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Frontline Plus Spot-On

  • Cat & Ferret » 3 Pipettes £16.22
  • Cat & Ferret » 6 Pipettes £26.87
  • Extra Large Dog (40+kg) » 3 Pipettes £27.79
  • Extra Large Dog (40+kg) » 6 Pipettes £46.42
  • Large Dog (20-40kg) » 3 Pipettes £24.64
  • Large Dog (20-40kg) » 6 Pipettes £39.88
  • Medium Dog (10-20kg) » 3 Pipettes £22.78
  • Medium Dog (10-20kg) » 6 Pipettes £35.84
  • Small Dog (2-10kg) » 3 Pipettes £20.81
  • Small Dog (2-10kg) » 6 Pipettes £33.56

Selection of 10 products from

£16.22 to £46.42

Description

New to the Frontline range comes Frontline Plus! Formulated with 2 tough killing ingredients; fipronil, which kills adult fleas and ticks and (S)-methoprene that attacks flea eggs and larvae. They work together to kill all month long, breaking flea life cycles and also destroying the next generation of flea eggs and larvae.

Frontline Plus Spot On Dog S, M, L, XL

Species: Dogs

Therapeutic Indication: Pharmaceuticals: Ectoparasiticides: For dogs

Active ingredient: Fipronil, (S)-methoprene

Product: Frontline Plus Spot On Dog

Product index: Frontline Plus Spot On Dog

Qualitative and quantitative composition

Frontline Combo Spot-On Dog

Small Medium Large X-Large
Weight (kg) 2-10 10-20 20-40 >40
Volume of unit dose (ml) 0.67 1.34 2.68 4.02
Fipronil (mg) 67 134 268 402
(s) methoprene (mg) 60.3 120.60 241.20 361.8
Butylhydroxytoluene (E321) (mg) 0.07 0.13 0.27 0.4
Butylhydroxyanisole (E320) (mg) 0.13 0.27 0.54 0.8

Pharmaceutical form

Spot-on solution. Clear amber solution.

Clinical particulars

Target species

Dogs

Indications for use

For the treatment of dogs weighing over 40 kg bodyweight -To be used against infestations with fleas, alone or in association with ticks and/or biting lice. -Treatment of flea infestations (Ctenocephalides spp.). Insecticidal efficacy against new infestations with adult fleas persist for 8 weeks. Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal activity) and larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for eight weeks after application. -Treatment of tick infestations (Ixodes ricinus, Dermacentor variabilis, Dermacentor reticulatus, Rhipicephalus sanguineus). The product has a persistent acaricidal efficacy for up to 4 weeks against ticks. -Treatment of infestations with biting lice (Trichodectes canis).

Contra-indications

In the absence of available data, the product should not be used on puppies less than 8 weeks old. Do not use on sick (e.g. systemic diseases, fever) or convalescent animals. Do not use in rabbits, as adverse reactions with even mortality could occur. In absence of studies, the use of the product is not recommended in non-target species. This product is specifically developed for dogs. Do not use in cats and ferrets, as this could lead to overdosing.

Special warnings for each target species

Bathing/immersion in water within 2 days after application of the product and more frequent bathing than once a week should be avoided, as no study has been performed to investigate how this affects the efficacy of the product. Emollient shampoos can be used prior to treatment, but reduce the duration of protection against fleas to approximately 5 weeks when used weekly after application of the product. Weekly bathing with a 2% chlorhexidine medicated shampoo did not affect efficacy against fleas during a 6 week long study. Dogs should not be allowed to swim in watercourses for 2 days after application (See “Special precautions for disposal” section) There may be an attachment of a few ticks. For this reason a transmission of infectious diseases cannot be completely excluded if conditions are unfavourable. Fleas from pets often infest the animal's basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly. When treating infestations of parasites, all in-contact animals should be treated with an appropriate product at the same time.

Special precautions for use in animals

Avoid contact with the animal's eyes. It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment. Animals should be weighed accurately prior to treatment.

Special precautions to be taken by the person administering the product to animals

Keep pipettes in original packaging until ready to use. This product can cause mucous membrane, skin and eye irritation. Therefore, contact of the product with mouth, skin and eyes should be avoided. If the product is accidentally swallowed, seek medical advice immediately and show the package leaflet to the physician. Animals or operators with a known hypersensitivity (allergy) to insecticides or alcohol should avoid contact with this product. Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water. After accidental ocular exposure the eye should be rinsed carefully with pure water. Wash hands after use. Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children. Do not smoke, drink or eat during application.

Adverse reactions

Among the very rare suspected adverse reactions, transient skin reactions on the application site (skin discoloration, local hair loss, itching, redness) and general itching or hair loss have been reported after use. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs), vomiting or respiratory symptoms have also been observed after use. If licking occurs, a brief period of excessive salivation may be observed due mainly to the nature of the carrier. Do not overdose.

Use during pregnancy, lactation or lay

The product can be used during pregnancy and lactation.

Interactions

Do not use simultaneously with other flea products which are applied directly on to the animal.

Amounts to be administered and administration route

By topical application to the skin. In the absence of safety studies, the minimum treatment interval is 4 weeks.

