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ACP for Dogs and Cats

ACP for Dogs and Cats
2mg/ml for Injection » 20ml Bottle
10mg Tablet (Priced per Tablet)

  • 2mg/ml for Injection » 20ml Bottle £137.99
  • 10mg Tablet (Priced per Tablet) £0.49

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Description

ACP is available as an injection or as 10mg tablets and the active ingredients is acepromezine. It is used as a mild tranquiliser or sedative for dogs and cats. It is no longer licensed for use in horses. ACP produces a mild to moderate sedative effect. Increasing the dose will not usually cause deeper sedation, but will instead make the sedation last longer. ACP also has some anti-emetic, anti-histamine and other effects. The injectable form is available for use by veterinary surgeons.

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Medication Datasheets

10mg Tablet (Priced per Tablet)

ACP Tablets

Qualitative and quantitative composition

Active substance: mg/tablet

Acepromazine 10mg

(as Acepromazine maleate 13.54mg)

For a full list of excipients, see Pharmaceutical Particulars section.

Pharmaceutical form

Tablet.

Pale yellow biconvex tablet, approximately 6.5 mm in diameter, scored on one side only.

Clinical particulars

Target species

Dog and cat.

Indications for use, specifying the target species

Anaesthetic premedication: Following acepromazine administration, the amount of anaesthetic dose necessary to induce anaesthesia is considerably reduced. This reduction is approximately one-third of a suitable induction agent.

Tranquillisation: Acepromazine tranquillisation (ataraxy) involves a modification of temperament which is not associated with hypnosis, narcosis, or marked sedation. This is achieved with low doses of acepromazine.

Sedation: At higher dose rates acepromazine is a sedative.

Travel Sickness: A dose of 1 mg per kg given orally a quarter to half an hour before a light meal is effective in the prevention of travel sickness. Idiopathic vomiting may be controlled by acepromazine.

Contraindications

Do not use in pregnant animals.

Do not use on a long term basis in individual animals.

Special warnings for each target species

There are no known special warnings.

Special precautions for use

Special precautions for use in animals

Acepromazine is hypotensive. Particular care should therefore be taken in hypovolaemic subjects; rehydration should precede acepromazine administration.

In some dogs, particularly Boxers and other short-nosed breeds, spontaneous fainting or syncope may occur, due to sinoatrial block caused by excessive vagal tone, and an attack may be precipitated by acepromazine, so a low dose should be used. Where there is a history of this type of syncope, or if it is suspected because of excessive sinus arrhythmia, it may be advantageous to control the dysrhythmia with atropine given just before the acepromazine.

Large breeds: it has been noted that large breeds of dog are particularly sensitive to acepromazine and the minimum dose possible should be used in these breeds.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

In the event of accidental ingestion seek medical advice, showing the package leaflet to the physician.

Wash hands after use.

Adverse reactions (frequency and seriousness)

See section above, Special precautions for use.

Use during pregnancy, lactation or lay

No formal studies on the safety of ACP Tablets in pregnant animals have been conducted (see Contraindications section).

Interaction with other medicinal products and other forms of interaction

Acepromazine is additive to the actions of other depressants and will potentiate general anaesthesia (see indications for use section).

Amounts to be administered and administration route

0.25 - 3 mg per kg bodyweight by oral administration. Onset of effects will be observed after 10 - 15 minutes.

Normally single doses of acepromazine are administered (see Contraindications section).

Overdose (symptoms, emergency procedures, antidotes), if necessary

Transient dose‑dependent hypotension may occur in cases of accidental overdose. Therapy should consist of discontinuing any other hypotensive treatment, supportive care such as intravenous infusion of warm isotonic saline to correct hypotension and close monitoring.

Epinephrine (adrenaline) is contra-indicated in the treatment of acute hypotension produced by overdosage of acepromazine maleate, since further depression of systemic blood pressure can result.

Withdrawal period(s)

Not applicable.

