Butagran Equi 200mg/g, Oral Powder for Horses

Butagran Equi 200mg/g, Oral Powder for Horses
100 x 5g Sachet

  • 100 x 5g Sachet £87.49
  • 5g Sachet £0.89

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Description

For the treatment of musculo-skeletal conditions where relief from pain and a reduction in the associated inflammation is required e.g. in lameness associated with osteoarthritic conditions, bursitis, laminitis and soft tissue inflammation, particularly where continued mobility is considered desirable.

It is also of value in limiting post-surgical inflammation, myositis and other soft tissue inflammation. The product can be used as an anti-pyretic where this is considered advisable e.g. in viral respiratory infections.

Butagran Equi 200mg/g, Oral Powder for Horses

Species: Horses and other equidae Therapeutic indication: Pharmaceuticals: Anti-inflammatory preparations: Oral: Horse NSAIDs Active ingredient: Phenylbutazone Product:Butagran Equi 200mg/g, Oral Powder for Horses Product index: Butagran Equi Withdrawal notes: Horses: Not for use in horses intended for human consumption. Treated horses should never be slaughtered for human consumption. The horse must be declared as not intended for human consumption under national horse passport regulation.

Qualitative and quantitative composition

Per g: Active substance: Phenylbutazone 200 mg Also contains excipients including: Butter vanilla flavour

Pharmaceutical form

Oral powder. White powder.

Clinical particulars

Target species

Horses

Indications for use

The product is indicated for the treatment of musculo-skeletal conditions where relief from pain and a reduction in the associated inflammation is required e.g. in lameness associated with osteoarthritic conditions, bursitis, laminitis and soft tissue inflammation, particularly where continued mobility is considered desirable. It is also of value in limiting post-surgical inflammation, myositis and other soft tissue inflammation. The product can be used as an anti-pyretic where this is considered advisable e.g. in viral respiratory infections.

Contra-indications

Do not use in animals with known hypersensitivity to the active ingredient. Use is contraindicated in animals suffering from cardiac, hepatic or renal disease, where there is the possibility of gastrointestinal ulceration or bleeding or where there is evidence of a blood dyscrasia.

Special warnings for each target species

The clinical effects of phenylbutazone can be evident for at least three days following cessation of therapy. This should be borne in mind when examining horses for soundness. FEI regards phenylbutazone as a prohibited substance, it should not be administered at least 8 days before the competition.

Special precautions for use

i) Special precautions for use in animals Do not exceed the stated dose as the therapeutic index of phenylbutazone is low. Use in any animal less than 6 weeks of age or in aged animals may involve additional risk. If such use cannot be avoided, animals may require careful clinical management. Avoid use in any dehydrated, hypovolaemic or hypotensive animal as there is a potential risk of increased renal toxicity. Keep water readily available during the treatment period to avoid dehydration. NSAIDs can cause inhibition of phagocytosis and hence in the treatment of inflammatory conditions associated with bacterial infections, appropriate concurrent antimicrobial therapy should be instigated. ii) Special precautions to be taken by the person administering the veterinary medicinal product to animals Wash hands after use. Avoid contact with the eyes. In case of accidental eye contact, irrigate eyes with plenty of clean water. If irritation persists, seek medical advice. Care should be taken to avoid inhaling or ingesting the powder. In the event of accidental inhalation or ingestion seek medical advice and show the product packaging.

Adverse reactions

In common with other NSAIDs that inhibit prostaglandin synthesis, there may be gastric and/or renal intolerance. This is usually associated with overdosage and such events are rare. Recovery is usual on cessation of treatment and following the initiation of supportive symptomatic therapy. Ponies are very sensitive to gastric ulceration with this product, even at therapeutic doses (diarrhoea, ulceration in the mouth and hypoproteinaemia may also be seen).

Use during pregnancy, lactation or lay

Pregnancy: Care should be exercised if administered to pregnant mares. Although no adverse effects of phenylbutazone on the foetus or maintenance of pregnancy have been reported during field use, no definitive safety studies have been carried out in the mare. Foetotoxic effects of phenylbutazone have been recorded in experimental animal species at high dose levels. Lactation: The safety of the product in lactating mares has not been demonstrated If the administration of phenylbutazone to pregnant or lactating mares is considered essential the potential benefits should be weighed against the potential hazard to the mare and/or foal. Avoid use around time of parturition.

