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Vetergesic Injection for Dogs & Cats

Vetergesic Injection for Dogs & Cats
Multi-Dose » 10ml Bottle

  • Multi-Dose » 10ml Bottle £40.49
  • Single Dose » 1ml Vial (Pack of 5) £18.49

Selection of 2 products from

£18.49 to £40.49

Description

Vetergesic is normally used to aid the control of pain in dogs and cats.

A prescription is required which we will confirm with the prescribing veterinary surgeon.

Need help or advice? Contact us:

  • Landline: 01582 842096
  • Mon - Fri: 8:30am - 5:00pm
  • Sat: 9:00am - 1:00pm (Collections only)
  • Email: [email protected]

All prices include VAT where applicable.

Medication Datasheets

Single Dose » 1ml Vial (Pack of 5)

Vetergesic 0.3 mg/ml Solution for Injection for Dogs and Cats

Qualitative and quantitative composition

Buprenorphine 0.3mg/ml (as buprenorphine hydrochloride 0.324 mg/ml)

Pharmaceutical form

Solution for injection. Clear, colourless solution for injection

Clinical particulars

Target species

Dogs and cats.

Indications for use

Post-operative analgesia and sedation in the dog. Post-operative analgesia in the cat.

Contra-indications

None known

Special warnings for each target species

Animals administered opioids possessing sedative and analgesic properties may show variable responses. Therefore, the responses of individual animals should be monitored and subsequent doses should be adjusted accordingly. In some cases repeat doses may fail to provide additional analgesia. In these cases, consideration should be given to use of an analgesic from an alternative class.

Special precautions for use

Buprenorphine may occasionally cause significant respiratory depression and, as with other opioid drugs, care should be taken when treating animals with impaired respiratory function or animals that are receiving drugs that can cause respiratory depression. Volunteer studies in man have indicated that opiate antagonists may not fully reverse the effects of buprenorphine. Naloxone may be of benefit in reversing reduced respiratory rate and respiratory stimulants such as Doxapram are also effective in man. Because of the prolonged duration of effect of buprenorphine in comparison to such drugs, they may need to be administered repeatedly or by continuous infusion.

Buprenorphine may cause some drowsiness, which may be potentiated by other centrally-acting agents, including tranquillisers, sedatives and hypnotics. The product should not be used in conjunction with morphine or other opioid-type analgesics (e.g. etorphine, fentanyl, pethidine, methadone, papaveretum and butorphanol).

As buprenorphine is metabolised by the liver, its intensity and duration of action may be affected in animals with impaired liver function.

Safety has not been fully evaluated in clinically compromised cats e.g. those suffering from renal or hepatic dysfunction, cardiovascular disease or shock. Use in such cases should be based on the risk-benefit assessment of the veterinarian.

Repeated administration earlier than the recommended repeat interval suggested is not recommended.

Adverse reactions

Salivation, bradycardia, hypothermia, agitation, dehydration and meiosis can occur in the dog, and rarely hypertension and tachycardia.

Mydriasis and signs of euphoria (excessive purring, pacing, rubbing) commonly occur in cats and will usually resolve within 24 hours.

Use during pregnancy or lactation

No foetal malformations were noted in reproduction studies in rats when buprenorphine was administered by subcutaneous, intramuscular, or intravenous routes. Although post-implantation losses and early foetal deaths were observed, these may have resulted from a lower level of parental care owing to sedation of the mothers.

The product should not be used pre-operatively in cases of Caesarean section, due to the risk of respiratory depression in the offspring periparturiently, and should only be used post-operatively with care. Although the reproduction studies in animals do not indicate a teratogenic risk, buprenorphine should be used with caution in pregnant animals.

Studies in lactating rats have shown that, after intramuscular administration of buprenorphine, concentrations of unchanged buprenorphine in the milk equalled or exceeded that in the plasma. As it is likely that buprenorphine will be excreted in the milk of other species, care should be taken when administering buprenorphine to lactating animals.

Interactions

Buprenorphine may cause some drowsiness, which may be potentiated by other centrally acting agents, including tranquillisers, sedatives and hypnotics.

Although there is evidence in humans to indicate that therapeutic doses of buprenorphine do not reduce the analgesic efficacy of standard doses of an opioid agonist and that when buprenorphine is employed within the normal therapeutic range, standard doses of opioid agonist may be administered before the effects of the former have ended without compromising analgesia, it is recommended that buprenorphine is not used in conjunction with morphine or other opioid-type analgesics, e.g. etorphine, fentanyl, pethidine, methadone, papaveretum or butorphanol.

