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Galastop Oral Solution for Dogs

Galastop Oral Solution for Dogs
7ml Bottle
15ml Bottle

  • 7ml Bottle £21.49
  • 15ml Bottle £41.99

Selection of 2 products from

£21.49 to £41.99

Description

Galastop is used to stop the signs of phantom pregnancy in bitches, including the production of milk. Usually the bitch's behaviour signs are the first to respond (such as nesting behaviour) then milk production dries up. Galastop can also be used after the birth of puppies if this is required. Galastop is supplied as a liquid which is given once daily by mouth for at least 4 days. If required, treatment can be continued for up to 12 days. Most bitches respond after a few days.

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Medication Datasheets

7ml Bottle

Galastop 50 μg/ml oral solution

Presentation

A pale yellow, viscous non aqueous solution for oral administration containing 50 μg/ml cabergoline in a miglyol base.

Uses

Cabergoline is an ergoline derivative with a potent, selective and long-lasting inhibitory effect on prolactin secretion. Prolactin is the key hormone for lactogenesis and for the initiation and maintenance of lactation after parturition.

Treatment of false pregnancy in bitches

Inhibition of prolactin secretion by cabergoline results in a rapid resolution of the signs of false pregnancy, including lactation and behavioural changes.

Suppression of lactation in bitches

Suppression of lactation in the bitch may be required under certain clinical circumstances (for example following removal of puppies soon after birth, or following early weaning). Inhibition of prolactin secretion by Galastop® results in a rapid cessation of lactation and a reduction in the size of the mammary glands.

Dosage and administration

Galastop® should be administered orally either directly into the mouth or by mixing with food.

The dosage is 0.1 ml/kg bodyweight (equivalent to 5 μg/kg body weight of cabergoline) once daily for 4-6 consecutive days, depending on the severity of the clinical condition.

For dogs less than 5 kg bodyweight it is advisable to measure the dosage in drops, 3 drops being equivalent to 0.1 ml.

The solution can be given either with the dropper or the syringe.

If the signs fail to resolve after a single course of treatment, or if they recur after the end of treatment, then the course of treatment may be repeated.

For treatment of false pregnancy, clinical studies have demonstrated efficacy between 80-100%. Behavioural signs are alleviated first, followed by reduction in mammary gland enlargement, then finally suppression of lactation.

Contra-indications, warnings, etc

Do not use in pregnant animals since Galastop may cause abortion. Do not use in lactating bitches unless suppression of lactation is required.

Galastop may induce transient hypotension in treated animals. Do not use in animals concurrently being treated with hypotensive drugs. Do not use directly after surgery whilst the animal is still under the influence of the anaesthetic agents.

Do not use with dopamine antagonist.

Special warnings for each target species

Additional supportive treatments should involve restriction of water and carbohydrate intake and increase exercise.

Special precautions for use in animals

Cabergoline has the capacity to cause abortion in bitches in the later stages of pregnancy. Under no circumstances should Galastop be used in pregnant bitches.

Cabergoline may induce transient hypotension in treated animals and use of Galastop in animals concurrently being treated with hypotensive drugs, or in animals directly after surgery whilst the animal is still under the influence of anaesthetic agents, might result in more significant hypotension and such usage is contra-indicated.

Special precautions to be taken by the person administering the medicinal product to animals

Wash hands after use. Avoid contact with skin and eyes wash of any splashes immediately. Care should be taken to avoid contact between the solution and women of childbearing age. Women of childbearing age should wear gloves when administering the product.

For animal treatment only. Keep out of reach and sight of children.

Adverse reactions

Use in pregnant animals

Experimental data have shown that cabergoline has the capacity to cause abortion in bitches in the later stages of pregnancy: this effect was seen in all bitches tested. Therefore a contra-indication against use of Galastop in pregnancy is essential.

Induction of hypotension

Experimental data have shown that cabergoline has a hypotensive effect. This side-effect would not be expected to have adverse effects in clinical use because:

- The degree of this effect is not great and would not be expected to have adverse effects in healthy animals;

- In none of the experiments undertaken with cabergoline for whatever purpose and in whatever species has any evidence been observed of any adverse clinical reactions resulting from this hypotensive effect.

Nevertheless if an animal had low blood pressure for other reasons (e.g. concurrent use of hypotensive drugs, influence of anaesthetic agents), cabergoline might have adverse effects, and a warning to prevent usage of Galastop under such conditions is included.

Emetic effects

The tolerance data show that cabergoline has emetic activity in the dog. This effect appears to be dose related, and is marked at doses of 10 µg/kg and above (the ED50 – the dose causing emesis in 50% of treated dogs – being calculated at 19 µg/kg).

In the clinical studies vomiting and anorexia was observed in a proportion of bitches treated as recommended for Galastop: in those studies where frequency was recorded, a total of 361 bitches were treated as recommended; of these 28 bitches (8%) vomited and 58 bitches (16%) showed anorexia.

