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Urilin Syrup for Dogs

Urilin Syrup for Dogs
45ml Bottle

  • 45ml Bottle £14.50
  • 100ml Bottle £29.50

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£14.50 to £29.50

Description

Urilin is used to control the leaking of urine which occurs in some bitches after they have been spayed. It helps to increase the tone of the muscles near the exit to the bladder so that inadvertent passage of urine while at rest is prevented. Urilin is given three times daily at first. Once leaking has stopped, it is sometime possible to gradually reduce the quantity or frequency of the Urilin administered. Urilin is provided in a squeezable plastic bottle and the dose is measured by counting the number of drops which are added to food. One drop of Urilin is required per 2.34kg bodyweight three times daily at the full starting dose.

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Medication Datasheets

45ml Bottle

Urilin® 40 mg/ml Syrup for Dogs

Qualitative and quantitative composition

1 ml contains: Active substance:

Phenylpropanolamine 40.29 mg (equivalent to 50.0 mg phenylpropanolamine hydrochloride)

Excipients: Sodium methyl parahydroxybenzoate (E219) 1.5 mg

Sodium propyl parahydroxybenzoate (E217) 0.15 mg.

Pharmaceutical form

Syrup. Clear viscous solution.

Clinical particulars

Target species

Dogs (bitches).

Indications for use

For the treatment of urinary incontinence associated with acquired urethral sphincter incompetence in the bitch only.

The efficacy of phenylpropanolamine has only been demonstrated in ovariohysterectomised bitches.

Contraindications

Please see Use during pregnancy and lactation.

Do not use in animals treated with non-selective monoamine oxidase inhibitors.

Do not use in cases of known hypersensitivity to the active substance or to any of the excipients.

Special warnings for each target species

It is not appropriate to use the product for the behavioural cause of inappropriate urination.

Special precautions for use in animals

Because phenylpropanolamine is a sympathomimetic agent, it may affect the cardiovascular system, especially blood pressure and heart rate, and therefore should be used with caution in animals with cardiovascular diseases.

Care should be exercised in treating animals with severe renal or hepatic insufficiency, diabetes mellitus, hyperadrenocorticism, glaucoma or other metabolic disorders.

In bitches less than 1 year old the possibility of anatomical disorders contributing to incontinence should be considered prior to treatment.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

People with known hypersensitivity to phenylpropanolamine should avoid contact with the veterinary medicinal product.

Phenylpropanolamine hydrochloride is toxic when overdoses are ingested. Adverse effects may include dizziness, headache, nausea, insomnia or restlessness, and increased blood pressure. High overdose may be fatal, especially in children.

To avoid accidental ingestion, the product must be used and kept out of the sight and reach of children.

Always replace the cap firmly after use to ensure that the child resistant closure operates correctly.

In the event of accidental ingestion, seek immediate medical attention showing the doctor the package leaflet.

Contact with eyes and skin should be avoided.

In the event of accidental skin contact, wash the contaminated area with soap and water. Wash hands after use of the product.

Redness and irritation may develop after eye or skin contact with the product.

In the event of accidental eye contact, rinse the eye with clean water for about 15 minutes and seek medical advice.

Adverse reactions

In some dogs, loose stools, liquid diarrhoea, a decrease in appetite, arrhythmia and collapse have been reported following treatment with phenylpropanolamine. Occasional nausea and vomiting have also been reported. Treatment was continued depending on the severity of the undesirable effect observed.

As phenylpropanolamine is a sympathomimetic agent it is possible to produce a wide range of effects, most of which mimic the results of excess stimulation of the sympathetic nervous system (e.g. effects on the heart rate and blood pressure).

Dizziness and restlessness were also occasionally reported.

Hypersensitivity may occur in very rare cases.

Use during pregnancy and lactation

Do not use in pregnant or lactating bitches.

Interactions

Care should be exercised in administering the product with other sympathomimetic drugs, anticholinergic drugs, tricyclic antidepressants or specific type B monoamine oxidase.

Amounts to be administered and administration route

For oral administration.

0.8 mg/kg body weight phenylpropanolamine (equivalent to 1 mg/kg phenylpropanolamine HCl) three times daily in the feed, corresponding to 0.1 ml Urilin syrup/5 kg body weight three times daily.

1 drop for every 2.34 kg body weight three times daily in feed.

Overdose

In healthy dogs, no side effects were observed at up to 5 times the recommended dose. However, an overdose could produce signs of excessive stimulation of the sympathetic nervous system.

