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Equilis Vaccine For Horses

Equilis Vaccine For Horses
Prequenza Te » Pack of 5
Strep E » 1ml Dose (Pack of 10)

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  • Prequenza Te » Pack of 5 £152.50
  • Strep E » 1ml Dose (Pack of 10) £205.99

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Medication Datasheets

Strep E » 1ml Dose (Pack of 10)

Equilis Strep E, lyophilisate and solvent for suspension for injection, for horses

Qualitative and quantitative composition

Active substance per dose of 0.2 ml vaccine:

Live deletion mutant Streptococcus equi strain TW928 109.0 to 109.4 cfu*

*colony forming units


For the full list of excipients, see section “Pharmaceutical Particulars”.

Pharmaceutical form

Lyophilisate and solvent for suspension for injection.

Lyophilisate: off-white or cream-coloured pellet.

Solvent: clear colourless solution.

Clinical particulars

Target species


Indications for use

For immunisation of horses against Streptococcus equi to reduce clinical signs and occurrence of lymph node abscesses.

Onset of immunity: 2 weeks after basic vaccination.

Duration of immunity: up to 3 months.

The vaccine is intended for use in horses for which a risk of Streptococcus equi infection has been clearly identified, due to contact with horses from areas where this pathogen is known to be present, e.g. stables with horses that travel to shows and/or competitions in such areas, or stables that obtain or have livery horses from such areas.



Special warnings for each target species

Shedding of the vaccine strain from the injection site can be observed for a period of four days after vaccination.

From literature, it is known that a very low number of horses may develop purpura haemorrhagica if they are vaccinated shortly after infection. Purpura haemorrhagica has not been observed in any of the safety studies performed during development of Equilis StrepE. As the incidence of purpura haemorrhagica is very low, its occurrence cannot be ruled out completely.

In the challenge studies performed by the company, insufficient protection was seen in approximately one quarter of horses vaccinated with the recommended dose.

Do not use antibiotics within one week after vaccination.

The vaccine strain is sensitive to penicillins, tetracyclines, macrolides and lincomycin.

The vaccine strain is resistant to aminoglycosides, sulphonamides, flumequine and trimetroprim-sulfa combinations.

Special precautions for use

Only healthy horses should be vaccinated.

Ensure that the lyophilisate is completely reconstituted before use.

Basic vaccination performed during an outbreak is not efficacious because immunity is insufficient until basic vaccination has been completed.

Operator warnings:

To the user:

This product contains a live bacterial deletion mutant with a limited growth potential in mammalian tissue. Accidental self-injection may result in an inflammatory reaction with severe pain and swelling. Special care must be taken when connecting the applicator to the needle to avoid needle-stick injuries. In case of accidental self-injection, seek medical advice immediately and show the package insert or the label to the physician even if only a very small amount is injected.

To the physician:

This product contains a live auxotrophic deletion mutant Streptococcus equi vaccine strain with attenuated virulence. However, the bacterial compounds of this product can cause an inflammatory reaction with intense and painful swelling after accidental injection.

Anti-inflammatory therapy is indicated even if only a very small amount of the product in injected. An additional antibiotic treatment should be considered for safety reasons. The sensitivity of the vaccine strain to antibiotics is listed above (under section “Special Warnings”).

Adverse reactions

After vaccination a diffusely swollen reaction, which may be warm or painful, develops at the injection site within 4 hours. The reaction is maximal at 2–3 days post vaccination with a maximum area of 3 cm by 8 cm. This swelling resolves completely within 3 weeks and normally has no effect on the appetite of the vaccinated animal and causes no apparent discomfort. The vaccine organism may establish a small suppurative inflammation locally at the injection site, leading to a disruption of the overlaying lip mucosa and subsequent discharge fluid and inflammatory cells. A slight cloudy discharge commonly occurs from the mucosal injection site at 3 or 4 days post vaccination.

Slight enlargements, which may be transient painful, of the retropharyngeal and mandibular lymph nodes may occur for a few days after vaccination. In very rare cases an abscess may develop at the injection site or in the regional lymph nodes.

Further, an increase in rectal temperature up to 2 °C may occur on the day of vaccination. In rare cases, inappetence, fever, shivering and diffuse oedematous swellings (e.g. facial oedema, swollen muzzle/upper lip) may be observed. In very rare cases depression may develop.

The frequency of adverse reactions is defined using the following convention:

Use during pregnancy, lactation or lay

Do not use in pregnant or lactating mares.


No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.

Amounts to be administered and administration route

Submucosal vaccination with 0.2 ml of reconstituted product.

Vaccination scheme:

Basic vaccination: horses from 4 months of age onwards receive two vaccinations of one dose with a 4 week interval.


Revaccinate every three months to maintain immunity.

A priming response is maintained for up to six months after basic vaccination. Therefore only a single dose of vaccine is needed to restore immunity.

It is recommended that all horses stabled together are vaccinated.

Allow the sterile solvent to reach room temperature (15 - 25 °C). Aseptically reconstitute the lyophilisate with 0.3 ml of the sterile solvent provided. Allow the reconstituted vaccine to sit for 1 minute and then carefully swirl the contents to mix. Do NOT shake. Withdraw 0.2 ml of the reconstituted vaccine into the syringe provided (see Figure 1) and connect the applicator to the needle (see Figure 2). Restrain the animal’s head, lift the upper lip and insert the needle into the inside of the upper lip until the applicator rests on the lip. Administer the whole contents of the syringe into the inside of the upper lip (see Figure 3).

Figure 1:

Figure 2:

Figure 3:


In addition to the clinical signs given under section 'Adverse Reactions', vaccination with a ten times overdose may induce an abscess in one of the submandibular lymph nodes. The abscesses drain purulent material from 2 weeks after vaccination, but heal without intervention within a month thereafter. Furthermore, an increase in rectal temperature up to 2.5 °C may occur on the day of vaccination. Slight apathy may occasionally be observed one day after vaccination.

Withdrawal periods

Zero days.

Pharmacological particulars

Immunological properties:

Pharmacotherapeutic group: immunological for equidae, live bacterial vaccine, ATCvet code: QI05AE.

To stimulate immunity against Streptococcus equi.

The vaccine strain is a deletion mutant with a limited growth potential in mammalian tissue. It is able to multiply locally at the submucosal injection site during a short period and is shed into the oro-nasal cavity during a few days, but the vaccine strain does not survive on the oro-nasal mucosa and does not disseminate systemically at the recommended dose.

Pharmaceutical particulars


NAO-1 stabiliser

Water for injections

Major incompatibilities

Do not mix with any other veterinary medicinal products except the solvent supplied for use with the vaccine.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years.

Shelf life after reconstitution according to directions: 4 hours.

Special precautions for storage


Store in a refrigerator (2 °C – 8 °C). Protect from light.


This medicinal product does not require any special storage conditions.

Immediate packaging

Each package of Equilis StrepE contains: 10 vials with lyophilisate and 10 vials of 0.5 ml solvent, each in 3 ml Type I glass vials closed with a halogenobutyl rubber stopper and sealed with a coded aluminium cap, 10 applicators, 10 syringes with needles.


Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Intervet International BV, The Netherlands

Marketing Authorisation Number


Date of the first authorisation or date of renewal

7 May 2004.

Date of revision of the text

October 2014.

Any other information

For animal treatment only. Keep out of the sight and reach of children.

Legal category

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. To find the exact cost of shipping your item, and to see all options available, follow these steps:

  1. Put the items you wish to order in your basket
  2. Proceed to checkout and enter your delivery address, including country
  3. Delivery information including price will automatically update to what is available to you

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.


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