In most cases these adverse effects were transient and of little significance, occurring after the first one or two treatments only. In only 3 bitches in the clinical trials (less that 1%) was treatment stopped because of vomiting.

In a small proportion of cases (qualitative frequency not available), a degree of drowsiness was observed in the first 2 days of treatment.

Use during pregnancy, lactation or lay

Cabergoline has the capacity to cause abortion in bitches in the later stages of pregnancy and under no circumstances should Galastop be used in pregnant bitches.

Galastop is indicated for the suppression of lactation in bitches: inhibition of prolactin secretion by cabergoline results in a rapid cessation of lactation and a reduction in the size of the mammary glands. Galastop should not be used in lactating bitches unless suppression of lactation is required.

Interactions

Interactions between cabergoline and other veterinary medicinal products have not been observed.

Since cabergoline exerts its therapeutic effect by direct stimulation of dopamine receptors, Galastop should not be administered concurrently with drugs which have dopamine antagonist activity (such as phenothiazines, butyrophenones), as these might reduce its prolactin inhibiting effects.

Overdose

The experimental data indicate that a single overdose with Galastop might result in an increased likelihood of post-treatment vomiting, and possibly an increase in post-treatment hypotension.

General supportive measures should be undertaken to remove any unabsorbed drug and maintain blood pressure, if necessary. It is unlikely that the administration of dopamine antagonist drugs would be necessary, but this course of action could be considered.

Pharmaceutical precautions

Store below 25°C. Protect from light. Do not refrigerate. After opening, use the product within 28 days. Store in tightly closed original container.

Any unused product or waste materials should be disposed of in accordance with local requirements.

Legal category

Packaging quantities

Amber type III glass bottle with screw cap, containing 7 ml or 15 ml 0.005% cabergoline oily solution; supplied with a clear type I glass pipette (graduated dropper) with protective cover

Further information

Nil.

Marketing Authorisation Number

Vm 28350/4001

15ml Bottle

Galastop 50 μg/ml oral solution

Presentation

A pale yellow, viscous non aqueous solution for oral administration containing 50 μg/ml cabergoline in a miglyol base.

Uses

Cabergoline is an ergoline derivative with a potent, selective and long-lasting inhibitory effect on prolactin secretion. Prolactin is the key hormone for lactogenesis and for the initiation and maintenance of lactation after parturition.

Treatment of false pregnancy in bitches

Inhibition of prolactin secretion by cabergoline results in a rapid resolution of the signs of false pregnancy, including lactation and behavioural changes.

Suppression of lactation in bitches

Suppression of lactation in the bitch may be required under certain clinical circumstances (for example following removal of puppies soon after birth, or following early weaning). Inhibition of prolactin secretion by Galastop® results in a rapid cessation of lactation and a reduction in the size of the mammary glands.

Dosage and administration

Galastop® should be administered orally either directly into the mouth or by mixing with food.

The dosage is 0.1 ml/kg bodyweight (equivalent to 5 μg/kg body weight of cabergoline) once daily for 4-6 consecutive days, depending on the severity of the clinical condition.

For dogs less than 5 kg bodyweight it is advisable to measure the dosage in drops, 3 drops being equivalent to 0.1 ml.

The solution can be given either with the dropper or the syringe.

If the signs fail to resolve after a single course of treatment, or if they recur after the end of treatment, then the course of treatment may be repeated.

For treatment of false pregnancy, clinical studies have demonstrated efficacy between 80-100%. Behavioural signs are alleviated first, followed by reduction in mammary gland enlargement, then finally suppression of lactation.

Contra-indications, warnings, etc

Do not use in pregnant animals since Galastop may cause abortion. Do not use in lactating bitches unless suppression of lactation is required.

Galastop may induce transient hypotension in treated animals. Do not use in animals concurrently being treated with hypotensive drugs. Do not use directly after surgery whilst the animal is still under the influence of the anaesthetic agents.

Do not use with dopamine antagonist.

Special warnings for each target species

Additional supportive treatments should involve restriction of water and carbohydrate intake and increase exercise.

Special precautions for use in animals

Cabergoline has the capacity to cause abortion in bitches in the later stages of pregnancy. Under no circumstances should Galastop be used in pregnant bitches.

Cabergoline may induce transient hypotension in treated animals and use of Galastop in animals concurrently being treated with hypotensive drugs, or in animals directly after surgery whilst the animal is still under the influence of anaesthetic agents, might result in more significant hypotension and such usage is contra-indicated.

Special precautions to be taken by the person administering the medicinal product to animals

Wash hands after use. Avoid contact with skin and eyes wash of any splashes immediately. Care should be taken to avoid contact between the solution and women of childbearing age. Women of childbearing age should wear gloves when administering the product.

