Ypozane Tablets for Dogs

Ypozane Tablets for Dogs

  • 1.875mg » Box of 7 £16.49
  • 3.75mg » Box of 7 £24.49
  • 7.5mg » Box of 7 £37.49
  • 15mg » Box of 7 £54.49

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£16.49 to £54.49


Ypozane is used to treat a condition which causes an enlarged prostate gland in older male dogs. Known medically as “benign prostatic hypertrophy”, this is not related to cancer but does mean that the enlarged gland gets in the way of adjacent organs, often causing difficulty with going to the toilet and sometimes abdominal pain. The normal function of the prostate is to produces a fluid that is part of the semen. It serves no useful job for the average pet dog. Ypozane contains a hormone which effectively blocks the effect of testosterone on the prostate, allowing it to shrink back to a more normal size.

Ypozane is given once daily for one week. The useful effect is normally noticed about 1 week later, and it then persists for 5 months. Repeat courses of treatment can be given. It is also possible to give Ypozane concurrently with antibiotics if bacterial prostatitis is being treated. There are no known adverse interactions with other medications.

Qualitative and quantitative composition

Each tablet contains 1.875 mg, 3.75 mg, 7.5 mg or 15 mg osaterone acetate

Pharmaceutical form

Round, white, biconvex tablet of 5.5 mm, 7 mm, 9 mm and 12 mm.

Clinical particulars

Target species

Dogs (male)

Indications for use

Treatment of benign prostatic hypertrophy (BPH) in male dogs.



Special warnings for each target species

In dogs with BPH associated with prostatitis, the product can be administered concurrently with antimicrobials

Special precautions for use

Special precautions for use in animals

A transient reduction of plasma cortisol concentration may occur; this may continue for several weeks after administration. Appropriate monitoring should be implemented in dogs under stress (e.g. postoperative) or those with hypoadrenocorticism. The response to an ACTH stimulation test may also be suppressed for several weeks after administration of osaterone.

Use with caution in dogs with a history of liver disease, as safety of use of the product in these dogs has not been thoroughly investigated, and as treatment of some dogs with liver disease has resulted in reversible elevation of ALT and ALP in clinical trials.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Wash hands after administration.

In the case of accidental ingestion by a person, seek medical advice immediately and show the package leaflet or the label to the physician.

A single oral dose of 40 mg osaterone acetate in human males was followed by a sporadic decrease in FSH, LH and testosterone, reversible after 16 days. There was no clinical effect. In female laboratory animals, osaterone acetate caused serious adverse effects on reproductive functions. Therefore, women of child-bearing age should avoid contact with, or wear disposable gloves, when administering the product.

Adverse reactions

A transient increase in appetite occurs very commonly.

Transient behavioural changes such as increased or decreased activity, or more sociable behaviour, arecommon.

Other adverse reactions, including transient vomiting and/or diarrhoea, polyuria/polydipsia, lethargy or feminisation syndrome including mammary gland hyperplasia occur uncommonly.

A transient reduction in plasma cortisol occurs in most treated animals.

In clinical trials, treatment with the veterinary medicinal product was not discontinued and all dogs recovered without any specific therapy.

Use during pregnancy, lactation orlay

Not applicable


None known

Amounts to be administered and administration route

For oral use.

Administer 0.25 – 0.5 mg osaterone acetate per kilogram bodyweight, once a day, for 7 days as follows:

Dog's weight

YPOZANE Tablets to be administered

Number of tablets per day

Treatment duration

3 to 7.5 kg*

1.875 mg tablet

1 Tablet

7 days

7.5 to 15 kg

3.75 mg tablet

15 to 30 kg

7.5 mg tablet

30 to 60 kg

15 mg tablet

*No data are available for dogs less than 3 kg bodyweight.

Tablets can be given either directly into the mouth or with food. The maximum dose should not be exceeded.

The onset of clinical response to treatment is usually seen within 2 weeks. The clinical response persists for at least 5 months after treatment.

Re-evaluation by the veterinarian should take place 5 months after treatment or earlier if clinical signs recur. A decision to retreat at this or at a later time point should be based on veterinary examination taking into account the risk benefit profile of the product. If clinical response to treatment is considerably shorter than expected, a re-evaluation of the diagnosis is necessary.


An overdose study (up to 1.25 mg/kg bodyweight for 10 days, repeated one month later) did not show undesirable effects except for a decrease of cortisol plasma concentration.

Withdrawal periods

Not applicable.

Pharmacological particulars

Pharmacodynamic properties

Osaterone is a steroid anti-androgen, which inhibits the effects of an excess production of male hormone (testosterone).

Osaterone acetate is a steroid chemically related to progesterone, and as such it has potent progestagen and potent anti-androgen activity. Also, the major metabolite of osaterone acetate (15β-hydroxylated - osaterone acetate) has anti-androgenic activity. Osaterone acetate inhibits the effects of an excess of male hormone (testosterone) through various mechanisms. It competitively prevents the binding of androgens to their prostatic receptors and blocks the transport of testosterone into the prostate.

No adverse effects on semen quality have been observed.

Pharmacokinetic properties

After oral administration with food in dogs, osaterone acetate is rapidly absorbed (Tmax about 2 hours) and undergoes a first-pass effect mainly in the liver. After a dose of 0.25 mg/kg/day, the mean maximum concentration (Cmax) in plasma is about 60 µg/l.

Osaterone acetate is converted to its main, 15β-hydroxylated metabolite, which is also pharmacologically active. Osaterone acetate and its metabolite are bound to plasma proteins (around 90% and 80% respectively), mainly to albumin. This binding is reversible and not affected by other substances known to specifically bind to albumin.

Osaterone is eliminated within 14 days, mainly in faeces via biliary excretion (60%) and to a lesser extent (25%) in urine. Elimination is slow with a mean half-life (T½) of about 80 hours. After repeated administration of osaterone acetate at 0.25 mg/kg/day for 7 days, the factor of accumulation is about 3- 4 without change in the rates of absorption or elimination. Fifteen days after the last administration, the mean plasma concentration is about 6.5 µg/l.

Pharmaceutical particulars



Pregelatinised starch

Carmellose calcium

Maize starch


Magnesium stearate

Major incompatibilities

Not applicable

Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.

Special precautions for storage

This veterinary medicinal product does not require any special storage conditions.

Immediate packaging

Carton box containing one aluminium/aluminium blister with 7 tablets.


Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing authorisation number


Date of the first authorisation or date of renewal


Date of revision of the text


Any other information


Legal category


Need help or advice? Contact us:

  • Landline: 01582 842096
  • Mon - Fri: 8:30am - 5:00pm
  • Sat: 9:00am - 1:00pm
  • Email: [email protected]

All prices include VAT where applicable.

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to air freight restrictions aerosols cannot ever be sent abroad by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.


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