Vetergesic has been used successfully with a wide range of premedicant and anaesthetic agents including acepromazine, alphaxalone/alphadalone, atropine, halothane, isoflurane, ketamine, medetomidine, propofol, sevoflurane, thiopentone and xylazine without any observed adverse effects.

Amounts to be administered and administration route

Vetergesic should be injected intramuscularly.

Post-Operative Analgesia

Dog: 10 – 20 microgram per kg (0.3 – 0.6mL per 10 kg) repeated if necessary after 3 – 4 hours with 10 microgram or 5 – 6 hours with 20 microgram doses.

Cat: 10 – 20 microgram per kg (0.3 – 0.6mL per 10 kg), repeated if necessary, once, after 2 hours.

Sedation:

Dog: 10 – 20 microgram per kg (0.3 – 0.6mL per 10 kg)

To ensure that analgesia is present immediately on recovery, the product can be administered preoperatively. If additional analgesia is subsequently required, this may be achieved by administration of a further dose of Vetergesic or concomitant use of a suitable injectable NSAID.

An appropriately graduated syringe must be used to allow accurate dosing.

When administered pre-operatively in conjunction with other premedicants, it may be possible to reduce the amount of premedicant, such as acepromazine or medetomidine, and also the amount of inhalational anaesthetic used.

Overdose

In cases of overdosage, supportive measures should be instituted, and, if appropriate, naloxone or respiratory stimulants may be used. However, dose levels many times higher than those indicated above have been used without serious side effects.

Withdrawal periods

Not Applicable

Pharmacological particulars

Pharmacodynamic properties

In summary buprenorphine is a potent, long-acting analgesic acting at opiate receptors in the central nervous system.

Buprenorphine exerts its analgesic effect via high affinity binding to various subclasses of opiate receptors, particularly µ, in the central nervous system. At clinical dose levels for analgesia, buprenorphine demonstrates high efficacy and binds to opiate receptors with high affinity and high receptor avidity, such that its dissociation from the receptor site is slow, as demonstrated in in vitro studies. This unique property of buprenorphine could account for its longer duration of activity when compared to morphine. In circumstances where excessive opiate agonist is already bound to opiate receptors, buprenorphine can exert a narcotic antagonistic activity as a consequence of its high-affinity opiate receptor binding, such that an antagonistic effect on morphine equivalent to naloxone has been demonstrated.

Pharmacokinetic properties

Buprenorphine is rapidly absorbed after intramuscular injection in various animal species and man. The substance is highly lipophilic and the volume of distribution in body compartments is large. Pharmacological effects occur within 30 minutes after injection and peak effects are usually observed at about 1 – 1.5 hours. Following intramuscular administration to cats, the mean terminal half-life was 6.3 hours and the clearance was 23 mL/kg/min, however, there was considerable inter-cat variability in pharmacokinetic parameters.

Combined pharmacokinetic and pharmacodynamic studies in cats have demonstrated a marked hysteresis between plasma concentrations and analgesic effect. Plasma concentrations of buprenorphine should not be used to formulate individual animal dosage regimens, which should be determined by monitoring of the patient’s response.

The major route of excretion in all species except the rabbit (where urinary excretion predominates) is the faeces. Buprenorphine undergoes N-dealkylation and glucuronide conjugation by the intestinal wall and the liver and its metabolites are excreted via the bile into the gastro-intestinal tract.

In tissue distribution studies carried out in rats and rhesus monkeys the highest concentrations of drug-related material were observed in liver, lung and brain. Peak levels occurred rapidly and declined to low levels by 24 hours after dosing.

Protein binding studies in rats have shown that buprenorphine is highly bound to plasma proteins, principally to alpha and beta globulins.

Pharmaceutical particulars

Excipients

Glucose anhydrous, Hydrochloric acid, Dilute (for pH adjustment), Water for injection.

Major incompatibilities

None known

Shelf life

3 years.

Special precautions for storage

Do not store above 25ºC. Protect from light.

This product does not contain an antimicrobial preservative. Any solution remaining in an ampoule following withdrawal of the required dose should be discarded.

Immediate packaging

Presented in 1ml clear, Type I glass, snap ampoules, in boxes of five.

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Marketing Authorisation Number

Vm 15052/4080

Date of the first authorisation or date of renewal

24th April 1995

Date of revision of the text

July 2015

Any other information

Special precautions to be taken by the person administering the medicinal product to the animals

Wash hands/affected area thoroughly after any accidental spillage. Care should be taken to avoid accidental self-injection. Following accidental self-injection or ingestion, seek medical advice taking the product literature with you. Following eye contamination or skin contact, wash thoroughly with cold running water.

