Rimifin Tablets for Dogs

Rimifin Tablets for Dogs
20mg » Priced per Tablet

  • 20mg » Priced per Tablet £0.29
  • 50mg » Priced per Tablet £0.49
  • 100mg » Priced per Tablet £0.89

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£0.29 to £0.89

Description

Rimifin contains the well known NSAID (non-steroidal anti-inflammatory drug) Carprofen. It is used in dogs to treat degenerative joint disease (osteoarthritis) and other causes of musculo-skeletal pain and inflammation. Rimifin Tablets can also be given after surgical operations to reduce pain and inflammation. Rimifin is given once daily by mouth, preferably with food.

Presentation

A plain round flat bevelled edge white tablet with a breakline on one side.

Each Rimifin 20mg Tablets for Dogs contains carprofen 20mg

Each Rimifin 50mg Tablets for Dogs contains carprofen 50mg

Each Rimifin 100mg Tablets for Dogs contains carprofen 100mg

Uses

Reduction of inflammation and pain caused by musculo-skeletal disorders and degenerative joint disease. As a follow up to parenteral analgesia in the management of post-operative pain following soft tissue surgery.

Dosage and administration

For oral administration.

4mg carprofen per kg bodyweight per day.

An initial dose of 4mg carprofen per kg bodyweight given as a single daily dose or in two equally divided doses may, subject to clinical response, be reduced after 7 days to 2mg carprofen/kg bodyweight/day given as a single dose.

Duration of treatment will be dependant upon the response seen. Long term treatment should be under regular veterinary supervision.

To extend analgesic and anti-inflammatory cover post-operatively, parenteral preoperative treatment may be followed with Carprofen tablets at 4mg/kg/day for 2 days as required. Do not exceed the stated dose.

Contra-indications, warnings, etc

Do not use in cats.

Do not use in case of hypersensitivity to active substance or to any of the excipients.

Do not use in dogs suffering from cardiac, hepatic or renal disease, where there is a possibility of gastro-intestinal ulceration or bleeding, or where there is evidence of a blood dyscrasia.

Special precautions for use in animals

Use in dogs less than 6 weeks of age, or in aged dogs, may involve additional risk.

If such a use cannot be avoided, dogs may require careful clinical management.

Avoid use in any dehydrated, hypovolaemic or hypotensive dog, as there is a potential risk of increased renal toxicity.

Concurrent administration of potential nephrotoxic drugs should be avoided. NSAIDs can cause inhibition of phagocytosis and hence in the treatment of inflammatory conditions associated with bacterial infection, appropriate concurrent antimicrobial therapy should be instigated. Do not administer other NSAIDs concurrently or within 24 hours of each other. Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs, which can lead to toxic effects.

Special precautions to be taken by the person administering the product to animals

In the event or accidental ingestion of the tablets, seek medical advice and show the doctor the package leaflet. Wash hands after handling the product.

Adverse reactions (Frequency and Seriousness)

Typical undesirable effects associated with NSAIDs, such as vomiting, soft faeces/diarrhoea, faecal occult blood, loss of appetite and lethargy have been reported. These adverse reactions occur generally within the first treatment week and are in most cases transient and disappear following termination of the treatment but in very rare cases may be serious or fatal. If adverse reactions occur, use of the product should be stopped and the advice of a veterinarian should be sought. As with other NSAIDs there is a risk of rare renal or idiosyncratic hepatic adverse events.

Use during pregnancy or lactation

Studies in laboratory species (rat and rabbit) have shown evidence of foetotoxic effects of carprofen at doses close to the therapeutic dose. The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Do not use in pregnant or lactating bitches.

Interaction with other medicinal products and other forms of interaction

Carprofen must not be administered with glucocorticoids. Refer also to special precautions for use in animals.

Overdose (symptoms, emergency procedures, antidotes) (if necessary)

No signs of toxicity appeared when dogs were treated with carprofen at levels up to 6 mg/kg twice daily for 7 days (3 times the recommended dose rate of 4mg/kg) and 6mg/kg once daily for a further 7 days. (1.5 times the recommended dose rate of 4 mg/kg).There is no specific antidote for carprofen overdosage but general supportive therapy, as applied to clinical overdosage with NSAIDs should be applied.

Withdrawal period(s)

Not applicable

Pharmaceutical precautions

Shelf-life of the veterinary medicinal product as packaged for sale is 3 years. Any divided and unused tablets should be discarded immediately.

Store in a dry place in the original package. Protect from light.

Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.

Legal category

POM-V

Packaging Quantities

Blister packs made up of a PVC/PVdC (250 µm/40g/m2) with a 20mu Hard Temper Aluminium Foil.

Pack size: 200 tablets: A box of 20 blisters. Each blister contains 10 tablets

Further information

Pharmacotherapeutic group: Non-steroidal anti-inflammatory drug. ATC Vet Code: QM01AE91.

Pharmacodynamic Properties

Carprofen is a member of the 2-arylpropionic acid group of non-steroidal anti-inflammatory drugs (NSAIDs), and possesses anti-inflammatory, analgesic and antipyretic activity. Carprofen is a chiral drug with the S(+) enantiomer being more active than the R(-) enantiomer. Carprofen, like most other NSAIDs is an inhibitor of the enzyme cyclo-oxygenase of the arachidonic acid cascade. However, the inhibition of prostaglandin synthesis by carprofen is slight in relation to its anti-inflammatory and analgesic potency. The precise mode of action of carprofen is not clear.

Pharmacokinetic particulars

After oral administration, carprofen is well absorbed in the dog. Following the administration of Rimifin tablets in dogs, a mean Cmax (maximum concentration in serum) of 15.8 µg/ml and 12.2 µg/ml was achieved at approximately 2 hours and 1.7 hours for Carprofen R(-) and Carprofen S(+), respectively. For both enantiomers, the mean half-life was approximately 6 hours. The analgesic effect from each dose persists for at least 12 hours.

Carprofen has a small volume of distribution and a low systemic clearance. It is highly bound to plasma protein. Carprofen is metabolised in the liver by conjugation and oxidation. The excretion of the glycuronide conjugate is mainly faecal after biliary excretion.

Marketing Authorisation Holder (if different from distributor)

Chanelle Pharmaceuticals Manufacturing Limited

Loughrea

Co. Galway

Ireland

Marketing authorisation number

Rimifin Tablets 20mg Vm 08749/4006.

Rimifin Tablets 50mg Vm 08749/4007.

Rimifin Tablets 100mg Vm 08749/4008.

GTIN (Global Trade Item No)

Rimifin 20 mg

05099299022454

Rimifin 50 mg

05099299022461

Rimifin 100 mg

05099299022478

Need help or advice? Contact us:

  • Landline: 01582 842096
  • Mon - Fri: 8:30am - 5:00pm
  • Sat: 9:00am - 1:00pm
  • Email: [email protected]

All prices include VAT where applicable.

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to air freight restrictions aerosols cannot ever be sent abroad by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

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