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Protexin Denamarin is a dietary supplement containing a stabilised form of the SS-SAMe (S-adenosylmethionine) isomer and silybin complexed with phosphatidylcholine for cats and dogs.
Tablets should be given on an empty stomach at least one hour before a meal for optimum absorption (an overnight fast is preferred).
Once the tablet has been administered, allow at least 1 hour before feeding your pet.
The number of tablets administered may gradually be reduced, or increased, at any time at the recommendation of your veterinary surgeon.
Cats and Dogs under 5kg administer 1 x 90mg tablet daily
Dogs 5kg -15kg administer 1 x 225mg tablet daily
Dogs 15kg-30kg administer 1 x 425mg tablet daily
Dogs 30kg-55kg administer 2 x 425mg tablets daily
Dogs over 55kg administer 3 x 425mg tablets daily
The tablets should not be split or crumbled. Keep tablets in original blister pack until used.
Store in a cool, dry place
Product Composition 90mg Tablets
SAMe 90mg, Silybin 9mg, Additives; Methionine as S-adenosylmethionine, Composition; Silybin phytosome (Milk thistle extract/ Phosphatidylcholine complex), Mannitol.
Product Composition 225mg Tablets
SAMe 225mg, Silybin 24mg, Additives; Methionine as S-adenosylmethionine, Composition; Silybin phytosome (Milk thistle extract/ Phosphatidylcholine complex), Mannitol.
Product Composition 425mg Tablets
SAMe 425mg, Silybin 35mg, Additives; Methionine as S-adenosylmethionine, Composition; Silybin phytosome (Milk thistle extract/ Phosphatidylcholine complex), Mannitol.
All prices include VAT where applicable.
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Only verified purchasers of this product can leave a review.
Works for my dog, keeps her well !
Customer recommends this product
Helping my pooch
Customer recommends this product
So far so good , baileys been taking this for a month now
Customer recommends this product
Delivery was prompt. My dog does like taste of tablets first tablets he has refused but chicken paste smeared on works. Product is as advertised. Awaiting for his next blood test to assess if working, so far so good. They are expensive but seem to be best available recommended by my vet.
Customer recommends this product
Our elderly bitch had some health issues flagged up in her bloods and the vet suggested this supplement, which seems to have helped.
Customer recommends this product
Below are some recent questions we've received regarding Protexin Denamarin Liver Support for Cats and Dogs, including answers from our team.
Lucy
What is the dosage? One tablet per day or more?

<5kg 1 small tablet daily

5-15kg 1 medium tablet daily

15-30kg 1 large tablet daily

30-55kg 2 large tablets daily

55kg 3 large tablets daily
JOHN
Do I have to store these tablets at a special temperature ie in a fridge etc.
Store in a cool, dry place. Keep tablets in original blister pack until used. The tablets should not be split or crumbled.
Sally Embley
Hi can I give this to a 12 week old Deerhound puppy with liver shunt? Thanks
There is no reason this supplement will not be safe for supporting a 12 week old puppy's liver, however you should only give supplements/food/medication alongside your vets advice if they have a liver shunt. Changes to the diet can affect the condition depending on the severity so it is important your vet approves the use beforehand.
MRS TRACEY J MASTERS
my dog is 9.7kg which tablet should he have please
Your 9.7kg will need the Medium sized Denamarin tablets.
Dexter
I find it very difficult to get my dog to take the tablet. Sometimes it takes two or three attempts, by which time the tablet is losing its coating. Will this make any difference to the tablet's effectiveness? We have sometimes given it with a small amount of food, is this a problem?
The enteric coating of Denamarin protects the SAMe from degradation in the stomach so that the maximum amount can be absorbed in the small intestine. If the coating is lost then it is likely to be less effective. It is better as you say to give with a very small amount of food then give a main meal one hour later.
Amanda Lloyd
Is Protein Denamarin a better option then Hepatosyl plus for liver problems?
Both products contain very similar ingredients. However it is thought that Denamarin is more bio-available so more of the product is absorbed and used by the body. Although, to my knowledge there have not been any studies which compare the two so it is difficult to say with certainty that Denamarin is better.
Dan Jackson
Hello, as per the guidelines we give our Jack Russell the Denmarin 1 hour before eating, always in the morning. shortly we will be leaving her at a kennel for 8 days, will administering it with food be an issue for this short period. Some neighbours of ours always give it with food? Many thanks. Dan
Giving it with food is often what people have to do, though it is less good than doing it as recommended. It will reduce the effectiveness of that particular dose, because the active ingredient will not be absorbed fully from the gut and will "come out the other end" without ever getting to the liver. However some will be absorbed and for a short period of a few days it is unlikely to make a noticeable difference. Ideally ask the kennels to give the medication with a minimal amount of food, then give a meal later. If they cannot then it should not be a disaster.
JEAN FONE
Is a prescription required for Denamarin?
No, Protexin Denamarin can be bought without the need for a prescription.