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Sedivet
Injection 10mg/ml

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  • Injection 10mg/ml £106.99

Description

Sedative to facilitate handling, examination, minor surgical interventions and manipulations. Sedivet may be used as a premedication agent with ketamine or thiopentone for short duration anaesthesia, or used with ketamine or thiopentone prior to halothane inhalation or ‘topping up’ with ketamine or thiopentone for prolonged procedures. Sedivet has also been used with synthetic opiates (eg. butorphenol) to provide profound sedation/analgesia.

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Medication Datasheets

Injection 10mg/ml

Sedivet 10 mg/ml solution for injection for horses

Presentation

Clear colourless solution for injection. Each ml contains 10 mg romifidine hydrochloride (equivalent to 8.76 mg romifidine) as active substance and 2 mg chlorocresol as preservative.

Uses

Sedative to facilitate handling, examination, minor surgical interventions and manipulations.

Sedivet may be used as a premedication agent with ketamine or thiopentone for short duration anaesthesia, or used with ketamine or thiopentone prior to halothane inhalation or ‘topping up’ with ketamine or thiopentone for prolonged procedures.

Sedivet has also been used with synthetic opiates (eg. butorphenol) to provide profound sedation/analgesia.

Dosage and administration

For intravenous use only. A dose range of 0.4 – 1.2 ml Sedivet/100 kg bodyweight (equivalent to 40 to 120 micrograms romifidine HCl/kg) gives a dose-related response.

Onset of action, which is independent of dose, is 1 – 2 minutes. Maximum sedation is achieved after 5 – 10 minutes. Please see the chart below

Contra-indications, warnings, etc

The product should not be used in horses in the last month of pregnancy.

Special precautions for use in animals

In common with other sedatives of this class, defensive movements, i.e. kicking may occur even in apparently well sedated animals. These occurrences may be reduced by the use of opiates, e.g. butorphanol.

When used as a pre-anaesthetic agent, sedation should be apparent before the induction of anaesthesia. When the product is used as part of the anaesthetic procedure, care should be taken during the recovery phase to ensure that the horse is kept in a warm and quiet environment.

As with other drugs of this class, administration may cause bradycardia, which may be profound, benign reversible cardiac arrhythmia with second degree heart block and hypotension. These effects may be prevented by the administration of 0.01 mg/kg atropine 5 minutes prior to administration of the sedative. These effects are usually well-tolerated but care should be taken in patients with cardiovascular disease. Incoordination of the limbs and sweating may also occur. Hyperglycaemia and diuresis may accompany sedation. In very rare cases hypersensitivity may occur.

The sedative effect of the product may be potentiated by other psychoactive compounds, such as tranquillisers, other sedatives or morphine-like analgesics, therefore reducing the required dose of subsequent anaesthetic agents.

The concurrent i.v. use of potentiated sulphonamides with alpha2-agonists has been reported to cause cardiac arrhythmias which may be fatal. Whilst no such effects have been reported with Sedivet it is recommended that i.v. administration of TMP/S containing products should not be undertaken when horses have been sedated with Sedivet.

Dosages up to 5 times the highest recommended dose caused transient adverse reactions, such as sweating, bradycardia, second degree atrio-ventricular heart blocks, hypotension, ataxia, hyperglycaemia and diuresis. In case of overdose, adverse reactions, as listed above, are expected to be more severe and more frequent. In such cases, symptomatic treatment should be initiated; an alpha-2 adrenergic antagonist may be useful in reducing such effects.

Withdrawal period

Meat and offal: 6 days.

When used in combination with other products, consult the product literature of those products and apply whichever is the longer. However, if any of these products is contra-indicated for human consumption, then treated animals must not be slaughtered for human consumption.

Not authorised for use in lactating animals producing milk for human consumption.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

In the case of accidental oral intake or self-injection, seek medical advice immediately and show the package leaflet to the doctor but DO NOT DRIVE as sedation and changes in blood pressure may occur.

Avoid skin, eye or mucosal contact.

Immediately after exposure, wash the exposed skin with large amounts of fresh water. Remove contaminated clothes that are in direct contact with skin.

In the case of accidental contact of the product with eyes, rinse with large amounts of fresh water. If symptoms occur, seek the advice of a doctor.

If pregnant women handle the product, special caution should be observed not to self-inject as uterine contractions and decreased foetal blood pressure may occur after accidental systemic exposure.

Advice to doctors: Romifidine is an alpha2-adrenoreceptor agonist, symptoms after absorption may involve clinical effects including dose-dependent sedation, respiratory depression, bradycardia, hypotension, a dry mouth, and hyperglycaemia. Ventricular arrhythmias have also been reported. Respiratory and haemodynamic symptoms should be treated symptomatically.

Pharmaceutical precautions

Shelf-life of the medicinal product as packaged for sale: 5 years.

Shelf-life after first opening the immediate product: 28 days.

To be supplied only on veterinary prescription.

Keep out of the reach and sight of children. For animal treatment only.

Do not store above 25°C.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with national requirements.

Legal category

Packaging quantities

20ml clear Type I PhEur glass vial with grey bromobutyl stopper.

Further information

Pharmacodynamic properties

Romifidine exerts sedative and analgesic effects. Its sedative effect is induced by stimulation of alpha-2-adrenoreceptors in the central nervous system. The substance possesses a strong specific affinity for these receptors.

Pharmacokinetic properties

Absorption: Since Sedivet is recommended to be administered intravenously, its active ingredient is completely bioavailable.

Distribution: Approximately 20% of romifidine is bound to plasma proteins. The highest drug concentrations are to be found in the liver and kidney.

Metabolism: Romifidine is found predominantly in kidney and muscle, whereas liver contains only traces of the parent compound. The major metabolites present in urine and tissues are SHT 2130, STH 2337 and ESR 1235, which have been shown to be pharmacologically inactive.

Elimination: Romifidine is rapidly eliminated: approximately 80% of the administered dose is via urine and the remainder via faeces.

Marketing Authorisation Number

Vm 08327/4302

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

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Delivery of aerosols

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Delivery of temperature controlled items

Some products, such as non-ambient items and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

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