Simparica Flea & Tick Tablets

Simparica Flea & Tick Tablets
5mg » Pack of 3 Chewable Tablets

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  • 5mg » Pack of 3 Chewable Tablets £20.42
  • 10mg » Pack of 3 Chewable Tablets £20.42
  • 20mg » Pack of 3 Chewable Tablets £22.63
  • 40mg » Pack of 3 Chewable Tablets £24.08
  • 80mg » Pack of 3 Chewable Tablets £27.73
  • 120mg » Pack of 3 Chewable Tablets £40.29

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£20.42 to £40.29


This product is sourced in the United Kingdom and is intended for use in the United Kindgom only.

Simparica™ (sarolaner) Chewables are safe, monthly flea and tick protection for dogs that start working fast and remain effective all month long.

Simparica™ starts killing fleas within 3 hours and ticks within 8 hours, and it keeps going strong for 35 days without losing effectiveness at the end of the month.

Proven persistent protection against fleas and ticks.

Simparica is effective against fleas and ticks, even on day 35! You can count on Simparica to do the following:

  • Provide rapid relief for pets with existing flea infestations, even dogs with flea allergies
  • Improve clinical signs of flea allergies in dogs by eliminating fleas
  • Prevent and control home flea infestations, killing fleas before they can lay eggs
  • Quickly kill ticks, which may help reduce the risk of potentially life-threatening flea- and tick-borne diseases


Simparica chewable tablets are brown, square tablets with 5, 10, 20, 40 or 80 embossed on one side. Each tablet contains:

Simparica chewable tablets sarolaner (mg)
for dogs 1.3 - 2.5 kg 5
for dogs >2.5 - 5 kg 10
for dogs >5 - 10 kg 20
for dogs >10 - 20 kg 40
for dogs >20 - 40 kg 80
for dogs >40 - 60 kg 120


For the treatment of flea infestations (Ctenocephalides felis and Ctenocephalides canis) in dogs. Simparica has immediate and persistent flea killing activity against new infestations for at least 5 weeks. Simparica can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD). For the treatment of tick infestations (Dermacentor reticulatus, Ixodes hexagonus, Ixodes ricinus and Rhipicephalus sanguineus). Simparica has immediate and persistent tick killing activity for at least 5 weeks. For the treatment of sarcoptic mange (Sarcoptes scabiei). Fleas and ticks must attach to the host and commence feeding in order to be exposed to the active substance.

Dosage and administration

For oral use. Tablets can be administered with or without food. Simparica should be administered at a dose of 2-4 mg/kg bodyweight in accordance with the following table:

Bodyweight (kg) Tablet strength (mg sarolaner) Number of tablets to be administered
1.3 - 2.5 5 One
>2.5 - 5 10 One
>5 - 10 20 One
>10 - 20 40 One
>20 - 40 80 One
>40 - 60 120 One
>60 Appropriate combination of tablets

Use appropriate combination of available strengths to achieve the recommended dose of 2–4 mg/kg. Simparica tablets are chewable and palatable and readily consumed by dogs when offered by the owner. If the tablet is not taken up voluntarily by the dog it can also be given with food or directly into the mouth. The tablets should not be divided. Treatment schedule: For optimal control of flea and tick infestations, Simparica should be administered at monthly intervals and continued throughout the flea and/or tick season based on local epidemiological situations. For the treatment of sarcoptic mange (caused by Sarcoptes scabiei var. canis) a single dose should be administered at monthly intervals for two consecutive months.

Contra-indications, warnings, etc

Do not use in cases of hypersensitivity to the active substance or to any of the excipients. Parasites need to start feeding on the host to become exposed to sarolaner; therefore, the transmission of infectious parasite-borne diseases cannot be excluded. In the absence of available data, treatment of puppies less than 8 weeks of age and/or dogs less than 1.3 kg bodyweight should be based on a benefit-risk assessment by the responsible veterinarian. The safety of Simparica has not been established during pregnancy and lactation or in animals intended for breeding. Laboratory studies in rats and rabbits have not produced any evidence of any teratogenic effects. Use only according to the benefit/risk assessment by the responsible veterinarian. Simparica has been administered orally to 8 week old Beagle puppies at doses of 0, 1, 3, and 5 times the maximum dose of 4 mg/kg at 28 day intervals for 10 doses. No adverse effects were observed at the maximum dose of 4 mg/kg. In the overdose groups, transient and self-limiting neurological signs were observed in some animals: mild tremors at 3 times the maximum dose and convulsions at 5 times the maximum dose. All dogs recovered without treatment. Sarolaner is well tolerated in Collies with a deficient multidrug-resistance-protein 1 (MDR1 -/-) following single oral administration at 5 times the recommended dose. No treatment-related clinical signs were observed. User warnings Wash hands after handling the product. The accidental ingestion of the product may potentially result in adverse effects, such as transient excitatory neurological signs. To prevent children from accessing the product, only one chewable tablet at a time should be removed from the blister pack and only when required. The blister pack should then be returned into the carton immediately after use and the carton should be stored out of the sight and reach of children. In case of accidental ingestion, seek medical advice immediately and show the package leaflet or label to the physician.

