Clavaseptin Palatable Tablets

Clavaseptin Palatable Tablets
50mg » Priced per Tablet

  • 50mg » Priced per Tablet £0.39
  • 62.5mg » Priced per Tablet £0.59
  • 250mg » Priced per Tablet £1.00
  • 500mg » Priced per Tablet £1.79

Selection of 4 products from

£0.39 to £1.79

Description

Clavaseptin is known as a potentiated antibiotic. It contains two ingredients which work together to significantly increase the effectiveness against certain bacteria. The main antibiotic ingredient (amoxycillin) can be inactivated by certain types of bacteria, rendering them resistant. However the second ingredient (clavulanate) prevents the bacteria from inactivating the antibiotic, allowing the antibiotic to kill the bacteria. Hence Clavaseptin is active against a wide range of bacteria and this combination has become one of the main antibiotics used in veterinary medicine. Tablets are normally given twice daily at a dose rate of 12.5mg/kg bodyweight.

Presentation

Three tablet strengths are available: Clavaseptin 50mg Palatable Tablets containing 40mg Amoxicillin (as trihydrate) and 10mg Clavulanic Acid (as potassium salt). For use in cats and dogs.

Clavaseptin 250mg Palatable Tablets containing 200mg Amoxicillin (as trihydrate) and 50mg Clavulanic Acid (as potassium salt). For use in dogs.

Clavaseptin 500mg Palatable Tablets containing 400mg Amoxicillin (as trihydrate) and 100mg Clavulanic Acid (as potassium salt). For use in dogs.

Excipient: Brown Iron Oxide (E172)

Uses

In dogs: treatment or adjunctive treatment of periodontal infections caused by bacteria susceptible to amoxicillin in combination with clavulanic acid i.e. Pasteurella spp, Streptococcus spp and Escherichia coli.

In cats: treatment of skin infections (including wounds and abscesses) caused by bacteria susceptible to amoxicillin in combination with clavulanic acid i.e. Pasteurella spp, Staphylococcus spp, Streptococcus spp and Escherichia coli.

Dosage and administration

The recommended dose of Clavaseptin Palatable Tablets is 10 mg amoxicillin/2.5mg clavulanic acid/kg twice daily by the oral route in dogs and cats according to the following table.

Bodyweight (kg)

50mg tablets 1 tablet per 4kg bodyweight every 12h

250mg tablets 1 tablet per 20kg body weight every 12h

500mg tablets 1 tablet per 40kg bodyweight every 12h

[1.0-2.0]

½

[2.1-4.0]

1

[4.1-6.0]

[6.1-8.0]

2

[8.1-10]

½

[10.1-20]

1

[20.1-30]

[30.1-40]

2

1

[40.1-60]

[60.1-80]

2

Duration of treatment:

- 7 days for the treatment of periodontal infections in dogs

- 7 to 14 days for the treatment of skin infections in cats (including wounds and abscesses). The clinical status of animals should be re-evaluated after 7 days and the treatment prolonged for a further 7 days if necessary.

To ensure the correct dosage, bodyweight should be determined as accurately as possible to avoid under-dosing.

Administration is made easier by the palatable nature of the tablet.

Contra-indications, warnings, etc

Do not use in case of hypersensitivity to penicillins or other substances of the β-lactam group.

Do not administer to gerbils, guinea pigs, hamsters, rabbits and chinchillas.

Special precautions for use in animals

In animals with impaired liver and kidney function, the use of the product should be subject to a risk/benefit evaluation by the veterinary surgeon and the posology evaluated carefully.

Caution is advised in the use of Clavaseptin in any other small pet (non food-producing) herbivores.

Use of the product should be based on susceptibility testing.

Inappropriate use of the product may increase the prevalence of bacteria resistant to amoxicillin/clavulanic acid. Use of the product should take into account official and local antimicrobial policies.

Adverse reactions (frequency and seriousness)

Vomiting and diarrhoea may be observed. Treatment may be continued depending on the severity of the undesirable effect observed and a benefit/risk evaluation by the veterinary surgeon.

Hypersensitivity reactions (allergic skin reactions, anaphylaxis) may be observed. In these cases, administration should be discontinued and a symptomatic treatment given.

Use during pregnancy and lactation

The safety of the product has not been established during pregnancy and lactation. Laboratory studies in rats have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects. Use the product only accordingly to the benefit/risk assessment by the responsible veterinarian.

Interaction with other medicinal products and other forms of interaction

The bactericidal activity of amoxicillin may be reduced by the simultaneous use of bacteriostatic substances such as macrolides, tetracyclines, sulfonamides and chloramphenicol.

Overdose (symptoms, emergency procedures, antidotes), if necessary

At three times the recommended dose for a period of 28 days, diarrhoea was observed in dogs. In the event of an overdose, symptomatic treatment is advised.