Treatment should be symptomatic. α-adrenergic blockers may be appropriate in the case of severe overdose. However, no specific recommendation on drugs or dosages can be given.

Pharmacological particulars

Pharmacotherapeutic group: Phenylpropanolamine hydrochloride is a sympathomimetic agent.

ATCvet code: QG04BX91

Pharmacodynamic properties

Sympathetically innervated smooth muscles play a role in urethral closure, and both the α and β receptors are present. The α receptors play a role in urethral closure while β receptors innervate relaxation. The smooth muscle extends to the mid-urethra in females. The clinical effect of phenylpropanolamine is based on its stimulation effects on α-adrenergic receptors. This causes an increase in, and stabilisation of, the closure pressure in the urethra, which is innervated mainly by the adrenergic nerves.

Phenylpropanolamine is a racemic mixture of D and L enantiomers.

Pharmacokinetic properties

In the dog, the mean half-life of phenylpropanolamine is approximately 3 hours with maximal plasma concentrations being found after approximately 4 hours. No accumulation of phenylpropanolamine has been observed after a dose of 1 mg/kg 3 times daily over 15 days.

Pharmaceutical particulars

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years.

Shelf life after first opening the immediate packaging: 3 months.

Special precautions for storage

Do not store above 25°C.

Keep the container in the outer carton.

Immediate packaging

50 ml or 100 ml amber type III glass bottles containing 45 ml or 100 ml of syrup, with a low density polyethylene dropper and a polypropylene child resistant screw cap.

Not all pack sizes may be marketed.

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Dechra Limited, Snaygill Industrial Estate, Keighley Road, Skipton, North Yorkshire, BD23 2RW, UK.

Marketing Authorisation Number

Vm 10434/4003

Date of the first authorisation or date of renewal

28 January 2005

Date of revision of the text

August 2015

Any other information

For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children.

Legal category

100ml Bottle

Urilin® 40 mg/ml Syrup for Dogs

Qualitative and quantitative composition

1 ml contains: Active substance:

Phenylpropanolamine 40.29 mg (equivalent to 50.0 mg phenylpropanolamine hydrochloride)

Excipients: Sodium methyl parahydroxybenzoate (E219) 1.5 mg

Sodium propyl parahydroxybenzoate (E217) 0.15 mg.

Pharmaceutical form

Syrup. Clear viscous solution.

Clinical particulars

Target species

Dogs (bitches).

Indications for use

For the treatment of urinary incontinence associated with acquired urethral sphincter incompetence in the bitch only.

The efficacy of phenylpropanolamine has only been demonstrated in ovariohysterectomised bitches.

Contraindications

Please see Use during pregnancy and lactation.

Do not use in animals treated with non-selective monoamine oxidase inhibitors.

Do not use in cases of known hypersensitivity to the active substance or to any of the excipients.

Special warnings for each target species

It is not appropriate to use the product for the behavioural cause of inappropriate urination.

Special precautions for use in animals

Because phenylpropanolamine is a sympathomimetic agent, it may affect the cardiovascular system, especially blood pressure and heart rate, and therefore should be used with caution in animals with cardiovascular diseases.

Care should be exercised in treating animals with severe renal or hepatic insufficiency, diabetes mellitus, hyperadrenocorticism, glaucoma or other metabolic disorders.

In bitches less than 1 year old the possibility of anatomical disorders contributing to incontinence should be considered prior to treatment.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

People with known hypersensitivity to phenylpropanolamine should avoid contact with the veterinary medicinal product.

Phenylpropanolamine hydrochloride is toxic when overdoses are ingested. Adverse effects may include dizziness, headache, nausea, insomnia or restlessness, and increased blood pressure. High overdose may be fatal, especially in children.

To avoid accidental ingestion, the product must be used and kept out of the sight and reach of children.

Always replace the cap firmly after use to ensure that the child resistant closure operates correctly.

In the event of accidental ingestion, seek immediate medical attention showing the doctor the package leaflet.

Contact with eyes and skin should be avoided.

In the event of accidental skin contact, wash the contaminated area with soap and water. Wash hands after use of the product.

Redness and irritation may develop after eye or skin contact with the product.

In the event of accidental eye contact, rinse the eye with clean water for about 15 minutes and seek medical advice.

Adverse reactions

In some dogs, loose stools, liquid diarrhoea, a decrease in appetite, arrhythmia and collapse have been reported following treatment with phenylpropanolamine. Occasional nausea and vomiting have also been reported. Treatment was continued depending on the severity of the undesirable effect observed.

