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Nobivac DHPPi Injection for Dogs

Nobivac DHPPi Injection for Dogs
Box of 10 Doses

  • Box of 10 Doses £130.99
  • Box of 50 Doses £636.49
  • Single Dose £13.49

Selection of 3 products from

£13.49 to £636.49

Description

Nobivac DHPPi is our most commonly used routine vaccination for dogs. It provides protection against Canine Distemper, Hepatitis, Parvo virus and Para-influenza virus. It is supplied as a freeze-dried powder in single-use bottles and has to be diluted with either Nobivac Solvent or Nobivac Lepto 2 in order to also provide protection against Leptospirosis. A single injection of Nobivac DHPPi is sufficient to provide good immunity in most dogs any time from 10 weeks of age. Earlier vaccination can be given if the risk is considered significant, but a further dose must be given at or after 10 weeks of age. In some dogs, especially the very large breeds, adequate protection is more likely to be provided by vaccinating after 16 weeks of age, due to maternally derived immunity interfering with the vaccine.

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All prices include VAT where applicable.

Medication Datasheets

Single Dose

Nobivac DHP

Qualitative and quantitative composition

Active substances: Per dose of 1 ml reconstituted vaccine:

Canine distemper virus, strain Onderstepoort not less than 104.0 TCID50*

Canine adenovirus 2, strain Manhattan LPV3 not less than 104.0 TCID50*

Canine parvovirus, strain 154 not less than 107.0 TCID50*

*Tissue culture infective dose 50%

Excipients: For a full list of excipients, see section "Pharmaceutical Particulars".

Pharmaceutical form

Lyophilisate and solvent for suspension for injection.

Clinical particulars

Target species

Dogs

Indications for use

For the active immunisation of dogs to reduce clinical signs of disease caused by canine distemper virus infection; to prevent clinical signs and viral excretion caused by canine parvovirus infection; to reduce clinical signs of canine contagious hepatitis and viral excretion due to canine adenovirus 1 infection and to reduce clinical signs of respiratory infection and viral excretion caused by adenovirus type 2 infection.

Onset of immunity: one week

Duration of immunity: three years.

Contra-indications

None.

Special warnings for each target species

The efficacy of the CDV, CAV2 and CPV components of the vaccine may be reduced due to maternal antibody interference. However, the vaccine has been proven to be of benefit against virulent challenge in the presence of maternal antibody levels to CDV, CAV2 and CPV that are likely to be encountered under field conditions.

Special precautions for use

Only healthy dogs should be vaccinated. Dogs should not be exposed to unnecessary risk of infection within the first week after completion of the vaccination regimen. While the canine parvovirus vaccine strain may be shed at very low levels for up to 8 days after inoculation, there is no evidence that this results in clinical symptoms if non-vaccinated animals are infected.

Operator warnings:

In the case of accidental self-injection, wash the area immediately with water. If symptoms develop, seek medical attention and show the package leaflet or the label to the physician.

Adverse reactions

A common reaction after subcutaneous administration with the diluent provided, is a diffuse swelling up to 5 mm in diameter at the site of injection. Occasionally this swelling may be hard and painful and last for up to 3 days post injection.

In rare cases a transient rise in body temperature and/or a transient acute hypersensitivity reaction (anaphylaxis) - with signs that may include lethargy, facial oedema, pruritus, dyspnoea, vomiting, diarrhoea or collapse - may occur shortly after vaccination.

Use during pregnancy, lactation or lay

Can be used in pregnant bitches which have previously been vaccinated with the CDV (strain Onderstepoort), CAV2 (strain Manhattan LPV3) and CPV (strain 154) antigens included in the Nobivac vaccine series.

Interactions

Safety and efficacy data are available which demonstrate that this vaccine can be mixed and administered with the inactivated vaccines of the Nobivac series against canine leptospirosis caused by all or some of the following serovars: L. interrogans serogroup Canicola serovar Canicola, L. interrogans serogroup Icterohaemorrhagiae serovar Copenhageni, L. interrogans serogroup Australis serovar Bratislava, and L. kirschneri serogroup Grippotyphosa serovar Bananal/Liangguang.

