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Baycox
2.5% Solution (for Poultry) » 1 litre Bottle

  • 2.5% Solution (for Poultry) » 1 litre Bottle £97.49
  • 50mg/ml Suspension for Piglets, Lambs and Calves » 250ml Bottle £63.73
  • 50mg/ml Suspension for Piglets, Lambs and Calves » 1 litre Bottle £227.41

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£63.73 to £227.41

Description

Baycox is used to treat coccidiosis in young, growing animals. Two forms are available: one is for poultry and the other for piglets, lambs and calves. For poultry it is generally added to drinking water for 2 days. This can be repeated 5 days later for severe infections.
For piglets, lambs and calves, a single dose is normally given just before the onset of clinical signs.

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Medication Datasheets

2.5% Solution (for Poultry) » 1 litre Bottle

Baycox 25 mg/ml, solution for use in drinking water for chickens and turkeys

Presentation

A colourless to brown solution for use in drinking water containing 25 mg/ml toltrazuril as active substance.

Uses

For the treatment of coccidiosis in chickens (broilers, pullets and breeders) and turkeys, caused by infections with various species of Eimeria:

Chickens: E. acervulina, E. brunetti, E. maxima, E. mitis, E. necatrix, E. tenella.

Turkeys: E. adenoides and E. meleagrimitis.

Dosage and administration

For oral administration via the drinking water.

In order to ensure administration of a correct dose, accurately determine the body weight of the animals.

The dose is 7 mg toltrazuril per kg body weight (bw) per day (equivalent to 0.28 ml Baycox 25 mg/ml solution per kg bw per day). Treatment is carried out on two consecutive days.

The medicinal product should be administered either continuously over 24 hours or for one period of 8 hours per day – for 2 consecutive days.

Medicated drinking water should be refreshed every 24 hours.

The dosage should be based on the current, actual drinking water intake of the birds, because this varies depending on the bird species, on the age, state of health and intended use of the birds, and depending on the housing conditions (e.g. different ambient temperature, different lighting regime).

In the case of continuous treatment over 24 hours, the volume of the product to be mixed into the drinking water for the birds to be treated is calculated according to the following formula:

(0.28 ml [product] per kg bw per day x Average bw (kg) of the birds to be treated) ÷ Average drinking water intake in litres over 24 hours per bird = x ml [product] per litre drinking water.

Total volume of the product required per day (24 h):

The calculated volume (x ml [product] per litre) must be multiplied by the total consumption of drinking water (l) per day (24 h).

In the case of treatment for a period of 8 hours per day, the volume of the product to be mixed into the drinking water for the birds to be treated is calculated according to the following formula:

(0.28 ml [product] per kg bw per day x Average bw (kg) of the birds to be treated) ÷ Average drinking water intake in litres over 8 hours per bird = y ml [product] per litre drinking water.

Total volume of the product required for a treatment period of 8 hours: The calculated volume (y ml [product] per litre) must be multiplied by the total consumption of drinking water (l) per 8-hour period.

The appropriate volume of solution must be added daily to the drinking water while stirring.

If volumes of between 1 and 4 ml product are added per litre drinking water, solubility is guaranteed over the period of treatment.

In order to ensure that all the birds drink water evenly, sufficient space must be made available at the waterer. Free-range birds must be kept indoors during treatment.

After the end of the treatment, the watering system must be cleaned in an appropriate manner in order to prevent any exposure to residual subtherapeutic doses, particularly if liable to promote the development of resistance. Predilution and the administration through a dosing pump (proportioner) are not recommended. Use preferably a bulk tank.

Use during lay

Not authorised for use in poultry producing eggs for human consumption.

Contra-indications, warnings, etc

Do not use in birds with hypersensitivity to the active substance or to any of the excipients.

Hygiene measures help to reduce the risk of coccidiosis. It is therefore recommended that attention be paid during treatment to hygiene in confinement buildings, particularly in terms of general cleanliness and moisture reduction.

It is recommended to treat all animals in a pen. For best results, treatment should be initiated before the clinical signs of disease have spread throughout the whole group.

As with any antiparasitic agent, frequent and repeated use of antiprotozoal agents from the same class of active substances and underdosing due to underestimation of the live weight can lead to the development of resistance. It is important to keep to the recommended dose in order to minimise the risk of resistance.