Weight (kg) Dosage
2 - 10 1 x 0.67 ml pipette
10 - 20 1 x 1.34 ml pipette
20 - 40 1 x 2.68 ml pipette
>40 1 x 4.02 ml pipette

Method of administration:

Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents remain within the main body of the pipette. Snap back the tip. Part the coat on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several times to empty its contents completely and directly onto the skin in one spot. Temporary changes to the coat (clumped/greasy hair) may be noted at the application site.

Overdose

No adverse effects were observed in target animal safety studies in 8 week-old puppies, growing dogs and dogs weighing about 2 kg treated once at five times the recommended dose. The risk of experiencing adverse effects (see Adverse Reactions section) may however increase when overdosing, so animals should always be treated with the correct pipette size according to bodyweight.

Pharmacological particulars

Pharmacotherapeutic group: Ectoparasiticides for topical use incl. insecticides QP53. The product is an insecticidal and acaricidal solution for topical use, containing an association of an adulticidal active ingredient, fipronil, in combination with an ovicidal and larvicidal active ingredient, (S)-methoprene.

Pharmacodynamic properties

Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. It acts by interacting with ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects or acarines. Fipronil kills fleas within 24 hours and ticks (Dermacentor reticulatus, Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata) and lice within 48 hours post-exposure. (S)-Methoprene is an insect growth regulator (IGR) of the class of compounds known as juvenile hormone analogues that inhibit the development of immature stages of insects. This compound mimics the action of juvenile hormone and causes impaired development and death of the developing stages of fleas. The on-animal ovicidal activity of (S)-methoprene results from either direct penetration of the eggshell of newly laid eggs or from absorption through the cuticle of the adult fleas. (S)-methoprene is also effective in preventing flea larvae and pupae from developing, which prevents contamination of the environment of treated animals with the immature stages of fleas.

Pharmaceutical particulars

Excipients

Butylhydroxyanisole (E320), Butylhydroxytoluene (E321), Ethanol Polysorbate 80 (E433), Povidone, Diethylene glycol monoethyl ether

Major incompatibilities

None known.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years

Special precautions for storage

Do not store above 30°C. Store in the original package.

Immediate packaging

Box of 1 or 2 blister card (s) of 3 x 4.02 ml pipettes with a scored tip

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements. Fipronil and (S)-methoprene may adversely affect aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers.

Marketing Authorisation Number

Vm 08327/4268-71

Legal category

Legal category: NFA-VPS

GTIN

GTIN description:Frontline Plus Spot-On Dog Small x 3 pipettes GTIN:*03661103048831

GTIN description:Frontline Plus Spot-On Dog Small x 6 pipettes GTIN:*03661103048879

GTIN description:Frontline Plus Spot-On Dog Medium x 3 pipettes GTIN:*03661103048848

GTIN description:Frontline Plus Spot-On Dog Medium x 6 pipettes GTIN:*03661103048886

GTIN description:Frontline Plus Spot-On Dog Large x 3 pipettes GTIN:*03661103048855

GTIN description:Frontline Plus Spot-On Dog Large x 6 pipettes GTIN:*03661103048893

GTIN description:Frontline Plus Spot-On Dog X-Large x 3 pipettes GTIN:*03661103048862

GTIN description:Frontline Plus Spot-On Dog X-Large x 6 pipettes GTIN:*03661103048909

Frontline Plus Spot On Cat

Species: Cats

Therapeutic Indication: Pharmaceuticals: Ectoparasiticides: For cats

Active ingredient: Fipronil, (S)-methoprene

Product: Frontline Plus Spot On Cat

Product index: Frontline Plus Spot On Cat

Qualitative and quantitative composition

Each pipette of 0.5 ml contains: Active substances: Fipronil 50.00 mg (S)-methoprene 60.00 mg Excipients: Butylhydroxyanisole (E320) 0.10 mg Butylhydroxytoluene (E321) 0.05 mg For the full list of excipients, see below.

Pharmaceutical form

Spot-on solution. Clear amber solution

Clinical particulars

Target species Cats and ferrets

Indications for use

In cats:

- To be used against infestations with fleas, alone or in association with ticks and/or biting lice.

- Elimination of fleas (Ctenocephalides spp.). Insecticidal efficacy against new infestations with adult fleas persists for 4 weeks. Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal activity), larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for six weeks after application.

- Elimination of ticks (Ixodes ricinus, Dermacentor variabilis, Rhipicephalus sanguineus). The product has a persistent acaricidal efficacy for up to 2 weeks against ticks (based on experimental data)

- Elimination of biting lice (Felicola subrostratus).

In ferrets:

- To be used against infestations with fleas, alone or in association with ticks.

- Elimination of fleas (Ctenocephalides spp.). Insecticidal efficacy against new infestations with adult fleas persists for 4 weeks. Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal activity), larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas.

- Elimination of ticks (Ixodes ricinus). The product has a persistent acaricidal efficacy for 4 weeks against ticks (based on experimental data).

Contra-indications

In the absence of available data, the product should not be used on kittens less than 8 weeks old and/or weighing less than 1 kg. The product should not be used on ferrets less than 6 months old. Do not use on sick (e.g. systemic diseases, fever) or convalescent animals. Do not use in rabbits, as adverse reactions with even mortality could occur. In absence of studies, the use of the product is not recommended in non-target species.

