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  • 75mg Capsules » Pack of 10 £4.10
  • Special Offer 75mg Capsules » Pack of 20 £7.03
  • 75mg Capsules » Pack of 100 £40.73
  • 225mg Capsules » Pack of 10 £7.36
  • Special Offer 225mg Capsules » Pack of 20 £12.62
  • 225mg Capsules » Pack of 100 £73.82
  • 450mg Capsules » Pack of 10 £12.55
  • Special Offer 450mg Capsules » Pack of 20 £21.68
  • 450mg Capsules » Pack of 100 £125.79


Zylkène is a complementary feed for dogs, cats and horses which contains a natural product, derived from casein, a protein in milk. It is a molecule well known to promote the relaxation of newborns after breastfeeding. Launched in April 2008, Zylkène has become a familiar product for veterinary surgeons, behaviourists, nurses and pet owners for use in helping pets cope when facing unusual and unpredictable situations or before occasions such as a change in their normal environment.

Zylkène is a product that can help support dogs, cats and horses in situations where they find the need to adapt their behaviour to cope. These include kennel and cattery stays, house moves, kennel/box rest, arrival of a new pet or baby, sudden noises e.g. fireworks, travel, vet or groomer visits and Christmas festivities.

There are many ways our pets can respond to new and unpredictable situations and not all animals respond in the same way. Zylkène is palatable and easy to give; simply mix with food or give as a treat. Give just once a day.

Product Overview

There are many reports in the literature of remarkably good responses to Zylkène. In dogs and cats it is particularly good for travel, re-homing, grooming, visiting the vets etc. For horses, Zylkène Equine can easily be given in feed for clipping, travelling, shoeing etc.

Zylkène can help in many situations where animals might be expected to feel anxious or stressed. However do remember that you have a part to play too. Our animals have a phenomenal ability to pick up on signals we give them. Zylkène works best when combined with thoughtful and considerate handling from calm and sensible people!

Suitable for situations such as:

  • Changes in environment

  • Being left alone

  • New person, baby or pet being introduced

  • Travelling

  • Kennel or cattery visits

  • Fireworks

  • Loud noises and thunderstorms

  • Vet visits

  • Celebrations

  • Moving house

  • Lactation

  • Weaning

Feeding Guidelines

For oral administration.

The recommended daily amount should be given in one intake.

The capsule can be opened and the powder mixed with food or a treat.

Zylkène 75mg for cats and small dogs

Up to 5kg

1 capsule per day

Zylkène 75mg for cats and small dogs

5-10 kg

2 capsules per day

Zylkène 225mg for medium dogs


1 capsule per day

Zylkène 225mg for medium dogs


2 capsules per day

Zylkène 450mg for large dogs


1 capsule per day

Zylkène 450mg for large dogs


2 capsules per day

Short Term Use: use for 1-2 days before the predicted event or change in environment. Some animals may need earlier administration (5-7 days).

Longer Term Use: 1-2 months

Horses up to 500kg: 1 sachet daily
Horses over 500kg: 2 sachets daily

Horses are often dosed for 2 days prior to a particular event, as well as on the day itself. Longer periods can be given, up to permanent, daily medication.



Powder 77.3%: Maltodextrin, Casein (Trypsin hydrolysis bovine casein), Magnesium stearate

Capsule 22.7%: Bovine skin gelatine


Powder 76.9%: Casein (Trypsin hydrolysis bovine casein), Maltodextrin, Magnesium stearate,
Capsule 23.1% Bovine Skin gelatine


Powder 82.9%: Casein (Trypsin hydrologic bovine casein), Magnesium Stearate

Capsule 17.1%: Bovine skin gelatine

Analytical Constituents:


Crude protein 39%, Crude ash 4%, Moisture 8%, Crude fat 2.5%, Crude fibre 0%


Crude protein 75%, Crude ash 10.5%, Moisture 8%, Crude fat 2%, Crude fibre 0%


Crude protein 78%, Crude ash 12%, Moisture 8%, Crude fat 3%, Crude fibre 0%

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Questions & Answers for Zylkène

Below are some recent questions we've received regarding Zylkène, including answers from our team.

Ask Your Own Question

Wire fox terrier and grooming

16th Aug 2016
Dan Power
  • VioVet Customer Since: August 2016
  • From: Midlothian, United Kingdom

Dennis hates grooming and is struggling and biting at the groomers whilst getting cut. Can this product help as they are refusing to groom him in future if he isn't calmer.

