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Trimediazine is a combination of trimethoprim and sulfadiazine which together produce a powerful anti-bacterial effect. The broad spectrum of activity and high safety levels of Trimediazine mean that it is used for a wide range of infections in horses. These include respiratory, alimentary and general soft tissue infections. Examples would be pneumonia; pleurisy, strangles, infected wounds and septicaemia.
Contra-indications, warnings, etc
Avoid direct contact with skin and eyes. If contact occurs, wash affected area with copious amounts of water. Seek medical advice if irritation persists.
Gloves should be worn whilst handling this product.
Wash hands after use.
Use during pregnancy or lactation
This product can be safely administered during pregnancy and lactation.
Drug absorption may be greater if food is withheld for a few hours prior to dosing.
Do not use in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human consumption under national horse passport legislation.
All prices include VAT where applicable.
Trimediazine Plain is a white broad spectrum antibacterial powder for mixing with animal feed . Each sachet contains Trimethoprim 5% w/w and Sulfadiazine 25% w/w.
Trimediazine Plain is indicated for use in the treatment of bacterial diseases in horses, including upper and lower respiratory tract infections, alimentary tract infections and infected wounds.
For oral administration in the feed, .Tto be given at a rate of 30mg combined active ingredients per kg bodyweight.
Mix with a small quantity of feed. Each 50 g sachet provides a daily dose for a 500 kg horse. The dose may be administered daily, or divided and administered at 12 hourly intervals, for 5 days.
It is recommended that other feed be withdrawn until medicated feed has been consumed.
Do not use in horses with severe liver parenchymal damage or kidney damage or known sulphonamide sensitivity, or horses with blood dyscrasias or cardiac arrhythmias. Do not exceed 7 days continuous treatment
The use of Trimediazine Plain in horses under 1 year old should be avoided.
In the rat and rabbit, trimethoprim/sulfadiazine combinations did not produce any foetal abnormalities at doses of up to 600mg/kg, although minor effects on skeletal development were seen below this level. As no studies have been conducted in horses, use on pregnant mares should be avoided.
When administered to lactating females, small amounts of trimethoprim and sulfadiazine are present in the maternal milk. Since no studies have been reported on the effects of Trimediazine Plain on the development of new born foals, it would be prudent not to feed very young foals with milk obtained from mares being treated.
As there is no specific antidote, in case of overdose, treatment should be symptomatic.
Meat: 6 months
In accordance with the Horse Passport legislation (Commission Decision 2000/68/EC as implemented in national legislation) a 6 month withdrawal period applies to the use of this product.
Do not store above 25°C. Store in a dry place away from animal feeding stuffs. Add to feed immediately before administration. Discard any remaining medicated feed.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
10×50 g sachets.
ATC vet code: QJ01EW10
Sulfadiazine is a bacteriostatic antibiotic belonging to the sulphonamide group which acts by interference with the synthesis of nucleic acids. Trimethoprim is a reductase inhibitor which also interferes with the synthesis of bacterial nucleic acids. Sulfadiazine and trimethoprim act on the same metabolic pathway, resulting in potentiation of antibacterial activity.
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Below are some recent questions we've received regarding Trimediazine For Horses, including answers from our team.
dose the 45g paste contain only one syringe and one dosage, thanks
Yes the syringes are sold singly though you can order as many as you need. Each syringe provides one dose for a 500 kg horse. Each division on the dial-a-dose plunger provides sufficient product to treat 50 kg of bodyweight.