Operator warning

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.

1. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.

2. Handle this product with great care to avoid exposure, taking all recommended precautions.

3. If you develop symptoms following exposure, such as skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty in breathing are more serious symptoms and require urgent medical attention.

Wash hands after handling the tablets

Pharmaceutical precautions

Shelf-life of the veterinary medicinal product as packaged for sale: Clavaseptin 50 mg Tablets 2 years; Clavaseptin 250 mg and 500 mg tablets 3 years.

Shelf life after first opening the immediate packaging: 12 hours.

Do not store above 25°C. Store in the original package.

Return any halved tablet to the opened strip-pack and use within 12 hours.

Any unused product or waste material should be disposed of in accordance with national requirements.

Legal category

POM-V

Packaging Quantities

Clavaseptin 50mg Palatable Tablets: 10 and 50 blisters of 10 tablets

Clavaseptin 250mg Palatable Tablets: 10 and 25 blisters of 10 tablets

Clavaseptin 500mg Palatable Tablets: 10 blisters of 10 tablets.

Further information

Amoxicillin is an aminobenzylpenicillin from the β-lactam penicillin family which prevents the bacterial cell wall formation by interfering with the final step of peptidoglycan synthesis.

Clavulanic acid is an irreversible inhibitor of intracellular and extracellular β-lactamases which protects amoxicillin from inactivation by many β-lactamases.

Amoxicillin/clavulanate has a wide range of activity which includes β‑lactamase producing strains of both Gram-positive and Gram-negative aerobes, facultative anaerobes and obligate anaerobes.

Resistance to β-lactam antibiotics is mainly mediated by β-lactamases which hydrolyze antibiotics such as amoxicillin. It is mostly shown in Pseudomonadaceae (81.25%) and in Enterobacter spp. (55.5%).

After oral administration at the recommended dose in dogs and cats, the absorption of amoxicillin and clavulanic acid is fast. In dogs, the maximum plasma concentration of amoxicillin of 8.5 µg/ml is reached in 1.4 h and the maximum plasma concentration of clavulanic acid of 0.9 µg/ml is reached in 0.9h.

In cats, the maximum plasma concentration of amoxicillin of 6.6 µg/ml is reached in 1.8 h and the maximum plasma concentration of clavulanic acid of 3.7 µg/ml is reached in 0.75h. Elimination is also fast.

After repeated oral administration of the recommended dose in dogs and cats, there is no accumulation of amoxicillin or clavulanic acid and the steady state is reached rapidly after first administration.

Marketing authorisation number

Clavaseptin 50mg Palatable Tablets: Vm 08007/4113.

Clavaseptin 250mg Palatable Tablets: Vm 08007/4114.

Clavaseptin 500mg Palatable Tablets: Vm 08007/4115.

GTIN (Global Trade Item No)

Clavaseptin 50mg 10 x 10

03605877453873

Clavaseptin 50mg 50 x 10

03605877453958

Clavaseptin 250mg 10 x 10

03605877454085

Clavaseptin 250mg 25 x 10

03605877454160

Clavaseptin 500mg

03605877454245

Need help or advice? Contact us:

  • Landline: 01582 842096
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All prices include VAT where applicable.

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to air freight restrictions aerosols cannot ever be sent abroad by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (2)

Q & A

Below are some recent questions we've received regarding Clavaseptin Palatable Tablets, including answers from our team.

18 August 2015 at 3:56am

Treating an urinary infection

Staceykg

Looking at the difference between clavaseptin vs. clavamox in treating a urinary infection in a dog with elevated liver enzymes.

  • Non-Executive Director

This is like asking the difference between the Boots version of paracetamol and Tesco's. They are both manufactured to the same standards, they contain the same active ingredients and essentially there is no difference. Both antibiotics are equally acceptable to use when there has been an element of liver damage, which is what causes elevated liver enzyme levels in the blood. Likewise they are both indicated for urinary tract infections. More than that it is impossible to say. The choice of antibiotic is down to your vet, who is familiar with your dog.

14 April 2015 at 1:02am

Drug interaction between clavaseptin and prednisolone

Melissa

My cat is finishing up her last few doses of clavaseptin. She was given prednisolone a couple weeks prior from another issue..can I start giving her the prednisolone or do I need to wait a while after she finished her clavaseptin?

  • Non-Executive Director

These two medications are often given at the same time, so I would expect to treat the two conditions as appropriate for each. There is no general requirement to not give the two together. Howevere, prednisolone can reduce the immune response (especially at higher doses) so it might be best to ensure that any infection is clear before starting prednisolone again. This is something you should check with your own vet who is familiar with the precise details of this case and will be able to provide more relevant advice.