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SILEO (dexmedetomidine oromucosal gel) is an oromucosal gel formulation of dexmedetomidine hydrochloride provided in a 3 mL syringe at a concentration of 0.1 mg/mL. Using the syringe, SILEO is easily administered between the cheek and gum, allowing for transmucosal absorption. Because SILEO is formulated to provide a low dose of dexmedetomidine, the dog remains calm, yet fully functional, and is able to interact normally with the family.
|Bodyweight of dog (kg)||Number of dots|
|2.0 - 5.5||1 °|
|5.6 - 12||2 ° °|
|12.1 - 20||3 ° ° °|
|20.1 - 29||4 ° ° ° °|
|29.1 - 39||5 ° ° ° ° °|
|39.1 - 50||6 ° ° ° ° ° °|
|50.1 - 62.5||7 ° ° ° ° ° ° °|
|62.6 - 75.5||8 ° ° ° ° ° ° ° °|
|75.6 - 89||9 ° ° ° ° ° ° ° ° °|
|89.1 - 100||10 ° ° ° ° ° ° ° ° ° °|
|1. WEAR GLOVES Wear impermeable disposable gloves when handling the veterinary medicinal product and handling the oral gel.|
|2. HOLD PLUNGER Hold the oral syringe so that you can see the dot markings on the oral syringe plunger. Hold the plunger with your left hand.|
|3. UNLOCK Hold the plunger with your left hand and unlock the green ring-stop by turning it towards you until it is able to slide freely.|
|4. MOVE RING Move the ring-stop to the opposite end of the plunger.|
5. LOCK Hold the plunger with your right hand and lock the ring-stop by turning it away from you.
|6. UNLOCK Hold the plunger with your right hand and unlock the ring-stop by turning it towards you. Do not pull the plunger!|
7. MOVE RING Move the ring-stop towards the other end of the plunger for choosing the correct dose based on your veterinarian's prescription.
|8. SET DOSE AND LOCK Position the ring-stop so that the side nearest the barrel is in line with the graduation mark (black line), and the required number of dogs shows between the ring-stop and the barrel. Lock the ring-stop by turning it away from you. Before dosing make sure that the ring-stop is locked.|
|9. PULL CAP (TIGHT) Pull the cap strongly while holding the barrel. Note the cap is very tight (pull, do not twist). Save the cap for replacement.|
|10. DOSE INTO CHEEK Place the oral syringe tip between the dog's cheek and gum and press the plunger until the ring-stop causes the plunger to stop. IMPORTANT: The gel should not be swallowed. If the gel is swallowed, it may not be effective.|
|11. BACK TO PACKAGE Recap the oral syringe and return it to the outer package as the product is sensitive to light. Make sure that the carton is closed properly. Keep the package out of sight and reach of children at all times. Remove and discard gloves.|
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