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Nelio tablets contain the drug benazapril, which has an effect on the kidneys and blood circulation. Nelio is helpful for dogs with heart failure and for cats with reduced kidney function. Both cats and dogs will often eat Nelio flavoured tablets spontaneously, but they can be given in food if it is easier. They are recommended to be given just once daily
Each Nelio 2.5 mg tablet contains: Benazepril (as hydrochloride) 2.3 mg (equivalent to benazepril hydrochloride 2.5 mg)
Each Nelio 5 mg tablet contains: Benazepril (as hydrochloride) 4.6 mg (equivalent to benazepril hydrochloride 5 mg)
Nelio 2.5 mg: oblong scored beige tablet, divisible into halves.
Nelio 5 mg: clover shaped scored beige tablet, divisible into halves or quarters.
Cats
Nelio 2.5 mg - Treatment of chronic renal insufficiency.
Nelio 5 mg - Cats weighing more than 2.5 kg: Treatment of chronic renal insufficiency.
Do not use in case of known hypersensitivity to ACE inhibitors or to any ingredient of the product.
None
Efficacy and safety of benazepril have not been established in cats of weight less than 2.5 kg
No evidence of renal toxicity to benazepril has been observed in cats during clinical trials.
However, as is routine in cases of renal insufficiency, it is recommended to monitor plasma urea and creatinine levels.
Benazepril may cause mild, intermittent diarrhea in a small proportion of cats.
In cats with chronic renal insufficiency, benazepril may increase plasma creatinine concentrations at the start of therapy. This effect is related to the therapeutic effect of the product in reducing blood pressure, and therefore is not necessarily a reason to stop therapy in the absence of other signs.
Benazepril reduced erythrocyte counts in normal cats at high doses, but this effect was not observed at the recommended dose during clinical trials in cats with chronic renal insufficiency. As is routine in cases of chronic renal insufficiency, it is recommended to monitor erythrocyte counts during therapy.
Emesis, anorexia, dehydration and lethargy have been reported in rare occasions in cats.
Laboratory studies in rats have shown embryotoxic effects of Benazepril at non-maternotoxic doses (urinary system abnormalities in foetus). Benazepril administered to cats at a daily dose of 10 mg / kg for 52 weeks resulted in the reduction of ovary / oviduct weights. Safety of this product has not been tested in pregnant or lactating queens.
Do not use in pregnant or lactating females or in queens intended for breeding.
Blood pressure may be monitored during anesthesia in cats receiving benazepril.
Interactions with potassium preserving diuretics like spironolactone, triamterene or amiloride cannot be ruled out. It is recommended to monitor plasma potassium levels when using benazepril in combination with a potassium sparing diuretic as life threatening reactions are a possibility.
Oral administration of 0.46 mg of benazepril per kg and per day, equivalent to 0.50 mg of benazepril hydrochloride per kg and per day, as one administration, whether or not with a meal, i.e one Nelio 2.5 mg tablet per 5 kg body weight or one Nelio 5 mg tablet per 10 kg body weight.
In case of use of half tablets: Put the remaining half of the tablet back into the blister pocket and use for the next administration.
The tablets are flavoured and may be taken spontaneously by cats, but can also be administered directly into the cat's mouth or be given with food if necessary.
Transient and reversible signs of hypotension may appear in case of accidental overdose. Treatment is symptomatic, involving intravenous infusion with warm isotonic saline.
In cats a 10-fold overdosage daily for one year was asymptomatic.
Not Applicable
Benazepril hydrochloride is a prodrug hydrolysed in vivo to benazeprilat. This active metabolite inhibits angiotensin converting enzyme (ACE), thus preventing the conversion of inactive angiotensin I into active angiotensin II. Therefore, benazeprilat inhibits all effects induced by angiotensin II, in particular, vasoconstriction of both arteries and veins and retention of sodium and water by the kidney. Benazeprilat causes long-lasting inhibition of plasma ACE, with significant inhibition persisting for 24 hours after a single dose.
In cats with renal insufficiency, benazepril reduces systemic and intraglomerular blood pressure. At the same time, it decreases glomerular basal membrane permeability. In consequence, it reduces protein loss in the urine and renal insufficiency progression.
After oral administration, benazepril is rapidly absorbed from the gastrointestinal tract. One part of absorbed benazepril is hydrolyzed by hepatic enzymes to the active substance, benazeprilat; unchanged benazepril and hydrophilic metabolites account for the remainder. The absolute systemic bioavailability, calculated for oral benazepril versus intravenous benazepril is about 9% both in fasting and fed situations. After administration of Nelio 5 at 0.65 mg/kg in cats, peak benazeprilat concentrations (approximately 110 ng/ml) are achieved within about 1 and half hours. The apparent terminal half-life of benazeprilate was 12.5 h
Benazepril and benazeprilat are both extensively bound to plasma proteins.
Repeated administration leads to slight accumulation of benazeprilat in plasma, steady state being achieved in less than 4 days.
