Advantage 400 Spot On Flea Control Extra Large Dog

Advantage 400 Spot On Flea Control Extra Large Dog
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400 Extra Large Dogs Over 25kg » 4 Pipettes

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  • 400 Extra Large Dogs Over 25kg » 4 Pipettes £12.49


Why Worry about fleas?

Fleas can cause more than just irritation in dogs; they can lead to flea allergy dermatitis (FAD) or even anaemia (if it’s a severe infestation). Some pets develop allergies to flea saliva, which means even a few bites can lead to severe itching and sore skin infected fleas can also transmit tapeworm if swallowed during grooming. All very nasty stuff.

What’s more, fleas don’t just bite your furry friend, they bite humans too and can infest your home causing irritation to you and your family. Did you know it can take months to get rid of a infestation in your home as only 5% of fleas lice on tour pet, the other 95% are in your home environment as eggs, larvae and pupae.

One application of advantage, the vet-recommended flea treatment, with its fuss-free pipette application gets to work within one day and remains effective for up to four weeks. Advantage is able to kill fleas through contact, no biting required. *

Need help or advice? Contact us:

  • Landline: 01582 842096
  • Mon - Fri: 9:00am - 5:00pm
  • Sat: 9:00am - 1:00pm
  • Email: [email protected]

All prices include VAT where applicable.

Medication Datasheets

Reviews (1347)

Summary of Reviews for Advantage 400 Spot On Flea Control Extra Large Dog

Overall 5
Ease Of Use
Value For Money
Absence Of Side Effects
1319 out of 1347 (98%) customers would recommend this product.
5 stars (1134 reviews)
4 stars (180 reviews)
3 stars (8 reviews)
2 stars (5 reviews)
1 stars (20 reviews)

Only verified purchasers of this product can leave a review.

45 Worked well.
Verified Purchase

By on 5 March 2022

Very good.

Customer recommends this product

45 Good
Verified Purchase

By on 15 October 2021

Goof flea treatment. Usually use Advocate which I think is better but you need a Vet to prescribe and with the shortgae of vets atm, its impossible to get it! This works well though.

Customer recommends this product

55 Advantage extra large
Verified Purchase

By on 30 September 2021

Good product great price works fantastic on Alfie

Customer recommends this product

45 Advantage 400
Verified Purchase

By on 2 August 2021

Good product

Customer recommends this product

45 Advantage
Verified Purchase

By on 2 July 2021

Seems to work as well as others and a very good price. Our dog has not been scratching and no signs of any pests on her

Customer recommends this product

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Q & A

Below are some recent questions we've received regarding Advantage 400 Spot On Flea Control Extra Large Dog, including answers from our team.

14 August 2020 at 9:27am

Advantage flea


Does this cover lounge work and heart worm

  • VioVet Staff

Advantage Spot On covers fleas and lice, it will not cover lungworm or heartworm. If you would like to cover lungworm then I advise using Advocate. This is by the same company but also contains moxidectin to cover lungworm/roundworms. It is a prescription only product so you will need a written prescription from your vet to purchase it.

20 October 2018 at 7:06pm

Active ingredient

Lynn Whitlock

Please could you tell me what the active ingredient in Advantage flea control is please?

  • VioVet Staff

Hi Lynn,

Thanks for your enquiry.

The active ingredient is: imidacloprid

I hope this helps.

31 July 2018 at 2:08pm

Flea treatment for nursing bitch and pups


Can u use this product on a nursing bitch and one week old puppies

  • VioVet Staff

Hello Danielle,

Thank you for your question.

It is safe to apply to lactating females and doing this will treat the puppies or kittens as well as the adult, and can be used on dogs from 8 weeks old.

Hope that helps,


21 July 2018 at 11:38pm

Harvest Mites


Can Advantage kill harvest mites?

  • VioVet Staff

Hi Jennie,

Advantage treats fleas (on cats and dogs) and biting lice (on dogs) only.

Hope this helps.

8 June 2018 at 11:35am

Nursing Cat


Can I use this on my cat who is nursing 2 week old kittens?

  • VioVet Staff

Hello Emma,

Thank you for your question.

Yes you can use the Advantage flea control on your cat while she is nursing her kittens.

Hope this helps.

29 March 2018 at 5:12pm

Does this product need a prescription?

Jacqueline Hall

  • VioVet customer since 2013
  • From: Hampshire, United Kingdom

Does this product need a prescription?

  • VioVet Staff

No you do not need a prescription for Advantage but you do for Advantix.

6 December 2017 at 12:58pm

When can I use an alternative?

Geraldine Sayers Cowper

  • VioVet customer since 2017
  • From: Norfolk, United Kingdom

Advantage has stopped working on my elderly cat (20yrs old). How soon can I use an alternative - I applied Advantagge 2 weeks ago and she still has fleas.

  • VioVet Staff

It should be safe to try an alternative now if it has been 2 weeks since she last had Advantage. However it is unlikely that the Advantage has stopped working but that you need to treat the house too with a spray such as Indorex. Fleas hide in carpets, curtains, furniture, pet bedding etc and then can jump back onto your cat. Even if your cat has been treated it will take around 24hrs before the fleas are killed.

30 November 2017 at 1:31pm

Suitable for Guinea pigs?

Samantha Batty

Brought the Guinea pigs in for winter and I really don't want the cats to get fleas. Will this dosage be suitable for Guinea pigs?

  • VioVet Staff

Hello Samantha, t

Thank you for your question.

Unfortunately this product is not suitable for use on guinea pigs as it is only licensed for use on dogs, cats or rabbits.

We would recommend checking out the Xeno 450 Spot-On Parasite & Flea Treatment to treat guinea pigs for fleas. Here is a link to the product page:

I hope that helps.

19 November 2017 at 3:34pm

Puppy flea treatment


I am looking for advantage puppy flea treatment for a twelve week old puppy weighing approximately 12 kilos do you sell it and for how much?

  • VioVet Staff

Advantage is safe to use on puppies from 8 weeks old. If your puppy is 12kg then you will need Advantage 250 spot-on.

3 November 2017 at 9:41pm

Age of kitten vs weight


I have kitten who is 8 1/2 weeks. Is it definitely safe to use on her or does she have to be at least over a certain weight. I only ask cause my older cat had treatment when he was 8 weeks from something else, which said from 8 weeks so gave it to him only for him to nearly die :( as one dose overdosed him, later found out they were for from 8 weeks but from a certain weight :(

  • VioVet Staff

There is nothing on the Advantage data sheet to say there is a minimum weight at which it can be used, just that kittens should be over 8 weeks old, so it should be fine. However, if you are concerned you could use Fiproclear Spray instead which is suitable for use on all sizes of dog and cat from 2 days old.

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