Special warnings for each target species

Avoid the contact with the animal’s eyes. When treating infestations of parasites, all in-contact animals should be treated with an appropriate product at the same time.

Special precautions for use in animals

It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment. No data on the effect of bathing/shampooing on the efficacy of the product in cats and ferrets are available. However, based on information available for dogs shampooed as from 2 days after application of the product, it is not recommended to bath animals within 2 days after application of the product. There may be an attachment of single ticks. For this reason a transmission of infectious diseases cannot be completely excluded if conditions are unfavourable. Fleas from pets often infest the animal's basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly. The potential toxicity of the product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case. Animals should be weighed accurately prior to treatment.

Special precautions to be taken by the person administering the product to animals

Keep pipettes in original packaging until ready to use. This product can cause mucous membrane, skin and eye irritation. Therefore, contact of the product with mouth, skin and eyes should be avoided. If the product is accidentally swallowed, seek medical advice immediately and show the package leaflet to the physician. Animals or operators with a known hypersensitivity (allergy) to insecticides or alcohol should avoid contact with this product. Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water. After accidental exposure the eye should be rinsed carefully with pure water. Wash hands after use. Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children. Do not smoke, drink or eat during application.

Adverse reactions

Do not overdose. Cats Among the very rare suspected adverse reactions, transient skin reactions on the application site (scaling, local hair loss, itching, redness) and general itching or hair loss have been reported after use. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs) or vomiting have also been observed after use. If licking occurs, a brief period of excessive salivation may be observed due mainly to the nature of the carrier.

Use during pregnancy, lactation or lay

Cats The product can be used during pregnancy. For treatment during the lactating period, see “Special precautions for use in animals” section. Ferrets Laboratory studies in cats have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects. The safety of the veterinary medicinal product has not been established in ferrets during pregnancy and lactation. Use only according to the risk-benefit assessment by the responsible veterinarian.

Interactions

Do not use simultaneously with other flea products which are applied directly on to the animal.

Amounts to be administered and administration route

One pipette of 0.5 ml per cat, corresponding to a minimum recommended dose of 5 mg/kg for fipronil and 6 mg/kg for (S)-methoprene, by topical application to the skin. In the absence of safety studies, the minimum treatment interval is 4 weeks. One pipette of 0.5 mL per ferret corresponding to a dose of 50 mg for fipronil and 60 mg for (S)-methoprene per ferret, by topical application to the skin. The minimum treatment interval is 4 weeks.

Overdose

The risk of experiencing adverse effects may increase with overdosing (see Adverse Reactions Section). In cats No undesirable effects were observed in target animal safety studies in cats and kittens aged 8 weeks and older and weighing about 1 kg treated once a month at five times the recommended dose for six consecutive months. Itching may occur following treatment. Overdose application of the product will cause a sticky appearance of hairs at the treatment spot. However, should this occur, it will disappear within 24 hours post application. In ferrets In ferrets aged 6 months and older and treated once every 2 weeks for four treatments, at five times the recommended dose, body weight loss was observed in some animals.

Pharmacological particulars

Pharmacotherapeutic group: Ectoparasiticides for topical use incl. insecticides QP53. The product is an insecticidal and acaricidal solution for topical use, containing an association of an adulticidal active ingredient, fipronil, in combination with an ovicidal and larvicidal active ingredient, (S)-methoprene.

Pharmacodynamic properties

Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. It acts by interacting with ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects or acarines. Fipronil kills fleas within 24 hours, ticks (Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata) and lice within 48 hours post-exposure.

(S)-Methoprene is an insect growth regulator (IGR) of the class of compounds known as juvenile hormone analogues that inhibit the development of immature stages of insects. This compound mimics the action of juvenile hormone and causes impaired development and death of the developing stages of fleas. The on-animal ovicidal activity of (S)-methoprene results from either direct penetration of the eggshell of newly laid eggs or from absorption through the cuticle of the adult fleas. (S)-methoprene is also effective in preventing flea larvae and pupae from developing, which prevents contamination of the environment of treated animals with the immature stages of fleas.

Pharmaceutical particulars

Excipients Butylhydroxyanisole (E320), Butylhydroxytoluene (E321), Ethanol, Polysorbate 80 (E433), Povidone, Diethylene glycol monoethyl ether

Major incompatibilities None known.

Shelf life Shelf life of the veterinary medicinal product as packaged for sale: 3 years

Special precautions for storage Do not store above 30°C. Store in the original package.

Immediate packaging Box of 1 or 2 blister card(s) of 3 x 0.5 ml pipettes with a scored tip.

Disposal Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements. Fipronil and (S)-methoprene may adversely affect aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers.

Marketing Authorisation Number

Vm 08327/4267

Legal category

Legal category: NFA-VPS

GTIN

GTIN description:Frontline Plus Spot On Cat x 3 pipettes

GTIN:*03661103048817

GTIN description:Frontline Plus Spot On Cat x 6 pipettes

GTIN:*03661103048824

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