In cats, benazeprilat is excreted 85% via the biliary route and 15% via the urinary route. The clearance of benazeprilat is not affected in cats with decreased glomerular filtration; therefore no adjustment of the dose is required.
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Pig liver flavour, Yeast, Lactose monohydrate, Croscarmellose sodium, Anhydrous colloidal silica, Hydrogenated castor oil, Microcrystalline cellulose.
Not known.
Nelio 2.5 mg: 21 months.
Shelf-life of divisions of the tablets: 24 hours
Nelio 5 mg: 21 months.
Shelf-life of divisions of the tablets: 72 hours
Do not store above 30°C. Store in original package.
Nelio 2.5 mg Tablets: any part-used tablet should be returned to the opened blister and used within 24 hours
Nelio 5 mg Tablets: any part-used tablet should be returned to the opened blister and used within 3 days
Nelio 2.5 mg Tablets: Aluminium/Aluminium heat-sealed blister pack 10 tablets per strip.
Box with 1 strip of 10 tablets; Box with 2 strips of 10 tablets; Box with 5 strips of 10 tablets; Box with 10 strips of 10 tablets; Box with 14 strips of 10 tablets; Box with 18 strips of 10 tablets.
Nelio 5 mg Tablets: Blister complex: [PA-Al-PVC] / Aluminium heat sealed blisters with 10 tablets / blister.
Cardboard box with 1 blister of 10 tablets; Cardboard box with 2 blisters of 10 tablets; Cardboard box with 3 blisters of 10 tablets; Cardboard box with 5 blisters of 10 tablets; Cardboard box with 10 blisters of 10 tablets; Cardboard box with 20 blisters of 10 tablets; Cardboard box with 50 blisters of 10 tablets.
Not all pack sizes may be marketed.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Sogeval SA
Nelio 2.5 mg Tablets for Cats: Vm 20749/4018.
Nelio 5 mg Tablets for Cats: Vm 20749/4012
Nelio 2.5 mg Tablets for Cats: 16 February 2010
Nelio 5 mg Tablets for Cats: 27 February 2009
Nelio 2.5 mg Tablets for Cats: February 2010
Nelio 5 mg Tablets for Cats: February 2009
Special precautions to be taken by the person administering the veterinary medicinal product to animals: Pregnant women should take special care to avoid accidental oral exposure, because ACE inhibitors have been found to affect the unborn child during pregnancy in humans.
Wash hands after use. In case of accidental ingestion by children, seek medical advice immediately and show this label to the doctor.
POM-V
Each Nelio 5 mg Tablet contains: benazepril (as hydrochloride) 4.60 mg (equivalent to benazepril hydrochloride 5 mg)
Each Nelio 20 mg Tablet contains: benazepril(as hydrochloride) 18.42 mg (equivalent to benazepril hydrochloride 20 mg)
Clover shaped scored beige tablets, divisible into halves or quarters.
Dogs
Nelio 5 mg Tablet: Dogs weighing more than 2.5 kg: Treatment of congestive heart failure
Nelio 20 mg Tablet: Dogs weighing more than 20 kg: Treatment of congestive heart failure
Do not use in case of known hypersensitivity to ACE inhibitors or to any ingredient of the product.
Do not use in any dog that has evidence of cardiac output failure, for example, due to aortic stenosis
None
No evidence of renal toxicity to benazepril has been observed during clinical trials.
However, as is routine in cases of renal insufficiency, it is recommended to monitor plasma urea and creatinine levels.
Adverse reactions
At the start of the treatment, a decrease of the blood pressure and a transient increase of plasmatic concentrations of creatinine may occur.
On rare occasions, transient signs of hypotension, such as lethargy and ataxia may occur.
Studies in laboratory animals (rats) have shown embryotoxic effects (malformations of the fœtal urinary system) at doses not toxic for the mother. The safety of the medicinal product has not been studied in pregnant or lactating females.
Do not use during pregnancy or lactation. Do not use in breeders.
None known in dogs. In dogs with heart failure, benazepril has been given in combination with digoxin, diuretics and anti-arrhythmic drugs without demonstrable adverse interactions.
Interactions with potassium sparing diuretics, like spironolactone, triamteren and amiloride, can not be excluded.
The concurrent administration of potassium-sparing diuretics should only be considered under regular monitoring of plasma potassium.
The association of this product with other anti-hypertensive agents (e.g.: calcium channel blockers, β-blockers or diuretics), anaesthetics or sedatives may lead to additive hypotensive effect.
In humans, the association of ACE inhibitors and NSAIDs can lead to reduced anti-hypertensive efficacy or impaired renal function. Therefore concurrent administration with NSAIDs or other medications with hypotensive effect should be considered with care.
The concomitant administration of NSAIDs or ciclosporin requires a survey of the renal function.
Oral administration 0.23 mg of benazepril per kg bodyweight per day, equivalent to 0.25 mg of benazepril hydrochloride per kg bodyweight per day, as one administration, with or without a meal, i.e one Nelio 5 mg tablet per 20 kg body weight and one Nelio 20 mg tablet per 80 kg body weight.
