Librela® solution for injection for dogs

Librela® solution for injection for dogs
5mg » 2 Vials

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  • 5mg » 2 Vials £65.33
  • 10mg » 2 Vials £68.09
  • 15mg » 2 Vials £70.85
  • 20mg » 2 Vials £72.71
  • 30mg » 2 Vials £75.01

Selection of 5 products from

£65.33 to £75.01

Description

Librela is an innovative drug for the alleviation of pain associated with osteoarthritis in dogs. The medication contains a canine monoclonal antibody (mAb) which targets nerve growth factor (NGF). This inhibits NGF-mediated cell signalling which has been demonstrated to provide relief from pain associated with osteoarthritis. The product is administered by monthly injection and has been proven to reduce pain scores in dogs with osteoarthritis.

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Medication Datasheets

Reviews (2)

Summary of Reviews for Librela® solution for injection for dogs

Overall 4
Effectiveness
Ease Of Use
Value For Money
Absence Of Side Effects
2 out of 2 (100%) customers would recommend this product.
5 stars (0 reviews)
4 stars (2 reviews)
3 stars (0 reviews)
2 stars (0 reviews)
1 stars (0 reviews)

Only verified purchasers of this product can leave a review.

45 Librela
Verified Purchase

By on 29 May 2021

No wonder cure in a 13 year old Labrador suffering from osteoarthritis, but I noticed him walking a bit easier and for longer, in particular the first 2 weeks following the injection. I would recommend it.

Customer recommends this product

1 person found this review helpful

45 Librela
Verified Purchase

By on 1 May 2021

Absolutely amazing! Noticed a difference in Ed’s stiffness and pain. He is walking better and is so much brighter as his pain is obviously reduced! Very happy and will be continuing with this product.

Customer recommends this product

2 people found this review helpful

Q & A

Below are some recent questions we've received regarding Librela® solution for injection for dogs, including answers from our team.

11 June 2021 at 12:36pm

Frequency of doses

Linda kennett

Can librella be given earlier than monthly my dog has had 2 injections and I find at week 3 she is showing a lot of pain again.

  • VioVet Staff

The datasheet for this product only states it can be used monthly. Your prescribing vet can contact the manufacturer to discuss off license more frequent use and if this is beneficial, I recommend discussing this with them so they can advise.

3 June 2021 at 8:34pm

Kidney disease and librela

Penny

Is librela safe to use with dogs with failing kidneya?

  • VioVet Staff

Kidney disease is not a listed contraindication in the datasheet, in fact Librela is much safer for dogs with kidney disease than other medications for oesteoarthritis. I advise confirming whether the medication is safe for your dog with your prescribing vet.

2 June 2021 at 1:15pm

Librela and leveticitum

Julie parsons

Can my dog have the librela injection if he's on leveticitum?

  • VioVet Staff

The datasheet for this product states that no interactions were observed in field studies where this veterinary
medicinal product was administered concomitantly with veterinary
medicinal products containing parasiticides, antimicrobials, topical
antiseptics with or without corticosteroids, antihistamines and
vaccines. Levetiracetam is not listed here so it is not know if they react, but theoretically they should not and will be safe to use together. I would discuss this with your prescribing vet to be certain.

22 May 2021 at 2:11pm

Does Librela have a cumulative effect

J Smith

My dog initially showed improvement for eight days after the first dose of Librela but is slowly showing return of pain. Does Librela have a cumulative effect, meaning will further injections mean a longer period of relief for our dog.

  • VioVet Staff

The datasheet for this product states the following:

In a 6-month laboratory study of healthy, adult Beagles administered
bedinvetmab every 28 days at doses ranging from 1-10 mg/kg, AUC and Cmax
increased nearly in proportion to dose and steady-state was achieved
after approximately 2 doses. In a laboratory pharmacokinetic study at
the clinical label dose (0.5-1.0 mg/kg bw), peak serum drug levels
(Cmax) of 6.10 μg/ml were observed at 2-7 days (tmax = 5.6 days) after
subcutaneous dosing, the bioavailability was approximately 84%, the
elimination half-life was approximately 12 days, and the mean AUC0-∞ was
141 μg x d/ml.

This means that it took around 2 doses before a steady-state of the medication was achieved in the body. There is no 'cumulative' effect mentioned so I advise persisting at the recommended dose as advised by your vet to see the best benefits of the product.

