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Prazitel Plus Tablets for Dogs are an effective multi-wormer containing three different ingredients to cover all the intestinal worms likely to be found. A single dose is effective and should be given at a dose rate of up to 1 tablet per 10kg bodyweight for Prazitel Plus and 1 tablet per 35kg bodyweight for Prazitel Plus XL.
Prazitel Tablets for Cats are for the treatment of cats with mixed infections of nematodes and cestodes, including Ascarids, Hookworms, Whipworms and Tapeworms. Each tablet is flavoured for palatability and contains 20mg Praziquantel and 230g Pyrantel embonate. Use 1 tablet per 4kg of bodyweight.
Tablet size reference:
Cat tablets are circular, approximately 1cm in diameter and are scored down the middle to be easily divided into halves.
Dog Plus tablets are ciruclar, approximately 1.3cm in diameter and are scored twice, so can be broken into quarters.
Dog Plus XL tablets are oval, apprimately 2.5cm in length, 1.4cm at the widest point, and can be broken into halves.
Tablets can be given directly or mixed into food.
If necessary, break the tablets into halves or quarters to make administration by mouth or disguised in food easier.
Summary of Product Characteristics
1. NAME OF THE VETERINARY MEDICINAL PRODUCT
Prazitel 230/20 mg Flavoured Film-Coated Tablets for Cats
Milaxyn 230/20 mg Flavoured Film Coated Tablets for Cats (Germany)
Prazinon 230/20 mg Flavoured Film Coated Tablets for Cats (Croatia)
Prazitel 230/20 mg Film-Coated Tablets for Cats (Finland)
2. QUALITATIVE AND QUANTITATIVE COMPOSITION
Each film-coated tablet contains Pyrantel embonate 230 mg and Praziquantel 20 mg.
For the full list of excipients, see section 6.1.
3. PHARMACEUTICAL FORM
Film-coated tablets.
A white to off white round, biconvex coated tablet with a breakline on one side and plain on the other side.
The tablet can be divided into equal halves.
4. CLINICAL PARTICULARS
4.1 Target species
Cats.
4.2 Indications for use, specifying the target species
For the treatment of mixed infections caused by the following gastrointestinal roundworms and tapeworms:
Roundworms: Toxocara cati, Toxascaris leonina,
Tapeworms: Dipylidium caninum, Taenia taeniaeformis, Echinococcus multilocularis.
4.3 Contraindications
Do not use simultaneously with piperazine compounds.
Do not use in kittens less than 6 weeks of age.
Do not use in animals with known hypersensitivity to the active substances or to any of the excipients.
4.4 Special warnings for each target species
Fleas serve as intermediate hosts for one common type of tapeworm – Dipylidium caninum. Tapeworm infestation is certain to reoccur unless control of intermediate hosts such as fleas, mice, etc. is undertaken.
Parasitic resistance to a certain class of anthelmintics can occur after frequent and repeated use of an anthelmintic from this class.
4.5 Special precautions for use
Special precautions for use in animals
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
In the interests of good hygiene, persons administering the tablets directly to the cat, or by adding them to the cat’s food, should wash their hands afterwards.
In case of accidental ingestion, seek medical advice and show the package leaflet to the physician.
4.6 Adverse reactions (frequency and seriousness)
None known.
4.7 Use during pregnancy, lactation or lay
Do not use during pregnancy but may be used during lactation.
4.8 Interaction with other medicinal products and other forms of interaction
Do not use simultaneously with piperazine compounds.
4.9 Amounts to be administered and administration route
To ensure administration of a correct dose, body weight should be determined as accurately as possible.
Dosage
The recommended dose is: 20 mg/kg pyrantel (57.5 mg/kg pyrantel embonate) and 5 mg/kg praziquantel. This is equivalent to 1 tablet per 4 kg bodyweight.
| Body weight | tablets |
| 1.0 - 2.0 kg | ½ |
| 2.1 - 4.0 kg | 1 |
| 4.1 - 6.0 kg | 1 ½ |
| 6.1 - 8.0 kg | 2 |
Administration and duration of treatment
Single oral administration. The tablet should be given directly to the cat, but if necessary can be disguised in food.
In ascarid infestation, especially in kittens, complete elimination cannot be expected, so a risk of infection for humans can persist. Repeat treatments should, therefore, be carried out with a suitable roundworm product at 14 day intervals until 2-3 weeks after weaning.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
After doses higher than 5 times the recommended dose, signs of intolerance such as vomiting have been observed.
4.11 Withdrawal period(s)
Not applicable.
5. PHARMACOLOGICAL PROPERTIES
Pharmacotherapeutic group: Anthelmintics, praziquantel combinations.
