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Pardale-V is an analgesic for use in dogs. It is suitable for use after injuries or in other painful conditions. It is traditionally used to help joint pain. (NFA-VPS)
Below is the product datasheet.
Company name: Dechra Veterinary Products Limited
Address: (A business unit of Dechra Pharmaceuticals PLC)
Sansaw Business Park
Shropshire SY4 4AS
Telephone: 01939 211200
Fax: 01939 211201
Email: [email protected]
SUMMARY OF PRODUCT CHARACTERISTICS
1. NAME OF THE VETERINARY MEDICINAL PRODUCT
Pardale-V Oral Tablets
2. QUALITATIVE AND QUANTITATIVE COMPOSITION
Each tablet contains:
Paracetamol 400.0 mg
Codeine phosphate hemihydrate 9.0 mg
For the full list of excipients, see section 6.1.
3. PHARMACEUTICAL FORM
White, flat tablets with a bevelled edge and a break-line.
4. CLINICAL PARTICULARS
4.1 Target species
4.2 Indications for use, specifying the target species
For analgesic therapy in dogs only. The product is indicated for acute pain of traumatic origin, as a complementary treatment in pain associated with other conditions, and post operative analgesia.
Do not exceed stated dose or duration of treatment.
Use is contraindicated in animals suffering from cardiac, hepatic or renal disease, where there is a possibility of gastrointestinal ulceration or bleeding, or where there is evidence of a blood dyscrasia or hypersensitivity to the product.
Do not use this product for cats.
Do not use in cases of hypersensitivity to the active substances or any of the excipients.
Special warnings for each target species
Seek veterinary advice if the treated condition does not improve or worsens during treatment, or if any side-effects or adverse reactions are experienced.
Special precautions for use
Special precautions for use in animals
Use in animals less than 6 weeks of age or in aged animals may involve additional risk. If such use cannot be avoided, animals may require a reduced dosage and careful clinical management.
Avoid use in dehydrated, hypovolaemic or hypotensive animals, as there is a potential risk of increased renal toxicity.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Wash hands after use.
4.6 Adverse reactions (frequency and seriousness)
Occasional constipation may occur due to codeine content.
During the post-marketing surveillance, transient gastrointestinal signs such as vomiting and diarrhoea and systemic signs such as lethargy and anorexia have been observed very rarely.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
4.7 Use during pregnancy, lactation or lay
There are no known contraindications for use during pregnancy.
4.8 Interaction with other medicinal products and other forms of interaction
Concurrent administration of potentially nephrotoxic drugs should be avoided.
4.9 Amounts to be administered and administration route
For oral administration - 1 tablet/12 kg bodyweight every 8 hours.
Small dogs (up to 6 kg bodyweight): ½ tablet every 8 hours
Medium dogs (6 – 18 kg bodyweight): ½ - 1½ tablets every 8 hours
Large dogs (18 - 42 kg bodyweight): 1½ - 3½ tablets every 8 hours
Treat for a maximum of 5 days.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
Immediately seek the advice of a veterinary surgeon, and show him/her the product literature.
Carry out lavage and treat with intravenous injection of acetylcysteine (200 mg/ml) at a rate of 140 mg/kg every 6 hours for 7 treatments. Ascorbic acid (30 mg/kg) should also be given orally with each dose of acetylcysteine.
If necessary instigate fluid therapy using Ringers or bicarbonate solution.
Treat for codeine overdose with injection of Naloxone (1.0 mg/kg) repeated as necessary.
Provide oxygen support.
4.11 Withdrawal periods
5. PHARMACOLOGICAL PROPERTIES
Pharmacotherapeutic group: Analgesics, Other analgesics and antipyretics, Anilides
ATCVet Code: QN02BE71
5.1 Pharmacodynamic properties
Paracetamol is a para aminophenyl derivative with analgesic properties.
5.2 Pharmacokinetic particulars
Both paracetamol and codeine are readily absorbed from the gastrointestinal tract. They are metabolised in the liver (codeine to morphine and narcodeine).
Codeine and its metabolites are excreted almost entirely by the kidney, whilst less than 5 % of paracetamol is excreted unchanged.
6. PHARMACEUTICAL PARTICULARS
6.1 List of excipients
6.2 Major incompatibilities
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
6.4 Special precautions for storage
Do not store above 25°C.
6.5 Nature and composition of immediate packaging
Polypropylene container with a low density polyethylene tamper evident lid, containing 100 or 500 plain white, flat tablets with bevelled edges and a break line on one side and DPL on the other.
Not all pack sizes may be marketed
6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
MARKETING AUTHORISATION HOLDER
Snaygill Industrial Estate
8. MARKETING AUTHORISATION NUMBER
DATE OF FIRST AUTHORISATION
15 April 1993
DATE OF REVISION OF THE TEXT
13 December 2019
Approved 13 December 2019
All prices include VAT where applicable.
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Only verified purchasers of this product can leave a review.
The order was delivered promptly and I have started to give these (under vet's advice) to Sheba my GSD who has advanced osteoarthritis. Since I have not been giving her them for long I am not sure how effective they are as the vet said it would take time to see a result. I will be able to give a better review in a few weeks when the tablets have been given for longer so at this time I have only been able to give fair in the ratings
Customer recommends this product
It's reassuring to have some way of helping her when necessary
Customer recommends this product
This was prescribed by the vet once over and I bought the tablets to ease the pain my dog was suffering.
Customer recommends this product
Excellent tablet helps control the pain my dog suffers recommend by our vet
Customer recommends this product
These taken have proven to assist Bella with pain relief
Customer recommends this product
Below are some recent questions we've received regarding Pardale-V Tablets for Dogs, including answers from our team.
