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Clavaseptin Palatable Tablets

Clavaseptin Palatable Tablets
50mg » Priced per Tablet

  • 50mg » Priced per Tablet £0.39
  • 62.5mg » Priced per Tablet £0.59
  • 250mg » Priced per Tablet £1.00
  • 500mg » Priced per Tablet £1.79

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£0.39 to £1.79


Clavaseptin is known as a potentiated antibiotic. It contains two ingredients which work together to significantly increase the effectiveness against certain bacteria. The main antibiotic ingredient (amoxycillin) can be inactivated by certain types of bacteria, rendering them resistant. However the second ingredient (clavulanate) prevents the bacteria from inactivating the antibiotic, allowing the antibiotic to kill the bacteria. Hence Clavaseptin is active against a wide range of bacteria and this combination has become one of the main antibiotics used in veterinary medicine. Tablets are normally given twice daily at a dose rate of 12.5mg/kg bodyweight.

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Medication Datasheets

50mg » Priced per Tablet

Clavaseptin 50 mg and 62.5 mg Palatable Tablets for Dogs and Cats, Clavaseptin 250 mg and 500 mg Palatable Tablets for Dogs: 2016-03-31 14:15


Four tablet strengths are available: Clavaseptin 50 mg Palatable Tablets containing 40mg amoxicillin (as trihydrate) and 10mg clavulanic acid (as potassium salt). For use in cats and dogs.

Clavaseptin 62.5 mg Palatable Tablets containing 50 mg amoxicillin (as trihydrate) and 12.5 mg clavulanic acid (as potassium salt). For use in cats and dogs.

Clavaseptin 250 mg Palatable Tablets containing 200 mg amoxicillin (as trihydrate) and 50mg clavulanic acid (as potassium salt). For use in dogs.

Clavaseptin 500 mg Palatable Tablets containing 400mg amoxicillin (as trihydrate) and 100mg clavulanic acid (as potassium salt). For use in dogs.

Excipient: Brown Iron Oxide (E172)


In dogs: treatment or adjunctive treatment of periodontal infections caused by bacteria susceptible to amoxicillin in combination with clavulanic acid i.e. Pasteurella spp, Streptococcus spp and Escherichia coli.

In cats: treatment of skin infections (including wounds and abscesses) caused by bacteria susceptible to amoxicillin in combination with clavulanic acid i.e. Pasteurella spp, Staphylococcus spp, Streptococcus spp and Escherichia coli.

Dosage and administration

For oral administration.

To ensure the correct dosage, bodyweight should be determined as accurately as possible to avoid under-dosing.

The recommended dose of Clavaseptin Palatable Tablets is 10 mg amoxicillin/2.5mg clavulanic acid/kg twice daily by the oral route in dogs and cats.

In severe infections, the dose may be doubled to 20 mg amoxicillin/5 mg clavulanic acid/kg body weight twice daily.

Duration of treatment:

- 7 days for the treatment of periodontal infections in dogs

- 7 to 14 days for the treatment of skin infections in cats (including wounds and abscesses). The clinical status of animals should be re-evaluated after 7 days and the treatment prolonged for a further 7 days if necessary.

Administration is made easier by the palatable nature of the tablet.

Contra-indications, warnings, etc

Do not use in case of hypersensitivity to penicillins or other substances of the β-lactam group or to any of the excipients.

Do not administer to gerbils, guinea pigs, hamsters, rabbits and chinchillas.

Do not administer to horses and ruminating animals.

Do not use in animals with serious dysfunction of the kidneys accompanied by anuria or oliguaria.

Do not use in cases of known resistance to the combination of amoxicillin and clavulanic acid.

Special precautions for use in animals

In animals with impaired liver and kidney function, the use of the product should be subject to a risk/benefit evaluation by the veterinary surgeon and the posology evaluated carefully.

Caution is advised in the use of Clavaseptin in any other small pet (non food-producing) herbivores.

Use of the product should be based on susceptibility testing.

Inappropriate use of the product may increase the prevalence of bacteria resistant to amoxicillin/clavulanic acid and may decrease the effectiveness of treatment with other beta lactam antibiotics, due to the potential for cross resistance. Use of the product should take into account official and local antimicrobial policies. Do not use in cases of bacteria sensitive to narrow spectrum penicillins or to amoxicillin as a single substance.

Adverse reactions (frequency and seriousness)

Vomiting and diarrhoea may be observed. Treatment may be continued depending on the severity of the undesirable effect observed and a benefit/risk evaluation by the veterinary surgeon.

Hypersensitivity reactions (allergic skin reactions, anaphylaxis) may be observed. In these cases, administration should be discontinued and a symptomatic treatment given.

Use during pregnancy and lactation

The safety of the product has not been established during pregnancy and lactation. Laboratory studies in rats have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects. Use the product only accordingly to the benefit/risk assessment by the responsible veterinarian.