After administration with one of the leptospirosis vaccines, a mild and transient increase in body temperature (≤ 1°C) may occur for a few days after vaccination, with some pups showing less activity and/or a reduced appetite. A small transient swelling (≤ 4 cm), which can occasionally be firm and painful on palpation, may be observed at the site of injection. Any such swelling will either have disappeared or be clearly diminished by 14 days post-vaccination. After mixed administration of an overdose of Nobivac DHP and an overdose of the leptospirosis vaccines of the Nobivac series, transient local reactions such as diffuse to firm swellings from 1 to 5 cm in diameter may be observed, usually these will persist no longer than 5 weeks, however some may take a little longer to completely disappear.

Safety and efficacy data are available which demonstrate that this vaccine can be mixed and administered with the inactivated vaccine of the Nobivac series against rabies.

After administration with the rabies vaccine, where this product is authorised, transient local reactions such as diffuse to firm swellings from 1 to 4 cm in diameter may be observed for up to 3 weeks after vaccination. The swellings may be painful for up to 3 days post dosing.

Safety and efficacy data are available which demonstrate that this vaccine can be administered on the same day, but not mixed, with the live vaccine for intranasal administration of the Nobivac series against infectious tracheobronchitis caused by Bordetella bronchiseptica and/or canine parainfluenza virus.

When Nobivac DHP is used with any of the other Nobivac vaccines referred to above, the minimum vaccination age for each vaccine must be taken into account such that at the time of vaccination, the dogs are at or older than the oldest minimum vaccination age for the individual vaccines.

Consult product leaflets before administering products simultaneously.

No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product except the products mentioned above. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.

Amounts to be administered and administration route

The contents of one vial of reconstituted vaccine should be injected subcutaneously. Reconstitute immediately prior to use by the addition of the contents of one vial (1.0 ml) of the diluent provided or the vaccines of the Nobivac series against rabies or leptospirosis as mentioned in section "Interactions" (where these products are authorised). Sterile equipment should be used for administration. Avoid contamination of vaccine with traces of chemical sterilising agents. Do not use chemicals such as disinfectant or spirit to disinfect the skin prior to inoculation.

Vaccination regime

Primary course vaccination: A single injection should establish active immunity in dogs of 10 weeks of age or older. Where earlier protection is required a first dose may be given to puppies from 6 weeks of age, but because maternally derived passive antibody can interfere with the response to vaccination a final dose should be given 2–4 weeks later i.e. at 10 weeks of age or older.

Booster vaccination: To maintain protection a single booster dose is recommended every three years.

Overdose

No effects other than those given in section "Adverse Reactions".

Withdrawal periods

Not applicable.

Pharmacological particulars

Immunogical properties

Pharmacotherapeutic group: live viral vaccines

ATCvet code: QI07AD02 The vaccine contains attenuated antigens to stimulate active immunity in dogs against canine distemper virus, canine parvovirus, canine contagious hepatitis caused by canine adenovirus 1 and respiratory disease caused by canine adenovirus type 2.

Pharmaceutical particulars

Excipients

Gelatin, Sorbitol, Pancreatic digest of casein, Disodium phosphate dihydrate, Potassium dihydrogen phosphate, Water for injections.

Major incompatibilities

Do not mix with any other veterinary medicinal product except with the diluent provided or the vaccines of the Nobivac series mentioned in section "Interactions" (where these products are authorised).

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 24 months.

Shelf life after reconstitution: 30 minutes.

Special precautions for storage

Store in a refrigerator (+ 2 °C and + 8 °C). Do not freeze. Protect from light.

Immediate packaging

Clear, Glass Type I (Ph.Eur.) single vials with halogenobutyl rubber stopper, closed with a colour coded aluminium cap. Cardboard or plastic box containing 10 or 50 single dose vials. The diluent may be packed together with the vaccine or separately. Not all pack sizes may be marketed.

Disposal

Dispose of waste material by boiling, incineration or immersion in an appropriate disinfectant approved for use by the competent authorities.

Marketing Authorisation Number

Vm 01708/4513

Date of the first authorisation or date of renewal

28 July 2005.

Date of revision of the text

June 2014.

Any other information

For animal treatment only. Keep out of the sight and reach of children.

Legal category

Box of 50 Doses

Nobivac DHP

Qualitative and quantitative composition

Active substances: Per dose of 1 ml reconstituted vaccine:

Canine distemper virus, strain Onderstepoort not less than 104.0 TCID50*

Canine adenovirus 2, strain Manhattan LPV3 not less than 104.0 TCID50*

Canine parvovirus, strain 154 not less than 107.0 TCID50*

*Tissue culture infective dose 50%

Excipients: For a full list of excipients, see section "Pharmaceutical Particulars".