As phenylpropanolamine is a sympathomimetic agent it is possible to produce a wide range of effects, most of which mimic the results of excess stimulation of the sympathetic nervous system (e.g. effects on the heart rate and blood pressure).

Dizziness and restlessness were also occasionally reported.

Hypersensitivity may occur in very rare cases.

Use during pregnancy and lactation

Do not use in pregnant or lactating bitches.

Interactions

Care should be exercised in administering the product with other sympathomimetic drugs, anticholinergic drugs, tricyclic antidepressants or specific type B monoamine oxidase.

Amounts to be administered and administration route

For oral administration.

0.8 mg/kg body weight phenylpropanolamine (equivalent to 1 mg/kg phenylpropanolamine HCl) three times daily in the feed, corresponding to 0.1 ml Urilin syrup/5 kg body weight three times daily.

1 drop for every 2.34 kg body weight three times daily in feed.

Overdose

In healthy dogs, no side effects were observed at up to 5 times the recommended dose. However, an overdose could produce signs of excessive stimulation of the sympathetic nervous system.

Treatment should be symptomatic. α-adrenergic blockers may be appropriate in the case of severe overdose. However, no specific recommendation on drugs or dosages can be given.

Pharmacological particulars

Pharmacotherapeutic group: Phenylpropanolamine hydrochloride is a sympathomimetic agent.

ATCvet code: QG04BX91

Pharmacodynamic properties

Sympathetically innervated smooth muscles play a role in urethral closure, and both the α and β receptors are present. The α receptors play a role in urethral closure while β receptors innervate relaxation. The smooth muscle extends to the mid-urethra in females. The clinical effect of phenylpropanolamine is based on its stimulation effects on α-adrenergic receptors. This causes an increase in, and stabilisation of, the closure pressure in the urethra, which is innervated mainly by the adrenergic nerves.

Phenylpropanolamine is a racemic mixture of D and L enantiomers.

Pharmacokinetic properties

In the dog, the mean half-life of phenylpropanolamine is approximately 3 hours with maximal plasma concentrations being found after approximately 4 hours. No accumulation of phenylpropanolamine has been observed after a dose of 1 mg/kg 3 times daily over 15 days.

Pharmaceutical particulars

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years.

Shelf life after first opening the immediate packaging: 3 months.

Special precautions for storage

Do not store above 25°C.

Keep the container in the outer carton.

Immediate packaging

50 ml or 100 ml amber type III glass bottles containing 45 ml or 100 ml of syrup, with a low density polyethylene dropper and a polypropylene child resistant screw cap.

Not all pack sizes may be marketed.

Disposal

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Marketing Authorisation Holder (if different from distributor)

Dechra Limited, Snaygill Industrial Estate, Keighley Road, Skipton, North Yorkshire, BD23 2RW, UK.

Marketing Authorisation Number

Vm 10434/4003

Date of the first authorisation or date of renewal

28 January 2005

Date of revision of the text

August 2015

Any other information

For animal treatment only. To be supplied only on veterinary prescription. Keep out of the sight and reach of children.

Legal category

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to restrictions aerosols can't be sent by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (9)

Q & A

Below are some recent questions we've received regarding Urilin Syrup for Dogs, including answers from our team.

16 December 2014 at 8:42pm

Long term effects

Amy

I was just wondering if there are any long term effects following an overdose of urilin?

  • Non-Executive Director

It is very unlikely there would be any long-term effects from this at all, as long as the future dose is correct.

23 April 2014 at 9:58pm

What are the side effects, my girl is constantly licking and chewing her lady bits,

dora

dog is always licking and chewing her bits, drops to the floor and turns like some thing has bitten her bits. she has been to the vets. and has been on this medication for 18 months

  • Non-Executive Director

This is not a side effect of the medication. Almost certainly the treatment is proving not to be 100% effective and she is tending to leak a little urine periodically, maybe sitting in it. If the skin there is frequently moist with urine then it will feel very sore and she will turn to it when she gets sudden feelings of discomfort as she moves around. I would think that you should explain to your vet that this is happening. Lots of bitches need to be on a full dose 3 times per day for it to be effective. You need to check that she is on the correct amount for her body weight. Alternatively and better still, she could go onto a hormone replacement pill (assuming she has been spayed - most bitches needing this treatment have). There is a tablet called Incurin which is extremely effective for this, especially when combined with Urilin (often at just a half dose). Your vet might also recommend a cream like Fuciderm to be applied to the skin twice daily. This could make it more comfortable very quickly.