ATC vet code: QP52AA51
5.1 Pharmacodynamic properties
This product contains anthelmintics active against gastrointestinal roundworms and tapeworms. The product contains two active substances, as follows:
and
Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis and thereby allow expulsion from the gastro-intestinal (GI) system by peristalsis.
Praziquantel is very rapidly absorbed and distributed throughout the parasite. Both in vitro and in vivo studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolization of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.
In this fixed combination, pyrantel is active against the following ascarids: Toxocara cati, and Toxascaris leonina. Praziquantel is effective against tapeworms in particular Dipylidium caninum and Taenia taeniaeformis.
Since it contains praziquantel, the product is effective against Echinococcus multilocularis,.
5.2 Pharmacokinetic particulars
Praziquantel is rapidly absorbed, metabolised and distributed in the body. It is also believed to be excreted back into the intestinal lumen by the mucous membrane.
Following administration of the product to cats, peak plasma concentrations of praziquantel were achieved by approximately 2 hours.
Pyrantel is poorly absorbed so it is expected that a large proportion of the administered dose remains in the GIT where it exerts its therapeutic effect and it is excreted largely unchanged in the faeces.
Following administration of the product to cats, peak plasma concentrations of pyrantel were achieved by approximately 3 hours.
6. PHARMACEUTICAL PARTICULARS
6.1 List of excipients
Core tablet:
Maize starch,
Microcrystalline cellulose,
Crospovidone
Magnesium stearate,
Colloidal anhydrous silica,
Film coat
Grilled meat flavour
Opadry II White consisting of Polyvinyl Alcohol, Titanium Dioxide (E171), Macrogol 3350 and Talc (E553b)
6.2 Incompatibilities
Not Applicable
6.3 Shelf life
Shelf life of the veterinary medicinal product as packaged for sale: 4 years
Discard unused half tablets.
6.4. Special precautions for storage
This veterinary medicinal product does not require any special storage conditions
The product is presented in either:
Individual blisters made up of a PVC/PE/PCTFE white opaque copolymer and a 20µm heatseal
lacquer/aluminium containing 2, 4, 6, 8, 10, 12, 14, 16, 18 or 20 tablets.
or
Individual blisters made up of 45µm PVC/aluminium/orientated polyamide and a 20µm heatseal lacquer/aluminium containing 2 or 8 tablets.
The blisters are packed into cartons containing either: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 24, 28,
30, 32, 36, 40, 42, 44, 48, 50, 52, 56, 60, 64, 68, 70, 72, 76, 80, 84, 88, 92, 96, 98, 100, 104,
106, 108, 112, 116, 120, 128, 136, 140, 144, 150, 152, 160, 168, 176, 180, 184, 192, 200, 204,
206, 208, 216, 224, 232, 240, 248, 250, 280, 300, 500 or 1000 tablets
Not all pack sizes may be marketed.
6.6 Special precautions for the disposal of unused veterinary medicinal products or waste materials
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
7. MARKETING AUTHORISATION HOLDER
Chanelle Pharmaceuticals Manufacturing Ltd.,
Loughrea,
Co. Galway,
Ireland
8. MARKETING AUTHORISATION NUMBER(S)
VPA10987/101/001
All prices include VAT where applicable.
Prazitel Plus tablets are pale yellow pork-flavoured tablets with a cross breakline on one side. Each tablet contains 50mg Praziquantel, 50 mg Pyrantel (equivalent to 144 mg Pyrantel Embonate) and 150mg Febantel. The tablets can be divided into equal halves or quarters.
For the treatment of dogs with mixed infections of nematodes and cestodes of the following species
Nematodes:
Ascarids: Toxocara canis, Toxascaris leonina (adult and late immature forms).
Hookworms: Uncinaria stenocephala, Ancylostoma caninum (adults).
Whipworms: Trichuris vulpis (adults).
Cestodes:
Tapeworms: Echinococcus species, (E. granulosus, E. multilocularis), Taenia species,
(T. hydatigena, T. pisiformis, T. taeniformis)
Single dose for oral administration.
The recommended dose rates are: 15 mg/kg bodyweight febantel, 5 mg/kg pyrantel (equivalent to 14.4 mg/kg pyrantel embonate) and 5 mg/kg praziquantel. 1 Prazitel Plus tablet per 10 kg (22 lbs) bodyweight. The tablets can be given directly to the dog or disguised in food. No starvation is needed before, or after, treatment.
The tablet can be divided in two or four equal doses.
Bodyweight (kg)
Tablets
½ - 2.5
1/4
2.6-5.0
½
5.1-10.0
1
10.1-15.0
1½
15.1-20.0
2
20.1-25.0
2½
25.1-30.0
3
30.1-35.0
3½
35.1-40.0
4
>40.1
1 tablet per 10 kg
The advice of a veterinarian should be sought regarding the need for and the frequency of repeated treatment.
