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PropoFlo Plus
5 x 20ml Bottle

  • 5 x 20ml Bottle £37.49
  • 20ml Bottle £7.49

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Description

This product is sourced in the United Kingdom and is intended for use in the United Kindgom only.

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PropoFlo Plus 10 mg/ml emulsion for injection for dogs & cats

Species: Cats, Dogs Therapeutic indication: Pharmaceuticals: Neurological preparations: General anaesthetics Active ingredient: Propofol Product:PropoFlo® Plus Product index: PropoFlo Plus

Presentation

PropoFlo Plus is a white emulsion for injection containing 10 mg/ml propofol and 20 mg/ml benzyl alcohol (E1519) as excipient.

Uses

Indicated for therapeutic use in dogs and cats as a short acting, intravenous general anaesthetic with a short recovery period: For procedures of short duration, lasting up to approximately 5 minutes. For induction of general anaesthesia where maintenance is provided by inhalation anaesthetic agents. For induction and short-term maintenance of general anaesthesia by administration of incremental doses of the product to effect for approximately half an hour (30 minutes), not to exceed the total dose stated below.

Dosage and administration

The veterinary medicinal product is a sterile product for intravenous administration.

General handling procedures

Prior to use, the product should be inspected visually for absence of particulate matter and discolouration and discarded if present. Shake the vial gently but thoroughly before opening.

Dosage for induction by PropoFlo Plus

The induction dose is calculated according to bodyweight and may be administered to effect over a period of 10-40 seconds. The use of pre-anaesthetic drugs may markedly reduce propofol requirements. As with other sedative hypnotic agents, the amount of opioid, a‑2 agonist and/or benzodiazepine premedication will influence the response of the patient to an induction dose of the product. Where animals have been premedicated with an a‑2 agonist such as medetomidine, the dose of propofol (as with any other intravenous anaesthetic agent) should be reduced by up to 85% (e.g. from 6.5 mg/kg for unpremedicated dogs to 1.0 mg/kg for dogs premedicated with an a‑2 agonist). The average induction dose for dogs and cats, either unpremedicated or when premedicated with a non‑a‑2 agonist tranquilliser such as acepromazine, is given in the following table. These doses are for guidance only; the actual dose should be based on the response of the particular animal.

Dose mg/kg bodyweight Dose volume ml/kg bodyweight
DOGS
Unpremedicated 6.5 mg/kg 0.65 ml/kg
Premedicated
- with non-α-2 agonist 4.0 mg/kg 0.40 ml/kg
- with an α-2 agonist 1.0 mg/kg 0.10 ml/kg
CATS
Unpremedicated 8.0 mg/kg 0.80 ml/kg
Premedicated
- with non-α-2 agonist 6.0 mg/kg 0.60 ml/kg
- with an α-2 agonist 1.2 mg/kg 0.12 ml/kg

Dosage for maintenance by PropoFlo Plus

When anaesthesia is maintained by incremental injections, the dose rate will vary between animals. Administer incremental doses of the product to effect by giving small doses of around 0.1 ml/kg bodyweight (1.0 mg/kg bodyweight) of the induction dose when anaesthesia becomes too light. These doses may be repeated as often as required, allowing 20-30 seconds to assess the effect before further increments are given. Experience has shown that doses of approximately 1.25-2.5 mg (0.125-0.25 ml) per kg bodyweight sustain anaesthesia for periods of up to 5 minutes. Continuous and prolonged exposure (greater than 30 minutes) may lead to slower recovery, particularly in cats.

Maintenance by inhalation agents

When inhalation agents are used to maintain general anaesthesia, experience indicates that it may be necessary to use a higher initial concentration of the inhalant anaesthetic than is usually required following induction with barbiturate agents such as thiopentone.