Pharmaceutical precautions

Simparica does not require any special storage conditions. Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements. Keep out of the sight and reach of children. For animal treatment only.

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Further information

Sarolaner is an acaricide and insecticide belonging to the isoxazoline family. The primary target of action of sarolaner in insects and acarines is functional blockade of ligand-gated chloride channels (GABA-receptors and glutamate-receptors). Sarolaner blocks GABA- and glutamate-gated chloride channels in the central nervous system of insects and acarines. For fleas, the onset of efficacy is within 8 hours of attachment during the 28 day period after product administration. For ticks (I. ricinus), the onset of efficacy is within 12 hours of attachment during the 28 day period after product administration. Ticks on the animal prior to administration are killed within 24 hours. Simparica kills newly emerged fleas on the dog before they can lay eggs and therefore it prevents environmental flea contamination in areas to which the dog has access. In addition, in laboratory studies, sarolaner was shown to be active against other tick species such as Dermacentor variabilis, Ixodes scapularis, Amblyomma americanum, Amblyomma maculatum as well as the mite species Demodex canis and Otodectes cynotis. During clinical field trials, no interactions between Simparica chewable tablets for dogs and routinely used veterinary medicinal products were observed. In laboratory safety studies, no interactions were observed when sarolaner was co-administered with milbemycin oxime, moxidectin and pyrantel pamoate. (In these studies efficacy was not investigated). Sarolaner is highly bound to plasma proteins and might compete with other highly bound drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) and the cumarin derivative warfarin.

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Medication Datasheets

Reviews (8)

Summary of Reviews for Simparica Flea & Tick Tablets

Overall 5
Ease Of Use
Value For Money
Absence Of Side Effects
8 out of 8 (100%) customers would recommend this product.
5 stars (7 reviews)
4 stars (1 reviews)
3 stars (0 reviews)
2 stars (0 reviews)
1 stars (0 reviews)

Only verified purchasers of this product can leave a review.

45 Fea and Tick Control for dogs
Verified Purchase

By on 23 March 2022

Simple to administer

Customer recommends this product

55 Simparica
Verified Purchase

By on 6 March 2022

Excellent product
Speedy delivery

Customer recommends this product

55 Dragonlady
Verified Purchase

By on 16 June 2021

Fast and efficient service and a lot cheaper than getting them at the Vet's

Customer recommends this product

55 Flea control that actually works
Verified Purchase

By on 18 August 2020

Unlike other flea products that we have tried, this one actually works and has cleared up the problem. No harmful side effects have been evident

Customer recommends this product

55 Freedom from Fleas
Verified Purchase

By on 14 October 2019

Great product. Flea infestation eliminated within a few hours. Continuing to use it.

Customer recommends this product

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Q & A

Below are some recent questions we've received regarding Simparica Flea & Tick Tablets, including answers from our team.

7 May 2021 at 1:28pm


Donna Catherine Chapman

my dog weighs more than 80 kilos can i use this

  • VioVet Staff

The dose for this product as per the datasheet is 'Use appropriate combination of available strengths to achieve the recommended dose of 2–4 mg/kg.' This means you can use Simparica for an 80kg dog and you would need to give a total of 160mg, ie 1 x 120mg tablet and 1 x 40mg tablet. It is a prescription only product so you should discuss this further with your vet who can write you a written prescription for it.

13 March 2021 at 2:22am



Will this treat demodex in dogs?

  • VioVet Staff

Yes Simparica is licensed for the treatment of Demodicosis caused by Demodex mites.

4 December 2020 at 8:26am

Other medication

Dawn Chandler

  • VioVet customer since 2018
  • From: Cambridgeshire, United Kingdom

My lab is on Apoquel, would these tablets be okay to take with them or should I go for a spot on liquid?

  • VioVet Staff

Yes Simparica is perfectly safe to use alongside Apoquel. If your dog has allergies and this is the reason they are on Apoquel then I recommend using a spot on anti-parasite treatment where possible. Most tabletable parasite treatments will require the parasite to bite and ingest blood for them to die whilst spot ons can have some repellant properties, which is greatly beneficial if your dog is allergic to a certain parasite that you are unaware of.

24 September 2016 at 2:34pm

Will simparica wormer control lung worm ?

Ellen Higgins

  • VioVet customer since 2016
  • From: , United Kingdom

My vet suggested this to control demodex for my dog as he keeps having relapses even though he's been advocate so I was wondering what other medication would I need to give him to cover him for worms etc.

  • VioVet Staff

Between the Advocate and Simparica you are covering most internal and external parasites with the exception of tapeworms. If you continue to give Advocate alongside Simparica you could add in Droncit which is effective against tapeworm. Alternatively you could give Milbemax tablets (a mixed wormer) alongside the Simparica and be covered for everything also.

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