My vet first prescribed PardaleV 3weeks ago, to treat arthritis. He changed her to aNsaid Previcox yesterday.to give her anti inflammatory as well. However she has raised Liver enzyme levels, doubled since January. Although still not far above norm. My query is whether it is safe for her to have Previcox or safer to return to Pardale V to protect her Liver more? She is also on Denamarin Liver Support.
I’m not sure which painkiller will be best. Any help would be appreciated,
The Pardale-V data sheets states the following:
Use is contraindicated in animals suffering from cardiac, hepatic or
renal disease, where there is a possibility of gastrointestinal
ulceration or bleeding, or where there is evidence of a blood dyscrasia
or hypersensitivity to the product.
Hepatic disease is the scientific name for liver disease so I recommend discussing this with your vet. Most drugs are metabolised by the liver so it is not uncommon for a contraindication like this to be present and it may be perfectly safe to use Pardale-V. However I recommend contacting your vet and follow their advise as closely as possible.
We have been prescribed these by our vet for on and off hip pain in my 3 yr old collie x. They seem to suit him and his stomach although he does seem a little sleepy. Is this a normal reaction? We are only on day 3, if they continue to suit him and relieve the pain I will definitely be purchasing them and keeping our medicine pack topped up.
Tiredness or lethargy are not side effects usually associated with Pardale V and I would be surprised if it is these tablets causing the sleepiness. That said individual dogs can react differently to any medication so it is not impossible. The only real way to tell would be to stop the Pardale and see if he becomes brighter. If it is in fact the Pardale causing the tiredness then you need to decide if the benefits of the medication (ie pain relief) outweigh the negatives (lethargy). There are other NSAIDs that you could speak to your vet about trying.
My vet and your blurb state that Pardale v should only be given for5 days but can be taken again after a suitable break.How long is a suitable break please?
It is hard to suggest a "suitable break" and depends a little bit on the dog. A sensible amount of time would be around 2 weeks. However if you felt your dog required another course before then I would probably give it as the risks are small and it is important to keep your dog comfortable. Some dogs are in fact on Pardale-V longterm without problems. If your dog gets any vomiting or diarrhoea you should stop the tablets though.
My vet says it's more a matter of keeping my old15 year old goldie happy now but for me old habits die hard.Is Pardale v a safe drug to give with Metronidozole?He often has these because of upset tum.
Pardale-V (an anti-inflammatory painkiller) and Metronidazole (an antibiotic) are different classes of drug and generally considered safe to use alongside each other. However, as with many effective drugs there are sometimes side effects seen with longterm use of Pardale-V. Most often liver damage with some dogs seeming to be more susceptible than others. It is possible to monitor any damage to the liver with 6 monthly (or more frequently if you prefer) blood tests done by your vet. In dogs struggling in old age it is generally considered that an improved quality of life on anti-inflammatory painkillers outweighs the risks of side effects.
Can this drug cause hyperactivity?
Hyperactivity is unlikely. It might through pain relief make a dog feel much more perky and happy. If your dog seems to show any sort of odd reaction to any medication, it is best to re-evaluate if the medication should be given any more. Your vet should be bale to help with this. If in doubt, stop the medication, then perhaps try it again after a week or so and see what result you get,
I have a fifteen year old collie cross who is on Pardale-v for Ten days but the vet has talked about leaving her on it with her Loxicom which she takes regularly . After reading the comments I Believe her body is to old to handle the drug on a permanent bases .
Pardale-V is a safe drug if used carefully and sensibly. Like many drugs it does have potential side effects but if your dog is on an appropriate dose and your vet has ascertained that there are no underlying conditions which affect it, the risks are very small. It also works well in combination with Loxicom and has the potential to greatly reduce the stiffness and discomfort your dog might otherwise feel. Dogs tend to suffer in silence but that does not mean they do not want to be made more comfortable. It is up to you and your vet, but I would be inclined to give it a try and see how your dog gets on. You should stop both medications if your dog starts to have any vomiting or diarrhoea or goes off her food, but otherwise I would give it, regardless of her age.
Are they harmful to humans
My husband accidentally took a quarter of one will it be harmful
Obviously this is really a question to direct at your own doctor. However the active ingredient is very safe to use in people (and at a higher dose than that) so I doubt if there are any concerns.
Can these tablets be given alongside to a dog who is on steroids for allergies?
These tablets are not recommended to be given with steroids. Although they are generally safe, that is a combination which might well cause problems, so I certainly would not do it.
My Labrador has been prescribed x3 pardale v daily for 2 weeks post hip operation. Is this ok as I noticed suggestions not use for more than 5 days? Should he use alternative pain relief?
This is a safe product for dogs, though there is potential for it to build up in the body over time, especially if accidentally over-dosed. The guidance you refer to is sensible for general situations. If your vet has prescribed this dose in full knowledge of your own dogs bodyweight and general health, then I would expect it will be safe and effective. There are other medicines which could have been used so I am not sure I would have suggested Pardale-V myself, but it does have good qualities. It is of course OK for you to question your own vet about it.
We have 11year old diabetic dog with heart problems and arthritis. She has been prescribed pardale-v 2 tabs x 3 daily. Is this excessive and what side effects is she likely encounter. She is on 21 units of insulin. Cardalis 15 mg daily, and Cardisure 5mg twice daily
Pardale-V tablets are very safe if given for just a few days. If they are used continuously for longer periods then side effects are possible and are usually vomiting/diarrhoea but can relate to liver or kidney damage. This is something you should talk to your own vet about. There are other treatments to help with arthritis which are much more modern and potentially better than Pardale V, though they are more expensive.