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  • 2.5% Solution (for Poultry) » 1 litre Bottle £74.88
  • 50mg/ml Suspension for Piglets, Lambs and Calves » 250ml Bottle £50.90
  • 50mg/ml Suspension for Piglets, Lambs and Calves » 1 litre Bottle £178.41

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Description

Baycox is used to treat coccidiosis in young, growing animals. Two forms are available: one is for poultry and the other for piglets, lambs and calves. For poultry it is generally added to drinking water for 2 days. This can be repeated 5 days later for severe infections.
For piglets, lambs and calves, a single dose is normally given just before the onset of clinical signs.

Baycox 2.5% Oral Solution

Presentation

A clear colourless to brown oral solution containing as active ingredient 2.5% w/v (25 mg/ml) toltrazuril for dilution in drinking water and subsequent administration. The product also contains the following excipients, triethanolamine 30 mg/ml and macrogol 200.

Uses

For the treatment of coccidiosis in Broilers and Broiler Breeders. Baycox is effective against Eimeria acervulina, E. brunetti, E. maxima, E. necatrix, E. tenella, E. mitis.

Dosage and administration

Administration: via the drinking water

Dosage:

Baycox is mixed in the drinking water before use. Gentle mixing is required. Proportioning systems may be used (see Pharmaceutical Precautions).

The recommended dose rate is 7 mg toltrazuril per kg bodyweight per day given for 2 consecutive days. This corresponds to:

28 ml Baycox 2.5% Solution (equivalent to 700 mg toltrazuril) per 100 kg of bodyweight per day for 2 consecutive days.

As a guide for usage this is normally equivalent to 25 ppm (equivalent to 1 ml Baycox 2.5% Solution) per litre of drinking water for continuous medication over 48 hours, or to 75 ppm (equivalent to 3 ml Baycox 2.5%) per litre of drinking water given for 8 hours per day, on 2 consecutive days.

Treatment Regimen

Curative Treatment

Chicken: One medication period (over 2 days).

Only make up sufficient drinking water for requirements.

After calculations of the required amount of product, this volume should be carefully dispensed from the container into a domestic measuring jug reserved and labelled specifically for the purpose. Measurement must be made carefully to ensure correct dosage. Product must not be stored in the jug.

Contra-indications, warnings, etc

Baycox does not interfere with the development of immunity against coccidiosis. As with all anticoccidials, prolonged use may result in the development of resistant strains.

Dilutions more concentrated than 1:1,000 (1 ml Baycox 2.5% to 1 litre drinking water) may result in precipitation. Predilution is not recommended.

Baycox is compatible with coccidiostats and amoebostats. A three - five fold overdosage is readily tolerated without any symptoms. If the recommended dose is exceeded beyond 3 - 5 times there is a decrease in water intake.

Withdrawal period(s)

Meat: 18 days

Do not use in birds producing eggs for human consumption.

User Safety

Baycox is an alkaline solution.

Wear synthetic rubber gloves when handling the product.

Wash any splashes from skin and eyes immediately with water.

Wash hands and exposed skin after use.

Do not eat, drink or smoke whilst using the product.

Environmental Safety

Only make up sufficient drinking water for requirements. Wash out empty container with water 3 times when medicating birds and add washings to drinking water.

Store litter from treated houses as long as possible. However, it should only be stored where there is no risk of polluting surface water or groundwater. Do not apply to agricultural land at a rate greater than 1.5 tonnes/hectare/year. If spreading within an NVZ ensure that the NVZ action program rules are complied with.

The principle metabolite of toltrazuril is persistent and mobile in groundwater.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Pharmaceutical precautions

Do not store above 25ºC.

Following dilution in the drinking water Baycox is stable for 24 hours.

Any medicated water which is not consumed within 24 hours should be discarded safely.

Shelf-life of the veterinary medicinal product as packaged for sale: 5 years.

Shelf-life after dilution or reconstitution according to directions: 24 hours.

