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Peptizole Syringe for Horses

Peptizole Syringe for Horses
Pack of 7 Syringes

  • Pack of 7 Syringes £138.50
  • Single Syringe £19.99

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£19.99 to £138.50

Description

Peptizole is the latest product now available to help treat and prevent gastric ulcers in horses. It contains omeprazole which reduces gastric acid secretion in the stomach. A dose is given from the graduated syringe once daily for up to 28 days. One full syringe will provide a full dose for a horse of 700kg bodyweight. If Peptizole is being given as a preventative, rather then treatment of an existing ulcer, then a quarter dose is given each day. Syringes are graduated in 50kg bodyweight divisions.

Peptizole 370 mg/g Oral Paste for Horses

Presentation

Each 7 ml syringe of Peptizole contains 7.57 g of oral paste
Each gram of oral paste contains 370 mg of Omeprazole

Uses

For treatment of gastric ulcers and the prevention of recurrence of gastric ulcers.

Dosage & Administration

For oral administration.
Treatment of gastric ulcers: one administration per day during 28 consecutive days at the dose rate of 4 mg Omeprazole per kg body weight (1 division of the syringe/50 kg BW) followed immediately by a dosage regimen of one administration per day during 28 consecutive days at the dose rate of 1 mg Omeprazole per kg body weight, to reduce the recurrence of gastric ulcers during treatment.
Should recurrence occur, re-treatment at a dose rate of 4 mg Omeprazole per kg body weight (1 division of the syringe/50 kg BW) is recommended.
Prevention of recurrence of gastric ulcers: one administration per day at the
dose rate of 1 mg Omeprazole per kg body weight.
To deliver Omeprazole at the dose of 4 mg Omeprazole /kg, set the syringe plunger to the appropriate dose division for the horse’s weight. Each division on the syringe plunger delivers sufficient Omeprazole to treat 50 kg body weight. The contents of one syringe will treat a 700 kg horse at the rate of 4 mg Omeprazole per kg body weight.
To deliver Omeprazole at the dose of 1 mg Omeprazole /kg, set the syringe plunger to the dose division equivalent to one quarter of the horse’s body weight. For example, to treat a horse weighing 400 kg, set the plunger to 100 kg. At this dose, each division on the syringe plunger will deliver sufficient Omeprazole to treat 200 kg body weight.
It is recommended to associate the treatment with changes of husbandry and training practices.

Withdrawal Period

Meat and offal: 1 day
Not authorised for use in mares producing milk for human consumption

Contraindictions, Warnings etc

For animal treatment only.
Not recommended for animals under 4 weeks of age or weighing less than 70 kg bodyweight.
The use of Omeprazole in pregnant or lactating mares is not recommended.

Pharmaceutical Precautions


Keep out of the reach and sight of children.
Do not store above 30oC
Do not use this veterinary medicinal product after the expiry date which is stated on the carton and syringe after “EXP
Shelf life after first opening the container: 28 days
Replace cap after use.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
Medicines should not be disposed of via wastewater or household waste.
Ask your veterinary surgeon/pharmacist how to dispose of medicines no longer required. These measures should help to protect the environment.

Need help or advice? Contact us:

  • Landline: 01582 842096
  • Mon - Fri: 8:30am - 5:00pm
  • Sat: 9:00am - 1:00pm (Collections only)
  • Email: [email protected]

All prices include VAT where applicable.

Medication Datasheets

Single Syringe

Peptizole 370 mg/g Oral Paste for Horses

Qualitative and quantitative composition

Each gram contains: Active substance(s): Omeprazole 370 mgExcipients:Yellow Iron Oxide (E 172)2 mgFor a full list of excipients, see section Pharmaceutical Particulars

Active substance(s):

Omeprazole

370 mg

Excipients:

Yellow Iron Oxide (E 172)

2 mg

For a full list of excipients, see section Pharmaceutical Particulars

Pharmaceutical form

Oral paste.

A yellow to tan oily paste.

Clinical particulars

Target species

Horses

Indications for use, specifying the target species

For treatment of gastric ulcers and the prevention of recurrence of gastric ulcers.

Contraindications

Do not use in cases of hypersensitivity to the active substance or any of the excipients.