Interaction with other medicinal products and other forms of interaction

The bactericidal activity of amoxicillin may be reduced by the simultaneous use of bacteriostatic substances such as macrolides, tetracyclines, sulfonamides and chloramphenicol. The potential for allergic cross-reactivity with other pencillins should be considered. Penicillins may increase the effect of aminoglycosides.

Overdose (symptoms, emergency procedures, antidotes), if necessary

At three times the recommended dose for a period of 28 days, a decrease in cholesterol values and episodes of vomiting were observed in cats and diarrhoea was observed in dogs. In the event of an overdose, symptomatic treatment is advised.

Operator warning

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.

1. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.

2. Handle this product with great care to avoid exposure, taking all recommended precautions.

3. If you develop symptoms following exposure, such as skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty in breathing are more serious symptoms and require urgent medical attention.

Wash hands after handling the tablets

Pharmaceutical precautions

Do not store above 25°C. Store in the original package.

Return any halved tablet to the opened strip-pack and use within 16 hours.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Legal category

Packaging quantities

Clavaseptin 50 mg Palatable Tablets: 10 and 50 blisters of 10 tablets

Clavaseptin 62.5 mg Palatable Tablets: 10 and 25 blisters of 10 tablets

Clavaseptin 250 mg Palatable Tablets: 10 and 25 blisters of 10 tablets

Clavaseptin 500 mg Palatable Tablets: 10 blisters of 10 tablets.

Further information

Amoxicillin is an aminobenzylpenicillin from the β-lactam penicillin family which prevents the bacterial cell wall formation by interfering with the final step of peptidoglycan synthesis.

Clavulanic acid is an irreversible inhibitor of intracellular and extracellular β-lactamases which protects amoxicillin from inactivation by many β-lactamases.

Amoxicillin/clavulanate has a wide range of activity which includes β‑lactamase producing strains of both Gram-positive and Gram-negative aerobes, facultative anaerobes and obligate anaerobes.

Resistance to β-lactam antibiotics is mainly mediated by β-lactamases which hydrolyze antibiotics such as amoxicillin.

After oral administration at the recommended dose in dogs and cats, the absorption of amoxicillin and clavulanic acid is fast. In dogs, the maximum plasma concentration of amoxicillin of 8.5 µg/ml is reached in 1.4 h and the maximum plasma concentration of clavulanic acid of 0.9 µg/ml is reached in 0.9h.

In cats, the maximum plasma concentration of amoxicillin of 6.6 µg/ml is reached in 1.8 h and the maximum plasma concentration of clavulanic acid of 3.7 µg/ml is reached in 0.75h. Elimination is also fast.

Half-life is 1 hour in dogs and 1-2 hours in cats for both substances.

After repeated oral administration of the recommended dose in dogs and cats, there is no accumulation of amoxicillin or clavulanic acid and the steady state is reached rapidly after first administration.

Refer to individual SPCs for further information.

Marketing Authorisation Number

Clavaseptin 50 mg Palatable Tablets: Vm 08007/4113

Clavaseptin 62.5 mg Palatable Tablets: Vm 08007/4135

Clavaseptin 250 mg Palatable Tablets: Vm 08007/4114

Clavaseptin 500 mg Palatable Tablets: Vm 08007/4115

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to air freight restrictions aerosols cannot ever be sent abroad by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (2)

Q & A

Below are some recent questions we've received regarding Clavaseptin Palatable Tablets, including answers from our team.

18 August 2015 at 3:56am

Treating an urinary infection


Looking at the difference between clavaseptin vs. clavamox in treating a urinary infection in a dog with elevated liver enzymes.

  • Non-Executive Director

This is like asking the difference between the Boots version of paracetamol and Tesco's. They are both manufactured to the same standards, they contain the same active ingredients and essentially there is no difference. Both antibiotics are equally acceptable to use when there has been an element of liver damage, which is what causes elevated liver enzyme levels in the blood. Likewise they are both indicated for urinary tract infections. More than that it is impossible to say. The choice of antibiotic is down to your vet, who is familiar with your dog.

14 April 2015 at 1:02am

Drug interaction between clavaseptin and prednisolone


My cat is finishing up her last few doses of clavaseptin. She was given prednisolone a couple weeks prior from another issue..can I start giving her the prednisolone or do I need to wait a while after she finished her clavaseptin?

  • Non-Executive Director

These two medications are often given at the same time, so I would expect to treat the two conditions as appropriate for each. There is no general requirement to not give the two together. Howevere, prednisolone can reduce the immune response (especially at higher doses) so it might be best to ensure that any infection is clear before starting prednisolone again. This is something you should check with your own vet who is familiar with the precise details of this case and will be able to provide more relevant advice.