Legal category

POM-V

Packaging Quantities

1 litre white high density polyethylene bottles, closed with a green polypropylene cap (screw fit) with a red tamper evident seal.

Further information

Toltrazuril ATC Vet Code: QP51 AJ01

Anticoccidial, active against all intracellular stages but the mode of action is unknown.

In poultry toltrazuril is absorbed at a rate of at least 50%. The highest equivalent concentrations are found in liver. The active substance is rapidly metabolised in poultry. The main metabolite is characterised as a sulfone-derivative. About 1 week after the last dose this metabolite represents by far the most relevant residue in the animal.

Marketing authorisation number

Vm 00010/4084

GTIN (Global Trade Item No)

Baycox 2.5% Oral Solution

05032756084015

Baycox 50 mg/ml Oral Suspension for Piglets, Calves and Lambs

Presentation

Baycox 50 mg/ml oral suspension for Piglets, Calves and Lambs is a white or yellowish oral suspension containing as active ingredient 50 mg/ml toltrazuril with sodium benzoate (E211) 2.1 mg/ml and sodium propionate (E281) 2.1 mg/ml.

Uses

For the prevention of clinical signs of coccidiosis in neonatal piglets on farms with a confirmed history of coccidiosis caused by Isospora suis.

For the prevention of clinical signs of coccidiosis and reduction of coccidia shedding in housed calves replacing cows producing milk for human consumption (dairy cows) on farms with a confirmed history of coccidiosis caused by Eimeria bovis or Eimeria zuernii.

For the prevention of clinical signs of coccidiosis and reduction of coccidia shedding in lambs on farms with a confirmed history of coccidiosis caused by Eimeria crandallis and Eimeria ovinoidalis.

Target species -

Pig (Piglet)

Cattle (Calves - on dairy farms)

Sheep (Lambs)

Dosage and administration

The ready-to-use oral suspension must be shaken before use.

Piglets: Individual animal treatment. Each pig to be treated on day 3-5 of life with a single oral dose of 20 mg toltrazuril/kg body weight corresponding to 0.4 ml oral suspension per kg body weight. Due to the small volumes required to treat individual piglets, use of dosing equipment with a dose accuracy of 0.1 ml is recommended. Treatment during an outbreak will be of limited value for the individual piglet because of damage to the small intestine having already occurred.

Calves: Each animal should be treated with a single oral dose of 15 mg toltrazuril/kg body weight corresponding to 3.0 ml oral suspension per 10 kg body weight.

For the treatment of a group of animals of the same breed and same or similar age, the dosing should be done according to the heaviest animal of this group.

To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period.

Lambs: Each animal should be treated with a single oral dose of 20 mg toltrazuril/kg body weight corresponding to 0.4 ml oral suspension per kg body weight. To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period.

If animals are to be treated collectively rather than individually, they should be grouped according to their body weight and dosed accordingly, in order to avoid under- or over-dosing.

Use during pregnancy and lactation

Laboratory studies in rat and rabbit have not produced any evidence of a teratogenic, foetotoxic or maternotoxic effect.

Contra-indications, warnings, etc

For environmental reasons:

Do not use in calves weighing more than 80 kg bodyweight.

Do not use in fattening units such as veal or beef calves.

For more details see environmental safety.

As with any antiparasiticide frequent and repeated use of antiprotozoals from the same class may lead to the development of resistance. It is recommended to treat all animals in a pen.

Hygienic measures may reduce the risk of coccidiosis. It is therefore, recommended to improve concomitantly the hygienic conditions in the concerned facility, particularly dryness and cleanliness.

To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period.

To alter the course of an established clinical coccidial infection, in individual animals already showing signs of diarrhoea, additional supportive therapy may be required.

A threefold overdose is well tolerated by healthy piglets and calves without signs of intolerance.

No signs of overdose have been observed in lamb safety studies with threefold overdose at a single treatment and twofold overdose treatment on 2 consecutive days.

