Free delivery options available over £29*

Norodine Antibiotic

Norodine Antibiotic
Equine Paste » 45g Syringe (Pack of 3)
Injection 24 » 100ml Bottle

Images are for illustration purposes only. Packaging may change from time to time and images on our website may or may not be updated.

  • Bolus » 5g (Pack of 20) £19.00
  • Equine Paste » 45g Syringe (Pack of 3) £46.00
  • Injection 24 » 100ml Bottle £29.50

Selection of 3 products from

£19.00 to £46.00

Description

Norodine contains two ingredients which act synergistically to block important metabolic pathways in bacteria. This results in efficacy against a wide range of different bacteria and so Norodine can be used for many types of infection. It is used for infections affecting the respiratory and alimentary systems, as well as many other types of soft tissue infection, including infected wounds and septicaemia. The different formulations of Norodine are intended for use in dogs, cats, horses and calves.

Need help or advice? Contact us:

  • Landline: 01582 842096
  • Mon - Fri: 8:30am - 5:00pm
  • Sat: 9:00am - 1:00pm (Collections only)
  • Email: [email protected]

All prices include VAT where applicable.

Medication Datasheets

Injection 24 » 100ml Bottle

Norodine 24 Solution for Injection

Qualitative and quantitative composition

Active substance(s): Trimethoprim 4.00% w/vSulfadiazine20.00% w/vExcipients:Chlorocresol 0.1% w/wSodium Formaldehyde Sulphoxylate Dihydrate0.1% w/wFor a full list of excipients, see section Pharmaceutical Particulars

Active substance(s):

Trimethoprim

4.00% w/v

Sulfadiazine

20.00% w/v

Excipients:

Chlorocresol

0.1% w/w

Sodium Formaldehyde Sulphoxylate Dihydrate

0.1% w/w

For a full list of excipients, see section Pharmaceutical Particulars

Pharmaceutical form

Solution for Injection.

A sterile clear yellow aqueous solution.

Clinical particulars

Indications for use, specifying the target species

Norodine 24 Injectable Solution is indicated in the treatment of systemic infections caused by or associated with organisms sensitive to the Trimethoprim:Sulfadiazine combination. The spectrum of activity includes both Gram-positive and Gram-negative organisms including:

Contraindications

Norodine 24 Injectable Solution should not be given by routes other than those recommended. Not to be administered intraperitoneally, intra-arterially or intrathecally.

Do not administer to animals with known sulphonamide sensitivity, severe liver parenchymal damage or blood dyscrasias.

Special Warnings for each target species

None known

Special precautions for use

Special precautions for use in animals

For intravenous administration the product should be warmed to body temperature and injected slowly over as long a period as is reasonably practical. At the first sign of intolerance the injection should be interrupted and shock treatment initiated.

Adequate drinking water should be available during the therapeutic effect of the product.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Care should be taken to avoid accidental injection and contact with the skin. Wash hands after use.

Sulphonamides may cause hypertensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypesensitivity to sulphonamides may lead to cross reactions with other antibiotics. Allergic reactions to these substances may occasionally be serious.

Adverse reactions (frequency and seriousness)

Anaphylactic shock, potentially fatal, has been observed on rare occasions following administration of potentiated sulphonamide preparations, particularly by the intravenous route. Veterinary surgeons should be mindful of this possibility during the injection process

Use during pregnancy, lactation or lay

No known contra-indications exist for the use of Norodine 24 Injectable Solution in pregnant and lactating animals.

Interaction with other medicinal products and other forms of interaction

Do not administer to horses exhibiting drug-induced cardiac arrhythmias. Such arrhythmias may be associated with the administration of certain anaesthetic and sedative agents.

Amounts to be administered and administration route

Cattle and Pigs:

The recommended dose rate is 15 mg of active ingredients per kilogram bodyweight (1 ml per 16 kg bodyweight) by intramuscular or slow intravenous injection.

Norodine 24 Injectable Solution may be administered by intravenous injection when rapid blood levels of trimethoprim and Sulfadiazine are required.

Horses:

The recommended dose rate is 15 mg of active ingredients per kilogram bodyweight (1 ml per 16 kg bodyweight), by slow intravenous injection.

Dogs and Cats:

The recommended dose rate is 30 mg of active ingredients per kilogram bodyweight (1 ml per 8 kg bodyweight), by subcutaneous injection only.

The recommended site in dogs is the loose skin at the top of the neck.

A single injection may be sufficient in uncomplicated conditions, but in severe infections it may be repeated daily until 2 days after symptoms resolve, up to a maximum of 5 days.