A reduction in drinking water intake may be the first sign of an overdose. This is observed only after an overdose with more than 10 times the recommended dose.

Withdrawal periods

Chickens: Meat and offal: 16 days

Turkeys: Meat and offal: 16 days

Not authorised for use in poultry producing eggs for human consumption.

Do not use in pullets beyond the 15th week of life.

User Safety

Wear synthetic rubber gloves when handling the product.

Do not ingest. In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.

People with known hypersensitivity to the active substance should avoid contact with the veterinary medicinal product.

The veterinary medicinal product is an alkaline solution.

In case of direct contact with the eyes or skin, wash immediately and thoroughly with water.

Do not eat, drink or smoke during use.

Wash hands after use.

Environmental Safety

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Pharmaceutical precautions

In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

Shelf life of the veterinary medicinal product as packaged for sale: 5 years.

Shelf life after first opening the immediate packaging: 3 months

After a prolonged storage period, yellow to yellow-brown discoloration of the solution may occur, although this does not impair the quality of the product.

Shelf life after dilution or reconstitution according to directions: 24 hours.

Do not store above 25ºC.

Legal category

Packaging quantities

1000 ml white HDPE bottles closed with light green polypropylene screw cap with a red tamper evident seal.

Further information

Pharmacotherapeutic group: Antiprotozoal, triazine. ATCvet code: QP51AJ01.

Toltrazuril is an anticoccidial of the triazinetrione group, active against Eimeria spp. Toltrazuril induces changes in the fine structure of the developmental stages of coccidia. These are caused primarily by swelling of the endoplasmic reticulum and of the Golgi apparatus, abnormal changes to the perinuclear space and disturbances in cell division. Toltrazuril causes a decrease in the activity of respiratory chain enzymes in the parasites.

Toltrazuril undergoes at least 50% absorption in poultry. The highest concentrations are to be found in the liver and kidneys of the poultry. The active substance is broken down rapidly. The main metabolite is toltrazuril sulfone.

Marketing Authorisation Number

Vm 00010/4182

50mg/ml Suspension for Piglets, Lambs and Calves » 1 litre Bottle

SUMMARY OF PRODUCT CHARACTERISTICS

  1. NAME OF THE VETERINARY MEDICINAL PRODUCT

Baycox 50 mg/ml oral suspension for Piglets, Calves and Lambs

  1. QUALITATIVE AND QUANTITATIVE COMPOSITION

    1 ml contains:

Active substance:

Toltrazuril 50 mg

Excipients:

Sodium benzoate (E211) 2.1 mg Sodium propionate (E281) 2.1 mg

For a full list of excipients, see section 6.1.

  1. PHARMACEUTICAL FORM

Oral suspension White or yellowish suspension

  1. CLINICAL PARTICULARS

4.1 Target species

Pig (piglets), Calves (on dairy farms – see section 4.3) and Sheep (lambs)

4.2 Indications for use, specifying the target species

Piglets: For the prevention of clinical signs of coccidiosis in neonatal piglets on farms with a confirmed history of coccidiosis caused by Isospora suis.

Calves: For the prevention of clinical signs of coccidiosis and reduction of coccidia shedding in housed calves replacing cows producing milk for human consumption (dairy cows) on farms with a confirmed history of coccidiosis caused by Eimeria bovis or Eimeria zuernii.

Lambs: For the prevention of clinical signs of coccidiosis and reduction of coccidia shedding in lambs on farms with a confirmed history of coccidiosis caused by Eimeria crandallis and Eimeria ovinoidalis.

4.3 Contraindications

For environmental reasons: Do not use in calves weighing more than 80 kg bodyweight. Do not use in fattening units such as veal or beef calves For more details see sections 4.5, other precautions and section 5.3, environmental properties.

4.4 Special warnings

As with any antiparasiticide frequent and repeated use of antiprotozoals from the same class may lead to the development of resistance. It is recommended to treat all animals in a pen

Hygienic measures may reduce the risk of coccidiosis. It is therefore, recommended to improve concomitantly the hygienic conditions in the concerned facility, particularly dryness and cleanliness.

To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period.

To alter the course of an established clinical coccidial infection, in individual animals already showing signs of diarrhoea, additional supportive therapy may be required.