Withdrawal period(s)

Piglets

Meat and offal: 77 days

Calves

Meat and offal: 63 days

Not permitted for use in lactating animals producing milk for human consumption.

Lambs

Meat and offal: 42 days

Not permitted for use in lactating sheep producing milk for human consumption.

User Safety

Wash any splashes from skin or eyes immediately with water.

Environmental Safety

The major metabolite of toltrazuril, toltrazuril sulfone (ponazuril), has been shown to be both persistent (half-life >1 year) and mobile in soil and to be toxic to plants.

For environmental reasons:

In order to prevent any adverse effects on plants and possible contamination of groundwater manure from treated calves must not be spread onto land without dilution with manure from untreated cows. Manure from treated calves must be diluted with at least 3 times the weight of manure from mature cows before it can be spread onto land.

Lambs kept throughout the whole life span indoors under an intensive rearing system must not be treated beyond the age of 6 weeks or body weight of more than 20 kg at treatment. Manure from these animals should only be applied to the same piece of land every third year.

Any unused product or waste material should be disposed of in accordance with national requirements.

Pharmaceutical precautions

No special precautions for storage.

Shelf-life of the veterinary medicinal product as packaged for sale: 5 years.

Shelf-life after first opening the container: 3 months.

Legal category

POM-V

Packaging Quantities

High density polyethylene bottles containing 250 or 1,000 ml of a white or yellowish suspension with a green polypropylene screw cap.

Further information

Pharmacotherapeutic group: Antiprotozo-products, ATCvet code: QP 51 AJ 01

Toltrazuril is a triazinon derivative. It acts against coccidia of the genus Isospora and Eimeria. It is acting against all intracellular development stages of coccidia of the merogony (asexual multiplication) and gamogony (sexual phase). All stages are destroyed, thus the mode of action is coccidiocidal.

Piglets

After oral administration toltrazuril is slowly absorbed with a bioavailability of ≥70%. The main metabolite is characterised as toltrazuril sulfone. The elimination of toltrazuril is slow with a half-life elimination time around 3 days. The major route of excretion is via the faeces.

Calves

After oral administration in cattle toltrazuril is slowly absorbed. The maximal plasma concentration (Cmax = 36.6 mg/l) was observed between 24 and 48 hours (geometric mean 33.9 hours) following oral administration. The elimination of toltrazuril is slow with a terminal half-life time of approximately 2.5 days (64.2 hours). The main metabolite is characterised as toltrazuril sulfone. The major route of excretion is via the faeces.

Lambs

After oral administration toltrazuril is slowly absorbed in mammals. The main metabolite is characterised as toltrazuril sulfone. The maximal plasma concentration (Cmax = 62 mg/L) was observed 2 days following oral administration. The elimination of toltrazuril is slow with an elimination half-life time of approximately 9 days. The major route of excretion is via the faeces.

Environmental properties

The metabolite of toltrazuril, toltrazuril sulfone (ponazuril) is a persistent (half-life >1 year) and mobile compound and has adverse effects on both the growth and emergence of plants. Given the persistent properties of ponazuril repeated spreading of manure from treated animals may lead to an accumulation in the soil and consequently a risk to plants. The accumulation of ponazuril in soil together with its mobility also leads to a risk of leaching to groundwater.

Marketing authorisation number

Vm 00010/4170.

GTIN (Global Trade Item No)

Baycox 50 mg/ml oral suspension for Piglets, Calves and Lambs (250ml)

04007221028598

Baycox 50 mg/ml oral suspension for Piglets, Calves and Lambs (1 Litre)

04007221028598

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Questions & Answers for Baycox

Below are some recent questions we've received regarding Baycox, including answers from our team.

Ask Your Own Question

Canaries

16th Dec 2014
R. Greaves

is baycox safe to use to treat canaries,
if so at what dosage.

John Cousins
  • Veterinary Surgeon

This has been used in drinking water at a concentration of 180mg/l. You would have to check with your own vet before buying any as we are not permitted to prescribe it for species not in the datasheet.