  • Veterinary Surgeon

Zylkene will help to calm Dennis if he is biting due to fear and being anxious at the groomers. It is certainly worth a try although it may be that you need stronger medication which we can usually supply but will need to be prescribed by your vet. It may also be worth a look at which gives some good advice on dog behaviour issues.

Dosage for horse

25th May 2016

What dosage would you give stressy horse when ridden. Angel in the stable. Weighs 480kg

John Cousins
  • Veterinary Surgeon

For a horse under 500kg the amount is one sachet (of Zylkene Equine) per day. If you do this for a long time (over about 2 months) it will not be as effective, though it is perfectly safe. It can be done for a few days most effectively (to cover for a particular event etc).

Long term use?

9th May 2016
Abbie Sol
  • VioVet Customer Since: May 2014
  • From: Hertfordshire, United Kingdom

I've used this product successfully a few times since last year's firework night. My dog goes through phases of being anxious and unsettled at night times, especially in weird weather. How long can I use this for? I want to support him to feel calm but I want to do what's best for his body too. He's well fed (natural food, no additives), trained and exercised. We've tried a dap diffuser and sedatives (firework night) with no success. I've started using zulkene this time to help him stay settled through the night, he's started digging in his crate. It's the same place he's slept for five years. He's always shown this behaviour during thunderstorms etc but it's become a nightly occurrence. He's a 7yr old staffy, we keep to a similar weekly routine.

John Cousins
  • Veterinary Surgeon

Zylkene is a very safe product and is not going to cause any trouble even if you keep giving it all the time, but it would tend to have a diminishing affect if you were to do that. You can safely use it whenever the weather is "weird" or there are any unusual factors. You could try Aktivait or Senelife if your dog is particularly upset at night, They are safe supplements meant for older dogs but they can help in this situation. If your dog needs extra help for fireworks etc in future, then I would ask your vet about alprazolam, a human drug sold under the brand name Xanax. It is usually remarkably effective for "panic" situations in dogs, without causing and sedation (sedatives rarely work in fact).


14th Dec 2015

How many and what dosage per day to would I give a very anxious dog who weighs 6.2kg?

John Cousins
  • Veterinary Surgeon

You should give 2 of the small (75mg) capsules daily, for as long as required.


27th Oct 2015

Hi I have a 4 year old St. Bernard weighing approximately 65kg what dosage would she need. She is petrified of fireworks and I am struggling to calm her down and with the size she is it is hard work but she is destroying the place at the moment with the bangs.

Danielle Fletcher
  • Category Manager, Own Brand & E-SQP

Hi Wendy, your dog would need to have 2 x 450mg capsules per day. I'd recommend giving her the capsules daily throughout the firework season, and you may find that supporting her with something like an Adaptil or a Pet Remedy diffuser (plugged into the room she spends the most time) would give greater results. They work in different ways, and can be safely used alongside each other long term.

We have a few blog posts with advice and recommended products which I hope will be able to help you further:

Firework coping tips

Calming products for tackling firework fear

Building a den for your dog during fireworks

Do let me know if you have any further questions - best of luck, I hope she starts to cope better soon.

Dosage for Labrador

12th Oct 2015
Carolyn Wildon
  • VioVet Customer Since: September 2015
  • From: Lancashire, United Kingdom

My 11yr old Lab is terrified of fireworks & loud noises, even hearing the window cleaners ladder. I have always tried ignoring it & not responding to her, but it doesn't make any difference. She starts shaking & panting. She wears a thunder shirt which helps. How much dosage would she need of Zylkene. She weighs about 25kg.

Danielle Fletcher
  • Category Manager, Own Brand & E-SQP

Hi Carolyn, your dog would need 2 x 225mg capsules per day. I'd recommend giving Zylkène daily during the firework season but if you know when local fireworks will be, you can give it one or two days leading up to them, and on the day also. They can be given for a whole week in advance, and as she is also nervous with other loud noises, perhaps this would be most helpful to her.

There are also pheromone and plant based diffusers available such as Adaptil and Pet Remedy, which may help and help reduce anxiety in different ways, and would support Zylkene and are ideal for long term management. I hope this helps!

Long term use in my male cat...