4.5 Special precautions for use

Special precautions for use in animals

ii. Special precautions to be taken by the person administering the veterinary medicinal product to animals

Wash any splashes from skin or eyes immediately with water.

iii. Other Precautions

The major metabolite of toltrazuril, toltrazuril sulfone (ponazuril), has been shown to be both persistent (half-life >1 year) and mobile in soil and to be toxic to plants.

For environmental reasons:

In order to prevent any adverse effects on plants and possible contamination of groundwater manure from treated calves must not be spread onto land without dilution with manure from untreated cows. Manure from treated calves must be diluted with at least 3 times the weight of manure from mature cows before it can be spread onto land.

Lambs kept throughout the whole life span indoors under an intensive rearing system must not be treated beyond the age of 6 weeks or body weight of more than 20 kg at treatment. Manure from these animals should only be applied to the same piece of land every third year.

4.6 Adverse reactions (frequency and seriousness)

None known

4.7 Use during pregnancy, lactation or lay

Laboratory studies in rat and rabbit have not produced any evidence of a teratogenic, foetotoxic or maternotoxic effect.

4.8 Interaction with other medicinal products and other forms of interaction

None known

4.9 Amounts to be administered and administration route

All Species

The ready-to-use oral suspension must be shaken before use.

Piglets

Individual animal treatment. Each pig to be treated on day 3-5 of life with a single oral dose of 20 mg toltrazuril/kg body weight corresponding to 0.4 ml oral suspension per kg body weight. Due to the small volumes required to treat individual piglets, use of dosing equipment with a dose accuracy of 0.1 ml is recommended. Treatment during an outbreak will be of limited value for the individual piglet because of damage to the small intestine having already occurred.

Calves

Each animal should be treated with a single oral dose of 15 mg toltrazuril/kg body weight corresponding to 3.0 ml oral suspension per 10 kg body weight. For the treatment of a group of animals of the same breed and same or similar age, the dosing should be done according to the heaviest animal of this group. To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period.

Lambs

Each animal should be treated with a single oral dose of 20 mg toltrazuril/kg body weight corresponding to 0.4 ml oral suspension per kg body weight. To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period. If animals are to be treated collectively rather than individually, they should be grouped according to their body weight and dosed accordingly, in order to avoid under- or over-dosing.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary

A threefold overdose is well tolerated by healthy piglets and calves without signs of intolerance.

No signs of overdose have been observed in lamb safety studies with threefold overdose at a single treatment and twofold overdose treatment on 2 consecutive days.

4.11 Withdrawal period(s)

Piglets

Meat and offal: 77 days

Calves

Meat and offal: 63 days Not permitted for use in lactating animals producing milk for human consumption.

Lambs

Meat and offal: 42 days Not permitted for use in lactating sheep producing milk for human consumption.

  1. PHARMACOLOGICAL PROPERTIES

Pharmacotherapeutic group: Antiprotozo-products, ATCvet code: QP51AJ01

5.1 Pharmacodynamic properties

Toltrazuril is a triazinon derivative. It acts against coccidia of the genus Isospora and Eimeria. It is acting against all intracellular development stages of coccidia of the merogony (asexual multiplication) and gamogony (sexual phase). All stages are destroyed, thus the mode of action is coccidiocidal.

5.2 Pharmacokinetic particulars

Piglets

After oral administration toltrazuril is slowly absorbed with a bioavailability of 70%. The main metabolite is characterised as toltrazuril sulfone. The elimination of toltrazuril is slow with a half-life elimination time around 3 days. The major route of excretion is via the faeces. Calves

After oral administration in cattle toltrazuril is slowly absorbed. The maximal plasma concentration (Cmax = 36.6 mg/l) was observed between 24 and 48 hours (geometric mean 33.9 hours) following oral administration. The elimination of toltrazuril is slow with a terminal half-life time of approximately 2.5 days (64.2 hours). The main metabolite is characterised as toltrazuril sulfone. The major route of excretion is via the faeces.

