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Equipalazone contains 1g of phenylbutazone (bute). It is used in the treatment of musculo-skeletal conditions in horses and ponies.
Equipalazone has anti-inflammatory and pain relieving properties so it is useful in the treatment of lameness due to arthritis, laminitis, bursitis, carpitis, and also after surgery. It can be given for a short period, or long-term. Usually it is dosed once daily.
All prices include VAT where applicable.
1 sachet contains: Active substance:
Phenylbutazone 1 g
Oral powder. White/cream powder.
Horses and ponies (non-food producing).
For the treatment of musculoskeletal disorders in horses and ponies where the anti-inflammatory and analgesic properties of phenylbutazone can offer relief. Examples of conditions normally considered suitable for treatment with phenylbutazone include lameness associated with osteoarthritic conditions, acute and chronic laminitis, bursitis and carpitis, and in the reduction of post-surgical soft tissue reaction.
The therapeutic index of phenylbutazone is low. Do not exceed the stated dose or the duration of treatment.
Do not administer with other non-steroidal anti-inflammatory drugs (NSAIDs) concurrently or within 24 hours of each other.
Do not use in animals suffering from cardiac, hepatic or renal disease; where there is the possibility of gastrointestinal ulceration or bleeding; or where there is evidence of a blood dyscrasia.
Do not use in cases of known hypersensitivity to the active substance or to any of the excipients.
The clinical effect of phenylbutazone can be evident for at least three days following cessation of administration. This should be borne in mind when examining horses for soundness.
Use in any animal under six weeks of age, or in aged animals, may involve additional risks. If such use cannot be avoided, animals may require a reduced dosage and special clinical management.
Avoid use in any dehydrated, hypovolaemic or hypotensive animal as there is a risk of increased toxicity.
It is preferable that NSAIDs which inhibit prostaglandin synthesis are not administered to animals undergoing general anaesthesia until fully recovered.
Response to long term therapy should be monitored at regular intervals by a veterinary practitioner.
NSAIDs can cause inhibition of phagocytosis and hence in the treatment of inflammatory conditions associated with bacterial infections, appropriate concurrent antimicrobial therapy should be instigated.
The product should be handled with care at all times to reduce the risk of accidental ingestion, skin contact or dust inhalation. If accidental skin or eye contact occurs, the site should be washed immediately with water. If the product is ingested, seek medical advice and show the product packaging.
Advice to doctors: gastric lavage (emesis in children) should be performed urgently. Charcoal haemoperfusion has also been shown to be beneficial. Treatment should then be administered symptomatically.
In common with other NSAIDs that inhibit prostaglandin synthesis, there may be gastric and/or renal intolerance. This is usually associated with overdosage and such events are rare. Recovery is usual on cessation of treatment and following the initiation of supportive symptomatic therapy (see Overdose for further information). If adverse reactions occur, treatment shoud be discontinued and the advice of a veterinarian should be sought.
The safety of phenylbutazone in pregnancy has not been established. Use during pregnancy should be avoided whenever possible, particularly during the first trimester.
Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs to produce an increase in non-bound pharmacologically active concentrations which can lead to toxic effects. Concurrent administration of potential nephrotoxic drugs (e.g. aminoglycoside antibiotics) should be avoided. Gastrointestinal tract ulceration may be exacerbated by corticosteroids in animals given NSAIDs.
For oral administration only. When mixed with a concentrate feed, the product was shown to be palatable to horses.
The dosage should be adjusted according to the individual animal’s response, but the following may be taken as a guide:
Horses: 450 kg (1000 lb) body weight: the contents of two sachets to be administered twice on day 1 of treatment (equivalent to 8.8 mg/kg/day) followed by the contents of one sachet twice daily for four days (4.4 mg/kg/day), then one sachet daily, or on alternate days, sufficient to keep the horse comfortable (2.2 mg/kg/day).
Ponies: 225 kg (500 lb) body weight, one sachet (4.4 mg/kg) on alternate days.
Discontinue treatment if no response is evident after four to five days treatment.
For ease of administration mix the powder with a small quantity of feed.
Dampening of the veterinary medicinal product in feed 5 minutes prior to feeding has been shown to have no detrimental influence on the palatability of the product. However, the influence of prolonged dampening on palatability or stability of the product is not known.
Overdosing may result in gastric and large intestinal ulceration and general enteropathy. Renal papillary damage may also occur with impaired renal function. Subcutaneous oedema, especially under the jaw may become evident due to plasma protein loss.
There is no specific antidote. If signs of possible overdosage occur, treat the animal symptomatically.
The therapeutic index of phenylbutazone is low. In man, charcoal haemoperfusion in conjunction with dopamine has been used successfully to treat overdosage with phenylbutazone, but there is no experience of the use of this technique in the horse.
Not to be used in horses intended for human consumption. Treated horses may never be slaughtered for human consumption. The horse must have been declared as not intended for human consumption under national horse passport legislation.
Pharmacotherapeutic group: Anti-inflammatory and antirheumatic products, non-steroids.
ATCvet code: QM01AA01
Phenylbutazone acts by inhibiting the production of prostaglandins. Prostaglandins possess a wide variety of physiological properties, including those involved in the production of pain, inflammation and pyrexia. The main metabolite, oxyphenbutazone, possesses similar pharmacological properties.
Phenylbutazone is generally well absorbed following oral administration. The rate, but not the extent, of absorption may be affected due to binding of phenylbutazone to food and the contents of the gastrointestinal tract. Therefore, it is recommended that Equipalazone Powder is administered mixed with a small amount of bran or oats. Phenylbutazone is highly bound to plasma proteins.
Shelf life of the veterinary medicinal product as packaged for sale: 4 years.
Do not store above 25°C. Store in a dry place.
Sachets of a paper/polyethylene outer layer and aluminium/polyethylene inner layer, in packs of 100 sachets (25 strips of four sachets) and of 32 sachets (8 strips of four sachets). Each sachet contains 1.5 g Equipalazone Powder. Not all pack sizes may be marketed.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with national requirements.
Dechra Limited, Snaygill Industrial Estate, Keighley Road, Skipton, North Yorkshire, BD23 2RW, United Kingdom.
26 August 1994
For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children.
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For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.
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Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.
To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.
*For full details on returns, see our terms and conditions page.
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