19 May 2021 at 12:13pm

Does the vial come with a syringe to administer the injection

Jill Eagleton

  • VioVet customer since 2016
  • From: Devon, United Kingdom

My vet has prescribed Librela. Is it possible to administer the injection at home or does it have to be given by a vet?

  • VioVet Staff

This product does not come with a syrigne or needle, you can purchase these separately through our website though.
It is administered via injection so it is strongly advised you chat to your vet if wanting to perform this at home. They will need to write a prescription for purchase through our site anyway.

7 May 2021 at 12:01pm

Librela v Meloxicam

Val

Does Librela improve mobility in dogs more than the effects of administering Meloxicam.

  • VioVet Staff

This is very subjective and greatly varies on the level of arthritis your dog has. Meloxicam works to reduce pain by causing anti-inflammatory effects in the joint whilst Librela works on the pain receptors themselves directly. Unfortunately there is no simple 'one is better than the other' answer and I advise following your vet's advice on what to use.

30 April 2021 at 7:11pm

Effect?

Jane

How long after the first injection does it take for Librela to take effect? I have a 9 year old labrador with arthritis in both elbows. As a consequence of slowing up he has been putting on weight so he is on a restricted diet and in severe discomfort..... not much fun for a food loving dog!

  • VioVet Staff

According to the data sheet 17.8% of dogs will see an improvement after 7
days and 43.5% of dogs after 28 days. We recommend following your vets
advice and persisting with the treatment course as long as they advise.

29 April 2021 at 9:02am

Prednisolone

Maria

Can librela co-administered with Prednisolone?

  • VioVet Staff

The datasheet for this product states the following:

No interactions were observed in field studies where this veterinary
medicinal product was administered concomitantly with veterinary
medicinal products containing parasiticides, antimicrobials, topical
antiseptics with or without corticosteroids, antihistamines and
vaccines.

Prednisolone is a corticosteroid which means there were no observed issues using Librela alongside drugs like Prednisolone during clinical trials. This is a prescription medication though so you should discuss it's use with your vet anyway.

23 April 2021 at 3:39pm

Contraindications for other drugs

Denise

My dog is on a selection of differing drugs daily; Vetmedin, 2.5mg Prednisolone, Omeprazole, Traileve and Amantadine alongside monthly Cartrophen and Zycortal injections. My Vet wants to try monthly Librella injections in addition for his worsening Osteoarthritis . Would the above med cocktail cause any known contraindications for the use of Librella?

  • VioVet Staff

The safety data for this product regarding use with other drugs is as follows, as found on the datasheet:

In a laboratory study over a 2-week period in young, healthy dogs
without osteoarthritis, this veterinary medicinal product had no adverse
effect when concomitantly administered with a non-steroidal
anti-inflammatory product (carprofen).

There are no safety data on the concurrent long-term use of NSAIDs
and bedinvetmab in dogs. In clinical trials in humans, rapidly
progressive osteoarthritis has been reported in patients receiving
humanised anti-NGF monoclonal antibody therapy. The incidence of these
events increased with high doses and in those human patients that
received long-term (more than 90 days) non-steroidal anti-inflammatory
drugs (NSAIDs) concomitantly with an anti-NGF monoclonal antibody.

Dogs have no reported equivalent of human rapidly progressive osteoarthritis.
No other laboratory studies on the safety of concomitant
administration of this veterinary medicinal product with other
veterinary medicinal products have been conducted. No interactions were
observed in field studies where this veterinary medicinal product was
administered concomitantly with veterinary medicinal products containing
parasiticides, antimicrobials, topical antiseptics with or without
corticosteroids, antihistamines and vaccines.

This means that it is unknown whether an interaction with Vetmedin, Omeprazole, Tralieve, Amantadine, Zycortal and Cartrophen will occur. Studies have shown there were no issues with using prednisolone (a corticosteroid). There is no medical reason why the drug would interact with these medications though so it is likely to be safe, but you should run this past your vet first.

20 April 2021 at 2:58pm

Doseage vs Weight

Jim Swain

Hi, our great dane has been described this and receives 2*20mg vials together monthly. She weighs 63Kg but I can see from your product images that it states up to 40kg on the 20mg pack and up to 60kg on the 30mg pack. Does this mean she would be better having 30mg ?

thanks in advance

Jim

  • VioVet Staff

The dose according to the datasheet for this product is 0.5-1.0mg/kg. This means your 63kg dog would need a 31.5mg dose as a minimum. This is likely why your vet administers x 20mg vials as the largest vial size is 30mg and this would be too small for your dog.

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