Pharmacological particulars

Pharmacotherapeutic group:Antipsychotics

ATCvet code:QN05AA04

Pharmacodynamic properties

Acepromazine is a phenothiazine. It is a central nervous system depressant with associated activity on the autonomic system. Phenothiazines have a central action due to inhibition of dopamine pathways, resulting in alteration of mood, reduction in fear and removal of learned or conditioned responses.

Acepromazine possesses anti-emetic, anti-convulsant, hypothermic, hypotensive and anti-spasmodic properties, and shows a marked potentiating effect on barbiturate anaesthesia.

Pharmacokinetic particulars

The length of action of acepromazine appears to be prolonged and to be dose dependent.

Pharmaceutical particulars

List of excipients

Lactose monohydrate Maize starch Pregelatinised starch Povidone K29-32 Magnesium stearate

Incompatibilities

None known.

Shelf life

Shelf life of veterinary medicinal product as packaged for sale: 4 years.

Special precautions for storage

Do not store above 25°C. Protect from light.

Nature and composition of immediate packaging

White opaque polypropylene tub with a white opaque low density polyethylene lid, containing 500 tablets.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste material derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

NA

Marketing Authorisation Number

Vm 00879/4011

Date of the first authorisation or date of renewal

24 July 1992

Date of revision of the text

January 2016

Any other information

Legal category

2mg/ml for Injection » 20ml Bottle

ACP Injection 2 mg/ml

Qualitative and quantitative composition

Active substance:

Acepromazine 0.2 % w/v

(as acepromazine maleate 0.271)

Excipients:

Phenol (preservative) 0.3 % w/v

For a full list of excipients, see Pharmaceutical particulars section.

Pharmaceutical form

Solution for injection.

Pale yellow solution.

Clinical particulars

Target species

Dogs and cats.

Indications for use, specifying the target species

Anaesthetic Premedication: Following acepromazine administration, the amount of anaesthetic necessary to induce anaesthesia is considerably reduced. This reduction is approximately one-third of a suitable induction agent.

Tranquilisation: Acepromazine tranquilisation (ataraxy) involves a modification of temperament which is not associated with hypnosis, narcosis or marked sedation. This is achieved with low doses of acepromazine.

Sedation: At higher dose rates acepromazine is a sedative.

Contraindications

Do not use in pregnant animals.

Do not use on a long term basis in individual animals.

Special warnings for each target species

Subcutaneous injection is non-irritant and efficacious, especially in cats.

Special precautions for use

Special precautions for use in animals

Acepromazine is hypotensive. Particular care should therefore be taken in hypovolaemic animals; rehydration should precede acepromazine administration.

In some dogs, particularly Boxers and other short-nosed breeds, spontaneous fainting or syncope may occur due to sinoatrial block caused by excessive vagal tone. An attack may be precipitated by an injection of acepromazine, so a low dose should be used. Where there is a history of this type of syncope, or if it is suspected because of excessive sinus arrhythmia, it may be advantageous to control the dysrhythmia with atropine given just before the acepromazine.

Large breeds: It has been noted that large breeds of dog are particularly sensitive to acepromazine and the minimum dose possible should be used in these breeds.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Care should be taken when handling and administering this product to avoid exposure.

Take precautions to avoid accidental injection or self-administration of this potent drug. In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician. Symptomatic treatment may be required.

Avoid contact with eyes. If accidental eye contact occurs, flush gently with fresh running water for 15 minutes and seek medical advice if any irritation persists.

In the event of accidental skin contact, was the contaminated with large amounts of soap and water. Medical advice should be sought if irritation persists.

Wash hands and exposed skin thoroughly after use.

Adverse reactions (frequency and seriousness)

Cardiac dysrhythmia may follow rapid intravenous injection. See section, Special precautions for use in animals.

Use during pregnancy, lactation or lay

No formal studies on the safety of ACP Injection in pregnant animals have been conducted (see Contraindications section).

Interaction with other medicinal products and other forms of interaction

Acepromazine is additive to the actions of other depressants and will potentiate general anaesthesia (see Indications for use section).

