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2.5mg » Priced Per Tablet

  • 2.5mg » Priced Per Tablet £0.40
  • 5mg » Priced Per Tablet £0.49

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For the stabilisation of hyperthyroidism in cats prior to surgical thyroidectomy and for the long-term treatment of feline hyperthyroidism

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Medication Datasheets

2.5mg » Priced Per Tablet


Thiafeline 2.5 mg Film

coated Tablets for Cats (AT, BE, CZ, DE, EL, ES, FR, HU, IE, IT, LT, LU, LV, PT, RO, SK, UK)

Thiafeline vet 2.5 mg Film

coated Tablets for cats (FI, IS, PL, SE) Thiafeline vet (DK, NO, EE) 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains: Active substance: Thiamazole 2.5 mg Excipient(s): Titanium dioxide (E171) 0.45 mg Carmoisine (E122) 0.009 mg For a full list of excipients, see section 6.1. 3. PHARMACEUTICAL FORM


coated tablet. Pink biconvex tablets 5.5 mm diameter. 4. CLINICAL PARTICULARS 4.1 Target species Cats. 4.2 Indications for use, specifying the target species For the stabilisation of hyperthyroidism in cats prior to surgical thyroidectomy.

For the long

term treatment of feline hyperthyroidism. 4.3 Contraindications Do not use in cats suffering from systemic disease such as prima ry liver disease or diabetes mellitus. Do not use in cats showing signs of autoimmune disease. Do not use in animals with disorders of white blood cells, such as neutropenia and lymphopenia. Do not use in animals with platelet disorders and coagulopathies (particularly thrombocytopenia). Do not use in pregnant or lactating females. Refer to section 4.7. Do not use in cats with hypersensitivity to thiamazole or the excipient, polyethylene glycol. Revised: April 2017 AN: 01367/2016 Page 2 of 6 4.4 Special warnings for each target species As thiamazole c an cause haemoconcentration, cats should always have access to drinking water. 4.5 Special precautions for use Special precautions for use in animals If more than 10 mg per day is required animals should be monitored particularly carefully. Use of the product in cats with renal dysfunction should be subject to careful risk : benefit assessment by the clinician. Due to the effect thiamazole can have on reducing the glomerular filtration rate, the effect of therapy on renal function should be monitored cl osely as deterioration of an underlying condition may occur. Haematology must be monitored due to risk of leucopenia or haemolytic anaemia. Any animal that suddenly appears unwell during therapy, particularly if they are febrile, should have a blood sample taken for routine haematology and biochemistry. Neutropenic animals (neutrophil counts <2.5 x 10 9 /l) should be treated with prophylactic bactericidal antibacterial drugs and supportive therapy. Special precautions to be taken by the person administering the veterinary medicinal product to animals Wash hands after use. In the case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician. Thiamazole may cause vomiting, epigastric distress, headache , fever, arthralgia, pruritus and pancytopaenia. Treatment is symptomatic. Wash hands with soap and water after handling litter used by treated animals. Do not eat, drink or smoke while handling the tablet or used litter. Do not handle this product if you are allergic to


thyroid products. If allergic symptoms develop, such as a skin rash, swelling of the face, lips or eyes or difficulty in breathing, you should seek medical attention immediately and show the package leaflet or label to the doctor. Do not break or crush tablets.

As thiamazole is a suspected human teratogen, women of child

bearing age and pregnant women should wear gloves when handling litter of treated cats. Pregnant women should wear gloves when handling this product. 4.6 Adverse reactions (frequency and seriousness) Adverse reactions have been reported following long term control of hyperthyroidism. In many cases signs may be mild and transitory and not a reason for withdrawal of treatment. The more serious effects are mainly rev ersible when medication is stopped. Adverse reactions are uncommon. The most common clinical side effects reported include vomiting, inappetance/anorexia, lethargy, severe pruritus and excoriations of the head and neck, bleeding diathesis and icterus assoc iated with hepatopathy, and haematological abnormalities (eosinophilia, lymphocytosis, neutropenia, lymphopenia, slight leucopenia, agranulocytosis, thrombocytopenia or haemolytic anaemia). These

side effects resolved within 7

45 days after cessation of th iamazole therapy. Possible immunological side effects include anaemia, with rare side effects including thrombocytopenia and serum


nuclear antibodies),and, very rarely, Revised: April 2017 AN: 01367/2016 Page 3 of 6 lymphadenopathy can occur. Treatment should be stopped immediately and alternative therapy considered following a suitable period for recovery.

