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Ypozane is used to treat a condition which causes an enlarged prostate gland in older male dogs. Known medically as “benign prostatic hypertrophy”, this is not related to cancer but does mean that the enlarged gland gets in the way of adjacent organs, often causing difficulty with going to the toilet and sometimes abdominal pain. The normal function of the prostate is to produces a fluid that is part of the semen. It serves no useful job for the average pet dog. Ypozane contains a hormone which effectively blocks the effect of testosterone on the prostate, allowing it to shrink back to a more normal size.
Ypozane is given once daily for one week. The useful effect is normally noticed about 1 week later, and it then persists for 5 months. Repeat courses of treatment can be given. It is also possible to give Ypozane concurrently with antibiotics if bacterial prostatitis is being treated. There are no known adverse interactions with other medications.
Each tablet contains 1.875 mg, 3.75 mg, 7.5 mg or 15 mg osaterone acetate
Round, white, biconvex tablet of 5.5 mm, 7 mm, 9 mm and 12 mm.
Treatment of benign prostatic hypertrophy (BPH) in male dogs.
In dogs with BPH associated with prostatitis, the product can be administered concurrently with antimicrobials
Special precautions for use in animals
A transient reduction of plasma cortisol concentration may occur; this may continue for several weeks after administration. Appropriate monitoring should be implemented in dogs under stress (e.g. postoperative) or those with hypoadrenocorticism. The response to an ACTH stimulation test may also be suppressed for several weeks after administration of osaterone.
Use with caution in dogs with a history of liver disease, as safety of use of the product in these dogs has not been thoroughly investigated, and as treatment of some dogs with liver disease has resulted in reversible elevation of ALT and ALP in clinical trials.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Wash hands after administration.
In the case of accidental ingestion by a person, seek medical advice immediately and show the package leaflet or the label to the physician.
A single oral dose of 40 mg osaterone acetate in human males was followed by a sporadic decrease in FSH, LH and testosterone, reversible after 16 days. There was no clinical effect. In female laboratory animals, osaterone acetate caused serious adverse effects on reproductive functions. Therefore, women of child-bearing age should avoid contact with, or wear disposable gloves, when administering the product.
A transient increase in appetite occurs very commonly.
Transient behavioural changes such as increased or decreased activity, or more sociable behaviour, arecommon.
Other adverse reactions, including transient vomiting and/or diarrhoea, polyuria/polydipsia, lethargy or feminisation syndrome including mammary gland hyperplasia occur uncommonly.
A transient reduction in plasma cortisol occurs in most treated animals.
In clinical trials, treatment with the veterinary medicinal product was not discontinued and all dogs recovered without any specific therapy.
For oral use.
Administer 0.25 – 0.5 mg osaterone acetate per kilogram bodyweight, once a day, for 7 days as follows:
YPOZANE Tablets to be administered
Number of tablets per day
3 to 7.5 kg*
1.875 mg tablet
7.5 to 15 kg
3.75 mg tablet
15 to 30 kg
7.5 mg tablet
30 to 60 kg
15 mg tablet
*No data are available for dogs less than 3 kg bodyweight.
Tablets can be given either directly into the mouth or with food. The maximum dose should not be exceeded.
The onset of clinical response to treatment is usually seen within 2 weeks. The clinical response persists for at least 5 months after treatment.
Re-evaluation by the veterinarian should take place 5 months after treatment or earlier if clinical signs recur. A decision to retreat at this or at a later time point should be based on veterinary examination taking into account the risk benefit profile of the product. If clinical response to treatment is considerably shorter than expected, a re-evaluation of the diagnosis is necessary.
An overdose study (up to 1.25 mg/kg bodyweight for 10 days, repeated one month later) did not show undesirable effects except for a decrease of cortisol plasma concentration.
Osaterone is a steroid anti-androgen, which inhibits the effects of an excess production of male hormone (testosterone).
Osaterone acetate is a steroid chemically related to progesterone, and as such it has potent progestagen and potent anti-androgen activity. Also, the major metabolite of osaterone acetate (15β-hydroxylated - osaterone acetate) has anti-androgenic activity. Osaterone acetate inhibits the effects of an excess of male hormone (testosterone) through various mechanisms. It competitively prevents the binding of androgens to their prostatic receptors and blocks the transport of testosterone into the prostate.
No adverse effects on semen quality have been observed.
After oral administration with food in dogs, osaterone acetate is rapidly absorbed (Tmax about 2 hours) and undergoes a first-pass effect mainly in the liver. After a dose of 0.25 mg/kg/day, the mean maximum concentration (Cmax) in plasma is about 60 µg/l.
Osaterone acetate is converted to its main, 15β-hydroxylated metabolite, which is also pharmacologically active. Osaterone acetate and its metabolite are bound to plasma proteins (around 90% and 80% respectively), mainly to albumin. This binding is reversible and not affected by other substances known to specifically bind to albumin.
Osaterone is eliminated within 14 days, mainly in faeces via biliary excretion (60%) and to a lesser extent (25%) in urine. Elimination is slow with a mean half-life (T½) of about 80 hours. After repeated administration of osaterone acetate at 0.25 mg/kg/day for 7 days, the factor of accumulation is about 3- 4 without change in the rates of absorption or elimination. Fifteen days after the last administration, the mean plasma concentration is about 6.5 µg/l.
Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.
This veterinary medicinal product does not require any special storage conditions.
Carton box containing one aluminium/aluminium blister with 7 tablets.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
All prices include VAT where applicable. *The freephone number is free from most UK landlines only, mobiles are usually charged so we'd recommend calling our landline from your mobile or internationally.
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