Amounts to be administered and administration route

Premedication: 0.03 - 0.125 mg per kg bodyweight by intramuscular, subcutaneous or slow intravenous injection.

Other uses: By intramuscular or subcutaneous injection 0.0625 - 0.125 mg per kg bodyweight. Approximately equivalent to 0.625 - 1.25 ml of 2 mg/ml injection per 20 kg bodyweight. By intravenous injection - as for intramuscular, except that it is recommended the injection is made slowly.

The maximum dose that should be given is 4 mg acepromazine per animal.

Normally single doses of acepromazine are administered (see section Contraindications section).

Take adequate precautions to maintain sterility. Avoid the introduction of contamination during use. Should any apparent growth or discolouration occur, discard the product.

Overdose (symptoms, emergency procedures, antidotes), if necessary

Transient dose‑dependent hypotension may occur in cases of accidental overdose. Therapy should consist of discontinuing any other hypotensive treatment, supportive care such as intravenous infusion of warm isotonic saline to correct hypotension and close monitoring.

Epinephrine (adrenaline) is contra-indicated in the treatment of acute hypotension produced by overdosage of acepromazine maleate, since further depression of systemic blood pressure can result.

Withdrawal period(s)

Not applicable.

Pharmacological particulars

Pharmacotherapeutic group:Antipsychotics

ATCvet code:QN05AA04

Pharmacodynamic properties

Acepromazine is a phenothiazine. It is a central nervous system depressant with associated activity on the autonomic system. Phenothiazines have a central action due to inhibition of dopamine pathways, resulting in alteration of mood, reduction in fear and removal of learned or conditioned responses.

Acepromazine possesses anti-emetic, hypothermic, hypotensive and anti-spasmodic properties and shows a marked potentiating effect on barbiturate anaesthesia.

Pharmacokinetic particulars

The length of action of acepromazine appears to be prolonged and to be dose dependent.

Pharmaceutical particulars

List of excipients

Phenol

Sodium hydroxide or

Maleic acid (for pH adjustment)

Water for injections

Incompatibilities

None known.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years.

Shelf life after opening of the immediate packaging: 28 days.

Special precautions for storage

Do not store above 25°C. Protect from light. Following withdrawal of the first dose, use remainder of the product within 28 days. Discard unused material.

Nature and composition of immediate packaging

20 ml clear glass (Type II) vial, closed with a grey chlorobutyl rubber bung and aluminium crimped seal.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste material derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

NA

Marketing Authorisation Number

Vm 00879/4012

Date of the first authorisation or date of renewal

30 June 1992

Date of revision of the text

January 2016

Any other information

Legal category

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (2)

Q & A

Below are some recent questions we've received regarding ACP for Dogs and Cats, including answers from our team.

7 May 2016 at 10:02am

Acp for horses

Acp

Hi just wanted to know why you can't use Acp tablets on horses as I can't get the paste near my horse so the tablets would be great if I could get some

  • Non-Executive Director

ACP is ACP, so either formulation should work if they are given at an appropriate dose etc. However vets are supposed only to prescribe licensed medication and the tablets are licensed for dogs and cats. In the past they were often used for horses but when the gel was introduced and licensed for horses, this became the automatic "correct" treatment. It is up to your vet if they want to prescribe an unlicensed drug. You can ask them - they might feel able to do so if you have a good reason, but they are in a difficult position legally. We are able to supply whatever has been prescribed, but nothing else.

28 October 2015 at 8:57pm

Is there any medical conditions in a cat that would make ACP a risky choice for sedation?

cat

is there any medical conditions in a cat that would make ACP a risky choice for sedation?

  • Non-Executive Director

ACP is generally very safe as long as it is not over-dosed. Your vet should ensure it is safe before prescribing ACP knowing your individual cat.

11 September 2015 at 10:55am

ACP for cage rest cats?

Kat

My cat was run over a fortnight ago. He has a broken pelvis. Cage rest was fine for the first 4 days now he's going mad. He climbed the inside of his cage and fell and is now walking oddly (appointment made with vet). He won't rest! I was wondering if ACP is compatible for use alongside metacam? Mostly for night time (when he fell) and when we're having to go to work (to pay the vet bills) because he's going to do himself a mischief.

