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Benazecare Flavour Tablets for Dogs & Cats

Benazecare Flavour Tablets for Dogs & Cats
5mg Tablets for Dogs & Cats » Box of 14

  • 5mg Tablets for Dogs & Cats » Box of 14 £10.99
  • 5mg Tablets for Dogs & Cats » Box of 28 £22.00
  • 5mg Tablets for Dogs & Cats » Priced per Tablet £0.79
  • 20mg Tablets for Dogs » Box of 14 £22.00
  • 20mg Tablets for Dogs » Box of 28 £43.49
  • 20mg Tablets for Dogs » Priced per Tablet £1.60

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Description

Benazecare is used to treat congestive heart failure in dogs and chronic kidney failure in cats. In dogs with heart failure, benazeprilat reduces blood pressure and the total work load on the heart. In cats with poor kidney function, Benazecare lowers the protein loss in urine and also blood pressure. This helps to slow the advance of kidney disease, reducing further damage to the kidneys. Benazecare improves appetite, quality of life and expected life span of cats, especially those with advanced disease. Useful effects are normally seen after about 7 days treatment. Treatment should be continued for the rest of the animal's life.

Benazecare is often combined with other types of heart medication for dogs, to increase the overall benefit. Changes to the diet can also be beneficial to both dogs and cats under treatment. Veterinary advice should be taken regarding the most appropriate diets.

Please click here for the data sheet for Benazecare.

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Medication Datasheets

5mg Tablets for Dogs & Cats » Priced per Tablet

SUMMARY OF PRODUCT CHARACTERISTICS

  1. NAME OF THE VETERINARY MEDICINAL PRODUCT

Benazecare Flavour 5 mg Tablets for Dogs and Cats.

  1. QUALITATIVE AND QUANTITATIVE COMPOSITION

Active substance:

    Benazepril hydrochloride 5mg

For a full list of excipients, see section 6.1.

  1. PHARMACEUTICAL FORM

Tablet Beige oblong tablet with breakline on both sides.

  1. CLINICAL PARTICULARS

4.1 Target species

Dogs and cats.

4.2 Indications for use, specifying the target species

Dogs Treatment of congestive heart failure in dogs.

Cats Reduction of proteinuria associated with chronic kidney disease.

4.3 Contraindications

Do not use in case of hypersensitivity to the active substance or to any of the excipients. Do not use in cases of hypotension, hypovolaemia, hyponatraemia or acute renal failure. Do not use in cases of cardiac output failure due to aortic or pulmonary stenosis. Do not use during pregnancy or lactation (section 4.7).

4.4 Special warnings for each target species

None.

4.5 Special precautions for use

       i                      Special precautions for use in animals

No evidence of renal toxicity of the veterinary medicinal product has been observed (in dogs or cats) during clinical trials, however, as is routine in cases of chronic kidney disease, it is recommended to monitor plasma creatinine, urea and erythrocyte counts during therapy. The efficacy and safety of benazepril hydrochloride has not been established in dogs and cats below 2.5 kg body weight.

ii Special precautions to be taken by the person administering the veterinary medicinal product to animals

Wash hands after use. In case of accidental oral ingestion, seek medical advice immediately and show the label or the package leaflet to the physician. Pregnant women should take special care to avoid accidental oral exposure because angiotensin converting enzyme (ACE) inhibitors have been found to affect the unborn child during pregnancy in humans.

4.6 Adverse reactions (frequency and seriousness)

In double-blind clinical trials in dogs with congestive heart failure, benazepril hydrochloride was well tolerated with an incidence of adverse reactions lower than observed in placebo treated dogs.

A small number of dogs may exhibit transient vomiting, incoordination or signs of fatigue.

In cats and dogs with chronic kidney disease, benazepril hydrochloride may increase plasma creatinine concentrations at the start of therapy. A moderate increase in plasma creatinine concentrations following administration of ACE inhibitors is compatible with the reduction in glomerular hypertension induced by these agents, and is therefore not necessarily a reason to stop therapy in the absence of other signs.

Benazepril hydrochloride may increase food consumption and body weight in cats.

