Advantage 400 Spot On Flea Control Extra Large Dog

Advantage 400 Spot On Flea Control Extra Large Dog
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400 Extra Large Dogs Over 25kg » 4 Pipettes

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  • 400 Extra Large Dogs Over 25kg » 4 Pipettes £16.99

Description

Why Worry about fleas?

Fleas can cause more than just irritation in dogs; they can lead to flea allergy dermatitis (FAD) or even anaemia (if it’s a severe infestation). Some pets develop allergies to flea saliva, which means even a few bites can lead to severe itching and sore skin infected fleas can also transmit tapeworm if swallowed during grooming. All very nasty stuff.

What’s more, fleas don’t just bite your furry friend, they bite humans too and can infest your home causing irritation to you and your family. Did you know it can take months to get rid of a infestation in your home as only 5% of fleas lice on tour pet, the other 95% are in your home environment as eggs, larvae and pupae.

One application of advantage, the vet-recommended flea treatment, with its fuss-free pipette application gets to work within one day and remains effective for up to four weeks. Advantage is able to kill fleas through contact, no biting required. *

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Medication Datasheets

Reviews (1382)

Summary of Reviews for Advantage 400 Spot On Flea Control Extra Large Dog

Overall 5
Effectiveness
Ease Of Use
Value For Money
Absence Of Side Effects
1353 out of 1382 (98%) customers would recommend this product.
5 stars (1160 reviews)
4 stars (188 reviews)
3 stars (9 reviews)
2 stars (5 reviews)
1 stars (20 reviews)

Only verified purchasers of this product can leave a review.

Very good product at an excellent price.
Verified Purchase

By Jane Parker on 7 July 2026

Excellent product at a really good price. Many thanks.

Customer recommends this product

Very good flea treatment
Verified Purchase

By Anne Nicholls on 1 July 2026

Works well and is easy to use

Customer recommends this product

For treatment
Verified Purchase

By Susan Frost on 30 June 2026

Great product for preventing fleas & ticks

Customer does not recommend this product

Rescue dogs
Verified Purchase

By Lyn Errington on 14 May 2026

We always give this product to all new owners for their rescued dog

Customer recommends this product

Always works
Verified Purchase

By Christine Stokes on 24 March 2026

I like this flea treatment as it dosnt go in the dogs bloodstream. And it covers them for 4 weeks. It always works its Good stuff.

Customer recommends this product

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Q & A

Below are some recent questions we've received regarding Advantage 400 Spot On Flea Control Extra Large Dog, including answers from our team.

18 September 2025 at 11:53am

Giant dogs

SB

I have two Tibetan Mastiffs weighing 75kg and 78kg, so, do I have to purchase the extra large dog flea treatment and the medium dog In order to give them the correct dose?

  • VioVet Staff

For your Tibetan Mastiffs, weighing 75kg and 78kg, you would need to use Advantage 400 Spot On Flea Control for Extra Large Dogs, as it is specifically designed for dogs over 25kg, and the dose is stronger to handle larger breeds.
You don’t need to buy the medium dog treatment. One Extra Large Dog pack should cover both of your dogs, but since they are both on the larger end, you may need to apply a larger amount, depending on the product guidelines.
If you're unsure, it's always a good idea to consult with your
veterinarian, especially for larger breeds, to ensure the dosage is accurate.

14 November 2022 at 11:58am

Pregnant bitches

Sandra Bourn

Is this Advantage safe to use on my pregnant bitch .?

  • VioVet Staff

The datasheet states the following regarding it's use in pregnant bitches:
No reproductive toxic effects have been observed in rats and no primary embryotoxic or teratogenic toxic effects have been observed during the studies on rats and rabbits. Studies on pregnant and lactating bitches, queens and does together with their offspring are limited. Evidence so far indicates that no adverse effects are to be expected in these animals.

This means unfortunately there is not significant data to guarantee it is safe. It should only be used in a pregnant bitch alongside direct advice from your vet.

14 August 2020 at 9:27am

Advantage flea

Sus

Does this cover lounge work and heart worm

  • VioVet Staff

Advantage Spot On covers fleas and lice, it will not cover lungworm or heartworm. If you would like to cover lungworm then I advise using Advocate. This is by the same company but also contains moxidectin to cover lungworm/roundworms. It is a prescription only product so you will need a written prescription from your vet to purchase it.

20 October 2018 at 7:06pm

Active ingredient

Lynn Whitlock

Please could you tell me what the active ingredient in Advantage flea control is please?

  • VioVet Staff

Hi Lynn,

Thanks for your enquiry.

The active ingredient is: imidacloprid

I hope this helps.

31 July 2018 at 2:08pm

Flea treatment for nursing bitch and pups

Danielle

Can u use this product on a nursing bitch and one week old puppies

  • VioVet Staff

Hello Danielle,

Thank you for your question.

It is safe to apply to lactating females and doing this will treat the puppies or kittens as well as the adult, and can be used on dogs from 8 weeks old.

Hope that helps,

VioVet.

21 July 2018 at 11:38pm

Harvest Mites

Jennie

Can Advantage kill harvest mites?

  • VioVet Staff

Hi Jennie,

Advantage treats fleas (on cats and dogs) and biting lice (on dogs) only.

Hope this helps.

8 June 2018 at 11:35am

Nursing Cat

Emma

Can I use this on my cat who is nursing 2 week old kittens?

  • VioVet Staff

Hello Emma,

Thank you for your question.

Yes you can use the Advantage flea control on your cat while she is nursing her kittens.

Hope this helps.

29 March 2018 at 5:12pm

Does this product need a prescription?

Jacqueline Hall

  • VioVet customer since 2013
  • From: Hampshire, United Kingdom

Does this product need a prescription?

  • VioVet Staff

No you do not need a prescription for Advantage but you do for Advantix.

6 December 2017 at 12:58pm

When can I use an alternative?

Geraldine Sayers Cowper

Advantage has stopped working on my elderly cat (20yrs old). How soon can I use an alternative - I applied Advantagge 2 weeks ago and she still has fleas.

  • VioVet Staff

It should be safe to try an alternative now if it has been 2 weeks since she last had Advantage. However it is unlikely that the Advantage has stopped working but that you need to treat the house too with a spray such as Indorex. Fleas hide in carpets, curtains, furniture, pet bedding etc and then can jump back onto your cat. Even if your cat has been treated it will take around 24hrs before the fleas are killed.

30 November 2017 at 1:31pm

Suitable for Guinea pigs?

Samantha Batty

Brought the Guinea pigs in for winter and I really don't want the cats to get fleas. Will this dosage be suitable for Guinea pigs?

  • VioVet Staff

Hello Samantha, t

Thank you for your question.

Unfortunately this product is not suitable for use on guinea pigs as it is only licensed for use on dogs, cats or rabbits.

We would recommend checking out the Xeno 450 Spot-On Parasite & Flea Treatment to treat guinea pigs for fleas. Here is a link to the product page: https://www.viovet.co.uk/Xeno_450_Spot-On_Parasite_Flea_Treatment/c9683/?sct_t=1512049286&sct_q=xeno&sct_r=2

I hope that helps.

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