Profender Spot-on Solution for Cats

Profender Spot-on Solution for Cats
Large Cats 5-8kg » 2 Pipettes

  • Large Cats 5-8kg » 2 Pipettes £13.49
  • Medium Cats 2.5-5kg » 2 Pipettes £13.49
  • Small Cats 0.5-2.5kg » 2 Pipettes £10.00

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£10.00 to £13.49


Profender is used to treat cats against roundworms and tapeworms. It is provided as a convenient spot-on type of medication to enable easier dosing of cats. Profender is suitable for use on cats over 0.5kg in weight and more than 8 weeks old. A single application is sufficient for one treatment. Repeat treatment needs to be as often as required for the individual cat in question, though once every 3 months is usually appropriate. Profender is safe to use in cats during pregnancy or lactation.


Profender spot-on solution for cats is a clear yellow to brown solution containing 21.4 mg/ml emodepside and 85.8 mg/ml praziquantel, with 5.4 mg/ml butylhydroxyanisole (E320) as antioxidant. The product is presented in a single use plastic tube for dermal (spot-on) application.

Profender spot-on solution for small cats is a 0.35 ml tube containing 7.5 mg emodepside and 30 mg praziquantel.

Profender spot-on solution for medium cats is a 0.70 ml tube containing 15 mg emodepside and 60 mg praziquantel.

Profender spot-on solution for large cats is a 1.12 ml tube containing 24 mg emodepside and 96 mg praziquantel.


For cats suffering from, or at risk from, mixed parasitic infections caused by roundworms and tapeworms of the following species:

Roundworms (Nematodes)

Toxocara cati (mature adult, immature adult, L4 and L3)

Toxascaris leonina (mature adult, immature adult and L4)

Ancylostoma tubaeforme (mature adult, immature adult and L4)

Tapeworms (Cestodes)

Dipylidium caninum (adult)

Taenia taeniaeformis (adult)

Echinococcus multilocularis (adult)

Dosage and administration

Dosage and Treatment Schedule

See Table 1.

The recommended minimum doses are 3 mg emodepside/kg body weight and 12 mg praziquantel/kg body weight, equivalent to 0.14 ml Profender/kg body weight. A single administration per treatment is effective.

Table 1:

Body weight of cat (kg)

Pipette size to be used

Volume (ml)

Emodepside (mg/kg bw)

Praziquantel (mg/kg bw)

≥0.5 - 2.5

Profender for Small Cats


3 - 15

12 - 60

>2.5 - 5

Profender for Medium Cats


3 - 6

12 - 24

>5 - 8

Profender for Large Cats


3 - 4.8

12 - 19.2


Use an appropriate combination of pipettes

Method of administration

For external use only.

Remove one pipette from package. Hold pipette in upright position, twist and pull off cap and use the opposite end of the cap to break the seal. See Figure 1.

Profender 1

Figure 1: Opening a pipette

Part the fur on the cat’s neck at the base of the skull until the skin is visible. Place the tip of the pipette on the skin and squeeze firmly several times to empty the contents directly onto the skin. Application on the base of the skull will minimise the ability of the cat to lick the product off. See Figure 2.

Profender 2Profender 3

Figure 2: Administration

Use During Pregnancy and Lactation

Profender can be used during pregnancy and lactation.

Contra-indications, warnings, etc

Do not use in kittens under 8 weeks of age or weighing less than 0.5 kg.

Apply only to the skin surface and on intact skin.

Do not administer orally or parenterally.

Avoid the treated cat or other cats in the household licking the site of application while it is wet.

Salivation, vomiting and neurological signs (tremor) were observed occasionally when the product was administered at up to 10 times the recommended dose in adult cats and up to 5 times the recommended dose in kittens. These symptoms were thought to occur as a result of the cat licking the application site. The symptoms were completely reversible. There is no known specific antidote.

In very rare cases following administration of Profender transient alopecia, pruritus and/or inflammation were observed at the application site.

Emodepside is a substrate for P-glycoprotein. Co-treatment with other drugs that are P-glycoprotein substrates/inhibitors (for example, ivermectin and other antiparasitic macrocyclic lactones, erythromycin, prednisolone and cyclosporine) could give rise to pharmacokinetic drug interactions. The potential clinical consequences of such interactions have not been investigated.

Shampooing or immersion of the animal in water directly after treatment may reduce the efficacy of the product. Treated animals therefore should not be bathed until the solution has dried.

There is limited experience on the use of the product in sick and debilitated animals, thus the product should only be used based on a benefit-risk assessment for these animals.

Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class.

The solvent in this product may stain certain materials including leather, fabrics, plastics and finished surfaces. Allow the application site to dry before permitting contact with such materials.

User Safety

Read the package insert before use.

Do not smoke, eat or drink during application.

Avoid direct contact with application area while it is wet. Keep children away from treated animals during that time.

Wash hands after use.

In case of accidental spillage onto skin, wash off immediately with soap and water.

If the product accidentally gets into eyes, they should be thoroughly flushed with plenty of water.

If skin or eye symptoms persist, or in case of accidental ingestion, seek medical advice and show the package insert or the label to the physician.

Care should be taken not to allow children to have prolonged intensive contact (for example, by sleeping) with treated cats during the first 24 hours after application of the product.