Emesis, anorexia, dehydration, lethargy and diarrhoea have been reported in rare occasions in cats.

4.7 Use during pregnancy, lactation or lay

Do not use during pregnancy or lactation. The safety of benazepril hydrochloride has not been established in breeding, pregnant or lactating dogs and cats. Benazepril hydrochloride reduced ovary/oviduct weights in cats when administered daily at 10 mg/kg body weight for 52 weeks. Embryotoxic effects (foetal urinary tract malformation) were seen in trials with laboratory animals (rats) at maternally non-toxic doses.

4.8 Interaction with other medicinal products and other forms of interaction

In dogs with congestive heart failure, benazepril hydrochloride has been given in combination with digoxin, diuretics, pimobendan and anti-arrhythmic veterinary medicinal products without demonstrable adverse interactions.

In humans, the combination of ACE inhibitors and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) can lead to reduced anti-hypertensive efficacy or impaired renal function. The combination of benazepril hydrochloride and other anti-hypertensive agents (e.g. calcium channel blockers, β-blockers or diuretics), anaesthetics or sedatives may lead to additive hypotensive effects. Therefore, concurrent use of NSAIDs or other medications with a hypotensive effect should be considered with care. Renal function and signs of hypotension (lethargy, weakness etc) should be monitored closely and treated as necessary.

Interactions with potassium preserving diuretics like spironolactone, triamterene or amiloride cannot be ruled out. It is recommended to monitor plasma potassium levels when using benazepril hydrochloride in combination with a potassium sparing diuretic because of the risk of hyperkalaemia.

4.9 Amounts to be administered and administration route

Benazecare Flavour 5mg tablets should be given orally once daily, with or without food. The duration of treatment is unlimited.

Dogs Benazecare Flavour 5mg tablets should be administered orally at a minimum dose of 0.25 mg (range 0.25-0.5) benazepril hydrochloride/kg body weight once daily, according to the following table:

BENAZECARE FLAVOUR 5mg

Weight of dog (kg) Standard Dose Double Dose 5 – 10

10 – 20 0.5 tablet 1 tablet 1 tablet 2 tablets

The dose may be doubled, still administered once daily, to a minimum dose of 0.5 mg/kg (range 0.5-1.0), if judged clinically necessary and advised by the veterinary surgeon.

Cats Benazecare Flavour 5mg tablets should be administered orally at a minimum dose of 0.5 mg (range 0.5-1.0) benazepril hydrochloride/kg body weight once daily according to the following table:

Weight of cat (kg) BENAZACARE FLAVOUR 5mg 2.5 – 5 0.5 tablet

5 - 10 1 tablet

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary

Benazepril hydrochloride reduced erythrocyte counts in normal cats when dosed at 10 mg/kg body weight once daily for 12 months and in normal dogs when dosed at 150 mg/kg body weight once daily for 12 months, but this effect was not observed at the recommended dose during clinical trials in cats or dogs. Transient reversible hypotension may occur in cases of accidental overdose. Therapy should consist of intravenous infusion of warm isotonic saline.

4.11 Withdrawal period

Not applicable.

  1. PHARMACOLOGICAL PROPERTIES

Pharmacotherapeutic group: ACE Inhibitors, plain. ATC vet code: QC09AA07

Pharmacodynamic properties

Benazepril hydrochloride is a prodrug hydrolysed in vivo to its active metabolite, benazeprilat. Benazeprilat is a highly potent and selective inhibitor of ACE, thus preventing the conversion of inactive angiotensin I to active angiotensin II and thereby also reducing synthesis of aldosterone. Therefore, it blocks effects mediated by angiotensin II and aldosterone, including vasoconstriction of both arteries and veins, retention of sodium and water by the kidney and remodelling effects (including pathological cardiac hypertrophy and degenerative renal changes).

Benazepril hydrochloride causes long-lasting inhibition of plasma ACE activity in dogs and cats, with more than 95% inhibition at peak effect and significant activity (>80% in dogs and >90% in cats) persisting 24 hours after dosing.

Benazepril hydrochloride reduces the blood pressure and volume load on the heart in dogs with congestive heart failure.

