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Duphamox contains the well known antibiotic amoxycillin and is used in dogs and cats for a wide variety of infections. This includes infections of the respiratory system, the urinogenital system, the digestive tract, the eye, ear, skin and wounds. Duphamox is given twice daily.
Duphamox LA is a stable, injectable, off-white oily suspension containing 150 mg amoxicillin per ml as Amoxicillin Trihydrate Ph.Eur. Each ml also contains Butylated Hydroxyanisole Ph.Eur 0.08mg and Butylated Hydroxytoluene Ph.Eur 0.08mg as antioxidants.
Duphamox LA is indicated in the treatment and control of infections caused by organisms sensitive to amoxicillin.
Amoxicillin is a broad-spectrum semi-synthetic bactericidal in action for use in cattle, pigs, sheep, dogs and cats. In vitro it is effective against a wide range of Gram-positive and Gram-negative bacteria which include:
Escherichia coli, Klebsiella pneumoniae, Proteus mirablis, some Salmonella spp, Staphylococcus spp and Streptococcus spp (non penicillinase producing).
Not effective against beta-lactamase producing organisms. The product is suitable for the control of infections due to susceptible micro-organisms in cattle, sheep, pigs, dogs and cats where a single injection giving prolonged activity is required. It may also protect from secondary bacterial invasion due to sensitive organisms in cases where bacteria are not the initial cause of the disease. Indications include infections of: Alimentary tract; respiratory tract; skin and soft tissue; urogenital tract and in prevention of post-operative infections (treat before surgery).
Shake well before use. Administration is by the intramuscular route for cattle, sheep and pigs and by the intramuscular or subcutaneous route in dogs and cats. The recommended dosage rate is 15 mg/kg bodyweight repeatable if necessary after 48 hours. The product is recommended for single administration only. Massage the injection site after injection. If dose volume exceeds 20ml in cattle or 10ml in sheep and pigs, it should be divided and injected into two sites.
Dose volume is equivalent to 1ml per 10kg bodyweight.
As with other injectable products, normal aseptic precautions should be observed. Use a dry syringe for extraction of suspension to avoid hydrolysis of amoxicillin.
An appropriately graduated syringe must be used to allow accurate administration of the required dose volume. This is particularly important when injecting small volumes.
FOR ANIMAL TREATMENT ONLY
Not for use in known cases of hypersensitivity to penicillin or cephalosporins.
Not suitable for intravenous or intrathecal use.
Should not be used in rabbits, hamsters, gerbils and guinea pigs.
Not effective against beta-lactamase producing organisms.
Occasional local tissue reaction may result from use of this product.
Milk for human consumption must not be taken from a cow during treatment. Milk for human consumption may only be taken after 60 hours from the last treatment.
Not for use in sheep producing milk for human consumption.
Animals must not be slaughtered for human consumption during treatment. Cattle, sheep and pigs may be slaughtered for human consumption only after 21 days from the last treatment.
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.
1. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
2. Handle this product with great care to avoid exposure, taking all recommended precautions.
3. If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing, are more serious symptoms and require urgent medical attention.
Wash hands after use.
Do not store above 25°C. Protect from light. Shake the container before use.
This product does not contain an antimicrobial preservative. Swab the septum before removing each dose. Use a dry, sterile needle and syringe.
Keep out of the reach of children.
Following withdrawal of the first dose, use the product within 28 days. Discard unused material.
When the container is broached (opened) for the first time, the date on which any product remaining in the container should be discarded should be calculated. A statement of the in-use shelf-life of the product is given on the package insert. This discard date should be written in the space provided on the label.
Multidose vials of 50ml or 100 ml.
Not all pack sizes may be marketed.
After the administration of Duphamox LA, amoxicillin is absorbed and widely distributed in the body and high levels are found in kidney, urine, liver and bile.
Amoxicillin has a rapid bactericidal action which normally prevents the recrudescence of respiratory infections.
As with other penicillins, absence of toxicity is normally encountered. Animals with functional rumens should only be treated parenterally.
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.
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