Interactions

Concurrent administration of potential nephrotoxic drugs should be avoided. Phenylbutazone is extensively bound to plasma proteins. It may displace other drugs that are highly protein-bound e.g. some sulphonamides, warfarin or it may itself be displaced to produce an increase in non-bound pharmacologically active concentrations, which can lead to toxic effects. Concurrent therapy with other therapeutic agents should be undertaken with caution due to the risk of metabolic interactions. Phenylbutazone may interfere with the metabolism of other drugs e.g. warfarin, barbiturates, with resultant toxicity. There is evidence to indicate that the pharmacokinetics of penicillin and gentamicin products may be affected by concurrent administration of products containing phenylbutazone with a possible reduction of therapeutic efficacy, since tissue penetration may be reduced. The distribution of other drugs given concurrently may also be affected. Do not administer other NSAIDs concurrently or within 24 hours of each other. Phenylbutazone induces hepatic microsomal enzyme activity.

Amounts to be administered and administration route

For oral administration. For each 450 kg of body weight the following dosage guide should be used according to individual response: Day 1: Two sachets or 10 g of product twice daily (equivalent to 4.4 mg of phenylbutazone/kg of BW on each occasion). Day 2-4: One sachet or 5 g of product twice daily (equivalent to 2.2 mg of phenylbutazone/kg of BW on each occasion) followed by one sachet or 5 g of product daily (2.2 mg of phenylbutazone/kg of BW daily) or on alternate days as required. If no response is evident after 4-5 days, discontinue treatment. Hay may delay the absorption of phenylbutazone and so the onset of a clinical effect. It is advisable not to administer hay immediately prior to, or during the administration of the product. For ease of administration the product may be mixed with a limited quantity of bran or oats.

Overdose

Overdosing may result in gastric and large intestinal ulceration and general enteropathy. Renal papillary damage may also occur with impaired renal function. Subcutaneous oedema, especially under the jaw may become evident due to plasma protein loss. There is no specific antidote. If signs of possible overdosage occur, treat the animal symptomatically.

Withdrawal periods

Not for use in horses intended for human consumption. Treated horses may never be slaughtered for human consumption. The horse must have been declared as not intended for human consumption under national horse passport legislation.

Pharmacological particulars

Pharmacotherapeutic group: Anti-inflammatory and antirheumatic products, non-steroids ATCvet-code: QM01AA01 Pharmacodynamic properties Phenylbutazone is a pryazolone non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and anti-pyretic activity. These pharmacodynamic effects are achieved by the inhibition of prostaglandin synthetase (cyclo-oxygenase). Pharmacokinetic properties The plasma elimination half life of phenylbutazone in the horse varies from 3.5 - 8 hours. Normally peak plasma levels are achieved approximately 2-3 hours after administration. Oral bioavailability is high but concurrent feeding of hay can delay the time to peak concentration, decreases the peak plasma concentrations and so delay the onset of a clinical effect. Phenylbutazone binds heavily to plasma albumin. Phenylbutazone is metabolised in the liver to oxyphenbutazone, which also has similar pharmacological activity. Further metabolism takes place to gamma- hydroxyphenylbutazone. Excretion is mainly via the urine.

Pharmaceutical particulars

Excipients

Glucose Monohydrate Methylhydroxypropylcellulose (Hypromellose) Butter vanilla flavour

Major incompatibilities

Do not mix this product with any other veterinary medicinal product.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 36 months. Shelf life after first opening the immediate packaging: use immediately after opening

Special precautions for storage

Do not store above 25°C

Immediate packaging

- Heat-sealed PET/LDPE/aluminium foil/LDPE laminated sachet of 5 grams of product; - Heat-sealed aluminium foil/LDPE/paper/LDPE laminated sachet of 5 grams of product. - Sachets are packed in a cardboard box containing 100 sachets for single use.

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Dopharma Research B.V. Zalmweg 24 4941 VX Raamsdonksveer The Netherlands

Marketing Authorisation Number

Vm : 28365/4004

Significant changes

Date of the first authorisation or date of renewal

08 February 2013

Date of revision of the text

September 2014

Any other information

Nil

Legal category

Legal category: POM-V

GTIN

GTIN description:BUTOGRAN 100 X 5G GTIN:8714377282854

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  • Landline: 01582 842096
  • Mon - Fri: 8:30am - 5:00pm
  • Sat: 9:00am - 1:00pm
  • Email: [email protected]

All prices include VAT where applicable.

Delivery Information

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Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to air freight restrictions aerosols cannot ever be sent abroad by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

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