In cats with experimental renal insufficiency, benazepril hydrochloride normalized the elevated glomerular capillary pressure and reduced the systemic blood pressure.

Reduction in glomerular hypertension may retard the progression of kidney disease by inhibition of further damage to the kidneys. Placebo controlled clinical field studies in cats with chronic kidney disease (CKD) have demonstrated that benazepril hydrochloride significantly reduced levels of urine protein and urine protein to creatinine ratio (UPC); this effect is probably mediated via reduced glomerular hypertension and beneficial effects on the glomerular basement membrane. No effect of benazepril hydrochloride on survival in cats with CKD has been shown,but benazepril hydrochloride increased the appetite of the cats, particularly in more advanced cases.

5.2 Pharmacokinetic particulars

After oral administration of benazepril hydrochloride, peak levels of benazepril are attained rapidly (Tmax 0.5 hour in dogs and within 2 hours in cats) and decline quickly as the active substance is partially metabolised by liver enzymes to benazeprilat. The systemic bioavailability is incomplete (~13% in dogs) due to incomplete absorption (38% in dogs, <30% in cats) and first pass metabolism. In dogs, peak benazeprilat concentrations (Cmax of 37.6 ng/ml after a dose of 0.5 mg/kg benazepril hydrochloride) are achieved with a Tmax of 1.25 hours. In cats, peak benazeprilat concentrations (Cmax of 77.0 ng/ml after a dose of 0.5 mg/kg benazepril hydrochloride) are achieved with a Tmax of 2 hours.

Benazeprilat concentrations decline biphasically: the initial fast phase (t1/2=1.7 hours in dogs and t1/2=2.4 hours in cats) represents elimination of free drug, while the terminal phase (t1/2=19 hours in dogs and t1/2=29 hours in cats) reflects the release of benazeprilat that was bound to ACE, mainly in the tissues. Benazepril and benazeprilat are extensively bound to plasma proteins (85-90%), and in tissues are found mainly in the liver and kidney.

There is no significant difference in the pharmacokinetics of benazeprilat when benazepril hydrochloride is administered to fed or fasted dogs. Repeated administration of benazepril hydrochloride leads to slight bioaccumulation of benazeprilat (R=1.47 in dogs and R=1.36 in cats with 0.5 mg/kg), steady state being achieved within a few days (4 days in dogs).

Benazeprilat is excreted 54% via the biliary and 46% via the urinary route in dogs and 85% via the biliary and 15% via the urinary route in cats. The clearance of benazeprilat is not affected in dogs or cats with impaired renal function and therefore no adjustment of benazepril hydrochloride dose is required in either species in cases of renal insufficiency.

  1. PHARMACEUTICAL PARTICULARS

6.1 List of excipients

Lactose monohydrate Pregelatinized starch Croscarmellose sodium Castor oil, hydrogenated Beef flavour 201627

6.2 Incompatibilities

None known 6.3 Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years

Shelf life after first opening the immediate packaging: 48 hours. Any divided tablet portion remaining after 48 hours should be discarded.

6.4 Special precautions for storage

Do not store above 25C. Store in a dry place.

Divided tablets should be stored in the blister pack. The blister pack should be inserted back into the cardboard box.

6.5 Nature and composition of immediate packaging

Aluminium/aluminium blister packs containing 14 tablets, packed in a cardboard box with a package leaflet. Benazecare Flavour 5 mg tablets are supplied in packs of 14, 28, 56 or 140 tablets. Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

  1. MARKETING AUTHORISATION HOLDER

Animalcare Ltd 10 Great North Way York Business Park Nether Poppleton York YO26 6RB

  1. MARKETING AUTHORISATION NUMBER

Vm 10347/4021

  1. DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION

Date: 24th August 2011

  1. DATE OF REVISION OF THE TEXT

Date: July 2013 Approved: 26/07/2013

20mg Tablets for Dogs » Priced per Tablet

SUMMARY OF PRODUCT CHARACTERISTICS

NAME OF THE VETERINARY MEDICINAL PRODUCT

Benazecare Flavour 20 mg Tablets for Dogs

  1. QUALITATIVE AND QUANTITATIVE COMPOSITION
    

    Active substance:

      Each tablet contains 20 mg benazepril hydrochloride
    

    For a full list of excipients, see section 6.1.