Contra-indications, warnings, etc

Do not use for prolonged infusion (see below). Do not exceed a total dose in one anaesthetic episode of 24 mg/kg (2.4 ml/kg) of propofol in cats or dogs. This product should not be used for induction and maintenance of general anaesthesia by incremental doses that would exceed total dose limits specified above, due to the potential for toxic effects caused by the preservative, benzyl alcohol. Do not use in animals with known hypersensitivity to the active substance or to any of the excipients. This product is a stable emulsion; discard the vial if phase separation is observed. Shake the vial gently but thoroughly before withdrawing a dose. If this product is injected very slowly, an inadequate plane of anaesthesia can occur. During induction of anaesthesia in any species, mild hypotension and transient apnoea, similar to effects with other intravenous anaesthetic agents, may occur. Apnoea is most likely to occur within the first 5 minutes of administration of the product and must be treated with oxygen and artificial ventilation. Whenever the product is used, facilities for the maintenance of a patent airway, artificial ventilation and oxygen supplementation must be immediately available. As with other intravenous anaesthetic agents, caution should be exercised in dogs and cats with cardiac, respiratory, renal or hepatic impairment, or in hypovolaemic or debilitated animals. The safety of this product has not been established in dogs or cats younger than 5 months and should be used in these animals only according to the risk/benefit assessment by the responsible veterinarian. Use aseptic techniques when administering the product. Side effects during induction, maintenance and recovery are uncommon. As with other anaesthetic agents, the possibility of respiratory or cardiovascular depression should be considered. During induction of anaesthesia, mild hypotension and transient apnoea may occur. Induction is generally smooth, with occasional evidence of excitation (paddling of limbs, nystagmus, focal muscle twitching, opisthotonus). During the recovery phase, vomiting and excitation have been observed in a small proportion of animals. In clinical trials in cats and dogs, transient apnoea has been observed during induction. In cats sneezing, occasional retching and a paw/face licking characteristic during recovery have been observed in a small proportion of cases. If panting is evident before induction, it may continue throughout the subsequent periods of anaesthesia and recovery. Inadvertent perivascular administration rarely causes local tissue reactions. Repeated anaesthesia with propofol in cats may cause oxidative injury and Heinz body production. Recovery may also become prolonged. Limiting repeated anaesthesia to intervals of more than 48 hours will reduce the likelihood. The safety of this product in foetuses/neonates and during lactation has not been established. In humans parenterally administered benzyl alcohol has been associated with a fatal toxic syndrome in preterm neonates.

Pregnancy

Use only according to the risk/benefit assessment by the responsible veterinarian.

Lactation

Use only according to the risk/benefit assessment by the responsible veterinarian. Accidental overdosage is likely to cause cardio‑respiratory depression. Overdose is likely to cause apnoea. In cases of respiratory depression, stop drug administration, establish a patent airway, and initiate assisted or controlled ventilation with pure oxygen. Cardiovascular depression should be treated with plasma expanders, pressor agents, anti-arrhythmic agents or other techniques as appropriate for the observed abnormality. Propofol: A single dose of 19.5 mg/kg (1.95 ml/kg) in dogs and bolus and intermittent doses totalling 24 mg/kg (2.4 ml/kg) in cats did not cause harm. Bolus and intermittent doses totalling 38.6 mg/kg (3.9 ml/kg) produced paraesthesia in one of four cats and prolonged recovery in all four cats treated. Benzyl Alcohol (preservative): Benzyl alcohol toxicity may lead to prolonged recovery and hyperkinesia in cats, and neurological signs such as tremors in dogs and fatalities in both species. There is no specific antidote; supportive treatment should be given. In dogs, lethal doses of benzyl alcohol could result from administration of the maximum total dose of propofol stated above, every hour for 9 hours, based on pharmacokinetic modelling and literature reports. In cats, lethal doses of benzyl alcohol could occur within 6.5 hours of administration, based on literature reports, direct estimation and maintenance dose rates.

User warnings

People with known hypersensitivity to any of the ingredients should avoid contact with the veterinary medicinal product. This veterinary medicinal product is a potent drug, exercise caution to avoid accidental self-injection. Preferably use a guarded needle until the moment of injection. In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician. Advice to the doctor: do not leave the patient unattended. Maintain airways and give symptomatic and supportive treatment. In case of splashes on the skin or in the eyes, wash off immediately.

Pharmaceutical precautions

No special storage conditions required. Do not freeze. Keep the vial in the outer carton. Shelf-life after first opening the immediate packaging: 28 days. Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements. In the absence of compatibility studies, this veterinary medicinal product must not be mixed with any other veterinary medicinal products. Keep out of the sight and reach of children. For animal treatment only.

Legal category

Legal category: POM-V

Packaging quantities

Supplied in 20 ml (5 vials per carton) or 50 ml (1 vial per carton) Type 1 glass vials. Not all pack sizes may be marketed.

Further information

Propofol has been used after premedication with commonly used premedicants, e.g. atropine, acepromazine, diazepam, α‑2 adrenoceptor agents, prior to maintenance with inhalational agents, e.g. halothane, nitrous oxide, sevoflurane, isoflurane and prior to administration of analgesic agents, e.g. pethidine, buprenorphine. No pharmacological incompatibility has been encountered. The concurrent use of sedative or analgesic drugs is likely to reduce the dose of PropoFlo Plus required to produce and maintain anaesthesia.

Marketing Authorisation Number

Vm 42058/4199

GTIN

GTIN description:5 x 20 ml: GTIN:05414736031323

Need help or advice? Contact us:

  • Landline: 01582 842096
  • Mon - Fri: 8:30am - 5:00pm
  • Sat: 9:00am - 1:00pm (Collections only)
  • Email: [email protected]

All prices include VAT where applicable.

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to air freight restrictions aerosols cannot ever be sent abroad by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 842096. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

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