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Janssen Flukiver Oral Suspension

  • 5% v/w Oral Suspension » 1 litre Bottle £50.50
  • 5% v/w Oral Suspension » 5 litre Bottle £121.49

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Effective against immature and mature flukes, larval stages of Oestrus ovis (sheep nasal bot fly), and inhibited, immature and adult stages of Haemonchus contortus, including benzimidazole resistant strains. Ticks (Ixodes ricinus) feeding on sheep at the time of treatment are likely to producte fewer viable eggs.

Target Species: Sheep and Lambs

Each ml contains 50mg closantel (as closantel sodium)


Off-white to slightly yellow oral suspension containing equivalent of 50 mg closantel per ml (as closantel sodium dihydrate).


For the control of chronic and sub-acute fascioliasis (due to Fasciola hepatica) in sheep and lambs. For the control of Oestrus ovis (Sheep Nasal Bot Fly). For the control of inhibited, immature and adult stages of Haemonchus contortus (Barber Pole worm) including benzimidazole resistant strains.

Flukiver is active against mature and immature flukes.


% kill


97–100 %

6–8 weeks immature

91-95 %

5 weeks immature

91 %

3–4 weeks immature

23–73 %

Ticks (Ixodes ricinus) feeding on sheep at the time of treatment are likely to produce fewer viable eggs.

Dosage and administration

1 ml of Flukiver per 5 kg bodyweight (i.e. 10 mg closantel per kg bodyweight).

For example:



Up to 5 kg

1 ml

10 kg

2 ml

20 kg

4 ml

30 kg

6 ml

40 kg

8 ml

50 kg

10 ml

60 kg

12 ml

70 kg

14 ml

80 kg

16 ml

To ensure administration of a correct dose, bodyweight should be determined as accurately as possible; accuracy of the dosing device should be checked.

Give orally as a drench. Suitable for use with most types of standard drenching equipment. Shake well before use. Do not mix with other products.

Suggested dosing schedule


All sheep on fluke-infested pasture should be dosed at regular intervals during the fluke season (Sept–Mar). Regional fluke forecasts from DEFRA assist in the choice of dosing time and interval.

Since closantel has been shown to delay egg-laying for up to 13 weeks after artificial infection, treatment intervals of 10–12 weeks throughout the fluke season are recommended. In severe fluke seasons, more frequent dosing may be necessary.

The treatment of ewes with a single dose of Flukiver in the spring will contribute to reducing pasture contamination during the following summer and autumn.

Any sheep brought in from liver fluke infested areas should be dosed before they join the flock.

H. contortus

For the treatment and prevention of benzimidazole resistant and susceptible H. contortus, dose at lambing to help prevent pasture contamination by infected ewes. Treat all animals at 6 weekly intervals during high risk periods in summer and autumn.

Contra-indications, warnings, etc

Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:

•Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.

•Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device (if any).

Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

Resistance to closantel has been reported in Haemonchus outside the EU. The use of this product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.

When using a drenching gun, take care not to injure the mouth or pharynx.

Do not exceed the stated dose.

Withdrawal periods

Meat: 42 days

Do not use in sheep producing milk for human consumption.


Symptoms of acute overdosage are decreased vision or blindness, anorexia, incoordination and general weakness.

Operator warnings

Wash hands after administration.

Pharmaceutical precautions

The time between withdrawal of the first and last doses from the container should not be unduly prolonged. Do not store above 25 °C. Protect from light. For animal treatment only. Keep out of the reach and sight of children.

Legal category


Packaging Quantities

1 L, 2.5 L and 5 L plastic flexipacks. Not all pack sizes may be marketed.

Further information

Flukiver can be used in all age groups of sheep and lambs. It can also be used in rams at any time including during the breeding season. It can be used at any time during pregnancy.

Marketing authorisation number

Vm 00006/4142.

GTIN (Global Trade Item No)

Flukiver 5% w/v Oral Suspension 1 x 25L


Flukiver 5% w/v Oral Suspension 1 x 5L


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12th Feb 2018

can it be used on pregnant ewes

  • Veterinary Advisor

Flukiver can be used in all age groups of sheep and lambs. It can also be used in rams at any time including during the breeding season. It can be used at any time during pregnancy.