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ACP is available as an injection or as 10mg tablets and the active ingredients is acepromezine. It is used as a mild tranquiliser or sedative for dogs and cats. It is no longer licensed for use in horses. ACP produces a mild to moderate sedative effect. Increasing the dose will not usually cause deeper sedation, but will instead make the sedation last longer. ACP also has some anti-emetic, anti-histamine and other effects. The injectable form is available for use by veterinary surgeons.
ACP Tablets 10 mg are pale yellow in colour and contain acepromazine maleate equivalent to 10 mg acepromazine base. ACP Tablets 25 mg are pale yellow in colour and contain acepromazine maleate equivalent to 25 mg acepromazine base.
The tablets are intended for use only in cats and dogs.
Following acepromazine administration, the amount of anaesthetic necessary to induce anaesthesia is considerably reduced. This reduction is approximately one-third of a suitable induction agent.
Acepromazine tranquillisation (ataraxy) involves a modification of temperament which is not associated with hypnosis, narcosis or marked sedation. This is achieved with low doses of acepromazine.
At higher dose rates acepromazine is a sedative.
A dose of 1 mg per kg given orally a quarter to half an hour before a light meal is effective in the prevention of travel sickness. Idiopathic vomiting may be controlled by acepromazine.
Acepromazine possesses anti-emetic, hypothermic, hypotensive and anti-spasmodic properties and shows a marked potentiating effect on barbiturate anaesthesia.
0.25–3 mg per kg bodyweight by oral administration. Onset of effects will be observed after 10–15 minutes. Normally single doses of acepromazine are administered. Long term use is not recommended.
Acepromazine is hypotensive. Particular care should therefore be taken in hypovolaemic animals; rehydration should precede acepromazine administration.
In some dogs, particularly Boxers and other short-nosed breeds, spontaneous fainting or syncope may occur due to sinoatrial block caused by excessive vagal tone, and an attack may be precipitated by acepromazine. Where there is a history of this type of syncope, or if it is suspected because of excessive sinus arrhythmia, it may be advantageous to control the dysrhythmia with atropine given just before the acepromazine.
It has been noted that large breeds of dog are particularly sensitive to acepromazine and the minimum dose possible should be used in these breeds.
Slow intravenous injection of norepinephrine (noradrenaline) should be used whenever a hypertensive agent is required to reverse any fall in blood pressure.
Epinephrine (adrenaline) is contra-indicated in the treatment of acute hypotension produced by overdosage of acepromazine maleate, since further depression of systemic blood pressure can result. Other pressoramines such as norepinephrine or neosynephrine should be administered to reverse hypotensive effects. However, the reversing effect of norepinephrine is likely to be transient and repeated doses will normally be required.
Do not use in pregnant animals.
For animal treatment only.
Wash hands after use.
In the event of accidental ingestion seek medical advice taking this warning to show your doctor.
Use During pregnancy, lactation or lay
No formal studies on the safety of ACP Tablets in pregnant animals have been conducted.
Interaction with other medicinal products and other forms of interaction
Acepromazine is additive to the actions of other depressants and will potentiate general anaesthesia.
Do not store above 25°C. Protect from light. Keep out of reach of children.
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.
Nature and composition of immediate packaging
White opaque polypropylene tub with a white opaque low density polyethylene lid, containing 500 tablets.
Pharmacotherapeutic group: Antipsychotics
ATC vet code: QN05AA04
Acepromazine is a phenothiazine. It is a central nervous system depressant with associated activity on the autonomic system. Phenothiazines have a central action due to inhibition of dopamine pathways, resulting in alteration of mood, reduction in fear and removal of learned or conditioned responses.
Acepromazine possesses anti-emetic, anti-convulsant, hypothermic, hypotensive and anti-spasmodic properties, and shows a marked potentiating effect of barbiturate anaesthesia.
The length of action of acepromazine appears to be prolonged and to be dose dependent.
Shelf life of veterinary medicinal product as packaged for sale: 4 years.
10 mg Tablets Vm 12501/4123
25 mg Tablets Vm 12501/4122
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