Pharmaceutical form

Lyophilisate and solvent for suspension for injection.

Clinical particulars

Target species

Dogs

Indications for use

For the active immunisation of dogs to reduce clinical signs of disease caused by canine distemper virus infection; to prevent clinical signs and viral excretion caused by canine parvovirus infection; to reduce clinical signs of canine contagious hepatitis and viral excretion due to canine adenovirus 1 infection and to reduce clinical signs of respiratory infection and viral excretion caused by adenovirus type 2 infection.

Onset of immunity: one week

Duration of immunity: three years.

Contra-indications

None.

Special warnings for each target species

The efficacy of the CDV, CAV2 and CPV components of the vaccine may be reduced due to maternal antibody interference. However, the vaccine has been proven to be of benefit against virulent challenge in the presence of maternal antibody levels to CDV, CAV2 and CPV that are likely to be encountered under field conditions.

Special precautions for use

Only healthy dogs should be vaccinated. Dogs should not be exposed to unnecessary risk of infection within the first week after completion of the vaccination regimen. While the canine parvovirus vaccine strain may be shed at very low levels for up to 8 days after inoculation, there is no evidence that this results in clinical symptoms if non-vaccinated animals are infected.

Operator warnings:

In the case of accidental self-injection, wash the area immediately with water. If symptoms develop, seek medical attention and show the package leaflet or the label to the physician.

Adverse reactions

A common reaction after subcutaneous administration with the diluent provided, is a diffuse swelling up to 5 mm in diameter at the site of injection. Occasionally this swelling may be hard and painful and last for up to 3 days post injection.

In rare cases a transient rise in body temperature and/or a transient acute hypersensitivity reaction (anaphylaxis) - with signs that may include lethargy, facial oedema, pruritus, dyspnoea, vomiting, diarrhoea or collapse - may occur shortly after vaccination.

Use during pregnancy, lactation or lay

Can be used in pregnant bitches which have previously been vaccinated with the CDV (strain Onderstepoort), CAV2 (strain Manhattan LPV3) and CPV (strain 154) antigens included in the Nobivac vaccine series.

Interactions

Safety and efficacy data are available which demonstrate that this vaccine can be mixed and administered with the inactivated vaccines of the Nobivac series against canine leptospirosis caused by all or some of the following serovars: L. interrogans serogroup Canicola serovar Canicola, L. interrogans serogroup Icterohaemorrhagiae serovar Copenhageni, L. interrogans serogroup Australis serovar Bratislava, and L. kirschneri serogroup Grippotyphosa serovar Bananal/Liangguang.

After administration with one of the leptospirosis vaccines, a mild and transient increase in body temperature (≤ 1°C) may occur for a few days after vaccination, with some pups showing less activity and/or a reduced appetite. A small transient swelling (≤ 4 cm), which can occasionally be firm and painful on palpation, may be observed at the site of injection. Any such swelling will either have disappeared or be clearly diminished by 14 days post-vaccination. After mixed administration of an overdose of Nobivac DHP and an overdose of the leptospirosis vaccines of the Nobivac series, transient local reactions such as diffuse to firm swellings from 1 to 5 cm in diameter may be observed, usually these will persist no longer than 5 weeks, however some may take a little longer to completely disappear.

Safety and efficacy data are available which demonstrate that this vaccine can be mixed and administered with the inactivated vaccine of the Nobivac series against rabies.

After administration with the rabies vaccine, where this product is authorised, transient local reactions such as diffuse to firm swellings from 1 to 4 cm in diameter may be observed for up to 3 weeks after vaccination. The swellings may be painful for up to 3 days post dosing.

Safety and efficacy data are available which demonstrate that this vaccine can be administered on the same day, but not mixed, with the live vaccine for intranasal administration of the Nobivac series against infectious tracheobronchitis caused by Bordetella bronchiseptica and/or canine parainfluenza virus.

When Nobivac DHP is used with any of the other Nobivac vaccines referred to above, the minimum vaccination age for each vaccine must be taken into account such that at the time of vaccination, the dogs are at or older than the oldest minimum vaccination age for the individual vaccines.

Consult product leaflets before administering products simultaneously.

No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product except the products mentioned above. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.

