Urilin is used to control the leaking of urine which occurs in some bitches after they have been spayed. It helps to increase the tone of the muscles near the exit to the bladder so that inadvertent passage of urine while at rest is prevented. Urilin is given three times daily at first. Once leaking has stopped, it is sometime possible to gradually reduce the quantity or frequency of the Urilin administered. Urilin is provided in a squeezable plastic bottle and the dose is measured by counting the number of drops which are added to food. One drop of Urilin is required per 2.34kg bodyweight three times daily at the full starting dose.
All prices include VAT where applicable.
1 ml contains: Active substance:
Phenylpropanolamine 40.29 mg (equivalent to 50.0 mg phenylpropanolamine hydrochloride)
Excipients: Sodium methyl parahydroxybenzoate (E219) 1.5 mg
Sodium propyl parahydroxybenzoate (E217) 0.15 mg.
Syrup. Clear viscous solution.
For the treatment of urinary incontinence associated with acquired urethral sphincter incompetence in the bitch only.
The efficacy of phenylpropanolamine has only been demonstrated in ovariohysterectomised bitches.
Please see Use during pregnancy and lactation.
Do not use in animals treated with non-selective monoamine oxidase inhibitors.
Do not use in cases of known hypersensitivity to the active substance or to any of the excipients.
It is not appropriate to use the product for the behavioural cause of inappropriate urination.
Because phenylpropanolamine is a sympathomimetic agent, it may affect the cardiovascular system, especially blood pressure and heart rate, and therefore should be used with caution in animals with cardiovascular diseases.
Care should be exercised in treating animals with severe renal or hepatic insufficiency, diabetes mellitus, hyperadrenocorticism, glaucoma or other metabolic disorders.
In bitches less than 1 year old the possibility of anatomical disorders contributing to incontinence should be considered prior to treatment.
People with known hypersensitivity to phenylpropanolamine should avoid contact with the veterinary medicinal product.
Phenylpropanolamine hydrochloride is toxic when overdoses are ingested. Adverse effects may include dizziness, headache, nausea, insomnia or restlessness, and increased blood pressure. High overdose may be fatal, especially in children.
To avoid accidental ingestion, the product must be used and kept out of the sight and reach of children.
Always replace the cap firmly after use to ensure that the child resistant closure operates correctly.
In the event of accidental ingestion, seek immediate medical attention showing the doctor the package leaflet.
Contact with eyes and skin should be avoided.
In the event of accidental skin contact, wash the contaminated area with soap and water. Wash hands after use of the product.
Redness and irritation may develop after eye or skin contact with the product.
In the event of accidental eye contact, rinse the eye with clean water for about 15 minutes and seek medical advice.
In some dogs, loose stools, liquid diarrhoea, a decrease in appetite, arrhythmia and collapse have been reported following treatment with phenylpropanolamine. Occasional nausea and vomiting have also been reported. Treatment was continued depending on the severity of the undesirable effect observed.
As phenylpropanolamine is a sympathomimetic agent it is possible to produce a wide range of effects, most of which mimic the results of excess stimulation of the sympathetic nervous system (e.g. effects on the heart rate and blood pressure).
Dizziness and restlessness were also occasionally reported.
Hypersensitivity may occur in very rare cases.
Do not use in pregnant or lactating bitches.
Care should be exercised in administering the product with other sympathomimetic drugs, anticholinergic drugs, tricyclic antidepressants or specific type B monoamine oxidase.
For oral administration.
0.8 mg/kg body weight phenylpropanolamine (equivalent to 1 mg/kg phenylpropanolamine HCl) three times daily in the feed, corresponding to 0.1 ml Urilin syrup/5 kg body weight three times daily.
1 drop for every 2.34 kg body weight three times daily in feed.
In healthy dogs, no side effects were observed at up to 5 times the recommended dose. However, an overdose could produce signs of excessive stimulation of the sympathetic nervous system.
Treatment should be symptomatic. α-adrenergic blockers may be appropriate in the case of severe overdose. However, no specific recommendation on drugs or dosages can be given.
Pharmacotherapeutic group: Phenylpropanolamine hydrochloride is a sympathomimetic agent.
ATCvet code: QG04BX91
Sympathetically innervated smooth muscles play a role in urethral closure, and both the α and β receptors are present. The α receptors play a role in urethral closure while β receptors innervate relaxation. The smooth muscle extends to the mid-urethra in females. The clinical effect of phenylpropanolamine is based on its stimulation effects on α-adrenergic receptors. This causes an increase in, and stabilisation of, the closure pressure in the urethra, which is innervated mainly by the adrenergic nerves.
Phenylpropanolamine is a racemic mixture of D and L enantiomers.
In the dog, the mean half-life of phenylpropanolamine is approximately 3 hours with maximal plasma concentrations being found after approximately 4 hours. No accumulation of phenylpropanolamine has been observed after a dose of 1 mg/kg 3 times daily over 15 days.
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Shelf life after first opening the immediate packaging: 3 months.
Do not store above 25°C.
Keep the container in the outer carton.
50 ml or 100 ml amber type III glass bottles containing 45 ml or 100 ml of syrup, with a low density polyethylene dropper and a polypropylene child resistant screw cap.
Not all pack sizes may be marketed.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
Dechra Limited, Snaygill Industrial Estate, Keighley Road, Skipton, North Yorkshire, BD23 2RW, UK.
28 January 2005
For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children.
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Below are some recent questions we've received regarding Urilin Syrup for Dogs, including answers from our team.
I was just wondering if there are any long term effects following an overdose of urilin?
It is very unlikely there would be any long-term effects from this at all, as long as the future dose is correct.
dog is always licking and chewing her bits, drops to the floor and turns like some thing has bitten her bits. she has been to the vets. and has been on this medication for 18 months
This is not a side effect of the medication. Almost certainly the treatment is proving not to be 100% effective and she is tending to leak a little urine periodically, maybe sitting in it. If the skin there is frequently moist with urine then it will feel very sore and she will turn to it when she gets sudden feelings of discomfort as she moves around. I would think that you should explain to your vet that this is happening. Lots of bitches need to be on a full dose 3 times per day for it to be effective. You need to check that she is on the correct amount for her body weight. Alternatively and better still, she could go onto a hormone replacement pill (assuming she has been spayed - most bitches needing this treatment have). There is a tablet called Incurin which is extremely effective for this, especially when combined with Urilin (often at just a half dose). Your vet might also recommend a cream like Fuciderm to be applied to the skin twice daily. This could make it more comfortable very quickly.