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  • 75mg Capsules » Pack of 10 £4.10
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  • 225mg Capsules » Pack of 100 £73.82
  • 450mg Capsules » Pack of 10 £12.55
  • Special Offer 450mg Capsules » Pack of 20 £21.59
  • 450mg Capsules » Pack of 100 £125.79

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Zylkène is a complementary feed for dogs, cats and horses which contains a natural product, derived from casein, a protein in milk. It is a molecule well known to promote the relaxation of newborns after breastfeeding. Launched in April 2008, Zylkène has become a familiar product for veterinary surgeons, behaviourists, nurses and pet owners for use in helping pets cope when facing unusual and unpredictable situations or before occasions such as a change in their normal environment.

Zylkène is a product that can help support dogs, cats and horses in situations where they find the need to adapt their behaviour to cope. These include kennel and cattery stays, house moves, kennel/box rest, arrival of a new pet or baby, sudden noises e.g. fireworks, travel, vet or groomer visits and Christmas festivities.

There are many ways our pets can respond to new and unpredictable situations and not all animals respond in the same way. Zylkène is palatable and easy to give; simply mix with food or give as a treat. Give just once a day.

Product Overview

There are many reports in the literature of remarkably good responses to Zylkène. In dogs and cats it is particularly good for travel, re-homing, grooming, visiting the vets etc. For horses, Zylkène Equine can easily be given in feed for clipping, travelling, shoeing etc.

Zylkène can help in many situations where animals might be expected to feel anxious or stressed. However do remember that you have a part to play too. Our animals have a phenomenal ability to pick up on signals we give them. Zylkène works best when combined with thoughtful and considerate handling from calm and sensible people!

Suitable for situations such as:

  • Changes in environment

  • Being left alone

  • New person, baby or pet being introduced

  • Travelling

  • Kennel or cattery visits

  • Fireworks

  • Loud noises and thunderstorms

  • Vet visits

  • Celebrations

  • Moving house

  • Lactation

  • Weaning

Feeding Guidelines

For oral administration.

The recommended daily amount should be given in one intake.

The capsule can be opened and the powder mixed with food or a treat.

Zylkène 75mg for cats and small dogs

Up to 5kg

1 capsule per day

Zylkène 75mg for cats and small dogs

5-10 kg

2 capsules per day

Zylkène 225mg for medium dogs


1 capsule per day

Zylkène 225mg for medium dogs


2 capsules per day

Zylkène 450mg for large dogs


1 capsule per day

Zylkène 450mg for large dogs


2 capsules per day

Short Term Use: use for 1-2 days before the predicted event or change in environment. Some animals may need earlier administration (5-7 days).

Longer Term Use: 1-2 months

Horses up to 500kg: 1 sachet daily
Horses over 500kg: 2 sachets daily

Horses are often dosed for 2 days prior to a particular event, as well as on the day itself. Longer periods can be given, up to permanent, daily medication.



Powder 77.3%: Maltodextrin, Casein (Trypsin hydrolysis bovine casein), Magnesium stearate

Capsule 22.7%: Bovine skin gelatine


Powder 76.9%: Casein (Trypsin hydrolysis bovine casein), Maltodextrin, Magnesium stearate,
Capsule 23.1% Bovine Skin gelatine


Powder 82.9%: Casein (Trypsin hydrologic bovine casein), Magnesium Stearate

Capsule 17.1%: Bovine skin gelatine

Analytical Constituents:


Crude protein 39%, Crude ash 4%, Moisture 8%, Crude fat 2.5%, Crude fibre 0%


Crude protein 75%, Crude ash 10.5%, Moisture 8%, Crude fat 2%, Crude fibre 0%


Crude protein 78%, Crude ash 12%, Moisture 8%, Crude fat 3%, Crude fibre 0%

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Questions & Answers for Zylkène

Below are some recent questions we've received regarding Zylkène, including answers from our team.

Ask Your Own Question


13th Oct 2016
Derek Thomson
  • VioVet Customer Since: November 2012
  • From: Highland, United Kingdom

37.5 Kilos large Greyhound what dosage does he require, he is not overly anxious but they do bother him?

  • Veterinary Surgeon

The correct dose for your dog would be 2 large dog capsules a day. I would start them 2 days before the event- in this case I am presuming bonfire night! In particularly anxious dogs it is worth starting the capsules up to 7 days before the event but it sounds as though your dog will be fine starting 2 days before.

Cattery agression

15th Sep 2016
Susan Blanchflower
  • VioVet Customer Since: May 2016
  • From: Norfolk, United Kingdom

Would zylkene in your opinion help my main coons visit to the Cattery, he has been going to the same Cattery since he was young. The Cattery tells me he settles in OK but when it's time to go home he turns into a wild cat, spitting and growling and very aggressive, it takes him about a day to get back to his normal gentle personality.

  • Veterinary Surgeon

I would have thought zylkene would be very helpful for your cat in this situation. It certainly won't do him any harm so is definitely worth a try next time he goes to the cattery.

How long till it takes effect

12th Sep 2016
Olivia Curry
  • VioVet Customer Since: October 2014
  • From: North Yorkshire, United Kingdom


I have a very anxious miniature schnauzer and was prescribed these by my vet, he has been taking a daily dose for a couple of days, how long does it take until they start to show?

