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Metrobactin Tablets

Metrobactin Tablets
250mg Tablet » Pack of 250

  • 250mg Tablet » Pack of 250 £87.49
  • 250mg Tablet » Priced Per Tablet £0.39
  • 500mg Tablet » Pack of 250 £164.99
  • 500mg Tablet » Priced Per Tablet £0.70

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£0.39 to £164.99

Description

Metrobactin 500mg tablets contain the antibiotic metronidazole.

Metrobactin in treatment of gastrointestinal tract infections caused by Giardia spp. and Clostridia spp. (i.e. C. perfringens or C. difficile). It can also be used to treat infections of the urinary or genital tract, oral cavity, throat or skin caused by anaerobic bacteria susceptible to metronidazole.


The product is suitable for use in both dogs and cats.

Contraindications

Do not use in case of hepatic disorders.

Do not use in case of hypersensitivity to the active substance or to any of the excipients.

Need help or advice? Contact us:

  • Landline: 01582 842096
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All prices include VAT where applicable.

Medication Datasheets

250mg Tablet » Priced Per Tablet

Metrobactin® Tablets for Dogs and Cats

Qualitative and quantitative composition

Metrobactin 250 mg tablets for dogs and cats

1 tablet contains: Active substance:

Metronidazole 250 mg

Metrobactin 500 mg tablets for dogs and cats

1 tablet contains: Active substance:

Metronidazole 500 mg

Pharmaceutical form

Tablet. Light brown with brown spots, round and convex flavoured tablet with a cross-shaped break line on one side.

Tablets can be divided into 2 or 4 equal parts.

Clinical particulars

Target species

Dogs and cats

Indications for use

Treatment of gastrointestinal tract infections caused by Giardia spp. and Clostridia spp. (i.e. C. perfringens or C. difficile).

Treatment of infections of the urogenital tract, oral cavity, throat and skin caused by obligate anaerobic bacteria (e.g. Clostridia spp.) susceptible to metronidazole.

Contraindications

Do not use in case of hepatic disorders.

Do not use in case of hypersensitivity to the active substance or to any of the excipients.

Special precautions for use in animals

Due to the likely variability (time, geographical) in the occurrence of metronidazole resistant bacteria, bacteriological sampling and susceptibility testing are recommended.

Whenever possible, the product should only be used based on susceptibility testing. Official, national and regional anitmicrobial policies should be taken into account when the veterinary medicinal product is used.

In very rare cases, neurological signs may occur especially afer prolonged treatment with metronidazole.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Metronidazole has confirmed mutagenic and genotoxic properties in laboratory animals as well as in humans. Metronidazole is a confirmed carcinogen in laboratory animals and has possible carcinogenic effects in humans. However, there is inadequate evidence in humans for the carcinogenicity of metronidazole. Impervious gloves should be worn during administration of the product to avoid skin contact with the product.

To avoid accidental ingestion, particularly by a child, unused part-tablets should be returned to the open blister space and inserted back into the carton.

In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician. Wash hands thoroughly after handling the tablets.

Adverse reactions

The following adverse reactions may occur after administration of metronidazole: vomiting, hepatotoxicity, neutropenia and neurologic signs.

Use during pregnancy and lactation

Studies in laboratory animals have shown inconsistent results with regard to teratogenic/embryotoxic effects of metronidazole. Therefore, use of this product during pregnancy is not recommended. Metronidazole is excreted in milk and use during lactation is therefore not recommended.

Interactions

Metronidazole may have an inhibitory effect on the degradation of other drugs in the liver, such as phenytoin, cyclosporine and warfarin.

Cimetidine may decrease the hepatic metabolism of metronidazole resulting in increased serum concentration of metronidazole.

Phenobarbital may increase hepatic metabolism of metronidazole resulting in decreased serum concentration of metronidazole.

Amounts to be administered and administration route

For oral administration.

The recommended dose is 50 mg metronidazole per kg body weight per day, for 5 to 7 days. The daily dose may be divided equally for twice daily administration (i.e. 25 mg/kg body weight twice daily).

To ensure administration of the correct dosage body weight should be determined as accurately as possible. The following tables are intended as a guide to dispensing the product at the recommended dose rate of 50 mg per kg body weight per day.

Metrobactin 250 mg tablets for dogs and cats dosage table:

Metrobactin 500 mg tablets for dogs and cats dosage table:

Tablets can be divided into 2 or 4 equal parts to ensure accurate dosing. Place the tablet on a flat surface, with its scored side facing up and the convex (rounded) side facing the surface.

Halves: press down with your thumbs on both sides of the tablet.

Quarters: press down with your thumb in the middle of the tablet.

Overdose

Adverse events are more likely to occur at doses and treatment durations in excess of the recommended treatment regimen. If neurological signs occur, treatment should be discontinued and the patient should be treated symptomatically.