Following long

term treatment with thiamazole in rodents, an increased risk of neoplasia in the thyroid gland has been shown to occur, but no evidence is available in cats. 4.7 Use during pregnancy, lactation or lay Laboratory studies in rats and mice have shown evidence of teratogenic and embryotoxic effects of thiamazole. The safety of the product was not assessed in pregnant or lactating cats. Do not use in pregnant or lactating females . 4.8 Interaction with other medicinal products and other forms of interaction Concurrent treatment with phenobarbital may reduce the clinical efficacy of thiamazole. Thiamazole is known to reduce the hepatic oxidation of benzimidazole wormers and may le ad to increases in their plasma concentrations when given concurrently. Thiamazole is immunomodulatory, therefore this should be taken into account when considering vaccination programmes. 4.9 Amounts to be administered and administration route For oral a dministration only. For the stabilisation of feline hyperthyroidism prior to surgical thyroidectomy and for the long term treatment of feline hyperthyroidism, the recommended starting dose is 5 mg per day. Wherever possible, the total daily dose should be divided into two and administered morning and evening. Tablets should not be split. If, for reasons of compliance, once daily dosing with a 5 mg tablet is preferable, then this is acceptable although the 2.5 mg tablet given twice daily may be more efficacious in the short term. The 5 mg tablet is also suitable for cats requiring higher dose rates.
Haematology, biochemistry and serum total T4 should be assessed before initiating treatment and after 3 wee ks, 6 weeks, 10 weeks, 20 weeks, and thereafter every 3 months. At each of the recommended monitoring intervals, the dose should be titrated to effect according to the total T4 and to clinical response to treatment. Dose adjustments should be made in incre ments of 2.5 mg and the aim should be to achieve the lowest possible dose rate. If more than 10 mg per day is required animals should be monitored particularly carefully. The dose administered should not exceed 20 mg/day. For long term treatment of hypert hyroidism the animal should be treated for life. 4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary

In tolerance studies in young healthy cats, the following dose

related clinical signs occurred at doses of up to 30 mg/animal/day: anorexia, vomiting, lethargy, pruritus and haematological and biochemical abnormalities such as neutropenia, lymphopenia, reduced serum potassium and phosphorus levels, increased magnesium and

creatinine levels and the occurrence of anti

nuclear antibodies . At a dose of 30 mg/day some cats showed signs of haemolytic anaemia and severe clinical deterioration. Some of these signs may also occur in hyperthyroid cats treated at doses of up to 20 mg per day. Excessive doses in hyperthyroid cats may result in sig ns of hypothyroidism. This is however unlikely, as hypothyroidism is usually corrected by negative feedback mechanisms. Please refer to Section 4.6: Adverse reactions. Revised: April 2017 AN: 01367/2016 Page 4 of 6 If overdosage occurs, stop treatment and give symptomatic and supportive care. 4.11 Wit hdrawal period(s) Not applicable. 5. PHARMACOLOGICAL PROPERTIES

Pharmacotherapeutic group:antithyroid preparations, sulphur

containing imidazole derivates. ATC Vet Code: QH03BB02. 5.1 Pharmacodynamic properties Thiamazole acts by blocking the biosynthesis of thyroid hormone in vivo . The primary action is to inhibit binding of iodide to the enzyme thyroid peroxidase, thereby preventing the catalysed iodination of thyroglobulin and T 3 and T 4 synthesis. 5.2 Pharmac okinetic particulars Absorption Following oral dosing in healthy cats, thiamazole is rapidly and completely absorbed with a bioavailability of >75 %. However, there is a considerable variation between animals.

Peak plasma levels occur approximately 0.5

1 hour after dosing (t max = 0.69 h). C max is

between 1.1 and 2.7 μg/ml (1.78 μg/ml) and half

life is 3.3 h. Distribution From man and rats it is known that the drug can cross the placenta and concentrates in the foetal thyroid gland. There is also a high rat e of transfer into breast milk. The drug residence time in the thyroid gland is assumed to be longer than in the plasma. Metabolism and elimination The metabolism of thiamazole in cats has not been investigated, however, in rats thiamazole is rapidly metab olised in the thyroid gland. About 64 % of the administered dose being eliminated in the urine and only 7.8 % excreted in faeces. This is in contrast with man where the liver is important for the metabolic degradation of the compound. 6. PHARMACEUTICAL P ARTICULARS 6.1 List of excipients Tablet core: Lactose monohydrate Povidone Sodium starch glycolate Type A Silica, colloidal anhydrous Magnesium stearate Coating: Hypromellose Cellulose, microcrystalline Revised: April 2017 AN: 01367/2016 Page 5 of 6 Lactose monohydrate Macrogol Titanium dioxide (E171) Carmoisine (E122) 6.2 Incompatibilities Not applicable. 6.3 Shelf life


life of the veterinary medicinal product as packaged for sale: 3 years. 6.4. Special precautions for storage Keep the blister in the outer package in order to protect from light. 6.5 Nature and composition of immediate packaging 30 tablets in a cardboard carton containing 1 aluminium/pvc strips each strip with 30 tablets. 60 tablets in a cardboard carton containing 2 aluminium/pvc strips each strip with 30 tablets. 120 tablets in a cardboard carton containing 4 aluminium/pvc strips each strip with 30 tablets. 150 tablets in a cardboard carton containing 5 aluminium/pvc strips each strip with 30 tablets. 300 tablets in a cardboard carton containing 10 alumini um/pvc strips each strip with 30 tablets. Not all pack sizes may be marketed. 6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements. 7. MARKETING AUTHORISATION HOLDER Le Vet Beheer B.V. The Netherlands 8. MARKETING AUTHORISATION NUMBER Vm 41821/4005 9. DATE OF FIRST AUTHORISATION Revised: April 2017 AN: 01367/2016 Page 6 of 6 22 August 2013 10 . DATE OF REVISION OF THE TEXT April 2017 DISTRIBUTED BY Animalcare Ltd 10 Great North Way York Business Park Nether Poppleton York YO26 6RB Approved 10 April 2017

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.


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