An appropriately graduated syringe must be used to allow accurate administration of the required dose volume. This is particularly important when injecting small volumes.

Overdose (symptoms, emergency procedures, antidotes), if necessary

No treatment specified.

Withdrawal period

Not to be used for horses intended for human consumption. Treated horses may never be slaughtered for human consumption. The horse must have been declared as not intended for human consumption under national horse passport legislation.

Cattle:

Pigs:

Pharmacological particulars

Pharmacotherapeutic group:

ATC Vet Code: QJ01EW10

Pharmacodynamic properties

Sulfadiazine (SDZ) inhibits the incorporation of para-aminobenzoic acid into folic acid and trimethoprim (TMP) inhibits the enzyme dihydrofolate reductase (DHFR) which converts dihydrofolic acid into tetrahydrofolic acid. TMP and SDZ act together synergistically with a double-blockade mode of action. The combination is bactericidal, inhibiting sequential steps in the synthesis of purines which are required for DNA synthesis. TMP/SDZ combinations have a broad bactericidal action against many gram-positive and gram-negative aerobic bacteria, and a large proportion of anaerobic bacteria.

Sulfadiazine is moderately well absorbed after oral administration (rapidly by sheep and pigs but more slowly by cattle), is protein bound only to a limited extent and is well distributed. Metabolism occurs in the liver and the major products are acetylated derivatives which are excreted mainly by glomerular filtration. The plasma half lives in cattle, pigs and dogs are 2 - 3 and 4 hours respectively. The half-life when given to horses in combination with Trimethoprim is 3 hours. Trimethoprim is a weak base with low water solubility. It is readily absorbed from the gastro-intestinal tract, although it is degraded in the rumen. Trimethoprim is about 65% protein bound but, being lipid soluble, readily penetrates cellular barriers to become widely distributed. It is partly oxidised and conjugated in the liver and the metabolites, plus unchanged Trimethoprim are excreted in the urine.

The degree of metabolism varies: 80% in the dog and almost 100% in the cow. The half-life is also variable: 4 hours in the horse, 2 hours in the pig and 1 hour in the cow.

Given the wide interspecies variability in the half-life of both actives, it is not possible to attain pharmacokinetic matching of the two compounds, but there is evidence that synergism occurs over a wide range of dose ratios. The combination of 1:5 Trimethoprim:Sulfadiazine is well documented for veterinary use.

Pharmaceutical particulars

List of excipients

Chlorocresol

Sodium Formaldehyde Sulphoxylate Dihydrate

Disodium Edetate Dihydrate

N-Methyl Pyrrolidone

Sodium Hydroxide

Water for Injections

Incompatibilities

None known

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

Shelf life after first opening of the immediate packaging: 28 days

Special precautions for storage

Do not store above 25°C.

Protect from light.

Protect from freezing.

Following withdrawal of the first dose use the product within 28 days. Discard unused material.

Crystallisation of the product at low temperatures can be reversed by gentle warming.

Nature and composition of immediate packaging

Norodine 24 is presented in 50 ml and 100 ml amber Type II glass vials sealed with nitryl rubber bungs.

Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Norbrook Laboratories Limited

Station Works

Newry

Co. Down

BT35 6JP

Northern Ireland

Marketing Authorisation Number

Vm 02000/4061

Date of the first authorisation or date of renewal

1st June 1988

Date of revision of the text

June 2017

Any other information

Nil.

Legal category

Bolus » 5g (Pack of 20)

Norodine Bolus Tablet

Qualitative and quantitative composition

Each tablet contains: Active substance(s): Trimethoprim 200 mgSulfadiazine1.0 gExcipients:For a full list of excipients, see section Pharmaceutical Particulars

Active substance(s):

Trimethoprim

200 mg

Sulfadiazine

1.0 g

Excipients:

For a full list of excipients, see section Pharmaceutical Particulars

Pharmaceutical form

Tablet.

A white bolus-shaped tablet, deeply scored on one face.

Clinical particulars

Target species

Calves

Indications for use, specifying the target species

Norodine Bolus is indicated primarily for the treatment of bacterial scours but may also be used for the treatment of acute salmonellosis and bacterial pneumonia.

Contraindications

Norodine Bolus should not be administered to animals with functionally mature rumens.

Special Warnings for each target species

No special precautions.

Special precautions for use

Special precautions for use in animals

Official, national and regional antimicrobial policies should be taken into account when the product is used.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Take care to avoid skin and eye contact. Protective gloves should be worn whilst handling this product. Wash hands and exposed skin after use.

