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Film-coated tablet Kelapril 2.5 mg: White, oval divisible tablets scored on both sides Each 2.5 mg tablet contains: Active substance Benazepril hydrochloride: 2.3 mg benazepril (equivalent to 2.5 mg benazepril hydrochloride) Kelapril 5 mg: Light yellow, oval divisible tablets scored on both sides Each 5 mg tablet contains: Active substance Benazepril hydrochloride: 4.6 mg benazepril (equivalent to 5 mg benazepril hydrochloride) Kelapril 20mg: Reddish-pink, oval divisible tablets scored on both sides Each 20 mg tablet contains: Active substance Benazepril hydrochloride: 18.4mg benazepril (equivalent to 20 mg benazepril hydrochloride)
Dogs: treatment of congestive heart failure. Cats: Reduction of proteinuria associated with chronic kidney disease. (Kelapril 2.5 mg and 5 mg, tablets for dogs and cats only)
Oral use The product should be given orally once daily, with or without food. The duration of treatment is unlimited.
The product should be administered orally at a minimum dose of 0.25 mg (range 0.25-0.5) benazepril hydrochloride/kg body weight once daily, according to the following tables:
|Kelapril 2.5 mg|
|Weight of Dog (kg)||Standard Dose||Double Dose|
|2.5-5||0.5 tablet||1 tablet|
|>5-10||1 tablet||2 tablets|
|Kelapril 5 mg|
|Weight of dog (kg)||Standard Dose||Double Dose|
|>5-10 >10-20||0.5 tablet 1 tablet||1 tablet 2 tablets|
|Kelapril 20 mg Weight of dog (kg) >20-40 >40-80||Standard Dose 0.5 tablet 1 tablet||Double Dose 1 tablet 2 tablets|
The dose may be doubled, still administered once daily, to a minimum dose of 0.5 mg/kg (range 0.5-1.0), if judged clinically necessary and advised by the veterinary surgeon.
The product should be administered orally at a minimum dose of 0.5 mg (range 0.5-1.0) benazepril hydrochloride/kg body weight once daily according to the following table:
|Kelapril 2.5 mg Weight of cat (kg)|
|Kelapril 5 mg Weight of cat (kg) 2.5-5 >5-10||0.5 tablet 1 tablet|
Do not use in case of hypersensitivity to the active substance or to any of the excipients. Do not use in cases of hypotension, hypovolaemia, hyponatraemia or acute renal failure. Do not use in cases of cardiac output failure due to aortic or pulmonary stenosis. Do not use in pregnancy or lactation. (see further information below)
i. Special precautions for use in animals No evidence of renal toxicity of the veterinary medicinal product has been observed (in dogs or cats) during clinical trials, however, as is routine in cases of chronic kidney disease, it is recommended to monitor plasma creatinine, urea and erythrocyte counts during therapy. The efficacy and safety of the product has not been established in dogs and cats below 2.5 kg body weight. ii. Special precautions to be taken by the person administering the veterinary medicinal product to animals Wash hands after use. In case of accidental oral ingestion, seek medical advice immediately and show the label or the package leaflet to the physician. Pregnant women should take special care to avoid accidental oral exposure because angiotensin converting enzyme (ACE) inhibitors have been found to affect the unborn child during pregnancy in humans.
In double blind clinical trials in dogs with congestive heart failure, the product was well tolerated with an incidence of adverse reactions lower than observed in placebo-treated dogs. A small number of dogs may exhibit transient vomiting, incoordination or signs of fatigue. In cats and dogs with chronic kidney disease, the product may increase plasma creatinine concentrations at the start of therapy. A moderate increase in plasma creatinine concentrations following administration of ACE inhibitors is compatible with the reduction in glomerular hypertension induced by these agents, and is therefore not necessarily a reason to stop therapy in the absence of other signs. The product may increase food consumption and body weight in cats. Emesis, anorexia, dehydration, lethargy and diarrhoea have been reported in rare occasions in cats.
Do not use during pregnancy or lactation. The safety of the product has not been established in breeding, pregnant or lactating dogs and cats. Benazepril reduced ovary/oviduct weights in cats when administered daily at 10 mg/kg body weight for 52 weeks. Embryotoxic effects (foetal urinary tract malformation) were seen in trials with laboratory animals (rats) at maternally non-toxic doses.
In dogs with congestive heart failure, the product has been given in combination with digoxin, diuretics, pimobendan and anti-arrhythmic veterinary medicinal products without demonstrable adverse interactions. In humans, the combination of ACE inhibitors and Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) can lead to reduced anti-hypertensive efficacy or impaired renal function. The combination of the product and other anti-hypertensive agents (eg. calcium channel blockers, β-blockers or diuretics), anaesthetics or sedatives may lead to additive hypotensive effects. Therefore, concurrent use of NSAIDS or other medications with a hypotensive effect should be considered with care. Renal function and signs of hypotension (lethargy, weakness etc) should be monitored closely and treated as necessary. Interactions with potassium preserving diuretics like spironolactone, triamterene or amiloride cannot be ruled out. It is recommended to monitor plasma potassium levels when using the product in combination with a potassium sparing diuretic because of the risk of hyperkalaemia.
