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Relaquine Gel is a sedative given by mouth to horses. It produces mild to moderate sedation but no analgesic effect, so is not suitable on its own for painful procedures. The effects wear off after about 6 hours, but this varies considerably with the dose given and in individual horses.
All prices include VAT where applicable.
1 ml contains: Active substance:
Acepromazine 35.00 mg (as acepromazine maleate 47.50 mg)
Methyl parahydroxybenzoate (E218) 0.65 mg
Propyl parahydroxybenzoate 0.35 mg
Oral gel. Clear yellow gel for oral administration.
For sedation of horses.
Do not use in cases of post-traumatic shock or hypovolaemia.
Do not use in animals in a state of severe emotional excitation.
Do not use in animals with epilepsy.
Do not use in pregnant or lactating mares.
Do not use in animals with heart failure.
Do not use in animals with haematological disorders/coagulopathies.
Do not use in animals suffering from hypothermia.
Do not use in the case of known hypersensitivity to the active substance or any of the excipients of the product.
Do not use in neonates.
Sedation lasts for approximately six hours, although the actual time and depth of sedation are very dependent on the status of the individual animal.
Increasing the dosage above that recommended results in prolonged action and side effects but no greater sedation.
In stallions, the lowest dose range is indicated to minimise prolapse of the penis.
The product should be used with caution and with reduced dosage in the case of cardiac or hepatic disease or in debilitated, hypovolemic or anaemic animals.
Acepromazine has negligible analgesic effects. Painful activities should be avoided when handling tranquilised animals.
Tranquilised horses should be kept in a calm place and sensorial stimuli should be avoided as far as possible.
Wash hands and exposed skin thoroughly after use. Persons with sensitive skin or in continuous contact with the product are advised to wear impermeable gloves.
Avoid contact with eyes. If accidental eye contact occurs, flush gently with running water for 15 minutes and seek medical advice if any irritation persists.
In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician but, DO NOT DRIVE as sedation can occur.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment)
- common ( more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).
Since acepromazine decreases sympathetic nervous system tone, a transient drop in blood pressure may occur after administration.
Inhibition of temperature regulation.
The following reversible changes are possible in the haemogram:
- transient decrease in erythrocyte count and haemoglobin concentration;
- transient decrease in thrombocyte and leukocyte counts.
Because it increases prolactin secretion, the administration of acepromazine may lead to disturbances in fertility.
Penile prolapse may occur due to the relaxation of the retractor penis muscles. Retraction of the penis should be visible within two to three hours. If this does not take place, it is advised to contact a veterinary surgeon. Lack of retraction is of particular concern in breeding stallions.
Acepromazine has caused paraphimosis sometimes in sequel to priaprism.
In rare cases paradoxical excitation reactions can develop.
Contradictory clinical signs of aggressiveness and generalised CNS stimulation may occur.
Prolapse of the nictitating membrane has also been cited as a possible adverse effect in horses.
Acepromazine should not be used in pregnant or lactating mares.
Acepromazine has the potential to induce hypotension in newborns when administered as a premedication for caesarean section in the mare.
Please see also Adverse reactions section relating to disturbances in fertility.
Acepromazine potentiates the action of centrally depressant drugs.
Simultaneous administration, or administration to horses recently treated with organophosphates should be avoided since these molecules enhance the toxic effects of acepromazine.
Since acepromazine decreases sympathetic nervous system tone, simultaneous treatment with blood pressure lowering products should not take place.
Antacids may cause a decrease in the gastrointestinal absorption of acepromazine after oral administration.
Opiates may enhance the hypotensive effects of acepromazine.
For oral administration. Place the syringe in the animal's mouth and expel the required dose into the cheek pouch. The gel may also be mixed with food.
Amount(s) to be administered: Moderate sedation: 0.15 mg acepromazine per kg body weight.
The above dosage information is provided as a guideline. The dose may be varied to administer between 0.5 and 1.5 times the above recommendation depending on the level of sedation required, i.e. for mild sedation, administer half the recommended dose and for deeper sedation, administer 1½ times the recommended dose.
Because of the difficulty in ensuring the accurate delivery of small doses, the product should only be used in horses of less than 200 kg body weight in accordance with a benefit/risk assessment by the responsible veterinarian.
Overdosage results in an earlier onset of the sedative symptoms and in a prolonged effect.
Toxic effects are ataxia, hypotension, hypothermia and central nervous system (extrapyramidal) effects.
Noradrenaline, but not adrenaline, can be used to counteract the cardiovascular effects.
Not authorised for use in horses intended for human consumption.
Pharmacotherapeutic group: Nervous system.
ATCvet code: QN05AA04
Acepromazine is a phenothiazine derivative. This group of molecules belongs to the neuroleptics: they depress the central nervous system and exert associated effects on the autonomic system. These effects are due to their interference with different neurotransmitter receptors (dopaminergic, adrenergic) and to their interference with hypothalamic performance. The sedative activity starts within 15 to 30 minutes of treatment and lasts for 6-7 hours.
The desired effects observed after treatment with acepromazine include a general tranquilising effect, anti-emetic effect and a slight anti-histaminic effect. There is no analgesic action. The neuroleptic effects are variable between individual animals.
Acepromazine is partly absorbed from the gastrointestinal tract. Plasma protein binding is high and it is extensively distributed throughout the body tissues. Plasma levels are usually low. Acepromazine is highly metabolised, with the urine as the main route of excretion.
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Shelf life after first opening the immediate packaging: 28 days.
Do not store above 25°C. Protect from frost. Protect from light. After use, replace cap on syringe. Keep the broached syringe in the original carton and store in a dry place.
Container: White, high-density polyethylene syringe barrel. White, low-density polyethylene syringe plunger.
Closure: White, high-density polyethylene, push-fit cap.
Fill volume: 10 ml.
Dosing device: The product is presented in an oral dosing syringe which is graduated at 1 ml intervals.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Floris Veterinaire Produkten BV, Kempenlandstraat 33, 5262 GK Vught, The Netherlands.
10 March 2011
For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children.
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