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Malaseb is a shampoo containing chlorhexidine and miconazole. It is used to treat skin conditions in dogs where an overgrowth of bacteria or yeasts are present. This can happen in a variety of different skin conditions. On some occasions a course of treatment can provide a complete cure, but often regular periodic treatment is needed to prevent recurrence. It is important to apply Malaseb correctly to gain full effect. Firstly water should be applied to wet the coat, then Malaseb is added and worked into a lather over the skin. This should the be gently worked into the skin to ensure good contact is achieved. Particular importance should be attached to the skin near the lips, under the tail and between the toes. The lather then needs to be left to soak on the skin for a full 10 minutes. After this the Malaseb should be rinsed off using lots of luke-warm water. The dog should then be kept in a warm place until the coat has dried.
All prices include VAT where applicable.
1 ml contains: Active substances:
Chlorhexidine digluconate 20 mg (equivalent to chlorhexidine 11.26 mg)
Miconazole nitrate 20 mg (equivalent to miconazole 17.37 mg)
Excipients: Methylchloroisothiazolinone 0.0075 mg, Methylisothiazolinone 0.0025 mg, Sodium Benzoate 1.25mg.
Shampoo. A clear to slightly unclear, light yellow to light brown liquid.
Dogs and cats.
Dogs: For the treatment and control of seborrhoeic dermatitis associated with Malassezia pachydermatis and Staphylococcus intermedius.
Cats: As an aid in the treatment of ringworm due to Microsporum canis in conjunction with griseofulvin.
Do not use in case of hypersensitivity to the active substances or to any of the excipients.
Dogs and cats: In order to prevent reoccurrence of the infection, appropriate control methods should be employed in the animal’s environment (e.g. cleaning and disinfection of kennels, beds).
Cats: Malaseb shampoo should only be used in conjunction with griseofulvin when treating for ringworm. Shampooing cats may initially increase the recovery of M. canis by brush culture techniques. Both field and experimental studies have shown that environmental contamination with M. canis can be eliminated or reduced by the use of Malaseb shampoo twice weekly. In these studies, griseofulvin was administered continuously throughout the treatment period and both clinical improvement was enhanced and environmental contamination reduced compared to the use of griseofulvin alone.
Official, national and regional antimicrobial policies should be taken into account when the product is used.
For external use only.
In case of accidental contact with eyes, rinse with plenty of water.
Do not allow the animal to lick itself during shampooing and rinsing, or before it is dried. Take care to avoid the animal inhaling the product or getting it into the nose or mouth during shampooing.
Puppies and kittens should not come into contact with nursing females after treatment until the coat has dried.
People with known hypersensitivity to chlorhexidine, miconazole or any of the excipients should avoid contact with the veterinary medicinal product.
This product can cause eye irritation. Avoid contact with the eyes. In case of accidental contact with eyes, rinse with plenty of water. If irritation persists consult your doctor.
Avoid excessive handling and stroking of treated animals immediately following treatment.
Ringworm in the cat is infectious to humans and so it is advisable to wear gloves and have arms covered during clipping and shampooing of infected cats.
When shampooing a cat, in order to avoid prolonged contact with the shampoo, wash and dry hands gently. Do not scrub.
Exceptionally, a dog with atopy or a cat with allergic skin disease may develop a pruritic and/or erythematous reaction after treatment.
In very rare circumstances, dogs and cats may develop a skin reaction (itching, redness) after treatment.
Pregnancy: Malaseb shampoo in conjunction with griseofulvin should not be used in pregnant cats as griseofulvin is contraindicated in pregnancy.
Lactation: Please see Special precautions for use in animals.
Dogs: As a general rule, shampoo twice weekly until the symptoms subside, and weekly thereafter, or as necessary to keep the condition under control.
Cats: Shampoo twice weekly for a minimum period until coat brushings are negative for the culture of M. canis. The maximum length of the treatment period should not exceed 16 weeks. Depending on the length and type of the haircoat it should be considered whether it is necessary to clip the haircoat of the cat prior to treatment.
