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Domidine is an injection used to sedate and provide a some analgesia for horses and cattle. It facilitates examinations and minor surgical procedures to be carried out

Qualitative and quantitative composition

1 ml solution for injection contains: Active substances:

Detomidine hydrochloride 10.0 mg, this corresponds to 8.36 mg detomidine base.

Excipient: Methyl parahydroxybenzoate (E218) 1.0 mg

For a full list of excipients, see Excipients.

Pharmaceutical form

Solution for injection. Clear and colourless solution.

Clinical particulars

Target species

Horse, cattle.

Indications for use

For the sedation and slight analgesia of horses and cattle, to facilitate physical examinations and treatments, such as minor surgical interventions. Detomidine can be used for:

- Examinations (e.g. endoscopia, rectal and gynaecological examinations, X-rays).

- Minor surgical procedures (e.g. treatment of wounds, dental treatment, tendon treatment, excision of skin tumours, teat treatment).

- Before treatment and medication (e.g. stomach tube, horse shoeing).

For pre-medication prior to administration of injection or inhalation anaesthetics.


Do not use in animals with cardiac abnormalities or respiratory diseases.

Do not use in animals with liver insufficiency or renal failure.

Do not use in animals with general health problems (e.g. diabetes mellitus, dehydrated animals, shock or any other extraordinary stress conditions).

Do not use in combination with butorphanol in horses suffering from colic.

See also Use during pregnancy and lactation and Interactions.

Special warnings for each target species


Special precautions for use in animals

As sedation begins, especially horses may start to sway and lower the head rapidly while they remain standing. Cattle, especially young cattle, will try to lie down. To prevent injuries the location should therefore be chosen carefully. To avoid aspiration of feed or saliva, cattle should be maintained in sternal recumbency following treatment and head and neck of recumbent cattle should be lowered. Especially for horses usual precautionary measures should be taken to prevent self-injury. Detomidine should be prescribed with caution in horses which present with signs of colic or impaction.

Animals suffering from shock or liver or kidney disease should only be treated according to the benefit/risk assessment by the responsible veterinarian.

Detomidine/butorphanol combination should not be used in horses with a history of liver disease or cardiac irregularities.

It is recommended that feed should be withheld for at least 12 hours prior to anaesthesia.

Water or food should not be offered to treated animals until the drug effect has passed.

In painful procedures detomidine should be used only in combination with an analgesic or a local anaesthetic.

While waiting for sedation animals should remain in calm surroundings.

Special precautions to be taken by the persons administering the veterinary medicinal product to animals

In the case of accidental oral intake or self-injection, seek medical advice immediately and show the package leaflet to the physician but DO NOT DRIVE as sedation and changes in blood pressure may occur.

Avoid skin, eye or mucosal contact.

Wash the exposed skin immediately after exposure with large amounts of water.

Remove contaminated clothes that are in direct contact with skin.

In the case of accidental contact of the product with eyes, rinse abundantly with fresh water. If symptoms occur, seek the advice of a physician.

If pregnant women handle the product, special caution should be observed not to self-inject as uterine contractions and decreased foetal blood pressure may occur after accidental systemic exposure.

Advice to doctors: Detomidine is an alpha2-adrenoreceptor agonist. Symptoms after absorption may involve clinical effects including dose-dependent sedation, respiratory depression, bradycardia, hypotension, a dry mouth, and hyperglycaemia. Ventricular arrhythmias have also been reported. Respiratory and haemodynamic symptoms should be treated symptomatically.

Adverse reactions

Injection of detomidine may cause the following side effects:

- Bradycardia.

- Transient hypo- and/or hypertension.

- Respiratory depression, rarely hyperventilation,

- Increase in blood glucose.

- As with other sedatives, in rare cases paradoxical reactions (excitation) can develop.

- Ataxia.

- In horses: Cardiac arrhythmia, atrioventricular and sino-atrial block.

- In cattle: Inhibition of rumen motility, tympania, paralysis of the tongue.

At doses above 40 µg/kg body weight, the following symptoms can also be observed: sweating, pilo-erection and tremor of muscles, transient penis prolaps in stallions and geldings and mild, transient tympania of rumen and increased salivation in cattle.

In very rare cases horses may show mild symptoms of colic following administration of alpha-2 sympathomimetics because substances of this class transiently inhibit the motility of the intestines.

A diuretic effect is usually observed within 45 to 60 minutes after treatment.