Pharmacological particulars

Pharmacotherapeutic group: (nitro) imidazole derivatives

ATCvet code: QP51AA01, QJ01XD01

Pharmacodynamic properties

After metronidazole has penetrated the bacteria the molecule is reduced by the sensitive bacteria (anaerobe). The metabolites that are created have a toxic effect on the bacteria through binding to the bacterial DNA. In general metronidazole is bactericidal for sensitive bacteria in concentrations equal to or a little higher than the minimum inhibiting concentration (MIC).

Clinically metronidazole does not have any relevant effect on facultative anaerobe, obligate aerobe and micro-aerophilic bacteria.

Pharmacokinetic properties

Metronidazole is immediately and well absorbed after oral administration. After 1 hour a plasma concentration of 10 micrograms/ml was reached with a single dose of 50 mg. The bioavailability of metronidazole is almost 100% and the half life in the plasma is approximately 8-10 hours. Metronidazole penetrates well into the tissues and bodily fluids, such as saliva, milk, vaginal secretions and semen. Metronidazole is primarily metabolised in the liver. Within 24 hours after oral administration 35-65% of the administered dose (metronidazole and the metabolites thereof) es excreted in the urine.

Pharmaceutical particulars

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years

Shelf life of divided tablets: 3 days

Special precautions for storage

This veterinary medicinal product does not require any special storage conditions.

Immediate packaging

Aluminium - PVC/PE/PVDC blister

Cardboard box of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 25 or 50 blisters of 10 tablets

Cardboard box containing 10 boxes, each containing 1 or 10 blisters of 10 tablets

Not all pack sizes may be marketed.

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Le Vet Beheer B.V., Wilgenweg 7, 3421 TV Oudewater, The Netherlands.

Marketing Authorisation Number

Vm 41821/4029: 250 mg

Vm 41821/4030: 500 mg

Date of the first authorisation or date of renewal

18 December 2015

Date of revision of the text

January 2017

Any other information

For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children.

Legal category

500mg Tablet » Priced Per Tablet

Metrobactin® Tablets for Dogs and Cats

Qualitative and quantitative composition

Metrobactin 250 mg tablets for dogs and cats

1 tablet contains: Active substance:

Metronidazole 250 mg

Metrobactin 500 mg tablets for dogs and cats

1 tablet contains: Active substance:

Metronidazole 500 mg

Pharmaceutical form

Tablet. Light brown with brown spots, round and convex flavoured tablet with a cross-shaped break line on one side.

Tablets can be divided into 2 or 4 equal parts.

Clinical particulars

Target species

Dogs and cats

Indications for use

Treatment of gastrointestinal tract infections caused by Giardia spp. and Clostridia spp. (i.e. C. perfringens or C. difficile).

Treatment of infections of the urogenital tract, oral cavity, throat and skin caused by obligate anaerobic bacteria (e.g. Clostridia spp.) susceptible to metronidazole.

Contraindications

Do not use in case of hepatic disorders.

Do not use in case of hypersensitivity to the active substance or to any of the excipients.

Special precautions for use in animals

Due to the likely variability (time, geographical) in the occurrence of metronidazole resistant bacteria, bacteriological sampling and susceptibility testing are recommended.

Whenever possible, the product should only be used based on susceptibility testing. Official, national and regional anitmicrobial policies should be taken into account when the veterinary medicinal product is used.

In very rare cases, neurological signs may occur especially afer prolonged treatment with metronidazole.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Metronidazole has confirmed mutagenic and genotoxic properties in laboratory animals as well as in humans. Metronidazole is a confirmed carcinogen in laboratory animals and has possible carcinogenic effects in humans. However, there is inadequate evidence in humans for the carcinogenicity of metronidazole. Impervious gloves should be worn during administration of the product to avoid skin contact with the product.

To avoid accidental ingestion, particularly by a child, unused part-tablets should be returned to the open blister space and inserted back into the carton.

In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician. Wash hands thoroughly after handling the tablets.

Adverse reactions

The following adverse reactions may occur after administration of metronidazole: vomiting, hepatotoxicity, neutropenia and neurologic signs.

Use during pregnancy and lactation

Studies in laboratory animals have shown inconsistent results with regard to teratogenic/embryotoxic effects of metronidazole. Therefore, use of this product during pregnancy is not recommended. Metronidazole is excreted in milk and use during lactation is therefore not recommended.

Interactions

Metronidazole may have an inhibitory effect on the degradation of other drugs in the liver, such as phenytoin, cyclosporine and warfarin.

Cimetidine may decrease the hepatic metabolism of metronidazole resulting in increased serum concentration of metronidazole.