  2. PHARMACEUTICAL FORM
    

    Tablet Beige oblong tablet with breakline on both sides.

  3. CLINICAL PARTICULARS
    

4.1 Target species

Dogs

4.2 Indications for use, specifying the target species

Dogs: Treatment of congestive heart failure.

4.3 Contraindications

Do not use in case of hypersensitivity to the active substance or to any of the excipients. Do not use in cases of hypotension, hypovolaemia, hyponatraemia or acute renal failure. Do not use in cases of cardiac output failure due to aortic or pulmonary stenosis. Do not use during pregnancy or lactation (section 4.7).

4.4 Special warnings for each target species

None.

4.5 Special precautions for use

  Special precautions for use in animals

No evidence of renal toxicity of the veterinary medicinal product has been observed in dogs during clinical trials, however, as is routine in cases of chronic kidney disease, it is recommended to monitor plasma creatinine, urea and erythrocyte counts during therapy.

ii Special precautions to be taken by the person administering the veterinary medicinal product to animals

Wash hands after use. In case of accidental oral ingestion, seek medical advice immediately and show the label or the package leaflet to the physician. Pregnant women should take special care to avoid accidental oral exposure because angiotensin converting enzyme (ACE) inhibitors have been found to affect the unborn child during pregnancy in humans.

4.6 Adverse reactions (frequency and seriousness)

In double-blind clinical trials in dogs with congestive heart failure, benazepril hydrochloride was well tolerated with an incidence of adverse reactions lower than observed in placebo-treated dogs.

A small number of dogs may exhibit transient vomiting, incoordination or signs of fatigue.

In dogs with chronic kidney disease, benazepril hydrochloride may increase plasma creatinine concentrations at the start of therapy. A moderate increase in plasma creatinine concentrations following administration of ACE inhibitors is compatible with the reduction in glomerular hypertension induced by these agents, and is therefore not necessarily a reason to stop therapy in the absence of other signs.

4.7 Use during pregnancy, lactation or lay

Do not use during pregnancy or lactation. The safety of benazepril hydrochloride has not been established in breeding, pregnant or lactating dogs. Embryotoxic effects (foetal urinary tract malformation) were seen in trials with laboratory animals (rats) at maternally non-toxic doses..

4.8 Interaction with other medicinal products and other forms of interaction

In dogs with congestive heart failure, benazepril hydrochloride has been given in combination with digoxin, diuretics, pimobendan and anti-arrhythmic veterinary medicinal products without demonstrable adverse interactions.

In humans, the combination of ACE inhibitors and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) can lead to reduced anti-hypertensive efficacy or impaired renal function. The combination of benazepril hydrochloride and other anti-hypertensive agents (e.g. calcium channel blockers, β-blockers or diuretics), anaesthetics or sedatives may lead to additive hypotensive effects. Therefore, concurrent use of NSAIDs or other medications with a hypotensive effect should be considered with care. Renal function and signs of hypotension (lethargy, weakness etc) should be monitored closely and treated as necessary. Interactions with potassium preserving diuretics like spironolactone, triamterene or amiloride cannot be ruled out. It is recommended to monitor plasma potassium levels when using benazepril hydrochloride in combination with a potassium sparing diuretic because of the risk of hyperkalaemia.

4.9 Amounts to be administered and administration route

Benazecare Flavour 20mg tablets should be given orally once daily, with or without food. The duration of treatment is unlimited.

Benazecare Flavour 20mg tablets should be administered orally at a minimum dose of 0.25 mg (range 0.25-0.5) benazepril hydrochloride/kg body weight once daily, according to the following table:

BENAZECARE FLAVOUR 20mg

Weight of dog (kg) Standard Dose Double Dose

20 – 40 40 – 80 0.5 tablet 1 tablet 1 tablet 2 tablets

The dose may be doubled, still administered once daily, to a minimum dose of 0.5 mg/kg (range 0.5-1.0), if judged clinically necessary and advised by the veterinary surgeon.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary

Benazepril hydrochloride reduced erythrocyte counts in normal dogs when dosed at 150 mg/kg body weight once daily for 12 months, but this effect was not observed at the recommended dose during clinical trials in dogs. Transient reversible hypotension may occur in cases of accidental overdose. Therapy should consist of intravenous infusion of warm isotonic saline.

