generally used for just a few birds like you have. One small sachet could treat about 3,000 birds via the drinking water, so you would have to divide the contents of a sachet up very carefully to treat just 10 birds. Then you have to deal with the wasted product you do not need. It might be better for your vet to find a different treatment.