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If you live in the United States then it is still possible to buy Kinavet (licensed as Masivet in the UK) from VioVet.
We can accept a prescription from a US veterinary surgeon under a USDA permit obtained by VioVet. We have a template and description of the prescription process on our website here. We would need your vet to date, sign and stamp the prescription, which must also include pet details, product name, strength and dosage. We would recommend that you scan/photograph and then email your completed prescription from your vet to us on firstname.lastname@example.org or upload a file directly via your account on our website.
Orders must be placed by the owner of the dog being treated - we cannot supply veterinary surgeries with Masivet under any circumstances due to FDA / USDA regulations. We also require a specific written order from a licensed veterinarian stating that the animal should receive the unapproved product and provide a justification for the use of the unapproved drug. We also need an explanation as to why Masivet must be prescribed instead of an alternative medication.
We strongly recommend that you look into import regulations affecting you before placing an order. Royal Mail parcels are not routinely checked by customs but any regulations are applied by customs if they inspect a parcel. We will include all relevant documentation as required by our USDA Import Permit for Masivet with every order to smooth the importation process however the FDA may charge a $22.00 Adminsitration Fee for clearance of the documentation. This will be payable, if requested, to the UPS driver on delivery and is a Federal charge not a VioVet or UPS charge. Please be aware that Royal Mail Air Mail is an untracked service. We can offer delivery with UPS, which offers a tracking service and a quicker estimated delivery time, often under one week. The option for shipping with UPS will be available on orders only containing Masivet.
We can only send a maximum of a three month supply per animal per order. You will be contacted if your order exceeds this and your order will be amended to the appropriate quantity.
Orders can be placed on our website and payment can be made by card, PayPal or direct bank transfer (2.5% fee for for PayPal). Unfortunately we are unable to quote in US dollars- your card provider will be able to tell you the conversion rate they are currently using and will automatically take the correct amount for the payment.
If you would like any further information then email us at email@example.com and we'll do our best to help.
Masivet (licensed as Kinavet in the USA) is supplied as a tablet for use against a certain type of cancer affecting dogs. Masivet is regarded as safe enough to be used at home, and is given as a tablet once daily. It acts against mast cell tumours, by inhibiting cell division, therefore preventing further development of the tumours. Not all dogs respond, but the results can be very helpful for others. Close veterinary supervision is recommended at all times and Masivet is prescription only.
What is Masivet?
Masivet contains masitinib, which belongs to a class of medicines having an anticancer action. It is available as round, orange tablets (50 and 150 mg).
What is Masivet used for?
Masivet is used to treat dogs with mast-cell tumours (a type of cancer). It is used for tumourswhich are severe in character (grade 2 or 3) and which cannot be removed with surgery. It isonly used if the presence of a mutated form of the receptor protein c-kit in the tumours hasbeen confirmed before the start of treatment.
The tablets are given by mouth, once a day. The dose depends on the weight of the dog beingtreated.. The duration of treatment depends on the dog’s response to treatment.
How does Masivet work?
The active substance in Masivet, masitinib, is aprotein-tyrosine kinase inhibitor. This meansthat it blocks some specific enzymes known astyrosine kinases. These enzymes can be foundin some receptors on the surface of cells, including the c-kit receptor. Some types of mast-celltumour are linked to a mutation that causes excessive action of c-kit and stimulates the mastcells to divide uncontrollably. By blocking these receptors, Masivet might help to control celldivision, preventing further development of the tumours with this particular mutation.
How has Masivet been studied?
A number of studies with Masivet were carried out either in laboratory dogs or in animalpatients at veterinary practises in Europe and in the USA. The main study compared theeffectiveness of Masivet at the recommended dose of 12.5 mg per kilogramme bodyweightonce a day with placebo (a dummy treatment). The study included dogs of various breeds andboth sexes with mast-cell tumours that had come back after surgery or could not be removedwith surgery. The study population included dogs whose tumours contained mutated ornormal (‘wild-type’) c-kit receptors.
What is the risk associated with Masivet?
The most common side effects with Masivet are gastrointestinal reactions (diarrhoea andvomiting) and hair loss. These reactions are usually mild to moderate and temporary, last forup to four weeks. Dogs under Masivet treatment should be regularly monitored for side effectsby the veterinarian (at least monthly). In case of side effects, the veterinarian might decide tolower the dose of Masivet or to discontinue treatment.
Masivet must not be used in dogs with certain kinds of liver or kidney problems, or anaemia (low red blood cell counts) or neutropenia (low white blood cell counts). It must not be used in dogs less than six months of age or less than 4kg in weight, or bitches that are pregnant or lactating. It should not be used in dogs that may be hypersensitive (allergic) to masitinib orany of the other ingredients. For a full list of all side-effects reported with Masivet, see the Package Leaflet.
Four to six weeks after starting the treatment with Masivet, the veterinarian should check ifthe treatment is likely to be successful.
What are the precautions for the person who gives the medicine or comes into contact with theanimal?
The tablets must be administered whole and should not be divided, broken or ground up. If broken tablets, or the vomit, urine or faeces of a treated dog comes into contact with the skinor eyes, rinse immediately with plenty of water. Children should not have close contact with treated dogs, or their faeces or vomit. If Masivet is taken accidentally, seek medical advice immediately and show the Package Leaflet or the label to the doctor. Do not eat, drink or smoke while treating a dog. For more information, see the Package Leaflet.
Why has Masivet been approved?
The Committee for Medicinal Products for Veterinary Use (CVMP) concluded that thebenefits of Masivet exceed the risks for the treatment of non-resectable mast cell tumours(grade 2 or 3) that have a confirmed mutated c-kit tyrosine kinase receptor and recommended that Masivet be given a marketing authorisation. The benefit-risk balance may be found inmodule 6 of this EPAR.
Other information about Masivet
The European Commission granted a marketing authorisation valid throughout the European Union, for Masivet to AB Science S.A. on 17 November 2008. Information on the prescriptionstatus of this product may be found on the label/outer package. Because this disease is a life threatening condition and the overall number ofdogs affected is expected to be low, the CVMP guidelines on “Minor-Use-Minor-Species (MUMS) data requirements” were applied when assessing the dossier.
This summary was last updated on May 2009.
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