Legal category

Multi-Dose » 10ml Bottle

Vetergesic 0.3 mg/ml Solution for Injection for Dogs and Cats

Qualitative and quantitative composition

Buprenorphine 0.3mg/ml (as buprenorphine hydrochloride 0.324 mg/ml)

Pharmaceutical form

Solution for injection. Clear, colourless solution for injection

Clinical particulars

Target species

Dogs and cats.

Indications for use

Post-operative analgesia and sedation in the dog. Post-operative analgesia in the cat.

Contra-indications

None known

Special warnings for each target species

Animals administered opioids possessing sedative and analgesic properties may show variable responses. Therefore, the responses of individual animals should be monitored and subsequent doses should be adjusted accordingly. In some cases repeat doses may fail to provide additional analgesia. In these cases, consideration should be given to use of an analgesic from an alternative class.

Special precautions for use

Buprenorphine may occasionally cause significant respiratory depression and, as with other opioid drugs, care should be taken when treating animals with impaired respiratory function or animals that are receiving drugs that can cause respiratory depression. Volunteer studies in man have indicated that opiate antagonists may not fully reverse the effects of buprenorphine. Naloxone may be of benefit in reversing reduced respiratory rate and respiratory stimulants such as Doxapram are also effective in man. Because of the prolonged duration of effect of buprenorphine in comparison to such drugs, they may need to be administered repeatedly or by continuous infusion.

Buprenorphine may cause some drowsiness, which may be potentiated by other centrally-acting agents, including tranquillisers, sedatives and hypnotics. The product should not be used in conjunction with morphine or other opioid-type analgesics (e.g. etorphine, fentanyl, pethidine, methadone, papaveretum and butorphanol).

As buprenorphine is metabolised by the liver, its intensity and duration of action may be affected in animals with impaired liver function.

Safety has not been fully evaluated in clinically compromised cats e.g. those suffering from renal or hepatic dysfunction, cardiovascular disease or shock. Use in such cases should be based on the risk-benefit assessment of the veterinarian.

Repeated administration earlier than the recommended repeat interval suggested is not recommended.

Adverse reactions

Salivation, bradycardia, hypothermia, agitation, dehydration and meiosis can occur in the dog, and rarely hypertension and tachycardia.

Mydriasis and signs of euphoria (excessive purring, pacing, rubbing) commonly occur in cats and will usually resolve within 24 hours.

Use during pregnancy or lactation

No foetal malformations were noted in reproduction studies in rats when buprenorphine was administered by subcutaneous, intramuscular, or intravenous routes. Although post-implantation losses and early foetal deaths were observed, these may have resulted from a lower level of parental care owing to sedation of the mothers.

The product should not be used pre-operatively in cases of Caesarean section, due to the risk of respiratory depression in the offspring periparturiently, and should only be used post-operatively with care. Although the reproduction studies in animals do not indicate a teratogenic risk, buprenorphine should be used with caution in pregnant animals.

Studies in lactating rats have shown that, after intramuscular administration of buprenorphine, concentrations of unchanged buprenorphine in the milk equalled or exceeded that in the plasma. As it is likely that buprenorphine will be excreted in the milk of other species, care should be taken when administering buprenorphine to lactating animals.

Interactions

Buprenorphine may cause some drowsiness, which may be potentiated by other centrally acting agents, including tranquillisers, sedatives and hypnotics.

Although there is evidence in humans to indicate that therapeutic doses of buprenorphine do not reduce the analgesic efficacy of standard doses of an opioid agonist and that when buprenorphine is employed within the normal therapeutic range, standard doses of opioid agonist may be administered before the effects of the former have ended without compromising analgesia, it is recommended that buprenorphine is not used in conjunction with morphine or other opioid-type analgesics, e.g. etorphine, fentanyl, pethidine, methadone, papaveretum or butorphanol.

Vetergesic has been used successfully with a wide range of premedicant and anaesthetic agents including acepromazine, alphaxalone/alphadalone, atropine, halothane, isoflurane, ketamine, medetomidine, propofol, sevoflurane, thiopentone and xylazine without any observed adverse effects.

Amounts to be administered and administration route

Vetergesic should be injected intramuscularly.

Post-Operative Analgesia

Dog: 10 – 20 microgram per kg (0.3 – 0.6mL per 10 kg) repeated if necessary after 3 – 4 hours with 10 microgram or 5 – 6 hours with 20 microgram doses.

Cat: 10 – 20 microgram per kg (0.3 – 0.6mL per 10 kg), repeated if necessary, once, after 2 hours.