Use during pregnancy and lactation

Do not use this product during the last trimester of pregnancy. Use only accordingly to the benefit/risk assessment by the responsible veterinarian during pregnancy.


Concurrent use of other sedatives only after consultation of the warnings and precautions of the product concerned.

Detomidine should not be used in combination with sympathomimetic amines such as adrenaline, dobutamine and ephedrine.

The concurrent use of certain potentiated sulphonamides may cause cardiac arrhythmia with fatal outcome. Do not use in combination with sulphonamides.

Detomidine in combination with other sedatives and anaesthetics should be used carefully because additive/synergistic effects may be possible. Where anaesthesia is induced with a combination of detomidine and ketamine, prior to maintenance with halothane, the effects of halothane may be delayed and care must be taken to avoid overdosage. When detomidine is used as a pre-medicant prior to general anaesthesia, the product may delay the onset of induction.

Amounts to be administered and administration route

For intravenous (IV) or intramuscular (IM) administration. The product should be injected slowly. Onset of effect is more rapid following intravenous administration.

Dosage in µg/kg

Dosage in ml/100 kg

Level of sedation

Commencement of effect (min)


Duration of effect (hrs)











When prolonged sedation and analgesia is required, doses of 40 to 80 µg/kg can be used. The duration of effect is up to 3 hours.

For combination with other products to intensify the sedation or for pre-medication prior to general anaesthesia, doses of 10 to 30 µg/kg can be used.

It is recommended to wait 15 minutes after the detomidine administration before starting the planned procedure.

The body weight of the animal to be treated should be determined as accurately as possible to avoid overdosing.


In the event of an accidental overdose, cardiac arrhythmias, hypotension, delayed recovery and profound CNS and respiratory depression may occur. Should the effects of detomidine become life-threatening, administration of an alpha2-adrenergic antagonist is recommended.

Withdrawal periods

Horse, cattle:

Meat and offal: 2 days

Milk: 12 hours

Pharmacological particulars

Pharmacotherapeutic group: Hypnotics and sedatives. ATC Vet code: QN05CM90

Pharmacodynamic properties

Detomidine is an alpha2-adrenoceptor agonist. Detomidine is a sedative with analgesic properties (alpha2-adrenoceptor agonist). Detomidine causes sedation in animals and relieves pain. Duration and intensity of the effect is dependent from dose. The mode of action of detomidine is based on specific stimulation of central alpha2-adrenoceptors. The analgesic effect is based on inhibition of transfer of pain impulses in the CNS.

Because detomidine also acts on peripheral alphareceptors, increase of blood glucose, and at higher doses pilo-erection, sweating and diuresis can occur. Following an initial decrease in blood pressure, it will return to normal or slightly below normal, and heart frequency will decrease. The ECG will show an enlarged PR interval and in horses a mild atrioventricular-block. These effects are transient. In most animals respiratory frequency decreases. Hyperventilation is rarely observed.

Pharmacokinetic properties

Detomidine is absorbed rapidly after intramuscular injection. Tmax is 15-30 minutes. Bioavailability after intramuscular administration is 66-85%. After rapid distribution of detomidine into the tissues, it is metabolised nearly completely mainly in the liver, t ½ is 1 to 2 hours. Metabolites are mainly excreted via urine and faeces.

Pharmaceutical particulars


Methyl parahydroxbezoate (E218)

Sodium chloride

Sodium hydroxide (for pH adjustment)

Hydrochloric acid (for pH adjustment)

Water for injection

Major incompatibilities

In the absence of incompatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years

Shelf-life after first opening the immediate packaging: 28 days

Special precautions for storage

This veterinary medicinal product does not require any special storage conditions.

Immediate packaging

5, 10 and 20 ml vials (colourless glass (type I), teflon coated halogeneted rubber stopper (type I), secured with aluminium cap.)

Not all pack sizes may be marketed.


Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Eurovet Animal Health BV, Handelsweg 25, 5531 AE Bladel, The Netherlands.

Marketing authorisation number

Vm 16849/4008.

Date of the first authorisation or date of renewal

18 April 2011

Date of revision of the text

March 2013

Any other information

For animal treatment only. To be supplied only on veterinary prescription. Keep out of the reach and sight of children.

Legal category


GTIN (Global Trade Item No)

Domidine 10 mg/ml Solution for Injection for Horses and Cattle 5 ml:


Domidine 10 mg/ml Solution for Injection for Horses and Cattle 10 ml:


Domidine 10 mg/ml Solution for Injection for Horses and Cattle 20 ml:


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