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Species: Cats Therapeutic indication: Pharmaceuticals: Endectocides: For companion animals Active ingredient: Sarolaner, Selamectin Product:Stronghold Plus spot-on solution for cats Product index: Stronghold Plus
Stronghold Plus is a clear, colourless to yellow spot-on solution, with each unit dose (pipette) delivering the following active substances. Also contains 0.2 mg/ml butylated hydroxytoluene as excipient.
|Stronghold Plus spot-on solution||Pipette content (ml)||Selamectin (mg)||Sarolaner (mg)|
|Cats < 2.5 kg||0.25||15||2.5|
|Cats > 2.5 - 5 kg||0.5||30||5|
|Cats > 5 - 10 kg||1.0||60||10|
For cats with, or at risk from, mixed parasitic infestations by ticks and fleas, lice, mites, gastrointestinal nematodes or heartworm. Stronghold Plus is exclusively indicated when use against ticks and one or more of the other target parasites is indicated at the same time. Ectoparasites: - For the treatment and prevention of flea infestations (Ctenocephalides spp.). Stronghold Plus has immediate and persistent flea killing activity against new infestations for 5 weeks. The product kills adult fleas before they lay eggs for 5 weeks. Through its ovicidal and larvicidal action, Stronghold Plus may aid in the control of existing environmental flea infestations in areas to which the animal has access. - The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD). - Treatment of tick infestations. Stronghold Plus has immediate and persistent acaricidal effect for 5 weeks against Ixodes ricinus and Ixodes hexagonus, and 4 weeks against Dermacentor reticulatus and Rhipicephalus sanguineus. - Treatment of ear mites (Otodectes cynotis). - Treatment of biting lice infestations (Felicola subrostratus). Ticks must attach to the host and commence feeding in order to be exposed to sarolaner. Nematodes: - Treatment of adult roundworms (Toxocara cati) and adult intestinal hookworms (Ancylostoma tubaeforme). - Prevention of heartworm disease caused by Dirofilaria immitis with monthly administration.
Spot-on use. Stronghold Plus should be administered as a single spot-on (topical) application in accordance with the following table (corresponding to a minimum of 6 mg/kg selamectin and 1 mg/kg sarolaner).
Method and route of administration Apply topically to the skin at the base of the neck in front of the shoulder blades. The pipette should be removed from the protective package immediately prior to administration. Holding the pipette upright, firmly depress the cap to puncture the applicator seal, then remove the cap. Part the hair at the base of the cat’s neck in front of the shoulder blades to expose a small area of skin. Apply the tip of the pipette directly to the skin, without massaging. Squeeze the pipette firmly 3–4 times to empty the contents in one spot. Avoid contact between the product and your fingers. Transient cosmetic effects may occur at the application site such as temporary clumping or spiking of the hair, greasiness or dry white deposits, which normally resolve within 24 hours after product application. These effects do not affect the safety or efficacy of the veterinary medicinal product. Treatment schedule Fleas and ticks For optimal control of tick and flea infestations, the veterinary medicinal product should be administered at monthly intervals and continued throughout the flea and/or tick season based on local epidemiological situations. Following administration of the product, the adult fleas on the animal are killed within 24 hours, no viable eggs are produced, and larvae (found only in the environment) are also killed. This stops flea reproduction, breaks the flea lifecycle and may aid in the control of existing environmental flea infestations in areas to which the animal has access. Prevention of heartworm disease The product may be administered year-round or at least within one month of the animal’s first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. The final dose must be given within one month after the last exposure to mosquitoes. If a dose is missed and a monthly interval between dosing is exceeded, then immediate administration of the product and resumption of monthly dosing will minimise the opportunity for the development of adult heartworms. When replacing another heartworm preventive product in a heartworm disease prevention programme, the first dose of the product must be given within a month of the last dose of the former veterinary medicinal product. Treatment of roundworm and hookworm infections A single dose of the product should be administered. The need for and frequency of re-treatment should be in accordance with the advice of the prescribing veterinarian. Treatment of biting lice A single dose of the product should be administered. Treatment of ear mites A single dose of the product should be administered. Seek further veterinary examination 30 days after treatment to determine whether a second administration is necessary.