  • Non-Executive Director

ACP might help, you will need to check with your vet about this. It is not a great plan to be used for weeks though. Sometimes confining a cat to one room in the house works OK and it is remarkable how well most cases of fractured pelvis heal, despite what cats do. You will need to discuss this with your vet and make a plan with him/her.

5 March 2015 at 12:15am

Sedating sheep?

Emily Lorenz

When I moved into my house last March, the house came with 4 sheep. As the new spring approaches, it's coming time to shear them. Would this work to sedate sheep long enough to keep them calm for shearing? They're very scared of people. Hoping this would make them calm. Would it?

  • Non-Executive Director

ACP does have an effect in sheep, but can be unpredictable in very nervous sheep and may seem ineffective, even with quite a large dose.It is prescription only anyway, so your vet would have to write out a prescription for what they feel would be effective. Xylazine (Rompun) would be many vets' choice for this job. We could get some for you if you send us a prescription.

21 April 2014 at 11:07pm

Wanting to purchase dog sedative

Alma Vollans

Hi there. I am wishing to purchase a dog sedative. My dog is a very anxious one which is very nervous in crowded situations. I get married Saturday and I am concerned that he will be very distressed on the day.

  • Non-Executive Director

Medication like this has to be prescribed by your vet and has to be used with care, so we will not be able to help in this instance. Possibly your dog could be looked after elsewhere for the day?

28 October 2013 at 8:30pm

Can they be used on a nightly bases for several years as my basset won't settle

burt

My bassett has been on these on and off for two years especially when its windy a raining now this month I'm on his thirteenth tab stopped it several times and he was stressed and barking and wouldn't settle spent night on sofa with him I have a feeling I might need him on them for a few months not sure vet will alow such long use he's on ten mg could he be on them for a year if needed he only has several years left as is nearly eleven

  • Non-Executive Director

ACP does seem to be very safe, but it is not usually given every day for years.They might well not work so well after a while. There are quite a few herbal products which are intended to be used for the same thing and they appear very effective for some dogs, though not all. I would suggest trying a few alternative products so that you are not using the same thing all the time. If you hover your cursor over "Dogs" on the website menu, then click on the field labeled Behaviour & Brain, there are a lot of alternative products you could try. Zylkene works very well for some dogs, or Calmex seems to be popular. Adaptil works well for some too. Valerian compound is a very traditional treatment and still sells well too. Lots to choose from!

18 August 2013 at 5:13am

ACP tablets to treat 6 month female pup with ADHD

lorna

6 month mixed breed medium sized pup post desex operation( with ADAH) quietens down after 1 ACP tablet twice a day for 15 days. Is it dangerous to keep her on this medication, if so for how long. Healthy pup but with ADAH very hard to control and has possible signs of being savage as she matures. Elderly owner I wonder if there is any other safe medication to handle her complaint. Thank you, Lorna

  • Non-Executive Director

Long-term use of ACP is not recommended. Your dog might tend to become tolerant to the medication, and after a while it might start to have unexpected or adverse effects. There are herbal treatments which work well for some dogs, such as Dorwest Scullcap and Valerian tablets, which appear to be very safe. Zylkene tablets will have a calming effect on some dogs, though these are more expensive.

At just 6 months old, we would recommend getting advice from a qualified and experienced behaviourist, who will almost certainly have some good advice which would be worth following. This is much more likely to work well long-term than relying on medication. You could contact the Association of Pet Behaviour Counsellors at www.apbc.org.uk for the best advice. We have heard of many surprisingly good responses from this approach.

9 August 2013 at 3:06am

ACP shelf life

Graham Wright

Is it safe to give my dog ACP which was purchased 6 years ago.

  • Non-Executive Director

It might or might not be, it is impossible to know. Storage conditions, amongst other factors, can have a big effect. Therefore we would have to advise not to do it.