Some bitches which have been spayed will leak urine when they are asleep or at rest. This condition, which can start to happen a few years later, is partly due to the different hormone levels found. Incurin contains a low dose of Estriol, an oestrogen which acts on the bladder and urethra to help prevent urine leaking ("sphincter mechanism incontinence"). Usually the dose is one tablet per day, or a maximum of 2 daily. Many bitches show a good response and after a period of time, the dose can be reduced, or given on alternate days. Medication is usually required lifelong.
Active substance: estriol 1 mg/tablet.
See list of full excipients in section "Pharmaceutical particulars".
Round single-scored tablets.
The treatment of hormone-dependent urinary incontinence due to sphincter mechanism incompetence in ovariohysterectomised bitches.
Do not use in intact bitches, as the efficacy has only been established in ovariohysterectomised bitches. Animals showing a polyuria-polydipsia should not be treated with Incurin. The use of Incurin is contraindicated during pregnancy, lactation and in animals younger than 1 year.
High doses of oestrogen may have a tumour-promoting effect in target organs with oestrogen receptors (mammary glands).
In case of oestrogenic effects, the dose should be lowered.
Oestrogenic effects such as swollen vulva, swollen mammary glands and/or attractiveness to males and vomiting have been observed at the highest recommended dose of 2 mg per dog. The incidence is about 5-9 %. These effects are reversible after lowering the dose. In rare cases vaginal bleeding occurred. In rare cases development of alopecia has also been observed.
Do not use this product during pregnancy or lactation. See also Contraindications above.
For oral administration. A relationship between final effective dose and body weight has not been established and therefore the dose has to be determined for each dog on an individual basis. The following dosing schedule is advised: start treatment with 1 tablet (1 mg estriol) every day. If treatment is successful, lower the dose to half a tablet a day. If treatment is not successful, increase the dose to 2 tablets a day to be given in one dose. Some dogs do not need daily treatment; treatment every other day may be tried, once the effective daily dose has been established. The minimum dose given should not be less than 0.5 mg per dog per day. Ensure the dose used to achieve the therapeutic effect is as low as possible. Do not use more than 2 tablets per dog per day. If no response to treatment is obtained the diagnosis should be reconsidered in order to investigate other causes for the incontinence such as neurological disorders, bladder neoplasia, etc. Animals should be re-examined every 6 months during treatment.
In case of overdose typical oestrogen effects may occur. These effects are reversible after lowering the dose.
Pharmacotherapeutic group: estrogens, ATCvet code: QG03CA04.
Estriol is a short-acting natural oestrogen. In ovarioectomised female dogs it has a beneficial effect on urinary incontinence. In the target animal safety study and the clinical trials, including long-term treatment, no signs of bone marrow suppression were observed. This is probably due to the short-acting oestrogenic character of estriol.
After oral administration Estriol is nearly completely absorbed from gastrointestinal tract. Nearly the whole Estriol is bound to Albumin in Plasma. Estriol is excreted in conjugated from via the urine. After oral administration of multiple doses no accumulation occurs.
Amylopectin, Potato starch, Magnesium stearate and Lactose
Do not store above 30°C.
Blister package of clear PVC film backed by aluminium foil provided with heat seal coating (vinyl copolymer) on the side in contact with the tablets. One blister contains 30 tablets.
Pack size: carton box with 1 blister.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
15 March 2000
15 March 2010
All prices include VAT where applicable.
Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.
For UK delivery, we charge the following:
Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.
For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.
We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.
Due to air freight restrictions aerosols cannot ever be sent abroad by Royal Mail. We appreciate your understanding.
Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.
Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.
To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.
*For full details on returns, see our terms and conditions page.
Below are some recent questions we've received regarding Incurin 1mg Tablets for Dogs, including answers from our team.
My dog has been on Incurin for about 3 weeks and has become very itchy. She is constantly nibbling at herself all over and has a rash at the topo of her leg/belly.
Theoretically any medication can result in some sort of adverse reaction and an itchy skin is what sometimes happens. Having said that, there are a huge number of dogs which develop itchy skins, often at this time of year, and they are not on Incurin or anything else. The sensible thing would be to asky your vet if it would be safe to stop the Incurin and see what happens for a week or two. My feeling is that there is a high chance that the Incurin is nothing to do with it, but if the two things started at the same time, one has to be suspicious of the Incurin. A more likely reason would be an allergy to fleas or something. Are you treating for fleas? Have you seen any at all? Have you looked carefully(and for flea droppings in the coat)? It could be the Incurin but more likely something else. Either way, you need to find out what it is.