Sulphonamides may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to sulphonamides may lead to cross reactions with other antibiotics. Allergic reactions to these substances may occasionally be serious.

Adverse reactions (frequency and seriousness)

None.

Use during pregnancy, lactation or lay

Not applicable.

Interaction with other medicinal products and other forms of interaction

No known interactions.

Amounts to be administered and administration route

Oral: One tablet per 40 kg bodyweight daily. This gives 30 mg of combined active ingredients per kg bodyweight.

Treatment should be repeated daily until two days after the symptoms have resolved, but in cases of salmonellosis and bacterial pneumonia treatment should be continued for 5 consecutive days. Treatment must not be continued for more than 5 days.

The product may be administered whole, by hand or balling gun, or dispersed in water. Dosage by dispersion in water: Disperse each bolus by shaking in about 300 ml of water in dosing bottle. This may be facilitated by crushing the bolus before placing it in the bottle. After dosing by this method any unused material should be discarded.

To ensure the correct dosage, bodyweight should be determined as accurately as possible to avoid underdosing.

Overdose (symptoms, emergency procedures, antidotes), if necessary

Not applicable.

Withdrawal period

Meat: 15 days.

Pharmacological particulars

Pharmacotherapeutic group: Antibacterials for systemic use.

ATC Vet Code: QJ01EW10

Pharmacodynamic properties

Sulphadiazine (SDZ) inhibits the incorporation of para-aminobenzoic acid into folic acid and trimethoprim (TMP) inhibits the enzyme dihydrofolate reductase (DHFR) which converts dihydrofolic acid into tetrahydrofolic acid. TMP and SDZ act together synergistically with a double-blockage mode of action. The combination is bactericidal inhibiting sequential steps in the synthesis of purines which are required for DNA synthesis. TMP-SDZ combinations have a broad bactericidal action against many gram-positive and gram-negative aerobic bacteria, and a large proportion of anaerobic bacteria.

Pharmaceutical particulars

List of excipients

Lactose Monohydrate

Maize Starch

Cellulose microcrystalline

Magnesium Stearate

Water Purified

Incompatibilities

None known.

Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years

Special precautions for storage

Do not store above 25°C.

Store in a dry place.

Protect from light.

Nature and composition of immediate packaging

White or grey polypropylene 'securitainers', closed with white, low density polyethylene, tamper evident lids. Each container contains 20 or 50 tablets.

Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Norbrook Laboratories Limited

Station Works

Newry

Co. Down

BT35 6JP

Northern Ireland

Marketing Authorisation Number

Vm 02000/4079

Date of the first authorisation or date of renewal

17th December 1986

Date of revision of the text

December 2008

Any other information

Nil.

Legal category

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. To find the exact cost of shipping your item, and to see all options available, follow these steps:

  1. Put the items you wish to order in your basket
  2. Proceed to checkout and enter your delivery address, including country
  3. Delivery information including price will automatically update to what is available to you

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as non-ambient items and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (3)

Q & A

Below are some recent questions we've received regarding Norodine Antibiotic, including answers from our team.

17 October 2017 at 3:03pm

Doseage

marsden

of tabletswhat is the doseage for a 40kg dog per day

  • Veterinary Advisor

The dose specified by Norbrook for a 40kg dog would be 2.5 tablets daily. However Norodine is often given twice daily so it would be best to consult your vet for the dose they recommend.

4 November 2015 at 8:08pm

Routine prescriptions

Rebecca Lea

  • VioVet customer since 2015
  • From: Wiltshire, United Kingdom

I run a sales prep yard and need routine antibiotics/bute/gastroguard etc etc for a number of horses, up to 12.
Can I get my vet to write a general prescription covering all these drugs or do I need to lodge a specific prescription every time I need to order?

  • Non-Executive Director

Basically we can supply pretty much whatever your vet allows on the prescription. If you ordered vast amounts which were clearly above what a yard of your size could use, we would have to question it. However as long as your purchases seem reasonable for what you are doing, we will supply whatever we can. That means it is down to your vet to prescribe whatever he/she thinks is reasonable in the circumstances. If your vet is happy to provide a prescription which allows for all the medication you require, then you can send it to us and just draw amounts of medication off that one prescription as you need them. You might need a new prescription every 6 months or a year, but it could cover whatever you need. However this is entirely down to your own vet and he/she is given great freedom within the law to prescribe whatever is reasonable in the circumstances. Vets are given guidelines from the RCVS and different vets interpret these in slightly different ways, but essentially it is up to your own vet.