1st Oct 2015

I have a multi-cat household and one is very anxious and sprays a lot. Can I use the bigger capsules and divide the contents so it works out more economical? As if it's successful I'd like to use it long term.

John Cousins
  • Veterinary Surgeon

Yes it is perfectly OK to do this if it works. Make sure the product remains clean and dry.

I would also recommend a Feliway diffuser if you have not tried that already. There are some herbal calming products too which some people find help, such as the Dorwest Valerian drops.


7th Sep 2015

My Labrador is really fearful of coughing and is getting worse with other sounds. We're moving house soon & im worried with how he's going to cope with this huge change. He weighs 25-30kg what dose would you recommend and how long can he take it for?

John Cousins
  • Veterinary Surgeon

The recommended amount to give your dog would be one of the 450mg capsules per day. They are completely safe and are best given from before any you move house, for as long as you want and they are effective. They are not massively potent, but they do usually help.

You do not say how old your dog is, but if he is a young dog, you should expect him to improve with help, rather than get worse. If this is not happening I would suggest you get some expert advice on how to handle and train your dog (whatever age he is). My observation (which is not what one would expect) is that people who dote on their dogs and really feel for them when they are upset, somehow seem to encourage that behaviour in them. Owners who are more relaxed and nonchalant in the way they interact with their dog, seem to be better at bringing out that sort of behaviour in their dog. I presume that this is down to the sub-conscious signals we all give to our dogs. A good dog behaviourist might help you to bring out the best in your dog. Perhaps go to for help.

Fear and fear agression

11th Aug 2015

My small 3 year old has a huge problem with anxiety. She was abandoned at a few weeks old and was found in a forest full of fleas and worms in the middle of winter. She is healthy now but even though she has a loving home, very seldom left alone and never for longer than 4 hours she is always anxious. Every kind of noise, some that I cannot even hear, causes her to pace, growl and bark. I have tried everything possible. Discipline only causes her more fear, I have tried the sonic anti bark device, herbal calming tablets and the hormonal sprays and plug in. They made no difference. Nights have become so stressful as I get no sleep as she seldom relaxes, climbing over me continuously, almost trying to lie underneath me to get away from what she is hearing to block it out. Walks have become stressful as she can not be left off the lead. When she sees another dog she goes crazy and wants to attack. She went to dog training school and has been socialized but you wouldn't say so by the way she behaves. I know this is fear agression as she is fine with all of my friends dogs that she knows. I am at my wits end!! I have done hours of googling trying to solve this problem. I now conclude that medication might be the only solution. I really want her to be a happy, relaxed dog as she is a very sweet and loving. Any advise?

John Cousins
  • Veterinary Surgeon

Zylkene will certainly be a slight help, but I very much doubt if it would be a complete answer to all your needs. Personally I would suggest a combination of prescription medication along with expert guidance from a canine behaviour therapist, to help your dog to learn not to be so anxious. This might well be effective, but there are a few dogs which are so badly affected in this way that they never really get over it. It would be up to your vet to prescribe the appopriate medication, though we can usually provide whatever they suggest, as long as we are sent the written prescription. A good place to find help is

Help with epilepsy

20th Jul 2015
Dogs with epilepsy

My dog suffers with Ediopathic Epilepsy we find he has his fits, spontaneously at least once a month or two, it can be brought on by the heat or a stressful day for him, which can be resulted from anxiety from separating from the family, we find it hard to leave him alone encase this brings on a fit. I was wondering if this would help him, he is on medication called epiphem 60mg three twice daily, if you agree that this treatment would help him as well would it be safe to use with his medication?

John Cousins
  • Veterinary Surgeon

Zylkene should be safe to give to your dog and is acceptable to use with Epiphen. I am not sure that it would be helpful in the way you wish, but there is a chance that it might help with being left.

There are things you can do to make the event of being left more acceptable to a dog. Ideally you should get some help from a qualified behaviourist about this. Often the worst thing to do is exactly what people naturally do. If you make a fuss of your dog and then walk out of the door ("abandoning" him after seeming to be so nice) the stark contrast in those two events can be too much to cope with. If however you allow a "wind-down" period where for 30 minutes you ignore your dog and deliberately avoid doing anything affectionate, the dog will adjust to the fact that you are going to leave soon and will accept it better. Seems strange but can make a huge difference to the period just after you have left the house. Then of course you should always calmly great your dog when you get back (whatever may have happened in the meantime).