Wet the animal thoroughly with clean water and apply Malaseb shampoo to the animal at several points and massage into the coat. Use a sufficient amount of the shampoo to raise a lather on the coat and skin. Ensure that the shampoo is applied around the lips, under the tail and between the toes. Allow the animal to stand for 10 minutes, then rinse off with clean water and leave to dry naturally in a warm, draught-free environment.
The 250 ml bottle, for example, provides approximately 8-16 treatments for a 15 kg dog, or 5-10 treatments for a 25 kg dog or 25 cat treatments, depending on coat thickness.
Pharmacotherapeutic group: Dermatologicals
ATCvet code: QD01AC52
Chlorhexidine digluconate is a Bisbiguanide antimicrobial agent against Gram-positive and Gram-negative bacteria. It is both bactericidal and bacteriostatic depending on the concentration used.
Growth inhibition is achieved by a direct effect on ATP-ase so interfering with the energy transport mechanisms. The bactericidal effect of chlorhexidine results from coagulation of the bacterial cell contents.
Chlorhexidine digluconate is incorporated in the product for its activity against Staphylococcus intermedius. Typical MIC values found in clinical Staphylococcus intermedius isolates are 2.0 mg/l (2005). Staphylococcus intermedius resistance to chlorhexidine has not been reported.
Miconazole nitrate is an imidazole antifungal agent with activity against yeasts such as Malassezia pachydermatis.
It is both fungicidal and fungistatic depending on the concentration used. Miconazole inhibits ergosterol incorporation into cell membranes so increasing concentrations of cytotoxic hydrogen peroxide within the fungal cell wall.
Miconazole nitrate has been incorporated in the product for its activity against Malassezia pachydermatis. Typical MIC values found in clinical Malassezia pachydermatis isolates are 0.5-4.0 mg/l (2003/5). Malassezia pachydermatis resistance to miconazole has not been reported.
Chlorhexidine and miconazole in combination:
In vitro studies have demonstrated synergistic activity against Microsporum canis between chlorhexidine and miconazole.
High concentrations of chlorhexidine digluconate are achieved in the hair coat and on the skin for the 10 minute period following shampooing. These concentrations are well in excess of the MICs for Staphylococcus intermedius. Chlorhexidine digluconate is poorly absorbed from the gastrointestinal tract on ingestion. There is little or no percutaneous absorption. In humans, it has been shown that 26% remains on the skin at 29 hours after application.
High concentrations of miconazole nitrate are achieved in the hair coat and on the skin for the 10 minute period following shampooing. These concentrations are well in excess of the MICs for Malassezia pachydermatis.
Miconazole nitrate is poorly absorbed from the skin and gastrointestinal tract.
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Shelf life after first opening the immediate packaging: 3 months.
Do not store above 30°C.
Do not refrigerate or freeze.
The container is a 250 ml polyethylene bottle with a polypropylene screw cap.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Dechra Veterinary Products A/S, Mekuvej 9, DK-7171 Uldum, Denmark.
14 November 2007
For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children.
Malaseb® shampoo is manufactured under licence from Dermcare Vet, Australia, owner of the trade name Malaseb®. EU patent no. 0608308.
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*For full details on returns, see our terms and conditions page.
Below are some recent questions we've received regarding Malaseb Dog Shampoo, including answers from our team.
I need malaseb shampoo but don't have prescription, how do I go about getting it ? X
You need to ask your vet to write a prescription for you, then send us a copy of the prescription. We cannot supply you without that.
Does this shampoo work on mites?
This shampoo is anti-bacterial and anti-fungal but it has no direct effect on mites. These days mites are more easily controlled with appropriate spot-on treatments. (Most itchy dogs do not have mites though and your vet will be able to advise you on suitable treatments.)
does it cure it
Malaseb is usually used to help clear bacterial or fungal infections of the skin. Repeated use is normally needed, and sometimes antibiotic tablets care give too. It is certainly possible for the infection to be cleared completely and to never come back. However there are lots of other factors involved with skin infection and irritation. Depending on the individual patient, recovery may be partial or temporary. It is very likely that the situation will be much improved by using Malaseb, whatever else is going on, if a complete cure is not possible. It depends largely on the cause in the first place.