To ensure administration of a correct dose, body weight should be determined as accurately as possible
Fleas serve as intermediate hosts for one common type of tapeworm – Dipylidium caninum. Tapeworm infestation is certain to reoccur unless control of intermediate hosts such as fleas, mice, etc. is undertaken.
Tapeworm infestation is unlikely in pups less than 6 weeks of age.
Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class.
None.
In case of accidental ingestion, seek medical advice and show the package leaflet to the physician.
In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog’s food, should wash their hands afterwards.
Echinococcosis represents a hazard for humans. As echinococcosis is a notifiable disease to the World Organisation for Animal Health (OIE), specific guidelines on the treatment and follow-up, and on the safeguard of persons, need to be obtained from the relevant competent authority.
Adverse reactions (frequency and seriousness)
In very rare cases, gastrointestinal disorders (diarrhoea, emesis) have been observed.
Teratogenic effects attributed to high doses of febantel have been reported in sheep and rats. No studies have been performed in dogs during early pregnancy. Use of the product during pregnancy should be in accordance with a benefit risk assessment by the responsible veterinarian. It is recommended that the product is not used in dogs during the first 4 weeks of pregnancy. Do not exceed the stated dose when treating pregnant bitches.
Do not use simultaneously with piperazine compounds as the anthelmintic effects of pyrantel and piperazine may be antagonized.
Concurrent use with other cholinergic compounds can lead to toxicity.
Overdose (symptoms, emergency procedures, antidotes), if necessary
The combination of praziquantel, pyrantel embonate and febantel is well tolerated in dogs. In safety studies, a single dose of 5 times the recommended dose or greater gave rise to occasional vomiting.
Not applicable.
Do not use this veterinary medicinal product after the expiry date which is stated on the label after EXP. The expiry date refers to the last day of that month.
This veterinary medicinal product does not require any special storage conditions. Discard any unused divided tablets immediately.
Keep out of the sight and reach of children.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements. Medicines should not be disposed of via wastewater or household waste. Ask your veterinary surgeon how to dispose of medicines no longer required. These measures should help to protect the environment.
2, 24 and 104 tablets.
Vm 08749/4024
1 pork flavoured tablet contains 175 mg Praziquantel, 504 mg Pyrantel Embonate (equivalent to 175 mg pyrantel) and 525 mg Febantel.
The tablets can be divided into equal halves.
In adult dogs: Treatment of mixed infections by nematodes and cestodes of the following species
Nematodes: Ascarids: Toxocara canis, Toxascaris leonina (adult and late immature forms). Hookworms: Uncinaria stenocephala, Ancylostoma caninum (adults). Whipworms: Trichuris vulpis (adults)
Cestodes: Tapeworms: Echinococcus species, (E. granulosus, E. multilocularis), Taenia species, (T. hydatigena, T. pisiformis, T. taeniformis) Dipylidium caninum (adult and immature forms).
For oral administration.
The recommended dose rates are: 15mg/kg bodyweight febantel, 5 mg/kg pyrantel (equivalent to 14.4 mg/kg pyrantel embonate) and 5 mg/kg praziquantel. This is equivalent to 1 Prazitel Plus XL tablet per 35 kg bodyweight.
Dogs of > 35 kg bodyweight should be given 1 Prazitel Plus XL tablet plus the appropriate quantity of Prazitel Plus tablets equivalent to 1 tablet per 10 kg bodyweight.
Dogs weighing approx 17.5kg bodyweight should be given ½ Prazitel Plus XL tablet.
The tablets can be given directly to the dog or disguised in food. No starvation is needed before or after treatment.
If there is a risk for re-infestation, the advice of a veterinarian should be sought regarding the need for and the frequency of repeat administration.
To ensure administration of a correct dose, body weight should be determined as accurately as possible.
Do not use simultaneously with piperazine compounds .
Do not use in animals with a known sensitivity to the active ingredients or to any of the excipients.
Fleas serve as intermediate hosts for one common type of tapeworm – Dipylidium caninum. Tapeworm infestation is certain to reoccur unless control of intermediate hosts such as fleas, mice, etc. is undertaken.
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
∙ Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
∙ Underdosing, which may be due to underestimation of body weight, misadministration of the product.”
To ensure administration of a correct dose, body weight should be determined as accurately as possible.
In case of accidental ingestion, seek medical advice and show the package leaflet to the physician.
In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog’s food, should wash their hands afterwards.
In very rare cases, gastrointestinal disorders (diarrhoea, emesis) have been observed.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals )
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).
Teratogenic effects attributed to high doses of febantel have been reported in sheep and rats. No studies have been performed in dogs during early pregnancy. Use of the product during pregnancy should be in accordance with a benefit risk assessment by the responsible veterinarian. It is recommended that the product is not used in dogs during the first 4 weeks of pregnancy. Do not exceed the stated dose when treating pregnant bitches.