Thank you

  • Veterinary Surgeon

You should start to notice small changes after a few days but it could be a little longer before you really notice a difference. Zylkene is usually very helpful but if you find you do not got the complete effect you require seeking advice from an animal behaviourist alongside the zylkene is a good idea. You can also get some useful advice on

Wire fox terrier and grooming

16th Aug 2016
Dan Power
  • VioVet Customer Since: August 2016
  • From: Midlothian, United Kingdom

Dennis hates grooming and is struggling and biting at the groomers whilst getting cut. Can this product help as they are refusing to groom him in future if he isn't calmer.

  • Veterinary Surgeon

Zylkene will help to calm Dennis if he is biting due to fear and being anxious at the groomers. It is certainly worth a try although it may be that you need stronger medication which we can usually supply but will need to be prescribed by your vet. It may also be worth a look at which gives some good advice on dog behaviour issues.

Dosage for horse

25th May 2016

What dosage would you give stressy horse when ridden. Angel in the stable. Weighs 480kg

John Cousins
  • Veterinary Surgeon

For a horse under 500kg the amount is one sachet (of Zylkene Equine) per day. If you do this for a long time (over about 2 months) it will not be as effective, though it is perfectly safe. It can be done for a few days most effectively (to cover for a particular event etc).

Long term use?

9th May 2016
Abbie Sol
  • VioVet Customer Since: May 2014
  • From: Hertfordshire, United Kingdom

I've used this product successfully a few times since last year's firework night. My dog goes through phases of being anxious and unsettled at night times, especially in weird weather. How long can I use this for? I want to support him to feel calm but I want to do what's best for his body too. He's well fed (natural food, no additives), trained and exercised. We've tried a dap diffuser and sedatives (firework night) with no success. I've started using zulkene this time to help him stay settled through the night, he's started digging in his crate. It's the same place he's slept for five years. He's always shown this behaviour during thunderstorms etc but it's become a nightly occurrence. He's a 7yr old staffy, we keep to a similar weekly routine.

John Cousins
  • Veterinary Surgeon

Zylkene is a very safe product and is not going to cause any trouble even if you keep giving it all the time, but it would tend to have a diminishing affect if you were to do that. You can safely use it whenever the weather is "weird" or there are any unusual factors. You could try Aktivait or Senelife if your dog is particularly upset at night, They are safe supplements meant for older dogs but they can help in this situation. If your dog needs extra help for fireworks etc in future, then I would ask your vet about alprazolam, a human drug sold under the brand name Xanax. It is usually remarkably effective for "panic" situations in dogs, without causing and sedation (sedatives rarely work in fact).


14th Dec 2015

How many and what dosage per day to would I give a very anxious dog who weighs 6.2kg?

John Cousins
  • Veterinary Surgeon

You should give 2 of the small (75mg) capsules daily, for as long as required.


27th Oct 2015

Hi I have a 4 year old St. Bernard weighing approximately 65kg what dosage would she need. She is petrified of fireworks and I am struggling to calm her down and with the size she is it is hard work but she is destroying the place at the moment with the bangs.

Danielle Fletcher
  • Category Manager, Own Brand & E-SQP

Hi Wendy, your dog would need to have 2 x 450mg capsules per day. I'd recommend giving her the capsules daily throughout the firework season, and you may find that supporting her with something like an Adaptil or a Pet Remedy diffuser (plugged into the room she spends the most time) would give greater results. They work in different ways, and can be safely used alongside each other long term.

We have a few blog posts with advice and recommended products which I hope will be able to help you further:

Firework coping tips

Calming products for tackling firework fear

Building a den for your dog during fireworks

Do let me know if you have any further questions - best of luck, I hope she starts to cope better soon.

Dosage for Labrador

12th Oct 2015
Carolyn Wildon
  • VioVet Customer Since: September 2015
  • From: Lancashire, United Kingdom

My 11yr old Lab is terrified of fireworks & loud noises, even hearing the window cleaners ladder. I have always tried ignoring it & not responding to her, but it doesn't make any difference. She starts shaking & panting. She wears a thunder shirt which helps. How much dosage would she need of Zylkene. She weighs about 25kg.

Danielle Fletcher
  • Category Manager, Own Brand & E-SQP

Hi Carolyn, your dog would need 2 x 225mg capsules per day. I'd recommend giving Zylkène daily during the firework season but if you know when local fireworks will be, you can give it one or two days leading up to them, and on the day also. They can be given for a whole week in advance, and as she is also nervous with other loud noises, perhaps this would be most helpful to her.

There are also pheromone and plant based diffusers available such as Adaptil and Pet Remedy, which may help and help reduce anxiety in different ways, and would support Zylkene and are ideal for long term management. I hope this helps!

Long term use in my male cat...

1st Oct 2015

I have a multi-cat household and one is very anxious and sprays a lot. Can I use the bigger capsules and divide the contents so it works out more economical? As if it's successful I'd like to use it long term.

John Cousins
  • Veterinary Surgeon

Yes it is perfectly OK to do this if it works. Make sure the product remains clean and dry.

I would also recommend a Feliway diffuser if you have not tried that already. There are some herbal calming products too which some people find help, such as the Dorwest Valerian drops.