Special warnings for target species

The veterinarian should consider the need for performing relevant diagnostic tests before selection of the treatment dose rate.

Special precautions for use

Special precautions for use in animals

Not recommended for animals under 4 weeks of age or weighing less than 70 kg bodyweight.

Stress (including high performance training and competition), feeding, management and husbandry practices may be associated with the development of gastric ulceration in horses. Individuals responsible for the wellbeing of horses should consider reducing the ulcerogenic challenge by modifying husbandry practices to achieve one or more of the following: reduced stress, reduced fasting, increased intake of roughage and access to grazing.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

As this product may cause irritant and hypersensitivity reactions, avoid direct contact with skin and eyes. Use impervious gloves and do not eat or drink when handling and administering the product. Wash hands or any exposed skin after use. In case of contact with eyes, wash immediately with clean running water and seek medical advice. Persons developing a reaction after contact with the product should seek medical advice and avoid handling the product in future.

Adverse reactions (frequency and seriousness)

There are no known treatment-related clinical adverse effects.

In cases of hypersensitivity reactions, treatment should be discontinued immediately.

Use during pregnancy, lactation or lay

Laboratory studies in rats and rabbits have not produced any evidence of a teratogenic effect.

The safety of the product has not been assessed during pregnancy and lactation. The use of the product is not recommended in pregnant and lactating mares.

Interaction with other medicinal products and other forms of interaction

Omeprazole may delay the elimination of warfarin. No other interaction with medicines routinely used in the treatment of horses is expected, although interaction with drugs metabolised by liver enzymes cannot be excluded.

Amounts to be administered and administration route

Omeprazole is effective in horses of various breeds and under different management conditions; foals as young as four weeks of age and weighing over 70 kg; and breeding stallions.

For oral administration.

Treatment of gastric ulcers: one administration per day during 28 consecutive days at the dose rate of 4 mg Omeprazole per kg body weight (1 division of the oral syringe/50 kg BW) followed immediately by a dosage regimen of one administration per day during 28 consecutive days at the dose rate of 1 mg Omeprazole per kg body weight, to reduce the recurrence of gastric ulcers during treatment.

Should recurrence occur, re-treatment at a dose rate of 4 mg Omeprazole per kg body weight (1 division of the oral syringe/50 kg BW) is recommended.

It is recommended to associate the treatment with changes of husbandry and training practices.

Prevention of recurrence of gastric ulcers: one administration per day at the dose rate of 1 mg Omeprazole per kg body weight.

To deliver Omeprazole at the dose of 4 mg Omeprazole /kg, set the oral syringe plunger to the appropriate dose division for the horse’s weight. Each division on the oral syringe plunger delivers sufficient Omeprazole to treat 50 kg body weight. The contents of one oral syringe will treat a 700 kg horse at the rate of 4 mg Omeprazole per kg body weight.

To deliver Omeprazole at the dose of 1 mg Omeprazole /kg, set the oral syringe plunger to the dose division equivalent to one quarter of the horse’s body weight. For example, to treat a horse weighing 400 kg, set the plunger to 100 kg. At this dose, each division on the oral syringe plunger will deliver sufficient Omeprazole to treat 200 kg body weight.

Replace cap after use.

Overdose (symptoms, emergency procedures, antidotes), if necessary

No undesirable effects related to treatment were observed following daily use for 91 days at Omeprazole dosages up to 20 mg/kg in adult horses and in foals older than 2 months.

No undesirable effects related to treatment (in particular no adverse effect on the semen quality or reproductive behaviour) were observed following daily use for 71 days at an Omeprazole dosage of 12 mg/kg in breeding stallions.

No undesirable effects related to treatment were observed following daily use for 21 days at an Omeprazole dosage of 40 mg/kg in adult horses.

Withdrawal period

Horse: Meat and offal: 1 day

Not authorised for use in mares producing milk for human consumption.

Pharmacological particulars

Pharmacotherapeutic group: Drugs for acid related disorders, Proton pump inhibitors.

ATCVet code: QA 02 BC 01

Pharmacodynamic properties

In studies lasting up to 28 days, treatment with Omeprazole at the dose rate of 1 mg Omeprazole per kg body weight per day has been shown to help prevent the occurrence of gastric ulcers in horses exposed to ulcerogenic conditions.