Interaction with other medicinal products and other forms of interaction
Do not use simultaneously with piperazine compounds as the anthelmintic effects of pyrantel and piperazine may be antagonized.
Concurrent use with other cholinergic compounds can lead to toxicity.
Overdose (symptoms, emergency procedures, antidotes), if necessary
The combination of praziquantel, pyrantel embonate and febantel is well tolerated in dogs. In safety studies, a single dose of 5 times the recommended dose or greater gave rise to occasional vomiting.
Not applicable.
Keep out of the reach and sight of children
This veterinary medicinal product does not require any special storage conditions Do not use after expiry date stated on the label.
Each time an unused half tablet is stored, it should be returned to the open blister space and inserted back into the outer carton.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Shelf life of the veterinary medicinal product as packaged for sale: 3 years
Shelf-life of half tablets: 14 days
10 and 50 tablets.
Vm 08749/4035
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For UK delivery, we charge the following:
| Order Total | Weight | Delivery |
| £0-£28.99 | Under 2kg | £2.99 |
| 2kg+ | £4.99 | |
| £29-£38.99 | Under 2kg | Free |
| 2kg+ | £4.99 | |
| £39+ | Under 2kg | Free |
| 2kg+ | Free |
Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.
For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.
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Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.
Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.
Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.
To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.
*For full details on returns, see our terms and conditions page.
Below are some recent questions we've received regarding Prazitel Worming Tablets for Dogs & Cats, including answers from our team.
Becky
Can this product be given to puppies?
This wormer can be used on puppies from 2 weeks of age.
Susie
My mother cat has worms but only gave birth two weeks ago. Is it safe to give her a wormer?
Yes, this is perfectly safe. The kittens are likely to have worms also, as some types of roundworm can get into the mammary glands, and pass to the kittens in their mother's milk. While they are not weaned and she is cleaning them up when they go to the toilet, the kittens will be a source of infection for her also.
I'd recommend worming her with Prazitel every 4 weeks until they are fully weaned. The kittens can't have Prazitel until they at least 6 weeks old and weighing at least 1kg. While they're small, I recommend using something like Panacur Paste or Panacur Suspension with them at 2, 5, 8 and 12 weeeks of age (or just before they leave your home).
I hope this helps!
Is this for both worms
Are these for both type of worms
Yes, Prazitel treats all common types of roundworms (nematodes) and tapeworms (cestodes) found in dogs and cats, including Ascarids, Hookworms, and Whipworms. It unfortunately cannot treat heartworm though, you would need to ask your vet to prescribe a product for this if your dog is in a high risk area.
Pamelite
Prazitel Worming Tablets for Dogs & Cats
i did not receive a leaflet for use with the packet. i do not know how frequently to administer this tablet. is it once every four months ... or?
The usual frequency of administration for a wormer such as this would be once every 3 months. However it depends a bit on each dog. If your dog is a particular scavenger then you could worm up to once a month but usually every 3 months is enough.
Clare Ratcliffe
Is this wormer ok to use on kittens?
This wormer is fine to use in kittens over 6 weeks of age.
Nat c
A couple of my dogs weigh 12kg. Do they need two whole tablets or one and a half? Can I give half a tablet? Cheers
The correct dose is one and a half tablets to each dog.
Lucky13
Does the treat lungworm and roundworm as well? Do you need a prescription for this?
You do not need a prescription for this wormer. It treats tapeworms and all the main round worms, but is not claimed to have any activity against lungworm. The only product which is known to be helpful against the main type of lungworm in dogs is prescription-only (Advocate).
Sandra Crook
I wormed my dog 10 days ago and have just found out she is pregnant. Will this drug harm the pups?
Giving a worm dose in early pregnancy is not recommended because on principle this should be avoided with any medication. Usually there is no particular reason to worm a bitch in early pregnancy anyway, so the advice would be not to do it. That does not mean however that it is actually likely to be harmful. The chances of you noticing any adverse response are very slim. Many dogs are given worm doses while pregnant and it does not seem to cause a problem. I would not have advised that you did this if you had known she was pregnant, but now that it is done you should not worry. I very much doubt if it will cause any trouble at all.
Charlotte
Can I give prazitel to a pregnant Cat?
Prazitel is not recommended for use during pregnancy. It is safe however to give after giving birth and while lactating. Kittens should not be dosed directly until they are 6 weeks old.
Carol
how often do I need to give this wormer as they all seem to differ
For most dogs a multi-wormer like this is recommended to be given once every three months. Strictly speaking this varies with the type of dog, its health status overall and the environment it lives in. Since it is difficult to assess these factors individually, people tend to give blanket recommendations and once every 3 months is the most usual advice if there is nothing unusual about your dog.