Do not use in cats that are suffering from concomitant disease, or are debilitated and underweight (for size and age). Do not use in cases of hypersensitivity to the active substances or to any of the excipients. It is recommended, in accordance with good veterinary practice, that all animals 6 months of age or more, living in countries where a vector exists, should be tested for existing adult heartworm infections before beginning preventive use with Stronghold Plus. Stronghold Plus is not effective against adult D. immitis. The administration to animals with adult heartworm infection did not pose safety concerns. Whilst not routinely indicated, the potential benefits of performing periodic testing for heartworm infection in individual cases should be considered by the responsible veterinarian. Ticks need to start feeding on the host to become exposed to sarolaner; therefore, the transmission of infectious tick-borne diseases cannot be excluded. Use of Stronghold Plus is indicated in cats aged at least 8 weeks old and weighing at least 1.25 kg bodyweight. Stronghold Plus is to be applied to the skin surface only. Do not administer orally or parenterally. Do not apply when the animal’s hair coat is wet. For ear mite treatment, do not apply directly to the ear canal. It is important to apply the dose as indicated to prevent the animal from licking and ingesting the product. If significant ingestion occurs, transient gastrointestinal effects such as hypersalivation, emesis, soft faeces or reduced food consumption may be observed and should normally resolve without treatment. Keep treated animals away from fires and other sources of ignition for at least 30 minutes or until the hair coat is dry. Use of the veterinary medicinal product may result in mild and transient pruritus at the application site. Mild to moderate alopecia at the application site, erythema and drooling have been uncommonly (more than 1 but less than 10 animals in 1,000 animals) observed. User warnings: The product is harmful after ingestion. Keep the product in the original packaging until use, in order to prevent children from getting direct access to the product. Used pipettes should be disposed of immediately. In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician. The product may cause eye irritation. Avoid eye contact including hand-to-eye-contact. Avoid direct contact with treated animals until the application area is dry. Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If accidental eye exposure occurs, flush the eyes immediately with water and seek medical attention. Children are not allowed to play with treated cats for 4 hours after treatment. It is recommended to treat animals in the evening. On the day of treatment, treated animals should not be permitted to sleep in the same bed as their owner, especially children. People with sensitive skin or known allergy to veterinary medicinal products of this type should handle the veterinary medicinal product with caution. The product is highly flammable. Keep away from heat, sparks, open flame or other sources of ignition.
Store below 30°C. Do not remove the pipette from the blister until ready to use. Keep out of the sight and reach of children. For animal treatment only.
Legal category: POM-V
Stronghold Plus is available in packs of 3 and 6 pipettes. Not all pack sizes may be marketed.
For fleas, the onset of efficacy is within 24 hours for 5 weeks after product application. For ticks (I.ricinus), the onset of efficacy is within 24 hours of attachment for one month after product application. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or in animals intended for breeding. However, selamectin is considered safe for use in breeding, pregnant and lactating cats. While the safety of sarolaner has not been evaluated in breeding, pregnant or lactating cats, laboratory studies with sarolaner in rats and rabbits have not produced any evidence of teratogenic effects. Use only according to the benefit-risk assessment by the prescribing veterinarian. During clinical field testing, no interactions between this veterinary medicinal product and routinely used veterinary medicinal products were observed. No clinically significant adverse reactions were observed in kittens from 8 weeks of age treated with up to 5 times the maximum recommended dose of the product for up to 8 consecutive treatments at 28 day intervals, apart from a single cat administered 5 times the maximum dose that displayed transient hypersensitivity to touch, piloerection, mydriasis and mild tremor which resolved without treatment. After accidental ingestion of a full product dose, transient gastrointestinal effects such as salivation, soft faeces, emesis, and reduced food consumption may occur, however these should resolve without treatment.
GTIN description:Kitten/small cat 3 pack GTIN:05414736033150 GTIN description:Medium cat 3 pack GTIN:05414736033167 GTIN description:Large cat 3 pack GTIN:05414736033174
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