Librela® solution for injection for dogs

The datasheet for this product only states it can be used monthly. Your prescribing vet can contact the manufacturer to discuss off license more frequent use and if this is beneficial, I recommend discussing this with them so they can advise.

Kidney disease is not a listed contraindication in the datasheet, in fact Librela is much safer for dogs with kidney disease than other medications for oesteoarthritis. I advise confirming whether the medication is safe for your dog with your prescribing vet.

The datasheet for this product states that no interactions were observed in field studies where this veterinary
medicinal product was administered concomitantly with veterinary
medicinal products containing parasiticides, antimicrobials, topical
antiseptics with or without corticosteroids, antihistamines and
vaccines. Levetiracetam is not listed here so it is not know if they react, but theoretically they should not and will be safe to use together. I would discuss this with your prescribing vet to be certain.

The datasheet for this product states the following:

In a 6-month laboratory study of healthy, adult Beagles administered
bedinvetmab every 28 days at doses ranging from 1-10 mg/kg, AUC and Cmax
increased nearly in proportion to dose and steady-state was achieved
after approximately 2 doses. In a laboratory pharmacokinetic study at
the clinical label dose (0.5-1.0 mg/kg bw), peak serum drug levels
(Cmax) of 6.10 μg/ml were observed at 2-7 days (tmax = 5.6 days) after
subcutaneous dosing, the bioavailability was approximately 84%, the
elimination half-life was approximately 12 days, and the mean AUC0-∞ was
141 μg x d/ml.

This means that it took around 2 doses before a steady-state of the medication was achieved in the body. There is no 'cumulative' effect mentioned so I advise persisting at the recommended dose as advised by your vet to see the best benefits of the product.

This product does not come with a syrigne or needle, you can purchase these separately through our website though.
It is administered via injection so it is strongly advised you chat to your vet if wanting to perform this at home. They will need to write a prescription for purchase through our site anyway.

This is very subjective and greatly varies on the level of arthritis your dog has. Meloxicam works to reduce pain by causing anti-inflammatory effects in the joint whilst Librela works on the pain receptors themselves directly. Unfortunately there is no simple 'one is better than the other' answer and I advise following your vet's advice on what to use.

According to the data sheet 17.8% of dogs will see an improvement after 7
days and 43.5% of dogs after 28 days. We recommend following your vets
advice and persisting with the treatment course as long as they advise.

The datasheet for this product states the following:

No interactions were observed in field studies where this veterinary
medicinal product was administered concomitantly with veterinary
medicinal products containing parasiticides, antimicrobials, topical
antiseptics with or without corticosteroids, antihistamines and
vaccines.

Prednisolone is a corticosteroid which means there were no observed issues using Librela alongside drugs like Prednisolone during clinical trials. This is a prescription medication though so you should discuss it's use with your vet anyway.

The safety data for this product regarding use with other drugs is as follows, as found on the datasheet:

In a laboratory study over a 2-week period in young, healthy dogs
without osteoarthritis, this veterinary medicinal product had no adverse
effect when concomitantly administered with a non-steroidal
anti-inflammatory product (carprofen).
There are no safety data on the concurrent long-term use of NSAIDs
and bedinvetmab in dogs. In clinical trials in humans, rapidly
progressive osteoarthritis has been reported in patients receiving
humanised anti-NGF monoclonal antibody therapy. The incidence of these
events increased with high doses and in those human patients that
received long-term (more than 90 days) non-steroidal anti-inflammatory
drugs (NSAIDs) concomitantly with an anti-NGF monoclonal antibody.
Dogs have no reported equivalent of human rapidly progressive osteoarthritis.
No other laboratory studies on the safety of concomitant
administration of this veterinary medicinal product with other
veterinary medicinal products have been conducted. No interactions were
observed in field studies where this veterinary medicinal product was
administered concomitantly with veterinary medicinal products containing
parasiticides, antimicrobials, topical antiseptics with or without
corticosteroids, antihistamines and vaccines.

This means that it is unknown whether an interaction with Vetmedin, Omeprazole, Tralieve, Amantadine, Zycortal and Cartrophen will occur. Studies have shown there were no issues with using prednisolone (a corticosteroid). There is no medical reason why the drug would interact with these medications though so it is likely to be safe, but you should run this past your vet first.

The dose according to the datasheet for this product is 0.5-1.0mg/kg. This means your 63kg dog would need a 31.5mg dose as a minimum. This is likely why your vet administers x 20mg vials as the largest vial size is 30mg and this would be too small for your dog.