Frequent users of the product (for example, veterinarians, professional cat breeders) should wear disposable gloves when administering the product.

Although the product was well tolerated by pregnant cats, studies performed in rats and rabbits suggest that emodepside may interfere with embryo-foetal development. Therefore, women of child-bearing potential should avoid contact with, or wear disposable gloves when administering, the product.

Environmental Safety

Profender should not be allowed to enter surface water as emodepside has shown harmful effects on aquatic organisms.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Pharmaceutical precautions

Store in the original package in order to protect from moisture.

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.

Legal category


Packaging Quantities

White polypropylene pipettes with caps in aluminium blisters. Blister packs containing 2 or 40 unit dose pipettes.

Further information

Pharmacotherapeutic group: therapeutic antiparasitic agent; ATCvet code: QP52AA51.

Emodepside is a semi-synthetic compound belonging to the new chemical group of depsipeptides. It is active against roundworms (ascarids and hookworms). In this product, emodepside is responsible for the efficacy against Toxocara cati, Toxascaris leonina, and Ancylostoma tubaeforme.

It acts at the neuromuscular junction by stimulating presynaptic receptors belonging to the secretin receptor family which results in paralysis and death of the parasites.

Praziquantel is a pyrazinoisoquinoline derivative effective against tapeworms such as Dipylidium caninum, Echinococcus multilocularis, and Taenia taeniaeformis.

Praziquantel is rapidly absorbed via the surface of the parasites and acts primarily by changing the Ca++ permeability of the parasite membranes. This results in severe damage to the parasite integument, contraction and paralysis, disruption of metabolism and finally leads to the death of the parasite.

After topical application of this product to cats at the minimum therapeutic dose of 0.14 ml/kg bodyweight, mean maximum serum concentrations of 32.2 ± 23.9 µg emodepside/l and 61.3 ± 44.1 µg praziquantel/l were observed. Maximum concentrations were reached for emodepside 3.2 ± 2.7 days after application and 18.7 ± 47 hours for praziquantel. Both active substances are then slowly eliminated from the serum with a half-life of 9.2 ± 3.9 days for emodepside and 4.1 ± 1.5 days for praziquantel.

After oral application in the rat, emodepside is distributed to all organs. Highest concentration levels are found in the fat. Faecal excretion predominates with unchanged emodepside and hydroxylated derivatives as the major excretion products.

Studies in many different species show that praziquantel is rapidly metabolised in the liver. The main metabolites are monohydroxycyclohexyl derivatives of praziquantel. Renal elimination predominates.

Echinococcosis represents a hazard for humans. As Echinococcosis is a notifiable disease to the OIE, specific guidelines on the treatment and follow-up, and on the safeguard of persons, need to be obtained from the relevant competent authority.

Marketing Authorisation Holder (if different from distributor)

Marketing Authorisation Holder

Bayer Animal Health GmbH, D-51368 Leverkusen, Germany

Distributed by

UK: Bayer plc, Animal Health Division, Bayer House, Strawberry Hill, Newbury, Berkshire, RG14 1JA

Ireland: Bayer Ltd, Animal Health Division, The Atrium, Blackthorn Road, Sandyford Ind Est, Dublin 18

Marketing authorisation number


GTIN (Global Trade Item No)

Profender Spot-on Solution for Small Cats (2 Pack)


Profender Spot-on Solution for Small Cats (40 Pack)


Profender Spot-on Solution for Medium Cats (2 Pack)


Profender Spot-on Solution for Medium Cats (40 Pack)


Profender Spot-on Solution for Large Cats (2 Pack)


Profender Spot-on Solution for Large Cats (40 Pack)


Need help or advice? Contact us:

  • Landline: 01582 842096
  • Mon - Fri: 8:30am - 5:00pm
  • Sat: 9:00am - 1:00pm
  • Email: [email protected]

All prices include VAT where applicable.

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to air freight restrictions aerosols cannot ever be sent abroad by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (2)

Q & A

Below are some recent questions we've received regarding Profender Spot-on Solution for Cats, including answers from our team.

10 June 2015 7:03pm

Can i use for dogs


Can I use this one foe my dog:chihuahua 2 years old?

  • Non-Executive Director

Unfortunately this product is only made for cats. We cannot recommend it is used on a dog as it might well be ineffective and possibly unsafe. I have to say it would be better to use a worming tablet or perhaps one of the spot-on formulations which are intended for dogs (they are prescription only though).

1 December 2014 4:54pm

How many


how many types of worms does the profender for large cats kill

  • Non-Executive Director

The data sheet mentions 6 types of worm, 3 species of roundworm and 3 species of tapeworm. It might well so more than this, but has only been tested against the named species.

It says:-

For cats suffering from, or at risk from, mixed parasitic infections caused by roundworms and tapeworms of the following species:

Roundworms (Nematodes)

Toxocara cati (mature adult, immature adult, L4 and L3)

Toxascaris leonina (mature adult, immature adult and L4)

Ancylostoma tubaeforme (mature adult, immature adult and L4)

Tapeworms (Cestodes)

Dipylidium caninum (adult)

Taenia taeniaeformis (adult)

Echinococcus multilocularis (adult)