4.11 Withdrawal period

Not applicable.

  1. PHARMACOLOGICAL PROPERTIES

Pharmacotherapeutic group: ACE Inhibitors, plain. ATC vet code: QC09AA07

Pharmacodynamic properties

Benazepril hydrochloride is a prodrug hydrolysed in vivo to its active metabolite, benazeprilat. Benazeprilat is a highly potent and selective inhibitor of ACE, thus preventing the conversion of inactive angiotensin I to active angiotensin II and thereby also reducing synthesis of aldosterone. Therefore, it blocks effects mediated by angiotensin II and aldosterone, including vasoconstriction of both arteries and veins, retention of sodium and water by the kidney and remodelling effects (including pathological cardiac hypertrophy and degenerative renal changes).

Benazepril hydrochloride causes long-lasting inhibition of plasma ACE activity, with more than 95% inhibition at peak effect and significant activity (>80% in dogs) persisting 24 hours after dosing.

Benazepril hydrochloride reduces the blood pressure and volume load on the heart in dogs with congestive heart failure.

5.2 Pharmacokinetic particulars

After oral administration of benazepril hydrochloride, peak levels of benazepril are attained rapidly (Tmax 0.5 hour in dogs) and decline quickly as the active substance is partially metabolised by liver enzymes to benazeprilat. The systemic bioavailability is incomplete (~13% in dogs) due to incomplete absorption (38% in dogs) and first pass metabolism. In dogs, peak benazeprilat concentrations (Cmax of 37.6 ng/ml after a dose of 0.5 mg/kg benazepril hydrochloride) are achieved with a Tmax of 1.25 hours.

Benazeprilat concentrations decline biphasically: the initial fast phase (t1/2=1.7 hours in dogs) represents elimination of free drug, while the terminal phase (t1/2=19 hours in dogs) reflects the release of benazeprilat that was bound to ACE, mainly in the tissues. Benazepril and benazeprilat are extensively bound to plasma proteins (85-90%), and in tissues are found mainly in the liver and kidney.

There is no significant difference in the pharmacokinetics of benazeprilat when benazepril hydrochloride is administered to fed or fasted dogs. Repeated administration of benazepril hydrochloride leads to slight bioaccumulation of benazeprilat (R=1.47 in dogs with 0.5 mg/kg), steady state being achieved within a few days (4 days in dogs).

Benazeprilat is excreted 54% via the biliary and 46% via the urinary route in dogs. The clearance of benazeprilat is not affected in dogs with impaired renal function and therefore no adjustment of benazepril hydrochloride dose is required in cases of renal insufficiency.

  1. PHARMACEUTICAL PARTICULARS

6.1 List of excipients

Lactose monohydrate Pregelatinized starch Croscarmellose sodium Castor oil, hydrogenated Beef flavour 201627

6.2 Incompatibilities

None known

6.3 Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years

Shelf life after first opening the immediate packaging: 48 hours. Any divided tablet portion remaining after 48 hours should be discarded.

6.4 Special precautions for storage

Do not store above 25C. Store in a dry place. Divided tablets should be stored in the blister pack. The blister pack should be inserted back into the cardboard box.

6.5 Nature and composition of immediate packaging

Aluminium/aluminium blister packs containing 14 tablets packed in a cardboard box with a package leaflet. Benazecare Flavour 20 mg tablets are supplied in packs of 14, 28, 56 or 140 tablets. Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

  1. MARKETING AUTHORISATION HOLDER

Animalcare Ltd 10 Great North Way York Business Park Nether Poppleton York YO26 6RB

  1. MARKETING AUTHORISATION NUMBER

Vm 10347/4022

  1. DATE OF FIRST AUTHORISATION

Date: 24 August 2011

  1.  DATE OF REVISION OF THE TEXT
    

    Date: July 2013

Approved: 26/07/2013

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