Sedation:

Dog: 10 – 20 microgram per kg (0.3 – 0.6mL per 10 kg)

To ensure that analgesia is present immediately on recovery, the product can be administered preoperatively. If additional analgesia is subsequently required, this may be achieved by administration of a further dose of Vetergesic or concomitant use of a suitable injectable NSAID.

An appropriately graduated syringe must be used to allow accurate dosing.

When administered pre-operatively in conjunction with other premedicants, it may be possible to reduce the amount of premedicant, such as acepromazine or medetomidine, and also the amount of inhalational anaesthetic used.

Overdose

In cases of overdosage, supportive measures should be instituted, and, if appropriate, naloxone or respiratory stimulants may be used. However, dose levels many times higher than those indicated above have been used without serious side effects.

Withdrawal periods

Not Applicable

Pharmacological particulars

Pharmacodynamic properties

In summary buprenorphine is a potent, long-acting analgesic acting at opiate receptors in the central nervous system.

Buprenorphine exerts its analgesic effect via high affinity binding to various subclasses of opiate receptors, particularly µ, in the central nervous system. At clinical dose levels for analgesia, buprenorphine demonstrates high efficacy and binds to opiate receptors with high affinity and high receptor avidity, such that its dissociation from the receptor site is slow, as demonstrated in in vitro studies. This unique property of buprenorphine could account for its longer duration of activity when compared to morphine. In circumstances where excessive opiate agonist is already bound to opiate receptors, buprenorphine can exert a narcotic antagonistic activity as a consequence of its high-affinity opiate receptor binding, such that an antagonistic effect on morphine equivalent to naloxone has been demonstrated.

Pharmacokinetic properties

Buprenorphine is rapidly absorbed after intramuscular injection in various animal species and man. The substance is highly lipophilic and the volume of distribution in body compartments is large. Pharmacological effects occur within 30 minutes after injection and peak effects are usually observed at about 1 – 1.5 hours. Following intramuscular administration to cats, the mean terminal half-life was 6.3 hours and the clearance was 23 mL/kg/min, however, there was considerable inter-cat variability in pharmacokinetic parameters.

Combined pharmacokinetic and pharmacodynamic studies in cats have demonstrated a marked hysteresis between plasma concentrations and analgesic effect. Plasma concentrations of buprenorphine should not be used to formulate individual animal dosage regimens, which should be determined by monitoring of the patient’s response.

The major route of excretion in all species except the rabbit (where urinary excretion predominates) is the faeces. Buprenorphine undergoes N-dealkylation and glucuronide conjugation by the intestinal wall and the liver and its metabolites are excreted via the bile into the gastro-intestinal tract.

In tissue distribution studies carried out in rats and rhesus monkeys the highest concentrations of drug-related material were observed in liver, lung and brain. Peak levels occurred rapidly and declined to low levels by 24 hours after dosing.

Protein binding studies in rats have shown that buprenorphine is highly bound to plasma proteins, principally to alpha and beta globulins.

Pharmaceutical particulars

Excipients

Glucose anhydrous, Hydrochloric acid, Dilute (for pH adjustment), Water for injection.

Major incompatibilities

None known

Shelf life

3 years.

Special precautions for storage

Do not store above 25ºC. Protect from light.

This product does not contain an antimicrobial preservative. Any solution remaining in an ampoule following withdrawal of the required dose should be discarded.

Immediate packaging

Presented in 1ml clear, Type I glass, snap ampoules, in boxes of five.

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Marketing Authorisation Number

Vm 15052/4080

Date of the first authorisation or date of renewal

24th April 1995

Date of revision of the text

July 2015

Any other information

Special precautions to be taken by the person administering the medicinal product to the animals

Wash hands/affected area thoroughly after any accidental spillage. Care should be taken to avoid accidental self-injection. Following accidental self-injection or ingestion, seek medical advice taking the product literature with you. Following eye contamination or skin contact, wash thoroughly with cold running water.

Legal category

Delivery Information

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Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (2)

Q & A

Below are some recent questions we've received regarding Vetergesic Injection for Dogs & Cats, including answers from our team.

21 April 2014 at 11:41am

Should this drug be given to my cat oraly at 0.3

Martin

Is it safe to give this to my 10 year old cat twice a day oraly at 0.3ml as she has gastro limphoma and not on any other drugs at this time
It seems to only advocate by syringe

  • Non-Executive Director

Your vet has to prescribe this medication and to advise how it should be used. Although this product is intended to be given by injection, it can be given by mouth and this is sometimes recommended for cats in a home situation.