Lambs

After oral administration toltrazuril is slowly absorbed in mammals. The main metabolite is characterised as toltrazuril sulfone. The maximal plasma concentration (Cmax = 62 mg/L) was observed 2 days following oral administration. The elimination of toltrazuril is slow with an elimination half-life time of approximately 9 days. The major route of excretion is via the faeces

5.3 Environmental properties

The metabolite of toltrazuril, toltrazuril sulfone (ponazuril) is a persistent (half-life >1 year) and mobile compound and has adverse effects on both the growth and emergence of plants. Given the persistent properties of ponazuril repeated spreading of manure from treated animals may lead to an accumulation in the soil and consequently a risk to plants. The accumulation of ponazuril in soil together with its mobility also leads to a risk of leaching to groundwater. See also sections 4.3 and 4.5.

  1. PHARMACEUTICAL PARTICULARS

6.1 List of excipients

Sodium benzoate (E211)
Sodium propionate (E281)
Docusate sodium Simethicone emulsion Bentonite Citric acid, anhydrous Xanthan gum Propylene glycol Purified water,

6.2 Incompatibilities

None known.

6.3 Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 5 years

Shelf-life after first opening the container: 3 months.

6.4. Special precautions for storage

No special precautions for storage

6.5 Nature and composition of immediate packaging

High density polyethylene bottles containing 100, 250, 1,000 ml of a white or yellowish suspension with a blue polypropylene screw cap for the 100 ml bottle, and a green one for the 250 ml bottle and 1000 ml bottle.

Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

  1. MARKETING AUTHORISATION HOLDER

Bayer plc 400 South Oak Way Green Park Reading Berkshire RG2 6AD

  1. MARKETING AUTHORISATION NUMBER

Vm 00010/4170

  1. DATE OF FIRST AUTHORISATION

20 August 2009

  1. DATE OF REVISION OF THE TEXT

May 2017

Approved: 05 May 2017

50mg/ml Suspension for Piglets, Lambs and Calves » 250ml Bottle

Baycox 50 mg/ml Oral Suspension for Piglets, Calves and Lambs

Presentation

Baycox 50 mg/ml oral suspension for Piglets, Calves and Lambs is a white or yellowish oral suspension containing as active ingredient 50 mg/ml toltrazuril with sodium benzoate (E211) 2.1 mg/ml and sodium propionate (E281) 2.1 mg/ml.

Uses

Cattle (Calves - on dairy farms)

Sheep (Lambs)

Piglets

For the prevention of clinical signs of coccidiosis in neonatal piglets on farms with a confirmed history of coccidiosis caused by Isospora suis.

Calves

For the prevention of clinical signs of coccidiosis and reduction of coccidia shedding in housed calves replacing cows producing milk for human consumption (dairy cows) on farms with a confirmed history of coccidiosis caused by Eimeria bovis or Eimeria zuernii.

Lambs

For the prevention of clinical signs of coccidiosis and reduction of coccidia shedding in lambs on farms with a confirmed history of coccidiosis caused by Eimeria crandallis and Eimeria ovinoidalis.

Dosage and administration

The ready-to-use oral suspension must be shaken before use.

Piglets: Individual animal treatment. Each pig to be treated on day 3-5 of life with a single oral dose of 20 mg toltrazuril/kg body weight corresponding to 0.4 ml oral suspension per kg body weight. Due to the small volumes required to treat individual piglets, use of dosing equipment with a dose accuracy of 0.1 ml is recommended. Treatment during an outbreak will be of limited value for the individual piglet because of damage to the small intestine having already occurred.

Calves: Each animal should be treated with a single oral dose of 15 mg toltrazuril/kg body weight corresponding to 3.0 ml oral suspension per 10 kg body weight.

For the treatment of a group of animals of the same breed and same or similar age, the dosing should be done according to the heaviest animal of this group.

To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period.

Lambs: Each animal should be treated with a single oral dose of 20 mg toltrazuril/kg body weight corresponding to 0.4 ml oral suspension per kg body weight. To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period.

If animals are to be treated collectively rather than individually, they should be grouped according to their body weight and dosed accordingly, in order to avoid under- or over-dosing.

Use during pregnancy and lactation

Laboratory studies in rat and rabbit have not produced any evidence of a teratogenic, foetotoxic or maternotoxic effect.

Contra-indications, warnings, etc

For environmental reasons:

Do not use in calves weighing more than 80 kg bodyweight.

Do not use in fattening units such as veal or beef calves.

For more details see environmental safety.

