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Colvasone Injection

Colvasone Injection

  • 0.2% w/v Solution » 50ml Vial £14.50

Description

Colvasone is an injectable solution of Dexamethasone 0.2% which can be given by intravenous, intramuscular or subcutaneous injection. It can be used as part of the treatment regime for shock and certain infections or burns, as well as treating various inflammatory conditions and ketosis in cattle and sheep. The recommended dose for use in horses and cattle is 1ml per 25kg bodyweight. For dogs and cats the dose is 1ml per 10kg bodyweight.

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All prices include VAT where applicable.

Medication Datasheets

0.2% w/v Solution » 50ml Vial

SUMMARY OF PRODUCT CHARACTERISTICS

  1. Name of the veterinary medicinal product

    Colvasone 0.2% w/v Solution for injection

  2. Qualitative and quantitative composition

Active Substance:

Dexamethasone Sodium Phosphate 2 mg/ml

Excipients: Benzyl alcohol 20mg/ml.

For a full list of excipients, see section 6.1

  1. Pharmaceutical form

    Solution for injection. A clear, colourless solution.

  2. Clinical Particulars

Target species

Horses Cattle Dogs Cats

4.2 Indications for use, specifying the target species

Dexamethasone is a synthetic corticosteroid with a potent anti-inflammatory action.

Colvasone can be used for:
(1)  Intravenous therapy in cases where emergency treatment is indicated, particularly shock and circulatory collapse, fog fever, acute mastitis and burns. 
(2)  Acetonaemia (ketosis) in cattle.  Dexamethasone has a marked glucogenic action.
(3)  Inflammatory conditions in all species:  the product will suppress inflammation and is indicated in the treatment of arthritis, laminitis, dermatitis etc.

4.3 Contraindications

Systemic corticosteroid therapy is generally contra-indicated in patients with renal disease and diabetes mellitus.

4.4 Special Warnings for each target species

Use of the product in horses could induce laminitis and therefore careful observations should be made during treatment.

4.5 Special precautions for use

i. Special precautions for use in animals

Anti-inflammatory corticosteroids such as dexamethasone, are     known to exert a wide range of side-effects.  Whilst single high     doses are generally well tolerated, they may induce severe side-    effects in long term use and when esters possessing a long     duration of action are administered.  Dosage in medium to     long term use should therefore generally be kept to the minimum     necessary to control symptoms.

ii. Special precautions to be taken by the person administering the veterinary medicinal product to animals

    In case of accidental self-injection, seek medical advice     immediately and show the carton to the physician.  
    Pregnant women should not handle this veterinary medicinal     product. 
    Wash hands after use.

4.6 Adverse reactions (frequency and seriousness)

Steroids themselves, during treatment, may cause Cushingoid symptoms involving significant alteration of fat, carbohydrate, protein and mineral metabolism e.g. redistribution of body fat, muscle weakness and wastage and osteoporosis may result. During therapy effective doses suppress the Hypothalamo-Pituitary-Adrenal axis. Following cessation of treatment, symptoms of adrenal insufficiency extending to adrenocortical atrophy can arise and this may render the animal unable to deal adequately with stressful situations. Consideration should therefore be given to means of minimising problems of adrenal insufficiency following the withdrawal of treatment, e.g. a gradual reductions of dosage (for further discussion see standard texts).

Systemically acting corticosteroids may cause polyuria, polydipsia and polyphagia, particularly during the early stages of therapy.  Some corticosteroids may cause sodium and water retention and hypokalaemia in long term use.

Systemic corticosteroids have caused deposition of calcium in the skin (calcinosis cutis). Corticosteroids may delay wound healing and the immunosuppressant actions may weaken resistance to or exacerbate existing infections.

Gastrointestinal ulceration has been reported in animals treated with corticosteroids and g.i.t. ulceration may be exacerbated by steroids in patients given non-steroidal anti-inflammatory drugs and in corticosteroid-treated animals with spinal cord trauma. Steroids may cause enlargement of the liver (hepatomegaly) with increased serum hepatic enzymes.

4.7 Use during pregnancy, lactation or lay

Corticosteroids are not recommended for use in pregnant animals.  Administration in early pregnancy is known to have caused foetal abnormalities in laboratory animals.  Administration in late pregnancy may cause early parturition or abortion.

4.8 Interaction with other medicinal products and other forms of interaction

In the presence of bacterial infection, antibacterial drug cover is usually required when steroids are used. In the presence of viral infections, steroids may worsen or hasten the progress of the disease.

4.9 Amounts to be administered and administration route

By intravenous or intramuscular injection. Normal aseptic precautions should be observed.

Recommended Dosage Schedule:
Horses and cattle:            1 ml per 25 kg bodyweight
Dogs and cats:            1 ml per 10 kg bodyweight
e.g.
Horses                500 kg     -    20 ml
Cattle                    400 kg    -    16 ml
Dogs                    10 kg        -      1 ml
Cats                    5 kg        -         0.5 ml

To ensure accuracy of dosing, a suitably graduated syringe must be used when treating small animals.

  Overdose (symptoms, emergency procedures, antidotes), if necessary

Exacerbation of effects described in 4.6 above. No treatment specified.

Withdrawal period

Cattle (meat): 21 days. Cattle (milk): 84 hours.

Do not use in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.

The horse must have been declared as not intended for human cosumption under national horse passport legislation.

  1. pharmacological properties

Pharmacotherapeutic group: Coticosteroids for systemic use.

ATC Vet Code: QH02AB02

Pharmacodynamic properties

Dexamethasone is a potent synthetic glucocorticoid which is 30-35 times as potent as cortisol as an anti-inflammatory agent. The mechanism by which corticosterioids exert their effect at the cellular level remains unclear however several mechanisms have been proposed. There is evidence that corticosteroids are able to de-repress transcription of DNA to mRNA in the target cell nucleus. Other mechanisms proposed for the action of corticosteroids include boosting of cellular levels of cyclic AMP made possible by steroid inhibition of phosphodiesterases which would otherwise metabolise cyclic AMP. Some of the anti-inflammatory activity of corticosteroids could be due to inhibition of prostaglandin synthesis by suppression of the release of arachidonate, the prostaglandin precursor, from cell membranes.

  1. Pharmaceutical particulars

6.1 List of excipients

Benzyl Alchol

Sodium Phosphate Dodecahydrate Sodium Phosphate Disodium Edetate Dihydrate Water for injection

Incompatibilities

None known.

  Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 2 years Shelf life after first opening the immediate packaging: 28 days Special precautions for storage

Do not store above 25°C. Following withdrawal of the first dose, use the product within 28 days. Discard unused material.

  Nature and composition of immediate packaging

50 ml Amber Type II glass vials sealed with bromobutyl rubber bungs with aluminium overseals.

  Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste material derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

  1. MARKETING AUTHORISATION HOLDER

Norbrook Laboratories Limited Station Works Newry Co. Down, BT35 6JP Northern Ireland

  1. MARKETING AUTHORISATION NUMBER(S)

    Vm: 02000/4009

DATE OF FIRST AUTHORISATION

1st  September 1994 
  1. DATE OF REVISION OF THE TEXT

November 2009

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

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Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (1)

Q & A

Below are some recent questions we've received regarding Colvasone Injection, including answers from our team.

4 August 2015 at 8:24pm

Colovasone

Carol keating

Can colovasone injections cause liver cancer in shih tzu dogs

  • Non-Executive Director

Most of the cases of liver cancer are of unknown cause, so this is an area which is not fully understood. However the chances of Colvasone being involved as a cause seem exceedingly remote and personally I would not worry about this as a possible problem.