In case of use of quarters or half tablets: Put the remaining quantity of the tablet back into the blister pocket and use for the next administration.
The dose may be doubled, still administered once daily, if judged clinically necessary and advised by the veterinary surgeon.
The tablets are flavoured and may be taken spontaneously by dogs, but can also be administered directly into the dog’s mouth or be given with food if necessary.
Transient and reversible signs of hypotension may appear in case of accidental overdose. Treatment is symptomatic, involving intravenous infusion with warm isotonic saline.
Morphologic changes such as hypertrophy or hyperplasia of juxtaglomerular cells, increase of uremia and a weight loss of the heart due to an involution have been observed with doses over 10 mg/kg in healthy dogs.
Not Applicable
Benazepril hydrochloride is a prodrug hydrolysed in vivo to benazeprilat which inhibits angiotensin converting enzyme (ACE), thus preventing the conversion of inactive angiotensin I into active angiotensin II. Therefore, benazeprilat inhibits all effects mediated by angiotensin II, including vasoconstriction of both arteries and veins and retention of sodium and water by the kidney. Benazeprilat causes long-lasting inhibition of plasma ACE, with significant inhibition persisting for 24 hours after a single dose.
In dogs with heart failure, benazepril reduces the peripheral resistance, blood pressure of left ventricle and volume load on the heart.
Following oral administration, benazepril is rapidly absorbed from the gastrointestinal tract. Absorbed benazepril is partly hydrolyzed by hepatic enzymes to the active substance, benazeprilat; unchanged benazepril and hydrophilic metabolites account for the remainder. The absolute systemic bioavailability, calculated for oral benazepril versus intravenous benazepril is about 5-8 %, because of incomplete absorption and first pass metabolism.. After oral administration of 0.5 mg/kg of benazepril hydrochloride, peak benazeprilat plasmatic concentrations (Cmax approximately 30 ng.ml-1) are achieved within about 1 and half hours. The plasmatic concentrations (AUCtot) area under the curve is close to 193 ng.h.mL-1
Benazepril and benazeprilat are both extensively bound to plasma proteins and in tissue it mainly resides in kidney and liver. There is no significant difference in the pharmacokinetics, whether benazepril hydrochloride is administered to fed or fasted dogs.
The elimination half-life of benazeprilate is approximately 13 hours.
Repeated administration leads to slight accumulation, steady state being achieved in less than 4 days.
In dogs, benazepril is equally excreted by hepatic or urinary route.
The clearance of benazepril is not appreciably affected in dogs with impaired renal or hepatic functions and therefore no adjustment of the dose is required in cases of renal insufficiency.
-
Pig liver flavour, Yeast, Lactose monohydrate, Croscarmellose sodium, Anhydrous colloidal silica, Hydrogenated castor oil, Microcrystalline cellulose.
None known
Nelio 5 mg and Nelio 20 mg: 21 months.
Shelf-life of divisions of the tablets: 72 hours
Do not store above 30 °C. Store in original package in order to protect from moisture. Any part-used tablet should be returned to the opened blister and used within 3 days
Nelio 5 mg Tablets: [PA-Al-PVC] / Aluminium heat sealed blister strip of 10 tablets
Cardboard box with 1 blister strip of 10 tablets; Cardboard box with 5 blister strips of 10 tablets; Cardboard box with 10 blister strips of 10 tablets; Cardboard box with 25 blister strips of 10 tablets.
Nelio 20 mg Tablets: [PA-Al-PVC] / Aluminium heat sealed blister strip of 10 tablets.
Cardboard box with 1 blister strip of 10 tablets; Cardboard box with 5 blister strips of 10 tablets; Cardboard box with 10 blister strips of 10 tablets; Cardboard box with 14 blister strips of 10 tablets; Cardboard box with 18 blister strips of 10 tablets.
Not all pack sizes may be marketed.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Sogeval SA
Nelio 5 mg Tablets for Dogs: Vm 20749/4015.
Nelio 20 mg Tablets for Dogs: Vm 20749/4016.
Nelio 5 mg and 20 mg tablets for Dogs: 7 September 2009
Nelio 5 mg and 20 mg tablets for Dogs: September 2009
Special precautions to be taken by the person administering the veterinary medicinal product to animals: Pregnant women should take special care to avoid accidental oral exposure, because ACE inhibitors have been found to affect the unborn child during pregnancy in humans.
Wash hands after use. In case of accidental ingestion by children, seek medical advice immediately and show this label or the package leaflet to the doctor.
POM-V
All prices include VAT where applicable.
Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.
For UK delivery, we charge the following:
| Order Total | Weight | Delivery |
| £0-£28.99 | Under 2kg | £2.99 |
| 2kg+ | £4.99 | |
| £29-£38.99 | Under 2kg | Free |
| 2kg+ | £4.99 | |
| £39+ | Under 2kg | Free |
| 2kg+ | Free |
Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.
For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.
We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.
Due to air freight restrictions aerosols cannot ever be sent abroad by Royal Mail. We appreciate your understanding.
Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.
Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.
To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.
*For full details on returns, see our terms and conditions page.
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