Phenobarbital may increase hepatic metabolism of metronidazole resulting in decreased serum concentration of metronidazole.

Amounts to be administered and administration route

For oral administration.

The recommended dose is 50 mg metronidazole per kg body weight per day, for 5 to 7 days. The daily dose may be divided equally for twice daily administration (i.e. 25 mg/kg body weight twice daily).

To ensure administration of the correct dosage body weight should be determined as accurately as possible. The following tables are intended as a guide to dispensing the product at the recommended dose rate of 50 mg per kg body weight per day.

Metrobactin 250 mg tablets for dogs and cats dosage table:

Metrobactin 500 mg tablets for dogs and cats dosage table:

Tablets can be divided into 2 or 4 equal parts to ensure accurate dosing. Place the tablet on a flat surface, with its scored side facing up and the convex (rounded) side facing the surface.

Halves: press down with your thumbs on both sides of the tablet.

Quarters: press down with your thumb in the middle of the tablet.

Overdose

Adverse events are more likely to occur at doses and treatment durations in excess of the recommended treatment regimen. If neurological signs occur, treatment should be discontinued and the patient should be treated symptomatically.

Pharmacological particulars

Pharmacotherapeutic group: (nitro) imidazole derivatives

ATCvet code: QP51AA01, QJ01XD01

Pharmacodynamic properties

After metronidazole has penetrated the bacteria the molecule is reduced by the sensitive bacteria (anaerobe). The metabolites that are created have a toxic effect on the bacteria through binding to the bacterial DNA. In general metronidazole is bactericidal for sensitive bacteria in concentrations equal to or a little higher than the minimum inhibiting concentration (MIC).

Clinically metronidazole does not have any relevant effect on facultative anaerobe, obligate aerobe and micro-aerophilic bacteria.

Pharmacokinetic properties

Metronidazole is immediately and well absorbed after oral administration. After 1 hour a plasma concentration of 10 micrograms/ml was reached with a single dose of 50 mg. The bioavailability of metronidazole is almost 100% and the half life in the plasma is approximately 8-10 hours. Metronidazole penetrates well into the tissues and bodily fluids, such as saliva, milk, vaginal secretions and semen. Metronidazole is primarily metabolised in the liver. Within 24 hours after oral administration 35-65% of the administered dose (metronidazole and the metabolites thereof) es excreted in the urine.

Pharmaceutical particulars

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years

Shelf life of divided tablets: 3 days

Special precautions for storage

This veterinary medicinal product does not require any special storage conditions.

Immediate packaging

Aluminium - PVC/PE/PVDC blister

Cardboard box of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 25 or 50 blisters of 10 tablets

Cardboard box containing 10 boxes, each containing 1 or 10 blisters of 10 tablets

Not all pack sizes may be marketed.

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Le Vet Beheer B.V., Wilgenweg 7, 3421 TV Oudewater, The Netherlands.

Marketing Authorisation Number

Vm 41821/4029: 250 mg

Vm 41821/4030: 500 mg

Date of the first authorisation or date of renewal

18 December 2015

Date of revision of the text

January 2017

Any other information

For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children.

Legal category

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (1)

Q & A

Below are some recent questions we've received regarding Metrobactin Tablets, including answers from our team.

1 June 2018 at 11:56am

Is this product made to taste better to a cat then the human one?

Marie-Eve Bedard

  • VioVet customer since 2016
  • From: , Lebanon

Hi,

Are these tablets made specifically for animals and will be less gag and foaming at the mouth inducing then the human version? If so, can they still be portioned off as 250mg is quite a lot for a cat.

  • Veterinary Advisor

Yes, these tablets are made specifically for cats and dogs and do not have palatibility issues usually. That said some cats can be more fussy than others. The tablets can be split and given according to the weight of your cat. Please see dosage table below.

Metrobactin 250 mg tablets for dogs and cats dosage table:

Body weight (kg) Number of tablets daily
1 to 1.25 1⁄4
> 1.25 to 2.5 1⁄2
> 2.5 to 3.75 3⁄4
> 3.75 to 5 1
> 5 to 7.5 11⁄2
> 7.5 to 10 2
> 10 to 15 3
> 15 to 20 4

5 October 2016 at 7:01pm

Metronidozole

Carol Rich

  • VioVet customer since 2013
  • From: South Yorkshire, United Kingdom

Is Metrobactin exactly the same as Metronidozole?My old dog has Meronidozole long term for upset tum but this time been prescribed 3/4 of a tablet of these instead( He used to have 400mg metronidozole)?

  • Veterinary Advisor

Yes, Metrobactin contains Metronidazole. The Metrobactin tablets contain 500mg of Metronidazole as oppose to the 400mg Metronidazole tablets. This is why your vet has prescribed 3/4 of a tablet of Metrobactin rather than a whole one.