Omeprazole is a proton pump inhibitor belonging to the substituted benzimidazole class of compounds. It is an antacid, for treatment of peptic ulcers.

Omeprazole suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase enzyme system at the secretory surface of the parietal cell. The H+/K+- ATPase enzyme system is the acid (proton) pump within the gastric mucosa. Because H+/K+- ATPase is the final step involved in control of acid secretion, Omeprazole blocks secretion irrespective of the stimulus. Omeprazole irreversibly binds to the gastric parietal cell H+/K+- ATPase enzyme that pumps hydrogen ions into the lumen of the stomach in exchange for potassium ions.

At 8, 16 and 24 hours after dosing horses with Omeprazole at 4 mg/kg/day orally, pentagastrin-stimulated gastric acid secretion was inhibited by 99%, 95% and 90% and basal secretion was inhibited by 99%, 90% and 83%.

The full effect on the inhibition of acid secretion is reached by five days after the first administration.

Pharmacokinetic particulars

The median bioavailability of Omeprazole after oral administration as a paste is 10.5% (range 4.1 to 12.7%). The absorption is rapid with time to maximum plasma concentrations (Tmax) of approximately 1.25 hours after dosing. Cmax values for individual animals ranged between 121 ng/ml and 1470 ng/ml after one administration of the product at 4 mg/kg. There is a significant first-pass effect following oral administration. Omeprazole is rapidly metabolised principally into glucuronides of demethylated and hydroxylated Omeprazole sulphide (urinary metabolites) and methyl sulphide Omeprazole (biliary metabolite) as well as into reduced Omeprazole (both).

After oral administration at 4 mg/kg, Omeprazole is detectable in plasma for 9 hours after treatment and in urine as hydroxy Omeprazole and O-desmethyl Omeprazole at 24 hours but not at 48 hours. Omeprazole is eliminated quickly, mainly by urinary route (43 to 61% of the dose), and to a smaller extent by faecal route, with a terminal half-life ranging from approximately 0.5 to 8 hours.

After repeated oral administration, there is no evidence of accumulation.

Pharmaceutical particulars

List of excipients

Yellow Iron Oxide (E 172)

Ethanolamine

Cinnamon Leaf Oil

Liquid Paraffin

Major Incompatibilities

None Known.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

Shelf life after first opening the immediate packaging: 28 days

Special precautions for storage

Do not store above 30°C.

Replace cap after use.

Nature and composition of immediate packaging

Immediate package

Immediate packaging: 7 ml oral syringe containing 7.57 g of paste composed of polyethylene barrel, plunger and end cap, with polypropylene dosing rings.

Outer package and sales presentations

Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Norbrook Laboratories Limited

Station Works

Camlough Road

Newry

Co. Down

BT35 6JP

Northern Ireland

Marketing Authorisation Number

Vm 02000/4389

Date of the first authorisation or date of renewal

04 March 2014

Date of revision of the text

August 2018

Any other information

Nil.

Legal category

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (6)

Q & A

Below are some recent questions we've received regarding Peptizole Syringe for Horses, including answers from our team.

11 October 2017 at 3:14pm

Formulation

Vanessa

Is Peptizole a buffered formulation, or is it plain omeprazole? My vet says I should use a buffered one.

  • Veterinary Advisor

Yes, Peptizole is a buffered solution.

13 October 2015 at 8:55am

Prescription query

Sarah Wade

  • VioVet customer since 2012
  • From: North Yorkshire, United Kingdom

I have asked my vet to provide a prescription for my horse so that I can buy this from you as it is cheaper than from him. Will I need a new prescription every time I buy it?

  • Non-Executive Director

We can supply up to the amount (which should be clearly stated) which your vet allows on the written prescription. If your vet chooses to allow an extended course of treatment (which he/she is perfectly at liberty to do) then you can draw off that one prescription as you wish. It is largely down to how long your vet thinks your horse might need the medication for, and how helpful your vet wants to be. Many are very helpful if you just ask for what makes sense for you.

5 August 2015 at 5:01pm

Is Peptizole FEI legal?

Maggie

Please can you advise if Peptizole is completion legal to FEI standard?

  • Non-Executive Director

This product is safe to use in competition horses. It does not contain any banned substances.