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MSD Zanil Fluke Drench Treatment

  • 5 litre Bottle £110.99

MSD Zanil Fluke Treatment is an oral drench which is highly effective against adult flukes (which cause chronic disease) present in the bile duct of the animal. It can be administered to both cattle and sheep to control adult fluke at any time of year.

Based on the active ingredient oxyclozanide, which has no known resistance in the UK, Zanil is highly effective against the adult fluke responsible for chronic disease and – significantly for dairy farmers - is licensed for use in young, pregnant and lactating animals, with a 72-hour milk withhold period where milk is produced for human consumption.

Dosage rate is 3ml per 10kg bodyweight in cattle, up to a maximum of 105ml, and 4.5ml per 10kg bodyweight in sheep, up to a maximum of 20ml.


Zanil Fluke Drench 34 mg/ml Oral Suspension


Active substance: mg/ml

Oxyclozanide 34


Methyl hydroxybenzoate (E218) 1.5
Propyl hydroxybenzoate 0.15
Sodium metabisulphite (E223) 1.0

For full list of excipients, see section 6.1


Oral suspension
A smooth off white pourable suspension


4.1 Target Species

Cattle and Sheep

4.2 Indications for use, specifying the target species

Indications: For the treatment and control of chronic fascioliasis in cattle and sheep.

It removes practically all flukes (Fasciola spp.) present in the bile ducts of the liver.

4.3 Contraindications

Do not use in sheep producing milk for human consumption.

Do not use in cases of hypersensitivity to the active substance.

4.4 Special warnings for each target species

At normal dose levels, oxyclozanide is not active against immature flukes present in liver tissue.
Milking cattle, particularly high yielders, may occasionally show a reduction in yield of 5% or more for about 48 hours after handling. The effect of this small loss may be minimised by spreading herd dosing over a period of about a week.

4.5 Special precautions for use

i. Special precautions for use in animals

Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
Underdosing, which may be due to underestimation of body weight, misadministration of the product or lack of calibration of the dosing device (if any).
Suspected clinical cases of resistance to anthelmintics should be further investigates using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmaceutical class and having a different mode of action should be used.

To date no resistance to oxyclozanide has been reported. Use of the product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.

Care should be taken when administering by dosing gun.

Due regard must be given to the physical condition of the animals undergoing treatment, particularly those in advanced pregnancy and / or under stress from adverse weather conditions, poor nutrition, penning, handling etc.

ii. Special precautions to be taken by the person administering the veterinary medicinal product to animals

Do not eat, drink or smoke when using this product.
Wash splashes from eyes and skin immediately.
Take off any contaminated clothing immediately.
User should wear chemical resistant gloves during administration of the product.
Wash hands and exposed skin before meals and after work.

4.6 Adverse reactions (frequency and seriousness)

At normal oxyclozanide dose levels, cattle may show slight softening of the faeces with the occasional animal showing increased frequency of defecation and transient inappetence. The effects of oxyclozanide overdosage are dullness and some loosening of faeces in sheep and possible diarrhoea, inappetance and loss of weight in cattle. These effects are occasionally enhanced in animals with severe liver damage and/or dehydration at the time of dosing.

4.7 Use during pregnancy, lactation or lay

The product may be given to young, pregnant and lactating animals.

4.8 Interaction with other medicinal products and other forms of interaction

None known.

4.9 Amounts to be administered and administration route

The product can be given to young, pregnant and lactating animals and those in debilitated condition (in the absence of inter current disease).

Give as an oral drench. Shake the product well before use.

The body weight of animals should be assessed as accurately as possible before calculating the dosage. The accuracy of the dosing device should be checked.

If animals are to be treated collectively rather than individually, they should be grouped according to their bodyweight and dosed accordingly, in order to avoid under- or overdosing.

Dose according to body weight at the rate of 10 mg oxyclozanide per kg body weight for cattle and 15 mg oxyclozanide per kg body weight for sheep as follows:-

Cattle : 3 ml per 10 kg body weight

For example:-

Body weight Dose
50 kg (approx. 1 cwt) 15 ml
100 kg (approx. 2 cwt) 30 ml
150 kg (approx. 3 cwt) 45 ml
200 kg (approx. 4 cwt) 60 ml
250 kg (approx. 5 cwt) 75 ml
300 kg (approx. 6 cwt) 90 ml
350 kg and over (approx. 7 cwt and over) 105 ml
Drench can be given in the feed to cattle which are fed individually. Pour the recommended dose onto their concentrate ration. Molasses or salt may be added for shy feeders.

Sheep: 4.5 ml per 10 kg body weight

For example:-

Body weight Dose
10 kg (approx. 22 lb) 4.5 ml
20 kg (approx. 44 lb) 9.0 ml
30 kg (approx. 66 lb) 13.5 ml
40 kg (approx. 88 lb) 18.0 ml
45 kg and over (approx. 100 lb and over) 20.0 ml

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary

The effects of oxyclozanide overdosage are dullness and some loosening of faeces in sheep and possible diarrhoea, inappetence and loss of weight in cattle. These effects are occasionally enhanced in animals with severe liver damage and/or dehydration at the time of dosing.

4.11 Withdrawal period(s)

Meat and offal: 28 days.
Milk: 72 hours.

Meat and offal: 28 days.
Milk: Do not use in sheep producing milk for human consumption.


Pharmacotherapeutic group: Anthelmintics, Oxyclozanide

ATCvet code: QP52AG06

5.1 Pharmacodynamic properties

Oxyclozanide is an anthelmintic of the salicylanilide group. It is effective against Fasciola species, acting as an uncoupler of oxidative phosphorylation. It may act at more than one site to decrease levels of ATP leading to metabolic malfunction and death of the parasite.

5.2 Pharmacokinetic particulars

Oxyclozanide is slowly absorbed after oral administration with peak plasma levels 24 hours after dosing. Excretion is predominantly faecal, biliary excretion being the most important route of elimination (cattle studies only).


6.1 List of excipients

Sodium metabisulphite (antioxidant) E223
Methyl hydroxybenzoate (preservative) E218
Propyl hydroxybenzoate (preservative)
Sodium laurilsulphate
Aluminium magnesium silicate
Carmellose sodium
Sodium citrate
Purified water

6.2 Incompatibilities

In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

6.3 Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years

6.4 Special precautions for storage

Do not store above 25°C.
Protect from light.
Do not freeze.

6.5 Nature and composition of immediate packaging

An off-white, smooth uniform suspension in the following packs:

5 and 10 litre high density polyethylene flexipacks with polypropylene or urea formaldehyde screw caps with wads of PVDC-faced paper or a pulpboard liner.

1, 2.5, 5 litre high density polyethylene back packs with polypropylene screwcaps.

6.6 Special precautions for the disposal of unused veterinary medicinal
product or waste materials derived from the use of such products

Do not contaminate ponds, waterways or ditches with the product or used container.
Harmful to aquatic life.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.


Intervet UK Ltd.
Walton Manor
Milton Keynes


Vm 01708/4595


Date: 01/09/1972


Date: June 2013

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11th Dec 2017

Very confusing direction on 5litre jar it suggests the maximum dose is 105ml which I gave to three animals these animals were dosed two days ago they weighed from 450kg to 650kg they were under dosed at 105 ml can you advise on what ti do

  • Veterinary Advisor

Very sorry- you are right that the dosing information is confusing. I would agree that the dosing information on the bottle suggests that for any cattle over 350kg then no more than 105mls is required so in actual fact you have dosed correctly.