For animal treatment only. Keep out of reach and sight of children.

Adverse reactions

Use in pregnant animals

Experimental data have shown that cabergoline has the capacity to cause abortion in bitches in the later stages of pregnancy: this effect was seen in all bitches tested. Therefore a contra-indication against use of Galastop in pregnancy is essential.

Induction of hypotension

Experimental data have shown that cabergoline has a hypotensive effect. This side-effect would not be expected to have adverse effects in clinical use because:

- The degree of this effect is not great and would not be expected to have adverse effects in healthy animals;

- In none of the experiments undertaken with cabergoline for whatever purpose and in whatever species has any evidence been observed of any adverse clinical reactions resulting from this hypotensive effect.

Nevertheless if an animal had low blood pressure for other reasons (e.g. concurrent use of hypotensive drugs, influence of anaesthetic agents), cabergoline might have adverse effects, and a warning to prevent usage of Galastop under such conditions is included.

Emetic effects

The tolerance data show that cabergoline has emetic activity in the dog. This effect appears to be dose related, and is marked at doses of 10 µg/kg and above (the ED50 – the dose causing emesis in 50% of treated dogs – being calculated at 19 µg/kg).

In the clinical studies vomiting and anorexia was observed in a proportion of bitches treated as recommended for Galastop: in those studies where frequency was recorded, a total of 361 bitches were treated as recommended; of these 28 bitches (8%) vomited and 58 bitches (16%) showed anorexia.

In most cases these adverse effects were transient and of little significance, occurring after the first one or two treatments only. In only 3 bitches in the clinical trials (less that 1%) was treatment stopped because of vomiting.

In a small proportion of cases (qualitative frequency not available), a degree of drowsiness was observed in the first 2 days of treatment.

Use during pregnancy, lactation or lay

Cabergoline has the capacity to cause abortion in bitches in the later stages of pregnancy and under no circumstances should Galastop be used in pregnant bitches.

Galastop is indicated for the suppression of lactation in bitches: inhibition of prolactin secretion by cabergoline results in a rapid cessation of lactation and a reduction in the size of the mammary glands. Galastop should not be used in lactating bitches unless suppression of lactation is required.

Interactions

Interactions between cabergoline and other veterinary medicinal products have not been observed.

Since cabergoline exerts its therapeutic effect by direct stimulation of dopamine receptors, Galastop should not be administered concurrently with drugs which have dopamine antagonist activity (such as phenothiazines, butyrophenones), as these might reduce its prolactin inhibiting effects.

Overdose

The experimental data indicate that a single overdose with Galastop might result in an increased likelihood of post-treatment vomiting, and possibly an increase in post-treatment hypotension.

General supportive measures should be undertaken to remove any unabsorbed drug and maintain blood pressure, if necessary. It is unlikely that the administration of dopamine antagonist drugs would be necessary, but this course of action could be considered.

Pharmaceutical precautions

Store below 25°C. Protect from light. Do not refrigerate. After opening, use the product within 28 days. Store in tightly closed original container.

Any unused product or waste materials should be disposed of in accordance with local requirements.

Legal category

Packaging quantities

Amber type III glass bottle with screw cap, containing 7 ml or 15 ml 0.005% cabergoline oily solution; supplied with a clear type I glass pipette (graduated dropper) with protective cover

Further information

Nil.

Marketing Authorisation Number

Vm 28350/4001

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews

Q & A

Below are some recent questions we've received regarding Galastop Oral Solution for Dogs, including answers from our team.

16 December 2015 at 6:35pm

Vomiting

Angela Minkowski

How long does vomiting and not eating last when dog is on galastop

  • Non-Executive Director

This is usually a temporary effect and lasts either one or two days, it is very rare for it to go on any longer. Usually it is mild too. This response is very much dose related and so it would be sensible for your dog to be re-weighed and the dose re-calculated just to make sure this is correct (though it probably is). There can of course be other causes of these symptoms so your vet should check the bitch to ensure there is no indication of another underlying cause.

22 June 2015 at 10:45am

Galastop medicine

Gary

gave my dog the medicine described by vet but since giving it her she seems very sleepy and week!!! Why

  • Non-Executive Director

This medication lowers the blood pressure in some dogs and can be associated with weakness and quietness for a short while, but this soon passes off. It is not usually something to be particularly alarmed about, but it is best not to combine it with any other medication in case this makes it worse. If the symptoms are not settling down quickly, you must of course contact your vet and get your dog checked over. Occasionally a different dosing schedule might be required.

16 June 2014 at 6:34pm

Galastop

Sheila

Can Galastop cause bitches to come into season.?

  • Non-Executive Director

Galastop is designed to inhibit the hormone which promotes milk production and some of the behavioral changes seen in phantom pregnancy. It should not be able to bring a bitch into season and I do not think it could.