As with any antiparasiticide frequent and repeated use of antiprotozoals from the same class may lead to the development of resistance. It is recommended to treat all animals in a pen.

Hygienic measures may reduce the risk of coccidiosis. It is therefore, recommended to improve concomitantly the hygienic conditions in the concerned facility, particularly dryness and cleanliness.

To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period.

To alter the course of an established clinical coccidial infection, in individual animals already showing signs of diarrhoea, additional supportive therapy may be required.

A threefold overdose is well tolerated by healthy piglets and calves without signs of intolerance.

No signs of overdose have been observed in lamb safety studies with threefold overdose at a single treatment and twofold overdose treatment on 2 consecutive days.

Withdrawal period(s)

Piglets

Meat and offal: 77 days

Calves

Meat and offal: 63 days

Not permitted for use in lactating animals producing milk for human consumption.

Lambs

Meat and offal: 42 days

Not permitted for use in lactating sheep producing milk for human consumption.

User Safety

Wash any splashes from skin or eyes immediately with water.

Environmental Safety

The major metabolite of toltrazuril, toltrazuril sulfone (ponazuril), has been shown to be both persistent (half-life >1 year) and mobile in soil and to be toxic to plants.

For environmental reasons:

In order to prevent any adverse effects on plants and possible contamination of groundwater, manure from treated calves must not be spread onto land without dilution with manure from untreated cows. Manure from treated calves must be diluted with at least 3 times the weight of manure from mature cows before it can be spread onto land.

Lambs kept throughout the whole life span indoors under an intensive rearing system must not be treated beyond the age of 6 weeks or body weight of more than 20 kg at treatment. Manure from these animals should only be applied to the same piece of land every third year.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Pharmaceutical precautions

No special precautions for storage.

Shelf-life of the veterinary medicinal product as packaged for sale: 5 years.

Shelf-life after first opening the container: 3 months.

Legal category

Packaging quantities

High density polyethylene bottles containing 250 or 1,000 ml of a white or yellowish suspension with a green polypropylene screw cap.

Further information

Pharmacotherapeutic group: Antiprotozo-products, ATCvet code: QP51AJ01

Toltrazuril is a triazinon derivative. It acts against coccidia of the genus Isospora and Eimeria. It is acting against all intracellular development stages of coccidia of the merogony (asexual multiplication) and gamogony (sexual phase). All stages are destroyed, thus the mode of action is coccidiocidal.

Piglets

After oral administration toltrazuril is slowly absorbed with a bioavailability of ≥70%. The main metabolite is characterised as toltrazuril sulfone. The elimination of toltrazuril is slow with a half-life elimination time around 3 days. The major route of excretion is via the faeces.

Calves

After oral administration in cattle toltrazuril is slowly absorbed. The maximal plasma concentration (Cmax = 36.6 mg/l) was observed between 24 and 48 hours (geometric mean 33.9 hours) following oral administration. The elimination of toltrazuril is slow with a terminal half-life time of approximately 2.5 days (64.2 hours). The main metabolite is characterised as toltrazuril sulfone. The major route of excretion is via the faeces.

Lambs

After oral administration toltrazuril is slowly absorbed in mammals. The main metabolite is characterised as toltrazuril sulfone. The maximal plasma concentration (Cmax = 62 mg/L) was observed 2 days following oral administration. The elimination of toltrazuril is slow with an elimination half-life time of approximately 9 days. The major route of excretion is via the faeces.

Environmental properties

The metabolite of toltrazuril, toltrazuril sulfone (ponazuril) is a persistent (half-life >1 year) and mobile compound and has adverse effects on both the growth and emergence of plants. Given the persistent properties of ponazuril repeated spreading of manure from treated animals may lead to an accumulation in the soil and consequently a risk to plants. The accumulation of ponazuril in soil together with its mobility also leads to a risk of leaching to groundwater.

Marketing Authorisation Number

Vm 00010/4170

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (2)

Q & A

Below are some recent questions we've received regarding Baycox, including answers from our team.

16 December 2014 at 7:34pm

Canaries

R. Greaves

is baycox safe to use to treat canaries,
if so at what dosage.

  • Non-Executive Director

This has been used in drinking water at a concentration of 180mg/l. You would have to check with your own vet before buying any as we are not permitted to prescribe it for species not in the datasheet.