Shelf life of the veterinary medicinal product as packaged for sale: Kelapril 2.5mg tablets for dogs and cats: 2 years Kelapril 5 mg tablets for dogs and cats: 30 months Kelapril 20 mg tablets for dogs: 3 years Tablet halves should be used within 2 days Store below 25°C in the original package (Kelapril 2.5 mg tablets for dogs and cats) Store below 30°C in the original package (Kelapril 5 mg tablets for dogs and cats and Kelapril 20 mg tablets for dogs) Store in a dry place. Each time an unused half tablet is stored, it should be returned to the open blister space inserted back into the cardboard box. For animal treatment only- to be supplied only on veterinary prescription. Keep out of the sight and reach of children Any unused veterinary medicinal product or waste material derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
Legal category: POM-V
PVC/PCTFE- aluminium blister containing 14 film-coated tablets. Cardboard box with - 2 blisters (28 tablets) - 7 blisters (98 tablets) Not all pack sizes may be marketed.
Pharmacodynamic properties Benazepril hydrochloride is a prodrug hydrolysed in vivo to its active metabolite, benazeprilat. Benazeprilat is a highly potent and selective inhibitor of ACE, thus preventing the conversion of inactive angiotensin l to active angiotensin ll and thereby also reducing synthesis of aldosterone. Therefore, it blocks effects mediated by angiotensin ll and aldosterone, including vasoconstriction of both arteries and veins, retention of sodium and water by the kidney and remodelling effects (including pathological cardiac hypertrophy and degenerative renal changes). The product causes long-lasting inhibition of plasma ACE activity in dogs and cats, with more than 95% inhibition at peak effects and significant activity (>80% in dogs and >90% in cats) persisting 24 hours after dosing. The product regulates the blood pressure and volume load on the heart in dogs with congestive heart failure. In cats with experimental renal insufficiency, the product normalized the elevated glomerular capillary pressure and reduced the systemic blood pressure. Reduction in glomerular hypertension may retard the progression of kidney disease by inhibition of further damage to the kidneys. Placebo controlled clinical field studies in cats with chronic kidney disease (CKD) have demonstrated hat the product significantly reduced levels of urine protein and urine protein to creatinine ratio (UPC); this effect is probably mediated via reduced glomerular hypertension and beneficial effects on the glomerular basement membrane. No effect of the product on survival in cats with CKD has been shown, but the product increased the appetite of the cats, particularly in more advanced cases. Pharmacokinetic Properties After oral administration of benazepril hydrochloride, peak levels of benazepril are attained rapidly (Tmax 0.58 hour in dogs and 0.43 hour in cats) and decline quickly as the drug is partially metabolised by liver enzymes to benazeprilat. The systemic bioavailability in incomplete (~13% in dogs) due to incomplete absorption (38% in dogs and <30% in cats) and first pass metabolism. In dogs, peak benazeprilat concentrations (Cmax of 39.4 ng/ml after a dose of 0.40 mg/kg benazepril hydrochloride) are achieved with a Tmax of 1.43h. In cats, peak benazeprilat concentrations (Cmax of 479.2 ng/ml after a dose of 0.95 mg/kg benazepril hydrochloride) are achieved with a Tmax of 1.91h. Benazeprilat concentrations decline biphasically: the initial fast phase (t1/2=1.7 hours in dogs and t1/2=2.4 hours in cats) represents elimination of free drug, while the terminal phase (t1/2=19 hours in dogs and t1/2=29 hours in cats) reflects the release of benazeprilat that was bound to ACE, mainly in the tissues. Benazepril and benazeprilat are extensively bound to plasma proteins (85-90%), and in tissues are found mainly in the liver and kidney. There is no significant difference in the pharmacokinetics of benazeprilat when benazepril hydrochloride is administered to fed or fasted dogs. Repeated administration of the product leads to slight bioaccumulation of benazeprilat (R=1.47 in dogs and R=1.36 in cats with 0.5 mg/kg), steady state being achieved within a few days (4 days with dogs). Benazeprilat is excreted 54% via the biliary and 46% via the urinary route in dogs and 85% via the biliary and 15% via the urinary route in cats. The clearance of benazeprilat is not affected in dogs or cats with impaired renal function and therefore no adjustment of the product dose is required in either species in cases of renal insufficiency.
KELA N.V. St. Lenaartseweg 48, 2320 Hoogstraten Belgium
Kelapril 2.5 mg, film coated tablets for dogs and cats- Vm 06126/4003 Kelapril 5 mg, film coated tablets for dogs and cats- Vm 06126/4004 Kelapril 20mg, film coated tablets for dogs- Vm 06126/4005
GTIN description:Kelapril 2.5mg 28 tabs: GTIN:0541489700692 GTIN description:Kelapril 2.5mg 98 tabs: GTIN:0541489700693 GTIN description:Kelapril 5mg 28 tabs: GTIN:0541489700694 GTIN description:Kelapril 5mg 98 tabs: GTIN:0541489700695 GTIN description:Kelapril 20mg 28 tabs: GTIN:0541489700696 GTIN description:Kelapril 20mg 98 tabs: GTIN:0541489700697
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