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Vitamin K tablets are usually given to dogs after known, or suspected, consumption of the anti-coagulant type of rodent poison. These poisons act by causing rodents to die of internal bleeding. Vitamin K is able to counteract the effects of the poison, but needs to be given to cover the whole period of time while the poison might be active within the dog. This can be for up to three weeks. It is usual to give the dog an injection of vitamin K at the start of the treatment, then tablets daily for 21 days.
Each divisible tablet contains:
Active substance: Phytomenadione 50.0 mg
List of excipients:
Tablet core: Silica (colloidal anhydrous), calcium hydrogen phosphate dihydrate, glycerol dibehenate, magnesium stearate, lactose monohydrate, croscarmellose sodium
Coating: Hypromellose, polydextrose, talc, maltodextrine, medium chain triglycerides
Film-coated tablet. Oblong tablet, slight yellow with 3 scored lines. The tablet can be divided into equal halves and quarters.
In dogs: Treatment of anticoagulant poisoning, following parenteral treatment.
For oral use.
5 mg phytomenadione per kg body weight per day, corresponding to 1 tablet per 10 kg body weight per day, once a day, for 21 days, in accordance with the following table:
Body weight (kg)
Number of tablets
from 2.5 to 5
from 5 to 7.5
from 7.5 to 10*
* Dog > 10 kg: ¼ tablet per 2.5 kg
Preferably use in non-fasted animals.
Oral treatment should be undertaken within 12 hours after the end of the emergency treatment by the intravenous route (2 intravenous injections of 5 mg vitamin K1 per kg body weight given 12 hours apart). See 'Special warnings for each target species'.
Return any divided tablet to the blister pack and use within 3 days. The blister pack should be inserted back into the cardboard carton.
Do not use in cases of known hypersensitivity to the active substance or to any of the excipients.
Special warnings for each target species: As the anticoagulant effects of rodenticides are known to be long lasting, it is recommended to administer vitamin K1 with an oral formulation for 3 weeks, and to evaluate the coagulation status (via one stage prothrombin times) 48 hours after the last administration. If it is prolonged, the treatment is maintained until the clotting time is normal 48 hours after cessation of treatment to avoid relapse. The duration of treatment can be extended as long as the anticoagulant persists in the body.
Special precautions for use in animals: The formation of prothrombin may be inadequate when dealing with patients with severe liver dysfunction. Therefore, careful monitoring of coagulation parameters after administration of vitamin K1 is required.
Special precautions to be taken by the person administering the veterinary medicinal product to animals: People with known hypersensitivity to phytomenadione should avoid contact with the veterinary medicinal product.
Wash hands after use.
Adverse reactions: None known.
Use during pregnancy and lactation: The safety of the veterinary medicinal product has not been established in bitches during pregnancy and lactation. Studies conducted in laboratory animals have shown no teratogenic or foetotoxic effects. Vitamin K1 crosses the placental barrier. Use only according to the benefit/risk assessment by the responsible veterinarian.
Interactions: Salicylates (NSAIDs) and cephalosporins presenting the N-methyl-thiotetrazole moiety may reduce the effect of vitamin K1, by inhibition of the vitamin K1 recycling.
Overdose: No signs of intolerance were displayed at 3 times the therapeutic dose, administered for 3 weeks.
Incompatibilities: None known.
Store in the original packaging, protect from light.
After opening the blister pocket, replace the remaining portion(s) of tablet in the blister pocket and return the blister strip to the cardboard carton.
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Shelf life of divided tablets: 3 days.
Disposal: Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Box containing white PVC/Aluminium thermosealed blisters of 7 tablets each.
Box of 1 thermosealed blisters of 7 tablets
Box of 2 thermosealed blisters of 7 tablets
Box of 3 thermosealed blisters of 7 tablets
Box of 4 thermosealed blisters of 7 tablets
Box of 5 thermosealed blisters of 7 tablets
Box of 12 thermosealed blisters of 7 tablets
Not all pack sizes may be marketed.
For animal treatment only. Keep out of the sight and reach of children.
Manufacturer responsible for batch release: Laboratoire TVM, 57 rue des Bardines, 63370 Lempdes, France.
Date of last review: March 2013
Laboratoire TVM, 57 rue des Bardines, 63370 Lempdes, France.
Vitamin K1 Laboratoire TVM 50 mg Film-coated Tablets for Dogs
14 tablets 03700454547751; 84 tablets 03700454547706
All prices include VAT where applicable.
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