Amounts to be administered and administration route

The contents of one vial of reconstituted vaccine should be injected subcutaneously. Reconstitute immediately prior to use by the addition of the contents of one vial (1.0 ml) of the diluent provided or the vaccines of the Nobivac series against rabies or leptospirosis as mentioned in section "Interactions" (where these products are authorised). Sterile equipment should be used for administration. Avoid contamination of vaccine with traces of chemical sterilising agents. Do not use chemicals such as disinfectant or spirit to disinfect the skin prior to inoculation.

Vaccination regime

Primary course vaccination: A single injection should establish active immunity in dogs of 10 weeks of age or older. Where earlier protection is required a first dose may be given to puppies from 6 weeks of age, but because maternally derived passive antibody can interfere with the response to vaccination a final dose should be given 2–4 weeks later i.e. at 10 weeks of age or older.

Booster vaccination: To maintain protection a single booster dose is recommended every three years.

Overdose

No effects other than those given in section "Adverse Reactions".

Withdrawal periods

Not applicable.

Pharmacological particulars

Immunogical properties

Pharmacotherapeutic group: live viral vaccines

ATCvet code: QI07AD02 The vaccine contains attenuated antigens to stimulate active immunity in dogs against canine distemper virus, canine parvovirus, canine contagious hepatitis caused by canine adenovirus 1 and respiratory disease caused by canine adenovirus type 2.

Pharmaceutical particulars

Excipients

Gelatin, Sorbitol, Pancreatic digest of casein, Disodium phosphate dihydrate, Potassium dihydrogen phosphate, Water for injections.

Major incompatibilities

Do not mix with any other veterinary medicinal product except with the diluent provided or the vaccines of the Nobivac series mentioned in section "Interactions" (where these products are authorised).

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 24 months.

Shelf life after reconstitution: 30 minutes.

Special precautions for storage

Store in a refrigerator (+ 2 °C and + 8 °C). Do not freeze. Protect from light.

Immediate packaging

Clear, Glass Type I (Ph.Eur.) single vials with halogenobutyl rubber stopper, closed with a colour coded aluminium cap. Cardboard or plastic box containing 10 or 50 single dose vials. The diluent may be packed together with the vaccine or separately. Not all pack sizes may be marketed.

Disposal

Dispose of waste material by boiling, incineration or immersion in an appropriate disinfectant approved for use by the competent authorities.

Marketing Authorisation Number

Vm 01708/4513

Date of the first authorisation or date of renewal

28 July 2005.

Date of revision of the text

June 2014.

Any other information

For animal treatment only. Keep out of the sight and reach of children.

Legal category

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews

Q & A

Below are some recent questions we've received regarding Nobivac DHPPi Injection for Dogs, including answers from our team.

7 December 2015 at 6:00pm

Vaccine

Vaccination enquiry

Hi
My pup was born 2.6.15 and received Nobivac DHPPi and Nobivac L4 batch c143d01 and A032a01 on 17.7.15. Please can you advise if this lasts 12mths?
Thanks
Claire

  • Non-Executive Director

Your pup needs to go and have a course of 2 injections as soon as possible to be properly protected. The vaccines given are the correct type but if given at that young age, the DHPPi might only have a temporary effect. This will vary from dog to dog, but generally it needs to be given at a minimum of 10 weeks old to last for a year. The L4 needs to be given twice, with 2-4 weeks between the injections. I guess your dog was supposed to have a follow-up of the same vaccines when 10 weeks old, but that has failed. Now it is 2 visits you need, with the L4 on both, and with DHPPi on one of them.

17 August 2014 at 4:24am

My pup doesn't eat

Pomeranian pup

After injecting nobivac lepto and nobivac dhppi for my 3 month old Pomeranian pup doesn't eat .this is the first time we inject him after her birth. I would like to know is it common or any serious issue

  • Non-Executive Director

The puppies of very small breeds are quite prone to mild vaccine reactions, where they become subdued for a while and do not eat well. If this persists then certainly a visit to the vets would be advised, but normally it passes after a few hours.

2 November 2013 at 11:45am

Vaccines

Ben Colwell

Hello
Does this come with the dilutent?
Many thanks
Ben

  • Technical Director

The diluent does not come with the DHPPi vaccine, but can purchased separately for a small charge (£1 currently) from the Nobivac Solvent (Diluent) page if required.